5BW2A

X-ray crystal structure of aplysia californica acetylcholine binding protein (ac-achbp) y55w in complex with 2-pyridin-3-yl-1-aza-bicyclo[2.2.2]octane; 2-(3-pyridyl)quinuclidine; 2-pq (ti-4699)
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
212
structure length
211
Chain Sequence
DKLHSQANLMRLKSDLFNRSMYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs
rcsb
molecule tags Acetylcholine binding protein
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 52
structure length 211
sequence length 212
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2015-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5bw2A00
3C84A 4ZJTA 4D01A 4TWHA 2XQ3A 3TLWA 4ILBA 1UX2A 3TLVA 2XQ8A 2VL0A 4TWFA 4UXUA 3P4WA 4HQPA 1I9BA 4UM1A 4XHEA 5L4HA 4ZZBA 2PH9A 4PIRA 3IGQA 2XQ7A 3SQ9A 4HFHA 5AINA 5LXBA 4ZR6A 2Y56A 1UV6A 3PMZA 4NPPA 2XZ5A 2XQ4A 2Y54A 4HFEA 4UM3P 3RIAA 4IL4A 3WTMA 4UM3S 2W8GA 2WNLA 5KZUA 2BYQA 4AFHA 4QAAA 5JMEA 5CO5A 5HEJA 4QACA 3UU6A 3C79A 3LSVA 2XZ6A 4LMKA 3UQ4A 4HFBA 3UU5A 3WTOA 3UU3A 5BP0A 5HCJA 3UUBA 3WTNA 5J0ZA 2WN9A 4WV9A 2BG9E 2WZYA 2XNUA 2YMDA 3GUAA 4FRRA 4LMJA 4COFA 5J5FA 5AFHA 3U8NA 3WTJA 5AFKA 5HEOA 4ZZCA 2BR7A 2Y58A 5SYOA 2XNVA 3JAFA 2BG9A 3RIFA 4TNVA 2UZ6A 3U8KA 4IL9A 2XYSA 4Z90A 4HFIA 4QH1A 4AFGA 2PGZA 4AFTA 4ALXA 2X00D 2W8FA 4IREA 2XNTA 4LMLA 3WIPA 5AFLA 2BYPA 4A98A 3RI5A 3RQUA 2Y57A 5FJVA 5AFJA 4B5DA 4NZBA 4QABA 5J5HA 4UY2A 4XK9A 5HEGA 4A97A 4BFQA 5J5IA 2BYSA 3WTHA 3JADA 2Y7YA 2ZJUA 2YMEA 4TWDA 4HFCA 5AFNA 3TLUA 2BYRA 3ZKRA 2YN6A 4HFDA 2X00A 2BG9B 4QH5A 2XQ9A 3RQWA 2C9TA 5CFBA 4TNWA 4X5TA 3TLSA 5AFMA 1UW6A 3T4MA 3EI0A 2WNJA 3SIOA 3P50A 2YKSA 3EAMA 2XYTA 4BQTA 4ZK4A 5L4EA 2XQAA 3WTKA 5IUXA 3UQ7A 2XQ5A 3ZDGA 4EZ1A 2ZJVA 5BW2A 3RHWA 5KE4A 3UU8A 5HCMA 3SQ6A 2BJ0A 5J5GA 4QH4A 5TVCA 3SH1A 4DBMA 4UM3A 3EHZA 4ILCA 2QC1B 4F8HA 3PEOA 5LG3A 2BR8A 3JAEA 4ZK1A 5L47A 5BRXA 4ZRUA 3ZDHA 2WNCA 5AFMB 3WTIA 3TLTA 3U8MA 3UU4A 2XQ6A 2BG9C 2BYNA 4ZJSA 3U8LA 3WTLA 4Z91A 5HEHA 3U8JA 5HEUA 2YOEA 4ILAA
chains in the Genus database with same CATH superfamily
