5C3HA

Fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 1
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
106
structure length
106
Chain Sequence
NFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Apoptosis
molecule keywords E3 ubiquitin-protein ligase XIAP
publication title Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
pubmed doi rcsb
source organism Homo sapiens
total genus 33
structure length 106
sequence length 106
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2015-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 5c3hA00
3CM2A 4WVSA 5C83A 4KMNA 3M0AD 3UW4A 3UIHA 3UIKA 3G76A 4A0IA 1XB1A 1JD6A 4J45A 3EYLA 2QRAA 3F7GA 3UIJA 3F7IA 2VSLA 3GT9A 4EC4A 4HY0A 1OXNA 3OZ1A 1F3HA 1C9QA 4MTIA 2JK7A 1OY7A 4MU7A 3HL5A 1TFQA 3UECA 1E31A 2RAXA 5C7CA 5C3KA 3SIPE 1F9XA 3D9UA 2I3IA 1G73C 4HY4A 2VM5A 3CM7A 4A0JA 2QFAA 1TFTA 4WVTA 3F7HA 4A0NA 5C0LA 5C7BA 2POPB 4LGEA 4KJVA 1JD4A 1SE0A 2OPZA 1TW6A 1M4MA 1JD5A 4J3YA 4KJUA 3SIQA 2POIA 4J44A 4OXCA 2UVLA 3UEGA 3MUPA 5C3HA 4LGUA 4KMPA 2OPYA 5C0KA 3UEIA 1QBHA 1NW9A 1I3OE 3UIGA 4J47A 3M0DD 4HY5A 3UEHA 4MTZA 3UEEA 3CLXA 3GTAA 5C84A 4WVUA 1SDZA 3UIIA 3UEFA 4J48A 3UEDA 2RAWA 5C7AA 4EB9A 1G3FA 4J46A 5C7DA 3UW5A 1XOXA 1XB0A 1Q4QA 2I3HA 3M1DA 3T6PA 1OXQA 3D9TA
chains in the Genus database with same CATH superfamily
3CM2A 4WVSA 5C83A 4KMNA 3M0AD 3UW4A 3UIHA 3UIKA 3G76A 4A0IA 1XB1A 1JD6A 4J45A 3EYLA 2QRAA 3F7GA 3UIJA 3F7IA 2VSLA 3GT9A 4EC4A 4HY0A 1OXNA 3OZ1A 1F3HA 1C9QA 4MTIA 2JK7A 1OY7A 4MU7A 3HL5A 1TFQA 3UECA 1E31A 2RAXA 5C7CA 5C3KA 3SIPE 1F9XA 3D9UA 2I3IA 1G73C 4HY4A 2VM5A 3CM7A 4A0JA 2QFAA 1TFTA 4WVTA 3F7HA 4A0NA 5C0LA 5C7BA 2POPB 4LGEA 4KJVA 1JD4A 1SE0A 2OPZA 1TW6A 1M4MA 1JD5A 4J3YA 4KJUA 3SIQA 2POIA 4J44A 4OXCA 2UVLA 3UEGA 3MUPA 5C3HA 4LGUA 4KMPA 2OPYA 5C0KA 3UEIA 1QBHA 1NW9A 1I3OE 3UIGA 4J47A 3M0DD 4HY5A 3UEHA 4MTZA 3UEEA 3CLXA 3GTAA 5C84A 4WVUA 1SDZA 3UIIA 3UEFA 4J48A 3UEDA 2RAWA 5C7AA 4EB9A 1G3FA 4J46A 5C7DA 3UW5A 1XOXA 1XB0A 1Q4QA 2I3HA 3M1DA 3T6PA 1OXQA 3D9TA
chains in the Genus database with same CATH topology
3CM2A 4WVSA 5C83A 4KMNA 3M0AD 3UW4A 3UIHA 3UIKA 3G76A 4A0IA 1XB1A 1JD6A 4J45A 3EYLA 2QRAA 3F7GA 3UIJA 3F7IA 2VSLA 3GT9A 4EC4A 4HY0A 1OXNA 3OZ1A 1F3HA 1C9QA 4MTIA 2JK7A 1OY7A 4MU7A 3HL5A 1TFQA 3UECA 1E31A 2RAXA 5C7CA 5C3KA 3SIPE 1F9XA 3D9UA 2I3IA 1G73C 4HY4A 2VM5A 3CM7A 4A0JA 2QFAA 1TFTA 4WVTA 3F7HA 4A0NA 5C0LA 5C7BA 2POPB 4LGEA 4KJVA 1JD4A 1SE0A 2OPZA 1TW6A 1M4MA 1JD5A 4J3YA 4KJUA 3SIQA 2POIA 4J44A 4OXCA 2UVLA 3UEGA 3MUPA 5C3HA 4LGUA 4KMPA 2OPYA 5C0KA 3UEIA 1QBHA 1NW9A 1I3OE 3UIGA 4J47A 3M0DD 4HY5A 3UEHA 4MTZA 3UEEA 3CLXA 3GTAA 5C84A 4WVUA 1SDZA 3UIIA 3UEFA 4J48A 3UEDA 2RAWA 5C7AA 4EB9A 1G3FA 4J46A 5C7DA 3UW5A 1XOXA 1XB0A 1Q4QA 2I3HA 3M1DA 3T6PA 1OXQA 3D9TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CM2 A;  4WVS A;  5C83 A;  4KMN A;  3M0A D;  3UW4 A;  3UIH A;  3UIK A;  3G76 A;  4A0I A;  1XB1 A;  1JD6 A;  4J45 A;  3EYL A;  2QRA A;  3F7G A;  3UIJ A;  3F7I A;  2VSL A;  3GT9 A;  4EC4 A;  4HY0 A;  1OXN A;  3OZ1 A;  1F3H A;  1C9Q A;  4MTI A;  