5BWZA

Crystal structure of s39e hdac8 in complex with droxinostat
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
365
structure length
361
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRAEMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Histone deacetylase 8
publication title Structure of S39E HDAC8 in complex with Droxinostat
rcsb
source organism Homo sapiens
total genus 133
structure length 361
sequence length 365
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-06-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5bwzA00
3F07A 3C0YA 4QA3A 4A69A 3ZNRA 3EZPA 5FUEA 1C3PA 3MZ7A 5EF8A 4CBYA 5G0GA 5EFGA 5EEFA 3Q9CA 5A2SA 2VQVA 3EZTA 5DC7A 4QA2A 4QA0A 5JI5A 3MENA 3F06A 5G0HA 4CQFA 2VQOA 5EEKA 5THTA 5FCWA 3F0RA 2V5XA 5G17A 1VKGA 3MZ4A 3MZ3A 5EENA 4QA1A 5DC5A 3Q9EA 5LI3A 2VQQA 4BKXB 5EFKB 4LXZA 2GH6A 5G1AA 5G1BA 5G13A 5EFBD 5G0XA 4QA7A 3MAXA 4RN2A 1C3RA 5IWGA 5EEMA 5EFHA 5G0YA 1T69A 5EFJD 4ZUQA 5THVA 3RQDA 5BWZA 4LY1A 1ZZ3A 3EWFA 5EF7A 1W22A 5G0JA 5EFNA 4RN0A 4QA5A 3EW8A 5D1DA 5G12A 4BZ8A 1T64A 4ZURA 5G11A 1ZZ1A 4BZ7A 4CBTA 4RN1A 5G0IA 3ZNSA 3SFFA 5D1BA 5IX0A 2V5WA 2VCGA 3C0ZA 5DC6A 5ICNB 2VQWG 4BZ5A 3Q9FA 2VQJA 4QA6A 5DC8A 3Q9BA 3MZ6A 5D1CA 4ZUOA 5EEIA 5G10A 5G1CA 4BZ9A 4ZUMA 4ZUPA 5THUA 5THSA 1C3SA 1T67A 5G3WA 1ZZ0A 4BZ6A 4ZUNA 3SFHA 4QA4A 3C10A 2VQMA
chains in the Genus database with same CATH superfamily
3F07A 4Q41A 1HQGA 3C0YA 4QA3A 4A69A 3E8QA 2EF5A 3ZNRA 2PHAA 3MFWA 3EZPA 5FUEA 1C3PA 3MZ7A 5EF8A 3SL1A 4CBYA 1RLAA 4IE2A 5G0GA 3SL0A 5EFGA 1PQ3A 5EEFA 3TF3A 1ZPGA 3Q9CA 5A2SA 2VQVA 3EZTA 5DC7A 3NIQA 4QA2A 4QA0A 4GSMA 5JI5A 3MENA 3E9BA 2EIVA 3F06A 4IXUA 5G0HA 4CQFA 3GMZA 5CEVA 2VQOA 3MFVA 5EEKA 1ZPEA 5THTA 3F0RA 5FCWA 1TA1A 2V5XA 4HZEA 3THHA 3GN0A 3CEVA 4IU0A 3NIOA 1T4PA 2RLAA 4MXRA 5G17A 1VKGA 3MZ4A 3MZ3A 5EENA 4QA1A 5DC5A 1WVBA 5RLAA 3Q9EA 5LI3A 3NIPA 2VQQA 4IU1A 4Q3PA 4RHQA 4BKXB 4HXQA 3PZLA 5EFKB 1P8MA 2GH6A 4LXZA 5G1AA 5G1BA 5G13A 4Q3RC 5EFBD 5G0XA 4QA7A 1WOIA 1WOGA 1T5FA 3MAXA 4RN2A 1C3RA 1GQ6A 1WOHA 5IWGA 5EEMA 4RHIA 4I06A 4GSVA 4RHLA 3LP4A 1T69A 5EFHA 4MYNA 4GSZA 5EFJD 5G0YA 5THVA 2CEVA 3RQDA 3SKKA 4ZUQA 3KV2A 3M1RA 4IE1A 1ZZ3A 4IXVA 3EWFA 2ZAVA 