3C84A 4ZJTA 4D01A 4TWHA 2XQ3A 3TLWA 4ILBA 1UX2A 3TLVA 2XQ8A 2VL0A 4TWFA 4UXUA 3P4WA 4HQPA 1I9BA 4UM1A 4XHEA 5L4HA 4ZZBA 2PH9A 4PIRA 3IGQA 2XQ7A 3SQ9A 4HFHA 5AINA 5LXBA 4ZR6A 2Y56A 1UV6A 3PMZA 4NPPA 2XZ5A 2XQ4A 2Y54A 4HFEA 4UM3P 3RIAA 4IL4A 3WTMA 4UM3S 2W8GA 2WNLA 5KZUA 2BYQA 4AFHA 4QAAA 5JMEA 5CO5A 5HEJA 4QACA 3UU6A 3C79A 3LSVA 2XZ6A 4LMKA 3UQ4A 4HFBA 3UU5A 3WTOA 3UU3A 5BP0A 5HCJA 3UUBA 3WTNA 5J0ZA 2WN9A 4WV9A 2BG9E 2WZYA 2XNUA 2YMDA 3GUAA 4FRRA 4LMJA 4COFA 5J5FA 5AFHA 3U8NA 3WTJA 5AFKA 5HEOA 4ZZCA 2BR7A 2Y58A 5SYOA 2XNVA 3JAFA 2BG9A 3RIFA 4TNVA 2UZ6A 3U8KA 4IL9A 2XYSA 4Z90A 4HFIA 4QH1A 4AFGA 2PGZA 4AFTA 4ALXA 2X00D 2W8FA 4IREA 2XNTA 4LMLA 3WIPA 5AFLA 2BYPA 4A98A 3RI5A 3RQUA 2Y57A 5FJVA 5AFJA 4B5DA 4NZBA 4QABA 5J5HA 4UY2A 4XK9A 5HEGA 4A97A 4BFQA 5J5IA 2BYSA 3WTHA 3JADA 2Y7YA 2ZJUA 2YMEA 4TWDA 4HFCA 5AFNA 3TLUA 2BYRA 3ZKRA 2YN6A 4HFDA 2X00A 2BG9B 4QH5A 2XQ9A 3RQWA 2C9TA 5CFBA 4TNWA 4X5TA 3TLSA 5AFMA 1UW6A 3T4MA 3EI0A 2WNJA 3SIOA 3P50A 2YKSA 3EAMA 2XYTA 4BQTA 4ZK4A 5L4EA 2XQAA 3WTKA 5IUXA 3UQ7A 2XQ5A 3ZDGA 4EZ1A 2ZJVA 5BW2A 3RHWA 5KE4A 3UU8A 5HCMA 3SQ6A 2BJ0A 5J5GA 4QH4A 5TVCA 3SH1A 4DBMA 4UM3A 3EHZA 4ILCA 2QC1B 4F8HA 3PEOA 5LG3A 2BR8A 3JAEA 4ZK1A 5L47A 5BRXA 4ZRUA 3ZDHA 2WNCA 5AFMB 3WTIA 3TLTA 3U8MA 3UU4A 2XQ6A 2BG9C 2BYNA 4ZJSA 3U8LA 3WTLA 4Z91A 5HEHA 3U8JA 5HEUA 2YOEA 4ILAA
chains in the Genus database with same CATH topology
3C84A 4ZJTA 4D01A 4TWHA 2XQ3A 3TLWA 4ILBA 1UX2A 3TLVA 2XQ8A 2VL0A 4TWFA 4UXUA 3P4WA 4HQPA 1I9BA 4UM1A 4XHEA 5L4HA 4ZZBA 2PH9A 4PIRA 3IGQA 2XQ7A 3SQ9A 4HFHA 5AINA 5LXBA 4ZR6A 2Y56A 1UV6A 3PMZA 4NPPA 2XZ5A 2XQ4A 2Y54A 4HFEA 4UM3P 3RIAA 4IL4A 3WTMA 4UM3S 2W8GA 2WNLA 5KZUA 2BYQA 4AFHA 4QAAA 5JMEA 5CO5A 5HEJA 4QACA 3UU6A 3C79A 3LSVA 2XZ6A 4LMKA 3UQ4A 4HFBA 3UU5A 3WTOA 3UU3A 5BP0A 5HCJA 3UUBA 3WTNA 5J0ZA 2WN9A 4WV9A 2BG9E 2WZYA 2XNUA 2YMDA 3GUAA 4FRRA 4LMJA 4COFA 5J5FA 5AFHA 3U8NA 3WTJA 5AFKA 5HEOA 4ZZCA 2BR7A 2Y58A 5SYOA 2XNVA 3JAFA 2BG9A 3RIFA 4TNVA 2UZ6A 3U8KA 4IL9A 2XYSA 4Z90A 4HFIA 4QH1A 4AFGA 2PGZA 4AFTA 4ALXA 2X00D 2W8FA 4IREA 2XNTA 4LMLA 3WIPA 5AFLA 2BYPA 4A98A 3RI5A 3RQUA 2Y57A 5FJVA 5AFJA 4B5DA 4NZBA 4QABA 5J5HA 4UY2A 4XK9A 5HEGA 4A97A 4BFQA 5J5IA 2BYSA 3WTHA 3JADA 2Y7YA 2ZJUA 2YMEA 4TWDA 4HFCA 5AFNA 3TLUA 2BYRA 3ZKRA 2YN6A 4HFDA 2X00A 2BG9B 4QH5A 2XQ9A 3RQWA 2C9TA 5CFBA 4TNWA 4X5TA 3TLSA 5AFMA 1UW6A 3T4MA 3EI0A 2WNJA 3SIOA 3P50A 2YKSA 