5C67C

Human mesotrypsin in complex with amyloid precursor protein inhibitor variant appi-m17g/i18f/f34v
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
53
structure length
53
Chain Sequence
EVCSEQAETGPCRAGFSRWYFDVTEGKCAPFVYGGCGGNRNNFDTEEYCMAVC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hyrdolase/hydrolase inhibitor
molecule keywords Trypsin-3
publication title Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.
pubmed doi rcsb
source organism Homo sapiens
total genus 11
structure length 53
sequence length 53
chains with identical sequence E
ec nomenclature
pdb deposition date 2015-06-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 5c67C00
2RA3C 3AUBA 3GYMI 1DTKA 3BYBA 1BHCA 4ISOB 3LDMA 3UOUB 4WXVC 5JB5A 2M99A 1B0CA 2DDJA 1YLDB 2PTCI 1P2MB 1K6UA 4WWYC 1UUBA 3TGJI 2KCRA 3BTHI 3AUGA 1TPAI 3T62D 4U30W 2LFLA 3TGKI 3AUCA 1FY8I 1BZXI 1SHPA 1TCPA 4U32X 1BRBI 3BTKI 1IRHA 1ZJDB 1CBWD 1Y62A 1EJMB 2CA7A 2LFKA 4Y10I 8PTIA 1P2II 9PTIA 2UUYB 1F7ZI 3P92E 1BTHP 1T8MB 1TAPA 3BTGI 2TPII 1TOCR 3FP8I 3BTQI 1TAWB 5JB7A 1F5RI 2FI4I 3BTEI 4BD9B 1D0DB 1OA55 2IJOI 1ADZA 2UUXA 4NTWB 3BTWI 1P2JI 4BNRI 5PTIA 2FI3I 1BTIA 3AUEA 3OTJI 1QLQA 1P2KI 3AUIA 1KUNA 1PITA 1LD6A 3P95E 1BPTA 3M7QB 4Y0YI 2DDIA 1T8LB 2ODYE 4Y11I 4BQDA 1BUNB 2HEXA 4NTYB 2M01A 2J6DA 3LDJA 4DG4C 4DTGK 3BTFI 1BF0A 2W8XA 3CI7A 1G6XA 3UIRC 1CA0D 1T8NB 1JC6A 6PTIA 3D65I 2TGPI 1CO7I 1DTXA 1BPIA 1TFXC 3AUHA 1YLCB 5C67C 1P2QB 2R9PE 1AAPA 1YC0I 4Y0ZI 3FP7J 1AALA 1ZR0B 1FAKI 3L3TE 5JB6A 4TPII 1KNTA 1KTHA 4ISNB 1T7CB 3FP6I 3BTTI 4NTXB 4ISLB 1DEMA 3LDIA 3BTDI 1YKTB 1BIKA 2FI5I 1OA65 1BZ5A 3BTMI 3L33E 2ZVXA 1LD5A 1T8OB 1UUAA 7PTIA 5JB4A 1FANA 1JV8A 2FTMB 4PTIA 1JV9A 2KNTA 2ZJXA 3TPII 2JOTA 3OFWA 2KAII 3WNYA 1MTND 1D0DA 3AUDA 1P2OB 3TGII 3U1JE 1EAWB 2FTLI 1NAGA 1BRCI 1P2NB 1KIGI 1DENA
chains in the Genus database with same CATH superfamily
2RA3C 3AUBA 3GYMI 1DTKA 3BYBA 1BHCA 4ISOB 3LDMA 3UOUB 4WXVC 5JB5A 2M99A 1B0CA 2DDJA 1YLDB 2PTCI 1P2MB 1K6UA 4WWYC 1UUBA 3TGJI 2KCRA 3BTHI 3AUGA 1TPAI 3T62D 4U30W 2LFLA 3TGKI 3AUCA 1FY8I 1BZXI 1SHPA 1TCPA 4U32X 1BRBI 3BTKI 1IRHA 1ZJDB 1CBWD 1Y62A 1EJMB 2CA7A 2LFKA 4Y10I 8PTIA 1P2II 9PTIA 2UUYB 1F7ZI 3P92E 1BTHP 1T8MB 1TAPA 3BTGI 2TPII 1TOCR 3FP8I 3BTQI 1TAWB 5JB7A 1F5RI 2FI4I 3BTEI 4BD9B 1D0DB 1OA55 2IJOI 1ADZA 2UUXA 4NTWB 3BTWI 1P2JI 4BNRI 5PTIA 2FI3I 1BTIA 3AUEA 3OTJI 1QLQA 1P2KI 