1W22A 4LY1A 5EF7A 5G0JA 4G3HA 5EFNA 4RN0A 2AEBA 4GWCA 4QA5A 3EW8A 5D1DA 5G12A 3TH7A 4BZ8A 1T64A 4ZURA 5G11A 4IU5A 4ITYA 2EF4A 4Q3TA 1ZZ1A 3E8ZA 4BZ7A 4CBTA 4RN1A 4RLAA 5G0IA 3ZNSA 1TBHA 3RLAA 3SFFA 1P8PA 3MJLA 1HQXA 4Q3VA 5D1BA 5IX0A 4Q3QA 2V5WA 2VCGA 2PHOA 3C0ZA 3E6VA 5DC6A 5HJ9A 5ICNB 1P8QA 2VQWG 3THJA 4BZ5A 5BWZA 4RHJA 4Q42A 1P8RA 4MYLA 3THEA 2PLLA 1HQHA 1TBJA 4IE3A 4GWDA 1T4TA 3Q9FA 1D3VA 3F80A 1XFKA 1HQFA 4FCIA 1T4RA 3DJ8A 2VQJA 3E6KA 1GQ7A 3MMRA 4Q40A 4RHKA 4QA6A 5DC8A 3Q9BA 3MZ6A 1TBLA 4FCKA 5D1CA 4ZUOA 3SJTA 5HJAA 5EEIA 4CEVA 4IU4A 3LP7A 1HQ5A 5G10A 1CEVA 1P8OA 5G1CA 1T4SA 1WVAA 4MYKA 4BZ9A 4MYFA 4ZUMA 4DZ4A 4ZUPA 4HWWA 5THUA 5THSA 4RHMA 1T5GA 1C3SA 1T67A 5G3WA 4Q3RA 4Q3SA 1R1OA 1ZZ0A 3LHLA 4BZ6A 1P8NA 2A0MA 1P8SA 4Q3UA 4ZUNA 3SFHA 4QA4A 3C10A 2VQMA
chains in the Genus database with same CATH topology
3F07A 3C0YA 4QA3A 4A69A 3ZNRA 3EZPA 5FUEA 1C3PA 3MZ7A 5EF8A 4CBYA 5G0GA 5EFGA 5EEFA 3Q9CA 5A2SA 2VQVA 3EZTA 5DC7A 4QA2A 4QA0A 5JI5A 3MENA 3F06A 5G0HA 4CQFA 2VQOA 5EEKA 5THTA 5FCWA 3F0RA 2V5XA 5G17A 1VKGA 3MZ4A 3MZ3A 5EENA 4QA1A 5DC5A 3Q9EA 5LI3A 2VQQA 4BKXB 5EFKB 4LXZA 2GH6A 5G1AA 5G1BA 5G13A 5EFBD 5G0XA 4QA7A 3MAXA 4RN2A 1C3RA 5IWGA 5EEMA 5EFHA 5G0YA 1T69A 5EFJD 4ZUQA 5THVA 3RQDA 5BWZA 4LY1A 1ZZ3A 3EWFA 5EF7A 1W22A 5G0JA 5EFNA 4RN0A 4QA5A 3EW8A 5D1DA 5G12A 4BZ8A 1T64A 4ZURA 5G11A 1ZZ1A 4BZ7A 4CBTA 4RN1A 5G0IA 3ZNSA 3SFFA 5D1BA 5IX0A 2V5WA 2VCGA 3C0ZA 5DC6A 5ICNB 2VQWG 4BZ5A 3Q9FA 2VQJA 4QA6A 5DC8A 3Q9BA 3MZ6A 5D1CA 4ZUOA 5EEIA 5G10A 5G1CA 4BZ9A 4ZUMA 4ZUPA 5THUA 5THSA 1C3SA 1T67A 5G3WA 1ZZ0A 4BZ6A 4ZUNA 3SFHA 4QA4A 3C10A 2VQMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F07 A;  3C0Y A;  4QA3 A;  4A69 A;  3ZNR A;  3EZP A;  5FUE A;  1C3P A;  3MZ7 A;  5EF8 A;  4CBY A;  5G0G A;  5EFG A;  5EEF A;  3Q9C A;  5A2S A;  2VQV A;  3EZT A;  5DC7 A;  4QA2 A;  4QA0 A;  5JI5 A;  3MEN A;  3F06 A;  5G0H A;  4CQF A;  2VQO A;  5EEK A;  5THT A;  5FCW A;  3F0R A;  2V5X A;  5G17 A;  1VKG A;  3MZ4 A;  3MZ3 A;  5EEN A;  4QA1 A;  5DC5 A;  3Q9E A;  5LI3 A;  2VQQ A;  4BKX B;  5EFK B;  4LXZ A;  2GH6 A;  5G1A A;  5G1B A;  5G13 A;  5EFB D;  5G0X A;  4QA7 A;  3MAX A;  4RN2 A;  1C3R A;  5IWG