3EAMA 2XYTA 4BQTA 4ZK4A 5L4EA 2XQAA 3WTKA 5IUXA 3UQ7A 2XQ5A 3ZDGA 4EZ1A 2ZJVA 5BW2A 3RHWA 5KE4A 3UU8A 5HCMA 3SQ6A 2BJ0A 5J5GA 4QH4A 5TVCA 3SH1A 4DBMA 4UM3A 3EHZA 4ILCA 2QC1B 4F8HA 3PEOA 5LG3A 2BR8A 3JAEA 4ZK1A 5L47A 5BRXA 4ZRUA 3ZDHA 2WNCA 5AFMB 3WTIA 3TLTA 3U8MA 3UU4A 2XQ6A 2BG9C 2BYNA 4ZJSA 3U8LA 3WTLA 4Z91A 5HEHA 3U8JA 5HEUA 2YOEA 4ILAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C84 A;  4ZJT A;  4D01 A;  4TWH A;  2XQ3 A;  3TLW A;  4ILB A;  1UX2 A;  3TLV A;  2XQ8 A;  2VL0 A;  4TWF A;  4UXU A;  3P4W A;  4HQP A;  1I9B A;  4UM1 A;  4XHE A;  5L4H A;  4ZZB A;  2PH9 A;  4PIR A;  3IGQ A;  2XQ7 A;  3SQ9 A;  4HFH A;  5AIN A;  5LXB A;  4ZR6 A;  2Y56 A;  1UV6 A;  3PMZ A;  4NPP A;  2XZ5 A;  2XQ4 A;  2Y54 A;  4HFE A;  4UM3 P;  3RIA A;  4IL4 A;  3WTM A;  4UM3 S;  2W8G A;  2WNL A;  5KZU A;  2BYQ A;  4AFH A;  4QAA A;  5JME A;  5CO5 A;  5HEJ A;  4QAC A;  3UU6 A;  3C79 A;  3LSV A;  2XZ6 A;  4LMK A;  3UQ4 A;  4HFB A;  3UU5 A;  3WTO A;  3UU3 A;  5BP0 A;  5HCJ A;  3UUB A;  3WTN A;  5J0Z A;  2WN9 A;  4WV9 A;  2BG9 E;  2WZY A;  2XNU A;  2YMD A;  3GUA A;  4FRR A;  4LMJ A;  4COF A;  5J5F A;  5AFH A;  3U8N A;  3WTJ A;  5AFK A;  5HEO A;  4ZZC A;  2BR7 A;  2Y58 A;  5SYO A;  2XNV A;  3JAF A;  2BG9 A;  3RIF A;  4TNV A;  2UZ6 A;  3U8K A;  4IL9 A;  2XYS A;  4Z90 A;  4HFI A;  4QH1 A;  4AFG A;  2PGZ A;  4AFT A;  4ALX A;  2X00 D;  2W8F A;  4IRE A;  2XNT A;  4LML A;  3WIP A;  5AFL A;  2BYP A;  4A98 A;  3RI5 A;  3RQU A;  2Y57 A;  5FJV A;  5AFJ A;  4B5D A;  4NZB A;  4QAB A;  5J5H A;  4UY2 A;  4XK9 A;  5HEG A;  4A97 A;  4BFQ A;  5J5I A;  2BYS A;  3WTH A;  3JAD A;  2Y7Y A;  2ZJU A;  2YME A;  4TWD A;  4HFC A;  5AFN A;  3TLU A;  2BYR A;  3ZKR A;  2YN6 A;  4HFD A;  2X00 A;  2BG9 B;  4QH5 A;  2XQ9 A;  3RQW A;  2C9T A;  5CFB A;  4TNW A;  4X5T A;  3TLS A;  5AFM A;  1UW6 A;  3T4M A;  3EI0 A;  2WNJ A;  3SIO A;  3P50 A;  2YKS A;  3EAM A;  2XYT A;  4BQT A;  4ZK4 A;  5L4E A;  2XQA A;  3WTK A;  5IUX A;  3UQ7 A;  2XQ5 A;  3ZDG A;  4EZ1 A;  2ZJV A;  5BW2 A;  3RHW A;  5KE4 A;  3UU8 A;  5HCM A;  3SQ6 A;  2BJ0 A;  5J5G A;  4QH4 A;  5TVC A;  3SH1 A;  4DBM A;  4UM3 A;  3EHZ A;  4ILC A;  2QC1 B;  4F8H A;  3PEO A;  5LG3 A;  2BR8 A;  3JAE A;  4ZK1 A;  5L47 A;  5BRX A;  4ZRU A;  3ZDH A;  2WNC A;  5AFM B;  3WTI A;  3TLT A;  3U8M A;  3UU4 A;  2XQ6 A;  2BG9 C;  2BYN A;  4ZJS A;  3U8L A;  3WTL A;  4Z91 A;  5HEH A;  3U8J A;  5HEU A;  2YOE A;  4ILA A; 
