5C7BA

Fragment-based drug discovery targeting inhibitor of apoptosis proteins: compound 5
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
106
structure length
106
Chain Sequence
NFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Apoptosis
molecule keywords E3 ubiquitin-protein ligase XIAP
publication title Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
pubmed doi rcsb
source organism Homo sapiens
total genus 32
structure length 106
sequence length 106
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2015-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00653 BIR Inhibitor of Apoptosis domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1170.10 Mainly Alpha Orthogonal Bundle Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A 5c7bA00
3SIPE 4A0JA 4J3YA 1TW6A 3OZ1A 3GT9A 1JD5A 2OPZA 4WVTA 3M0AD 4KMNA 4MTZA 1JD4A 4MTIA 5C7CA 3UECA 3UIKA 3GTAA 4J46A 1C9QA 4HY0A 4WVSA 1XOXA 3MUPA 1E31A 4J44A 4KMPA 4KJVA 4EB9A 3HL5A 4A0NA 3F7GA 5C83A 3D9UA 5C0KA 1F9XA 3UIIA 2UVLA 5C84A 5C0LA 2RAWA 3M0DD 2VSLA 3UEEA 1OY7A 3UEFA 2OPYA 2RAXA 3UIGA 3UEDA 3G76A 1SDZA 2JK7A 4A0IA 1F3HA 4MU7A 3UW4A 1QBHA 5C3KA 2I3HA 4LGEA 1I3OE 1TFTA 3F7IA 1XB1A 1OXNA 3UIJA 3EYLA 3F7HA 3UEIA 3SIQA 4KJUA 1M4MA 5C7BA 3D9TA 1JD6A 1SE0A 4LGUA 4HY5A 1Q4QA 4J45A 4HY4A 1OXQA 3CM2A 4J47A 2POPB 3CM7A 4WVUA 1XB0A 3UW5A 3T6PA 3UEGA 2POIA 3CLXA 5C7DA 4EC4A 2VM5A 1G73C 1TFQA 5C3HA 1G3FA 5C7AA 3UEHA 2QRAA 3M1DA 2QFAA 4OXCA 4J48A 1NW9A 3UIHA 2I3IA
chains in the Genus database with same CATH superfamily
3SIPE 4A0JA 4J3YA 1TW6A 3OZ1A 3GT9A 1JD5A 2OPZA 4WVTA 3M0AD 4KMNA 4MTZA 1JD4A 4MTIA 5C7CA 3UECA 3UIKA 3GTAA 4J46A 1C9QA 4HY0A 4WVSA 1XOXA 3MUPA 1E31A 4J44A 4KMPA 4KJVA 4EB9A 3HL5A 4A0NA 3F7GA 5C83A 3D9UA 5C0KA 1F9XA 3UIIA 2UVLA 5C84A 5C0LA 2RAWA 3M0DD 2VSLA 3UEEA 1OY7A 3UEFA 2OPYA 2RAXA 3UIGA 3UEDA 3G76A 1SDZA 2JK7A 4A0IA 1F3HA 4MU7A 3UW4A 1QBHA 5C3KA 2I3HA 4LGEA 1I3OE 1TFTA 3F7IA 1XB1A 1OXNA 3UIJA 3EYLA 3F7HA 3UEIA 3SIQA 4KJUA 1M4MA 5C7BA 3D9TA 1JD6A 1SE0A 4LGUA 4HY5A 1Q4QA 4J45A 4HY4A 1OXQA 3CM2A 4J47A 2POPB 3CM7A 4WVUA 1XB0A 3UW5A 3T6PA 3UEGA 2POIA 3CLXA 5C7DA 4EC4A 2VM5A 1G73C 1TFQA 5C3HA 1G3FA 5C7AA 3UEHA 2QRAA 3M1DA 2QFAA 4OXCA 4J48A 1NW9A 3UIHA 2I3IA