2JK7 A;  1OY7 A;  4MU7 A;  3HL5 A;  1TFQ A;  3UEC A;  1E31 A;  2RAX A;  5C7C A;  5C3K A;  3SIP E;  1F9X A;  3D9U A;  2I3I A;  1G73 C;  4HY4 A;  2VM5 A;  3CM7 A;  4A0J A;  2QFA A;  1TFT A;  4WVT A;  3F7H A;  4A0N A;  5C0L A;  5C7B A;  2POP B;  4LGE A;  4KJV A;  1JD4 A;  1SE0 A;  2OPZ A;  1TW6 A;  1M4M A;  1JD5 A;  4J3Y A;  4KJU A;  3SIQ A;  2POI A;  4J44 A;  4OXC A;  2UVL A;  3UEG A;  3MUP A;  5C3H A;  4LGU A;  4KMP A;  2OPY A;  5C0K A;  3UEI A;  1QBH A;  1NW9 A;  1I3O E;  3UIG A;  4J47 A;  3M0D D;  4HY5 A;  3UEH A;  4MTZ A;  3UEE A;  3CLX A;  3GTA A;  5C84 A;  4WVU A;  1SDZ A;  3UII A;  3UEF A;  4J48 A;  3UED A;  2RAW A;  5C7A A;  4EB9 A;  1G3F A;  4J46 A;  5C7D A;  3UW5 A;  1XOX A;  1XB0 A;  1Q4Q A;  2I3H A;  3M1D A;  3T6P A;  1OXQ A;  3D9T A; 
#chains in the Genus database with same CATH topology
 3CM2 A;  4WVS A;  5C83 A;  4KMN A;  3M0A D;  3UW4 A;  3UIH A;  3UIK A;  3G76 A;  4A0I A;  1XB1 A;  1JD6 A;  4J45 A;  3EYL A;  2QRA A;  3F7G A;  3UIJ A;  3F7I A;  2VSL A;  3GT9 A;  4EC4 A;  4HY0 A;  1OXN A;  3OZ1 A;  1F3H A;  1C9Q A;  4MTI A;  2JK7 A;  1OY7 A;  4MU7 A;  3HL5 A;  1TFQ A;  3UEC A;  1E31 A;  2RAX A;  5C7C A;  5C3K A;  3SIP E;  1F9X A;  3D9U A;  2I3I A;  1G73 C;  4HY4 A;  2VM5 A;  3CM7 A;  4A0J A;  2QFA A;  1TFT A;  4WVT A;  3F7H A;  4A0N A;  5C0L A;  5C7B A;  2POP B;  4LGE A;  4KJV A;  1JD4 A;  1SE0 A;  2OPZ A;  1TW6 A;  1M4M A;  1JD5 A;  4J3Y A;  4KJU A;  3SIQ A;  2POI A;  4J44 A;  4OXC A;  2UVL A;  3UEG A;  3MUP A;  5C3H A;  4LGU A;  4KMP A;  2OPY A;  5C0K A;  3UEI A;  1QBH A;  1NW9 A;  1I3O E;  3UIG A;  4J47 A;  3M0D D;  4HY5 A;  3UEH A;  4MTZ A;  3UEE A;  3CLX A;  3GTA A;  5C84 A;  4WVU A;  1SDZ A;  3UII A;  3UEF A;  4J48 A;  3UED A;  2RAW A;  5C7A A;  4EB9 A;  1G3F A;  4J46 A;  5C7D A;  3UW5 A;  1XOX A;  1XB0 A;  1Q4Q A;  2I3H A;  3M1D A;  3T6P A;  1OXQ A;  3D9T A; 
#chains in the Genus database with same CATH homology
 3CM2 A;  4WVS A;  5C83 A;  4KMN A;  3M0A D;  3UW4 A;  3UIH A;  3UIK A;  3G76 A;  4A0I A;  1XB1 A;  1JD6 A;  4J45 A;  3EYL A;  2QRA A;  3F7G A;  3UIJ A;  3F7I A;  2VSL A;  3GT9 A;  4EC4 A;  4HY0 A;  1OXN A;  3OZ1 A;  1F3H A;  1C9Q A;  4MTI A;  2JK7 A;  1OY7 A;  4MU7 A;  3HL5 A;  1TFQ A;  3UEC A;  1E31 A;  2RAX A;  5C7C A;  5C3K A;  3SIP E;  1F9X A;  3D9U A;  2I3I A;  1G73 C;  4HY4 A;  2VM5 A;  3CM7 A;  4A0J A;  2QFA A;  1TFT A;  4WVT A;  3F7H A;  4A0N A;  5C0L A;  5C7B A;  2POP B;  4LGE A;  4KJV A;  1JD4 A;  1SE0 A;  2OPZ A;  1TW6 A;  1M4M A;  1JD5 A;  4J3Y A;  4KJU A;  3SIQ A;  2POI A;  4J44 A;  4OXC A;  2UVL A;  3UEG A;  3MUP A;  5C3H A;  4LGU A;  4KMP A;  2OPY A;  5C0K A;  3UEI A;  1QBH A;  1NW9 A;  1I3O E;  3UIG A;  4J47 A;  3M0D D;  4HY5 A;  3UEH A;  4MTZ A;  3UEE A;  3CLX A;  3GTA A;  5C84 A;  4WVU A;  1SDZ A;  3UII A;  3UEF A;  4J48 A;  3UED A;  2RAW A;  5C7A A;  4EB9 A;  1G3F A;  4J46 A;  5C7D A;  3UW5 A;  1XOX A;  1XB0 A;  1Q4Q A;  2I3H A;  3M1D A;  3T6P A;  1OXQ A;  3D9T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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