#chains in the Genus database with same CATH topology
 3C84 A;  4ZJT A;  4D01 A;  4TWH A;  2XQ3 A;  3TLW A;  4ILB A;  1UX2 A;  3TLV A;  2XQ8 A;  2VL0 A;  4TWF A;  4UXU A;  3P4W A;  4HQP A;  1I9B A;  4UM1 A;  4XHE A;  5L4H A;  4ZZB A;  2PH9 A;  4PIR A;  3IGQ A;  2XQ7 A;  3SQ9 A;  4HFH A;  5AIN A;  5LXB A;  4ZR6 A;  2Y56 A;  1UV6 A;  3PMZ A;  4NPP A;  2XZ5 A;  2XQ4 A;  2Y54 A;  4HFE A;  4UM3 P;  3RIA A;  4IL4 A;  3WTM A;  4UM3 S;  2W8G A;  2WNL A;  5KZU A;  2BYQ A;  4AFH A;  4QAA A;  5JME A;  5CO5 A;  5HEJ A;  4QAC A;  3UU6 A;  3C79 A;  3LSV A;  2XZ6 A;  4LMK A;  3UQ4 A;  4HFB A;  3UU5 A;  3WTO A;  3UU3 A;  5BP0 A;  5HCJ A;  3UUB A;  3WTN A;  5J0Z A;  2WN9 A;  4WV9 A;  2BG9 E;  2WZY A;  2XNU A;  2YMD A;  3GUA A;  4FRR A;  4LMJ A;  4COF A;  5J5F A;  5AFH A;  3U8N A;  3WTJ A;  5AFK A;  5HEO A;  4ZZC A;  2BR7 A;  2Y58 A;  5SYO A;  2XNV A;  3JAF A;  2BG9 A;  3RIF A;  4TNV A;  2UZ6 A;  3U8K A;  4IL9 A;  2XYS A;  4Z90 A;  4HFI A;  4QH1 A;  4AFG A;  2PGZ A;  4AFT A;  4ALX A;  2X00 D;  2W8F A;  4IRE A;  2XNT A;  4LML A;  3WIP A;  5AFL A;  2BYP A;  4A98 A;  3RI5 A;  3RQU A;  2Y57 A;  5FJV A;  5AFJ A;  4B5D A;  4NZB A;  4QAB A;  5J5H A;  4UY2 A;  4XK9 A;  5HEG A;  4A97 A;  4BFQ A;  5J5I A;  2BYS A;  3WTH A;  3JAD A;  2Y7Y A;  2ZJU A;  2YME A;  4TWD A;  4HFC A;  5AFN A;  3TLU A;  2BYR A;  3ZKR A;  2YN6 A;  4HFD A;  2X00 A;  2BG9 B;  4QH5 A;  2XQ9 A;  3RQW A;  2C9T A;  5CFB A;  4TNW A;  4X5T A;  3TLS A;  5AFM A;  1UW6 A;  3T4M A;  3EI0 A;  2WNJ A;  3SIO A;  3P50 A;  2YKS A;  3EAM A;  2XYT A;  4BQT A;  4ZK4 A;  5L4E A;  2XQA A;  3WTK A;  5IUX A;  3UQ7 A;  2XQ5 A;  3ZDG A;  4EZ1 A;  2ZJV A;  5BW2 A;  3RHW A;  5KE4 A;  3UU8 A;  5HCM A;  3SQ6 A;  2BJ0 A;  5J5G A;  4QH4 A;  5TVC A;  3SH1 A;  4DBM A;  4UM3 A;  3EHZ A;  4ILC A;  2QC1 B;  4F8H A;  3PEO A;  5LG3 A;  2BR8 A;  3JAE A;  4ZK1 A;  5L47 A;  5BRX A;  4ZRU A;  3ZDH A;  2WNC A;  5AFM B;  3WTI A;  3TLT A;  3U8M A;  3UU4 A;  2XQ6 A;  2BG9 C;  2BYN A;  4ZJS A;  3U8L A;  3WTL A;  4Z91 A;  5HEH A;  3U8J A;  5HEU A;  2YOE A;  4ILA A; 