A;  5EEM A;  5EFH A;  5G0Y A;  1T69 A;  5EFJ D;  4ZUQ A;  5THV A;  3RQD A;  5BWZ A;  4LY1 A;  1ZZ3 A;  3EWF A;  5EF7 A;  1W22 A;  5G0J A;  5EFN A;  4RN0 A;  4QA5 A;  3EW8 A;  5D1D A;  5G12 A;  4BZ8 A;  1T64 A;  4ZUR A;  5G11 A;  1ZZ1 A;  4BZ7 A;  4CBT A;  4RN1 A;  5G0I A;  3ZNS A;  3SFF A;  5D1B A;  5IX0 A;  2V5W A;  2VCG A;  3C0Z A;  5DC6 A;  5ICN B;  2VQW G;  4BZ5 A;  3Q9F A;  2VQJ A;  4QA6 A;  5DC8 A;  3Q9B A;  3MZ6 A;  5D1C A;  4ZUO A;  5EEI A;  5G10 A;  5G1C A;  4BZ9 A;  4ZUM A;  4ZUP A;  5THU A;  5THS A;  1C3S A;  1T67 A;  5G3W A;  1ZZ0 A;  4BZ6 A;  4ZUN A;  3SFH A;  4QA4 A;  3C10 A;  2VQM A; 
#chains in the Genus database with same CATH topology
 3F07 A;  4Q41 A;  1HQG A;  3C0Y A;  4QA3 A;  4A69 A;  3E8Q A;  2EF5 A;  3ZNR A;  2PHA A;  3MFW A;  3EZP A;  5FUE A;  1C3P A;  3MZ7 A;  5EF8 A;  3SL1 A;  4CBY A;  1RLA A;  4IE2 A;  5G0G A;  3SL0 A;  5EFG A;  1PQ3 A;  5EEF A;  3TF3 A;  1ZPG A;  3Q9C A;  5A2S A;  2VQV A;  3EZT A;  5DC7 A;  3NIQ A;  4QA2 A;  4QA0 A;  4GSM A;  5JI5 A;  3MEN A;  3E9B A;  2EIV A;  3F06 A;  4IXU A;  5G0H A;  4CQF A;  3GMZ A;  5CEV A;  2VQO A;  3MFV A;  5EEK A;  1ZPE A;  5THT A;  3F0R A;  5FCW A;  1TA1 A;  2V5X A;  4HZE A;  3THH A;  3GN0 A;  3CEV A;  4IU0 A;  3NIO A;  1T4P A;  2RLA A;  4MXR A;  5G17 A;  1VKG A;  3MZ4 A;  3MZ3 A;  5EEN A;  4QA1 A;  5DC5 A;  1WVB A;  5RLA A;  3Q9E A;  5LI3 A;  3NIP A;  2VQQ A;  4IU1 A;  4Q3P A;  4RHQ A;  4BKX B;  4HXQ A;  3PZL A;  5EFK B;  1P8M A;  2GH6 A;  4LXZ A;  5G1A A;  5G1B A;  5G13 A;  4Q3R C;  5EFB D;  5G0X A;  4QA7 A;  1WOI A;  1WOG A;  1T5F A;  3MAX A;  4RN2 A;  1C3R A;  1GQ6 A;  1WOH A;  5IWG A;  5EEM A;  4RHI A;  4I06 A;  4GSV A;  4RHL A;  3LP4 A;  1T69 A;  5EFH A;  4MYN A;  4GSZ A;  5EFJ D;  5G0Y A;  5THV A;  2CEV A;  3RQD A;  3SKK A;  4ZUQ A;  3KV2 A;  3M1R A;  4IE1 A;  1ZZ3 A;  4IXV A;  3EWF A;  2ZAV A;  1W22 A;  4LY1 A;  5EF7 A;  5G0J A;  4G3H A;  5EFN A;  4RN0 A;  2AEB A;  4GWC A;  4QA5 A;  3EW8 A;  5D1D A;  5G12 A;  3TH7 A;  4BZ8 A;  1T64 A;  4ZUR A;  5G11 A;  4IU5 A;  4ITY A;  2EF4 A;  4Q3T A;  1ZZ1 A;  3E8Z A;  4BZ7 A;  4CBT A;  4RN1 A;  4RLA A;  5G0I A;  3ZNS A;  1TBH A;  3RLA A;  3SFF A;  1P8P A;  