3AUIA 1KUNA 1PITA 1LD6A 3P95E 1BPTA 3M7QB 4Y0YI 2DDIA 1T8LB 2ODYE 4Y11I 4BQDA 1BUNB 2HEXA 4NTYB 2M01A 2J6DA 3LDJA 4DG4C 4DTGK 3BTFI 1BF0A 2W8XA 3CI7A 1G6XA 3UIRC 1CA0D 1T8NB 1JC6A 6PTIA 3D65I 2TGPI 1CO7I 1DTXA 1BPIA 1TFXC 3AUHA 1YLCB 5C67C 1P2QB 2R9PE 1AAPA 1YC0I 4Y0ZI 3FP7J 1AALA 1ZR0B 1FAKI 3L3TE 5JB6A 4TPII 1KNTA 1KTHA 4ISNB 1T7CB 3FP6I 3BTTI 4NTXB 4ISLB 1DEMA 3LDIA 3BTDI 1YKTB 1BIKA 2FI5I 1OA65 1BZ5A 3BTMI 3L33E 2ZVXA 1LD5A 1T8OB 1UUAA 7PTIA 5JB4A 1FANA 1JV8A 2FTMB 4PTIA 1JV9A 2KNTA 2ZJXA 3TPII 2JOTA 3OFWA 2KAII 3WNYA 1MTND 1D0DA 3AUDA 1P2OB 3TGII 3U1JE 1EAWB 2FTLI 1NAGA 1BRCI 1P2NB 1KIGI 1DENA
chains in the Genus database with same CATH topology
2RA3C 3AUBA 3GYMI 1DTKA 3BYBA 1BHCA 4ISOB 3LDMA 3UOUB 4WXVC 5JB5A 2M99A 1B0CA 2DDJA 1YLDB 2PTCI 1P2MB 1K6UA 4WWYC 1UUBA 3TGJI 2KCRA 3BTHI 3AUGA 1TPAI 3T62D 4U30W 2LFLA 3TGKI 3AUCA 1FY8I 1BZXI 1SHPA 1TCPA 4U32X 1BRBI 3BTKI 1IRHA 1ZJDB 1CBWD 1Y62A 1EJMB 2CA7A 2LFKA 4Y10I 8PTIA 1P2II 9PTIA 2UUYB 1F7ZI 3P92E 1BTHP 1T8MB 1TAPA 3BTGI 2TPII 1TOCR 3FP8I 3BTQI 1TAWB 5JB7A 1F5RI 2FI4I 3BTEI 4BD9B 1D0DB 1OA55 2IJOI 1ADZA 2UUXA 4NTWB 3BTWI 1P2JI 4BNRI 5PTIA 2FI3I 1BTIA 3AUEA 3OTJI 1QLQA 1P2KI 3AUIA 1KUNA 1PITA 1LD6A 3P95E 1BPTA 3M7QB 4Y0YI 2DDIA 1T8LB 2ODYE 4Y11I 4BQDA 1BUNB 2HEXA 4NTYB 2M01A 2J6DA 3LDJA 4DG4C 4DTGK 3BTFI 1BF0A 2W8XA 3CI7A 1G6XA 3UIRC 1CA0D 1T8NB 1JC6A 6PTIA 3D65I 2TGPI 1CO7I 1DTXA 1BPIA 1TFXC 3AUHA 1YLCB 5C67C 1P2QB 2R9PE 1AAPA 1YC0I 4Y0ZI 3FP7J 1AALA 1ZR0B 1FAKI 3L3TE 5JB6A 4TPII 1KNTA 1KTHA 4ISNB 1T7CB 3FP6I 3BTTI 4NTXB 4ISLB 1DEMA 3LDIA 3BTDI 1YKTB 1BIKA 2FI5I 1OA65 1BZ5A 3BTMI 3L33E 2ZVXA 1LD5A 1T8OB 1UUAA 7PTIA 5JB4A 1FANA 1JV8A 2FTMB 4PTIA 1JV9A 2KNTA 2ZJXA 3TPII 2JOTA 3OFWA 2KAII 3WNYA 1MTND 1D0DA 3AUDA 1P2OB 3TGII 3U1JE 1EAWB 2FTLI 1NAGA 1BRCI 1P2NB 1KIGI 1DENA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RA3 C;  3AUB A;  3GYM I;  1DTK A;  3BYB A;  1BHC A;  4ISO B;  3LDM A;  3UOU B;  4WXV C;  5JB5 A;  2M99 A;  1B0C A;  2DDJ A;  1YLD B;  2PTC I;  1P2M B;  1K6U A;  4WWY C;  1UUB A;  3TGJ I;  2KCR A;  3BTH I;  3AUG A;  1TPA I;  3T62 D;  4U30 W;  2LFL A;  3TGK I;  3AUC A;  1FY8 I;  1BZX I;  1SHP A;  1TCP A;  4U32 X;  1BRB I;  3BTK I;  1IRH A;  1ZJD B;  1CBW D;  1Y62 A;  1EJM B;  2CA7 A;  2LFK A;  4Y10 I;  8PTI A;  1P2I I;  9PTI A;  2UUY B;  1F7Z I;  3P92 E;  1BTH P;  1T8M B;  1TAP A;  3BTG I;  2TPI I;  1TOC