5CM9A

Structural basis for the selectivity of guanine nucleotide exchange factors for the small g-protein ral
Total Genus 138
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
461
structure length
405
Chain Sequence
SVSVWDEEEDGATFTVTSRQYRPLDPLAPLPPPRSSRRLRAGTLEALVRHLLDARTAGADMMFTPALLATHRAFTSTPALFGLVADRLEALESYPPGELERTTGVAISVLSTWLASHPEDFGSEVKGQLDRLESFLLRTGYGSADLIRNLRARVDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSIGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGETTRDSLRVFSSLCQIFGFRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAILSELLRLQKECRGYDLRPNSDIQQWLQGLQPLTEAQSHRVSCEVEPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
pubmed doi rcsb
source organism Mus musculus
molecule tags Signaling protein
molecule keywords Ral guanine nucleotide dissociation stimulator-like 2
total genus 138
structure length 405
sequence length 461
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
A PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 5cm9A02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 5cm9A01
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH superfamily
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH topology
3QXLA 4US0S 4URVS 4NYJS 4MGKE 1XD2C 4MGZE 4MH0E 4URUS 4US1S 2II0A 2IJES 4US2S 1NVWS 1NVXS 4MGYE 4L9MA 4MGIE 2BYVE 4NYMS 3KSYA 4JGWA 1XD4A 5CM8A 5CM9A 4URYS 4URZS 1NVUS 3T6AA 4NYIS 4F7ZA 1NVVS 1BKDS 4URWS 4URXS 3CF6E 3T6GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
#chains in the Genus database with same CATH topology
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
#chains in the Genus database with same CATH homology
 3QXL A;  4US0 S;  4URV S;  4NYJ S;  4MGK E;  1XD2 C;  4MGZ E;  4MH0 E;  4URU S;  4US1 S;  2II0 A;  2IJE S;  4US2 S;  1NVW S;  1NVX S;  4MGY E;  4L9M A;  4MGI E;  2BYV E;  4NYM S;  3KSY A;  4JGW A;  1XD4 A;  5CM8 A;  5CM9 A;  4URY S;  4URZ S;  1NVU S;  3T6A A;  4NYI S;  4F7Z A;  1NVV S;  1BKD S;  4URW S;  4URX S;  3CF6 E;  3T6G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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