5BQNA

Crystal structure of the lhn fragment of botulinum neurotoxin type d, mutant h233y e230q
Total Genus 271
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
271
sequence length
871
structure length
838
Chain Sequence
MTWPVKDFNYSDPVNDNDILYLRIPQNKLITTPVKAFMITQNIWVIPERFSSDTNPSLSKPPRPTSKYQSYYDPSYLSTDEQKDTFLKGIIKLFKRINERDIGKKLINYLVVGSPFMGDSSTPEDTFDFTRHTTNIAVEKFENGSWKVTNIITPSVLIFGPLPNILDYTASLTLQGQQSNPSFEGFGTLSILKVAPEFLLTFSDVTSNQSSAVLGKSIFCMDPVIALMHQLTYSLHQLYGINIPSDKRIRPQVSEGFFSQDGPNVQFEELYTFGGLDVEIIPQIERSQLREKALGHYKDIAKRLNNINKTIPSSWISNIDKYKKIFSEKYNFDKDNTGNFVVNIDKFNSLYSDLTNVMSEVVYSSQYNVKNRTHYFSRHYLPVFANILDDNIYTIRDGFNLTNKGFNIENSGQNIERNPALQKLSSESVVDLFTKVCVDKSLQCIKVKNNRLPYVADKDSISQEIFENKIITDETNVVPINPEIVDPLLPNVNMEPLNLPGEEIVFYDDITKYVDYLNSYYYLESQKLSNNVENITLTTSVEEALGYSNKIYTFLPSLAEKVNKGVQAGLFLNWANEVVEDFTTNIMKKDTLDKISDVSVIIPYIGPALNIGNSALRGNFNQAFATAGVAFLLEGFPEFTIPALGVFTFYSSIQEREKIIKTIENCLEQRVKRWKDSYQWMVSNWLSRITTQFNHINYQMYDSLSYQADAIKAKIDLEYKKYSGSDKENIKSQVENLKNSLDVKISEAMNNINKFIRECSVTYLFKNMLPKVIDELNKFDLRTKTELINLIDSHNIILVGEVDRLKAKVNESFENTMPFNIFSYTNNSLLKDIINEYF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type D,Botulinum neurotoxin type D
total genus 271
structure length 838
sequence length 871
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2015-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
A PF07952 Toxin_trans Clostridium neurotoxin, Translocation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1120.10 Mainly Alpha Up-down Bundle Clostridium botulinum neurotoxin B, "coiled-coil" domain Clostridium botulinum neurotoxin b, "coiled-coil" domain 5bqnA02
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 5bqnA01
3BWIA 4ZKTB 3C8AA 1T3AA 1ZKXA 3C8BA 2FPQA 3V0BB 4HEVA 4ELCA 3C89A 3QW8A 4J1LA 1ZL6A 1G9DA 1S0EA 1G9BA 2W2DA 1F31A 2NYYA 2ILPA 2G7PA 3C88A 4KTXA 3NF3A 3K3QB 3BONA 4EL4A 2IMCA 5BQMA 1ZN3A 2QN0A 3QIZA 3FFZA 1S0FA 1ZB7A 5BQNA 2G7NA 3ZURA 3BOOA 3V0AB 2W2DB 1E1HA 3QW7A 1S0BA 3QW6A 1Z7HA 3V0BA 2ETFA 3FIEA 1T3CA 1G9AA 1S0DA 5BQMB 3BTAA 1ZL5A 1G9CA 1I1EA 2G7KA 1EPWA 2XHLA 2A97A 1S0GA 4EJ5A 3DEBA 2ISHA 1YVGA 3ZUSA 2NP0A 3QIXA 3DDAA 2NZ9A 3VUOA 1XTGA 4ZJXA 3QIYA 1S0CA 2IMAA 3QW5A 1ZKWA 3QJ0A 4KS6A 2ISGA 3DDBA 3BOKA 3D3XA 3ZUQA 4KUFA 3V0AA 2XHLB 1F82A 3FIIA 2G7QA 3DS9A 2ISEA 1XTFA 2IMBA 2A8AA 3DSEA