R;  3FP8 I;  3BTQ I;  1TAW B;  5JB7 A;  1F5R I;  2FI4 I;  3BTE I;  4BD9 B;  1D0D B;  1OA5 5;  2IJO I;  1ADZ A;  2UUX A;  4NTW B;  3BTW I;  1P2J I;  4BNR I;  5PTI A;  2FI3 I;  1BTI A;  3AUE A;  3OTJ I;  1QLQ A;  1P2K I;  3AUI A;  1KUN A;  1PIT A;  1LD6 A;  3P95 E;  1BPT A;  3M7Q B;  4Y0Y I;  2DDI A;  1T8L B;  2ODY E;  4Y11 I;  4BQD A;  1BUN B;  2HEX A;  4NTY B;  2M01 A;  2J6D A;  3LDJ A;  4DG4 C;  4DTG K;  3BTF I;  1BF0 A;  2W8X A;  3CI7 A;  1G6X A;  3UIR C;  1CA0 D;  1T8N B;  1JC6 A;  6PTI A;  3D65 I;  2TGP I;  1CO7 I;  1DTX A;  1BPI A;  1TFX C;  3AUH A;  1YLC B;  5C67 C;  1P2Q B;  2R9P E;  1AAP A;  1YC0 I;  4Y0Z I;  3FP7 J;  1AAL A;  1ZR0 B;  1FAK I;  3L3T E;  5JB6 A;  4TPI I;  1KNT A;  1KTH A;  4ISN B;  1T7C B;  3FP6 I;  3BTT I;  4NTX B;  4ISL B;  1DEM A;  3LDI A;  3BTD I;  1YKT B;  1BIK A;  2FI5 I;  1OA6 5;  1BZ5 A;  3BTM I;  3L33 E;  2ZVX A;  1LD5 A;  1T8O B;  1UUA A;  7PTI A;  5JB4 A;  1FAN A;  1JV8 A;  2FTM B;  4PTI A;  1JV9 A;  2KNT A;  2ZJX A;  3TPI I;  2JOT A;  3OFW A;  2KAI I;  3WNY A;  1MTN D;  1D0D A;  3AUD A;  1P2O B;  3TGI I;  3U1J E;  1EAW B;  2FTL I;  1NAG A;  1BRC I;  1P2N B;  1KIG I;  1DEN A; 
#chains in the Genus database with same CATH topology
 2RA3 C;  3AUB A;  3GYM I;  1DTK A;  3BYB A;  1BHC A;  4ISO B;  3LDM A;  3UOU B;  4WXV C;  5JB5 A;  2M99 A;  1B0C A;  2DDJ A;  1YLD B;  2PTC I;  1P2M B;  1K6U A;  4WWY C;  1UUB A;  3TGJ I;  2KCR A;  3BTH I;  3AUG A;  1TPA I;  3T62 D;  4U30 W;  2LFL A;  3TGK I;  3AUC A;  1FY8 I;  1BZX I;  1SHP A;  1TCP A;  4U32 X;  1BRB I;  3BTK I;  1IRH A;  1ZJD B;  1CBW D;  1Y62 A;  1EJM B;  2CA7 A;  2LFK A;  4Y10 I;  8PTI A;  1P2I I;  9PTI A;  2UUY B;  1F7Z I;  3P92 E;  1BTH P;  1T8M B;  1TAP A;  3BTG I;  2TPI I;  1TOC R;  3FP8 I;  3BTQ I;  1TAW B;  5JB7 A;  1F5R I;  2FI4 I;  3BTE I;  4BD9 B;  1D0D B;  1OA5 5;  2IJO I;  1ADZ A;  2UUX A;  4NTW B;  3BTW I;  1P2J I;  4BNR I;  5PTI A;  2FI3 I;  1BTI A;  3AUE A;  3OTJ I;  1QLQ A;  1P2K I;  3AUI A;  1KUN A;  1PIT A;  1LD6 A;  3P95 E;  1BPT A;  3M7Q B;  4Y0Y I;  2DDI A;  1T8L B;  2ODY E;  4Y11 I;  4BQD A;  1BUN B;  2HEX A;  4NTY B;  2M01 A;  2J6D A;  3LDJ A;  4DG4 C;  4DTG K;  3BTF I;  1BF0 A;  2W8X A;  3CI7 A;  1G6X A;  3UIR C;  1CA0 D;  1T8N B;  1JC6 A;  6PTI A;  3D65 I;  2TGP I;  1CO7 I;  1DTX A;  1BPI A;  1TFX C;  3AUH A;  1YLC B;  5C67 C;  1P2Q B;  2R9P E;  1AAP A;  1YC0 I;  