3MJL A;  1HQX A;  4Q3V A;  5D1B A;  5IX0 A;  4Q3Q A;  2V5W A;  2VCG A;  2PHO A;  3C0Z A;  3E6V A;  5DC6 A;  5HJ9 A;  5ICN B;  1P8Q A;  2VQW G;  3THJ A;  4BZ5 A;  5BWZ A;  4RHJ A;  4Q42 A;  1P8R A;  4MYL A;  3THE A;  2PLL A;  1HQH A;  1TBJ A;  4IE3 A;  4GWD A;  1T4T A;  3Q9F A;  1D3V A;  3F80 A;  1XFK A;  1HQF A;  4FCI A;  1T4R A;  3DJ8 A;  2VQJ A;  3E6K A;  1GQ7 A;  3MMR A;  4Q40 A;  4RHK A;  4QA6 A;  5DC8 A;  3Q9B A;  3MZ6 A;  1TBL A;  4FCK A;  5D1C A;  4ZUO A;  3SJT A;  5HJA A;  5EEI A;  4CEV A;  4IU4 A;  3LP7 A;  1HQ5 A;  5G10 A;  1CEV A;  1P8O A;  5G1C A;  1T4S A;  1WVA A;  4MYK A;  4BZ9 A;  4MYF A;  4ZUM A;  4DZ4 A;  4ZUP A;  4HWW A;  5THU A;  5THS A;  4RHM A;  1T5G A;  1C3S A;  1T67 A;  5G3W A;  4Q3R A;  4Q3S A;  1R1O A;  1ZZ0 A;  3LHL A;  4BZ6 A;  1P8N A;  2A0M A;  1P8S A;  4Q3U A;  4ZUN A;  3SFH A;  4QA4 A;  3C10 A;  2VQM A; 
#chains in the Genus database with same CATH homology
 3F07 A;  3C0Y A;  4QA3 A;  4A69 A;  3ZNR A;  3EZP A;  5FUE A;  1C3P A;  3MZ7 A;  5EF8 A;  4CBY A;  5G0G A;  5EFG A;  5EEF A;  3Q9C A;  5A2S A;  2VQV A;  3EZT A;  5DC7 A;  4QA2 A;  4QA0 A;  5JI5 A;  3MEN A;  3F06 A;  5G0H A;  4CQF A;  2VQO A;  5EEK A;  5THT A;  5FCW A;  3F0R A;  2V5X A;  5G17 A;  1VKG A;  3MZ4 A;  3MZ3 A;  5EEN A;  4QA1 A;  5DC5 A;  3Q9E A;  5LI3 A;  2VQQ A;  4BKX B;  5EFK B;  4LXZ A;  2GH6 A;  5G1A A;  5G1B A;  5G13 A;  5EFB D;  5G0X A;  4QA7 A;  3MAX A;  4RN2 A;  1C3R A;  5IWG A;  5EEM A;  5EFH A;  5G0Y A;  1T69 A;  5EFJ D;  4ZUQ A;  5THV A;  3RQD A;  5BWZ A;  4LY1 A;  1ZZ3 A;  3EWF A;  5EF7 A;  1W22 A;  5G0J A;  5EFN A;  4RN0 A;  4QA5 A;  3EW8 A;  5D1D A;  5G12 A;  4BZ8 A;  1T64 A;  4ZUR A;  5G11 A;  1ZZ1 A;  4BZ7 A;  4CBT A;  4RN1 A;  5G0I A;  3ZNS A;  3SFF A;  5D1B A;  5IX0 A;  2V5W A;  2VCG A;  3C0Z A;  5DC6 A;  5ICN B;  2VQW G;  4BZ5 A;  3Q9F A;  2VQJ A;  4QA6 A;  5DC8 A;  3Q9B A;  3MZ6 A;  5D1C A;  4ZUO A;  5EEI A;  5G10 A;  5G1C A;  4BZ9 A;  4ZUM A;  4ZUP A;  5THU A;  5THS A;  1C3S A;  1T67 A;  5G3W A;  1ZZ0 A;  4BZ6 A;  4ZUN A;  3SFH A;  4QA4 A;  3C10 A;  2VQM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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