chains in the Genus database with same CATH topology
3SIPE 4A0JA 4J3YA 1TW6A 3OZ1A 3GT9A 1JD5A 2OPZA 4WVTA 3M0AD 4KMNA 4MTZA 1JD4A 4MTIA 5C7CA 3UECA 3UIKA 3GTAA 4J46A 1C9QA 4HY0A 4WVSA 1XOXA 3MUPA 1E31A 4J44A 4KMPA 4KJVA 4EB9A 3HL5A 4A0NA 3F7GA 5C83A 3D9UA 5C0KA 1F9XA 3UIIA 2UVLA 5C84A 5C0LA 2RAWA 3M0DD 2VSLA 3UEEA 1OY7A 3UEFA 2OPYA 2RAXA 3UIGA 3UEDA 3G76A 1SDZA 2JK7A 4A0IA 1F3HA 4MU7A 3UW4A 1QBHA 5C3KA 2I3HA 4LGEA 1I3OE 1TFTA 3F7IA 1XB1A 1OXNA 3UIJA 3EYLA 3F7HA 3UEIA 3SIQA 4KJUA 1M4MA 5C7BA 3D9TA 1JD6A 1SE0A 4LGUA 4HY5A 1Q4QA 4J45A 4HY4A 1OXQA 3CM2A 4J47A 2POPB 3CM7A 4WVUA 1XB0A 3UW5A 3T6PA 3UEGA 2POIA 3CLXA 5C7DA 4EC4A 2VM5A 1G73C 1TFQA 5C3HA 1G3FA 5C7AA 3UEHA 2QRAA 3M1DA 2QFAA 4OXCA 4J48A 1NW9A 3UIHA 2I3IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SIP E;  4A0J A;  4J3Y A;  1TW6 A;  3OZ1 A;  3GT9 A;  1JD5 A;  2OPZ A;  4WVT A;  3M0A D;  4KMN A;  4MTZ A;  1JD4 A;  4MTI A;  5C7C A;  3UEC A;  3UIK A;  3GTA A;  4J46 A;  1C9Q A;  4HY0 A;  4WVS A;  1XOX A;  3MUP A;  1E31 A;  4J44 A;  4KMP A;  4KJV A;  4EB9 A;  3HL5 A;  4A0N A;  3F7G A;  5C83 A;  3D9U A;  5C0K A;  1F9X A;  3UII A;  2UVL A;  5C84 A;  5C0L A;  2RAW A;  3M0D D;  2VSL A;  3UEE A;  1OY7 A;  3UEF A;  2OPY A;  2RAX A;  3UIG A;  3UED A;  3G76 A;  1SDZ A;  2JK7 A;  4A0I A;  1F3H A;  4MU7 A;  3UW4 A;  1QBH A;  5C3K A;  2I3H A;  4LGE A;  1I3O E;  1TFT A;  3F7I A;  1XB1 A;  1OXN A;  3UIJ A;  3EYL A;  3F7H A;  3UEI A;  3SIQ A;  4KJU A;  1M4M A;  5C7B A;  3D9T A;  1JD6 A;  1SE0 A;  4LGU A;  4HY5 A;  1Q4Q A;  4J45 A;  4HY4 A;  1OXQ A;  3CM2 A;  4J47 A;  2POP B;  3CM7 A;  4WVU A;  1XB0 A;  3UW5 A;  3T6P A;  3UEG A;  2POI A;  3CLX A;  5C7D A;  4EC4 A;  2VM5 A;  1G73 C;  1TFQ A;  5C3H A;  1G3F A;  5C7A A;  3UEH A;  2QRA A;  3M1D A;  2QFA A;  4OXC A;  4J48 A;  1NW9 A;  3UIH A;  2I3I A; 
#chains in the Genus database with same CATH topology