4Y0Z I;  3FP7 J;  1AAL A;  1ZR0 B;  1FAK I;  3L3T E;  5JB6 A;  4TPI I;  1KNT A;  1KTH A;  4ISN B;  1T7C B;  3FP6 I;  3BTT I;  4NTX B;  4ISL B;  1DEM A;  3LDI A;  3BTD I;  1YKT B;  1BIK A;  2FI5 I;  1OA6 5;  1BZ5 A;  3BTM I;  3L33 E;  2ZVX A;  1LD5 A;  1T8O B;  1UUA A;  7PTI A;  5JB4 A;  1FAN A;  1JV8 A;  2FTM B;  4PTI A;  1JV9 A;  2KNT A;  2ZJX A;  3TPI I;  2JOT A;  3OFW A;  2KAI I;  3WNY A;  1MTN D;  1D0D A;  3AUD A;  1P2O B;  3TGI I;  3U1J E;  1EAW B;  2FTL I;  1NAG A;  1BRC I;  1P2N B;  1KIG I;  1DEN A; 
#chains in the Genus database with same CATH homology
 2RA3 C;  3AUB A;  3GYM I;  1DTK A;  3BYB A;  1BHC A;  4ISO B;  3LDM A;  3UOU B;  4WXV C;  5JB5 A;  2M99 A;  1B0C A;  2DDJ A;  1YLD B;  2PTC I;  1P2M B;  1K6U A;  4WWY C;  1UUB A;  3TGJ I;  2KCR A;  3BTH I;  3AUG A;  1TPA I;  3T62 D;  4U30 W;  2LFL A;  3TGK I;  3AUC A;  1FY8 I;  1BZX I;  1SHP A;  1TCP A;  4U32 X;  1BRB I;  3BTK I;  1IRH A;  1ZJD B;  1CBW D;  1Y62 A;  1EJM B;  2CA7 A;  2LFK A;  4Y10 I;  8PTI A;  1P2I I;  9PTI A;  2UUY B;  1F7Z I;  3P92 E;  1BTH P;  1T8M B;  1TAP A;  3BTG I;  2TPI I;  1TOC R;  3FP8 I;  3BTQ I;  1TAW B;  5JB7 A;  1F5R I;  2FI4 I;  3BTE I;  4BD9 B;  1D0D B;  1OA5 5;  2IJO I;  1ADZ A;  2UUX A;  4NTW B;  3BTW I;  1P2J I;  4BNR I;  5PTI A;  2FI3 I;  1BTI A;  3AUE A;  3OTJ I;  1QLQ A;  1P2K I;  3AUI A;  1KUN A;  1PIT A;  1LD6 A;  3P95 E;  1BPT A;  3M7Q B;  4Y0Y I;  2DDI A;  1T8L B;  2ODY E;  4Y11 I;  4BQD A;  1BUN B;  2HEX A;  4NTY B;  2M01 A;  2J6D A;  3LDJ A;  4DG4 C;  4DTG K;  3BTF I;  1BF0 A;  2W8X A;  3CI7 A;  1G6X A;  3UIR C;  1CA0 D;  1T8N B;  1JC6 A;  6PTI A;  3D65 I;  2TGP I;  1CO7 I;  1DTX A;  1BPI A;  1TFX C;  3AUH A;  1YLC B;  5C67 C;  1P2Q B;  2R9P E;  1AAP A;  1YC0 I;  4Y0Z I;  3FP7 J;  1AAL A;  1ZR0 B;  1FAK I;  3L3T E;  5JB6 A;  4TPI I;  1KNT A;  1KTH A;  4ISN B;  1T7C B;  3FP6 I;  3BTT I;  4NTX B;  4ISL B;  1DEM A;  3LDI A;  3BTD I;  1YKT B;  1BIK A;  2FI5 I;  1OA6 5;  1BZ5 A;  3BTM I;  3L33 E;  2ZVX A;  1LD5 A;  1T8O B;  1UUA A;  7PTI A;  5JB4 A;  1FAN A;  1JV8 A;  2FTM B;  4PTI A;  1JV9 A;  2KNT A;  2ZJX A;  3TPI I;  2JOT A;  3OFW A;  2KAI I;  3WNY A;  1MTN D;  1D0D A;  3AUD A;  1P2O B;  3TGI I;  3U1J E;  1EAW B;  2FTL I;  1NAG A;  1BRC I;  1P2N B;  1KIG I;  1DEN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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