#chains in the Genus database with same CATH homology
 3C84 A;  4ZJT A;  4D01 A;  4TWH A;  2XQ3 A;  3TLW A;  4ILB A;  1UX2 A;  3TLV A;  2XQ8 A;  2VL0 A;  4TWF A;  4UXU A;  3P4W A;  4HQP A;  1I9B A;  4UM1 A;  4XHE A;  5L4H A;  4ZZB A;  2PH9 A;  4PIR A;  3IGQ A;  2XQ7 A;  3SQ9 A;  4HFH A;  5AIN A;  5LXB A;  4ZR6 A;  2Y56 A;  1UV6 A;  3PMZ A;  4NPP A;  2XZ5 A;  2XQ4 A;  2Y54 A;  4HFE A;  4UM3 P;  3RIA A;  4IL4 A;  3WTM A;  4UM3 S;  2W8G A;  2WNL A;  5KZU A;  2BYQ A;  4AFH A;  4QAA A;  5JME A;  5CO5 A;  5HEJ A;  4QAC A;  3UU6 A;  3C79 A;  3LSV A;  2XZ6 A;  4LMK A;  3UQ4 A;  4HFB A;  3UU5 A;  3WTO A;  3UU3 A;  5BP0 A;  5HCJ A;  3UUB A;  3WTN A;  5J0Z A;  2WN9 A;  4WV9 A;  2BG9 E;  2WZY A;  2XNU A;  2YMD A;  3GUA A;  4FRR A;  4LMJ A;  4COF A;  5J5F A;  5AFH A;  3U8N A;  3WTJ A;  5AFK A;  5HEO A;  4ZZC A;  2BR7 A;  2Y58 A;  5SYO A;  2XNV A;  3JAF A;  2BG9 A;  3RIF A;  4TNV A;  2UZ6 A;  3U8K A;  4IL9 A;  2XYS A;  4Z90 A;  4HFI A;  4QH1 A;  4AFG A;  2PGZ A;  4AFT A;  4ALX A;  2X00 D;  2W8F A;  4IRE A;  2XNT A;  4LML A;  3WIP A;  5AFL A;  2BYP A;  4A98 A;  3RI5 A;  3RQU A;  2Y57 A;  5FJV A;  5AFJ A;  4B5D A;  4NZB A;  4QAB A;  5J5H A;  4UY2 A;  4XK9 A;  5HEG A;  4A97 A;  4BFQ A;  5J5I A;  2BYS A;  3WTH A;  3JAD A;  2Y7Y A;  2ZJU A;  2YME A;  4TWD A;  4HFC A;  5AFN A;  3TLU A;  2BYR A;  3ZKR A;  2YN6 A;  4HFD A;  2X00 A;  2BG9 B;  4QH5 A;  2XQ9 A;  3RQW A;  2C9T A;  5CFB A;  4TNW A;  4X5T A;  3TLS A;  5AFM A;  1UW6 A;  3T4M A;  3EI0 A;  2WNJ A;  3SIO A;  3P50 A;  2YKS A;  3EAM A;  2XYT A;  4BQT A;  4ZK4 A;  5L4E A;  2XQA A;  3WTK A;  5IUX A;  3UQ7 A;  2XQ5 A;  3ZDG A;  4EZ1 A;  2ZJV A;  5BW2 A;  3RHW A;  5KE4 A;  3UU8 A;  5HCM A;  3SQ6 A;  2BJ0 A;  5J5G A;  4QH4 A;  5TVC A;  3SH1 A;  4DBM A;  4UM3 A;  3EHZ A;  4ILC A;  2QC1 B;  4F8H A;  3PEO A;  5LG3 A;  2BR8 A;  3JAE A;  4ZK1 A;  5L47 A;  5BRX A;  4ZRU A;  3ZDH A;  2WNC A;  5AFM B;  3WTI A;  3TLT A;  3U8M A;  3UU4 A;  2XQ6 A;  2BG9 C;  2BYN A;  4ZJS A;  3U8L A;  3WTL A;  4Z91 A;  5HEH A;  3U8J A;  5HEU A;  2YOE A;  4ILA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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