chains in the Genus database with same CATH superfamily
3BWIA 4ZKTB 3C8AA 1T3AA 1ZKXA 3C8BA 2FPQA 3V0BB 4HEVA 4ELCA 3C89A 3QW8A 4J1LA 1ZL6A 1G9DA 1S0EA 1G9BA 2W2DA 1F31A 2NYYA 2YPTA 2ILPA 2G7PA 3C88A 4KTXA 3NF3A 3K3QB 3BONA 4EL4A 2IMCA 5BQMA 1ZN3A 2QN0A 3QIZA 3FFZA 1S0FA 1ZB7A 5BQNA 2G7NA 3ZURA 3BOOA 3V0AB 2W2DB 4JIUA 1E1HA 3QW7A 1S0BA 3QW6A 1Z7HA 3V0BA 2ETFA 3FIEA 1T3CA 1G9AA 1S0DA 5BQMB 3BTAA 1ZL5A 3CQBA 1G9CA 1I1EA 2G7KA 1EPWA 2XHLA 2A97A 1S0GA 4EJ5A 3DEBA 2ISHA 1YVGA 3ZUSA 2EJQA 2NP0A 3QIXA 3DDAA 2NZ9A 3VUOA 4QHFA 1XTGA 4ZJXA 3QIYA 1S0CA 2IMAA 3QW5A 1ZKWA 3QJ0A 4KS6A 2ISGA 3DDBA 4JIXA 3BOKA 4IL3A 3D3XA 3ZUQA 4KUFA 3V0AA 2XHLB 1F82A 3FIIA 2G7QA 3DS9A 2ISEA 3E11A 1XTFA 2IMBA 2A8AA 3DSEA 4AW6A
chains in the Genus database with same CATH topology
3BWIA 4ZKTB 3C8AA 1T3AA 1ZKXA 3C8BA 2FPQA 3V0BB 4HEVA 4ELCA 3C89A 3QW8A 4J1LA 1ZL6A 1G9DA 1S0EA 1G9BA 2W2DA 1F31A 2NYYA 2ILPA 2G7PA 3C88A 4KTXA 3NF3A 3K3QB 3BONA 4EL4A 2IMCA 5BQMA 1ZN3A 2QN0A 3QIZA 3FFZA 1S0FA 1ZB7A 5BQNA 2G7NA 3ZURA 3BOOA 3V0AB 2W2DB 1E1HA 3QW7A 1S0BA 3QW6A 1Z7HA 3V0BA 2ETFA 3FIEA 1T3CA 1G9AA 1S0DA 5BQMB 3BTAA 1ZL5A 1G9CA 1I1EA 2G7KA 1EPWA 2XHLA 2A97A 1S0GA 4EJ5A 3DEBA 2ISHA 1YVGA 3ZUSA 2NP0A 3QIXA 3DDAA 2NZ9A 3VUOA 1XTGA 4ZJXA 3QIYA 1S0CA 2IMAA 3QW5A 1ZKWA 3QJ0A 4KS6A 2ISGA 3DDBA 3BOKA 3D3XA 3ZUQA 4KUFA 3V0AA 2XHLB 1F82A 3FIIA 2G7QA 3DS9A 2ISEA 1XTFA 2IMBA 2A8AA 3DSEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BWI A;  4ZKT B;  3C8A A;  1T3A A;  1ZKX A;  3C8B A;  2FPQ A;  3V0B B;  4HEV A;  4ELC A;  3C89 A;  3QW8 A;  4J1L A;  1ZL6 A;  1G9D A;  1S0E A;  1G9B A;  2W2D A;  1F31 A;  2NYY A;  2ILP A;  2G7P A;  3C88 A;  4KTX A;  3NF3 A;  3K3Q B;  3BON A;  4EL4 A;  2IMC A;  5BQM A;  1ZN3 A;  2QN0 A;  3QIZ A;  3FFZ A;  1S0F A;  1ZB7 A;  5BQN A;  2G7N A;  3ZUR A;  3BOO A;  3V0A B;  2W2D B;  1E1H A;  3QW7 A;  1S0B A;  3QW6 A;  1Z7H A;  3V0B A;  2ETF A;  3FIE A;  1T3C A;  1G9A A;  1S0D A;  5BQM B;  3BTA A;  1ZL5 A;  1G9C A;  1I1E A;  2G7K A;  1EPW A;  2XHL A;  2A97 A;  1S0G A;  4EJ5 A;  3DEB A;  2ISH A;  1YVG A;  3ZUS A;  2NP0 A;  3QIX A;  3DDA A;  2NZ9 A;  3VUO A;  1XTG A;  4ZJX A;  3QIY A;  1S0C A;  2IMA A;  3QW5 A;  1ZKW A;  3QJ0 A;  4KS6 A;  2ISG A;  3DDB A;  3BOK A;  3D3X A;  3ZUQ A;  4KUF A;  3V0A A;  2XHL B;  1F82 A;  3FII A;  2G7Q A;  3DS9 A;  2ISE A;  1XTF A;  2IMB A;  2A8A A;  3DSE A; 