 3SIP E;  4A0J A;  4J3Y A;  1TW6 A;  3OZ1 A;  3GT9 A;  1JD5 A;  2OPZ A;  4WVT A;  3M0A D;  4KMN A;  4MTZ A;  1JD4 A;  4MTI A;  5C7C A;  3UEC A;  3UIK A;  3GTA A;  4J46 A;  1C9Q A;  4HY0 A;  4WVS A;  1XOX A;  3MUP A;  1E31 A;  4J44 A;  4KMP A;  4KJV A;  4EB9 A;  3HL5 A;  4A0N A;  3F7G A;  5C83 A;  3D9U A;  5C0K A;  1F9X A;  3UII A;  2UVL A;  5C84 A;  5C0L A;  2RAW A;  3M0D D;  2VSL A;  3UEE A;  1OY7 A;  3UEF A;  2OPY A;  2RAX A;  3UIG A;  3UED A;  3G76 A;  1SDZ A;  2JK7 A;  4A0I A;  1F3H A;  4MU7 A;  3UW4 A;  1QBH A;  5C3K A;  2I3H A;  4LGE A;  1I3O E;  1TFT A;  3F7I A;  1XB1 A;  1OXN A;  3UIJ A;  3EYL A;  3F7H A;  3UEI A;  3SIQ A;  4KJU A;  1M4M A;  5C7B A;  3D9T A;  1JD6 A;  1SE0 A;  4LGU A;  4HY5 A;  1Q4Q A;  4J45 A;  4HY4 A;  1OXQ A;  3CM2 A;  4J47 A;  2POP B;  3CM7 A;  4WVU A;  1XB0 A;  3UW5 A;  3T6P A;  3UEG A;  2POI A;  3CLX A;  5C7D A;  4EC4 A;  2VM5 A;  1G73 C;  1TFQ A;  5C3H A;  1G3F A;  5C7A A;  3UEH A;  2QRA A;  3M1D A;  2QFA A;  4OXC A;  4J48 A;  1NW9 A;  3UIH A;  2I3I A; 
#chains in the Genus database with same CATH homology
 3SIP E;  4A0J A;  4J3Y A;  1TW6 A;  3OZ1 A;  3GT9 A;  1JD5 A;  2OPZ A;  4WVT A;  3M0A D;  4KMN A;  4MTZ A;  1JD4 A;  4MTI A;  5C7C A;  3UEC A;  3UIK A;  3GTA A;  4J46 A;  1C9Q A;  4HY0 A;  4WVS A;  1XOX A;  3MUP A;  1E31 A;  4J44 A;  4KMP A;  4KJV A;  4EB9 A;  3HL5 A;  4A0N A;  3F7G A;  5C83 A;  3D9U A;  5C0K A;  1F9X A;  3UII A;  2UVL A;  5C84 A;  5C0L A;  2RAW A;  3M0D D;  2VSL A;  3UEE A;  1OY7 A;  3UEF A;  2OPY A;  2RAX A;  3UIG A;  3UED A;  3G76 A;  1SDZ A;  2JK7 A;  4A0I A;  1F3H A;  4MU7 A;  3UW4 A;  1QBH A;  5C3K A;  2I3H A;  4LGE A;  1I3O E;  1TFT A;  3F7I A;  1XB1 A;  1OXN A;  3UIJ A;  3EYL A;  3F7H A;  3UEI A;  3SIQ A;  4KJU A;  1M4M A;  5C7B A;  3D9T A;  1JD6 A;  1SE0 A;  4LGU A;  4HY5 A;  1Q4Q A;  4J45 A;  4HY4 A;  1OXQ A;  3CM2 A;  4J47 A;  2POP B;  3CM7 A;  4WVU A;  1XB0 A;  3UW5 A;  3T6P A;  3UEG A;  2POI A;  3CLX A;  5C7D A;  4EC4 A;  2VM5 A;  1G73 C;  1TFQ A;  5C3H A;  1G3F A;  5C7A A;  3UEH A;  2QRA A;  3M1D A;  2QFA A;  4OXC A;  4J48 A;  1NW9 A;  3UIH A;  2I3I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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