#chains in the Genus database with same CATH topology
 3BWI A;  4ZKT B;  3C8A A;  1T3A A;  1ZKX A;  3C8B A;  2FPQ A;  3V0B B;  4HEV A;  4ELC A;  3C89 A;  3QW8 A;  4J1L A;  1ZL6 A;  1G9D A;  1S0E A;  1G9B A;  2W2D A;  1F31 A;  2NYY A;  2YPT A;  2ILP A;  2G7P A;  3C88 A;  4KTX A;  3NF3 A;  3K3Q B;  3BON A;  4EL4 A;  2IMC A;  5BQM A;  1ZN3 A;  2QN0 A;  3QIZ A;  3FFZ A;  1S0F A;  1ZB7 A;  5BQN A;  2G7N A;  3ZUR A;  3BOO A;  3V0A B;  2W2D B;  4JIU A;  1E1H A;  3QW7 A;  1S0B A;  3QW6 A;  1Z7H A;  3V0B A;  2ETF A;  3FIE A;  1T3C A;  1G9A A;  1S0D A;  5BQM B;  3BTA A;  1ZL5 A;  3CQB A;  1G9C A;  1I1E A;  2G7K A;  1EPW A;  2XHL A;  2A97 A;  1S0G A;  4EJ5 A;  3DEB A;  2ISH A;  1YVG A;  3ZUS A;  2EJQ A;  2NP0 A;  3QIX A;  3DDA A;  2NZ9 A;  3VUO A;  4QHF A;  1XTG A;  4ZJX A;  3QIY A;  1S0C A;  2IMA A;  3QW5 A;  1ZKW A;  3QJ0 A;  4KS6 A;  2ISG A;  3DDB A;  4JIX A;  3BOK A;  4IL3 A;  3D3X A;  3ZUQ A;  4KUF A;  3V0A A;  2XHL B;  1F82 A;  3FII A;  2G7Q A;  3DS9 A;  2ISE A;  3E11 A;  1XTF A;  2IMB A;  2A8A A;  3DSE A;  4AW6 A; 
#chains in the Genus database with same CATH homology
 3BWI A;  4ZKT B;  3C8A A;  1T3A A;  1ZKX A;  3C8B A;  2FPQ A;  3V0B B;  4HEV A;  4ELC A;  3C89 A;  3QW8 A;  4J1L A;  1ZL6 A;  1G9D A;  1S0E A;  1G9B A;  2W2D A;  1F31 A;  2NYY A;  2ILP A;  2G7P A;  3C88 A;  4KTX A;  3NF3 A;  3K3Q B;  3BON A;  4EL4 A;  2IMC A;  5BQM A;  1ZN3 A;  2QN0 A;  3QIZ A;  3FFZ A;  1S0F A;  1ZB7 A;  5BQN A;  2G7N A;  3ZUR A;  3BOO A;  3V0A B;  2W2D B;  1E1H A;  3QW7 A;  1S0B A;  3QW6 A;  1Z7H A;  3V0B A;  2ETF A;  3FIE A;  1T3C A;  1G9A A;  1S0D A;  5BQM B;  3BTA A;  1ZL5 A;  1G9C A;  1I1E A;  2G7K A;  1EPW A;  2XHL A;  2A97 A;  1S0G A;  4EJ5 A;  3DEB A;  2ISH A;  1YVG A;  3ZUS A;  2NP0 A;  3QIX A;  3DDA A;  2NZ9 A;  3VUO A;  1XTG A;  4ZJX A;  3QIY A;  1S0C A;  2IMA A;  3QW5 A;  1ZKW A;  3QJ0 A;  4KS6 A;  2ISG A;  3DDB A;  3BOK A;  3D3X A;  3ZUQ A;  4KUF A;  3V0A A;  2XHL B;  1F82 A;  3FII A;  2G7Q A;  3DS9 A;  2ISE A;  1XTF A;  2IMB A;  2A8A A;  3DSE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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