5CM9A

Structural basis for the selectivity of guanine nucleotide exchange factors for the small g-protein ral
Total Genus 138
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
461
structure length
405
Chain Sequence
SVSVWDEEEDGATFTVTSRQYRPLDPLAPLPPPRSSRRLRAGTLEALVRHLLDARTAGADMMFTPALLATHRAFTSTPALFGLVADRLEALESYPPGELERTTGVAISVLSTWLASHPEDFGSEVKGQLDRLESFLLRTGYGSADLIRNLRARVDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSIGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGETTRDSLRVFSSLCQIFGFRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAILSELLRLQKECRGYDLRPNSDIQQWLQGLQPLTEAQSHRVSCEVEPPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
pubmed doi rcsb
molecule tags Signaling protein
source organism Mus musculus
molecule keywords Ral guanine nucleotide dissociation stimulator-like 2
total genus 138
structure length 405
sequence length 461
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
A PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 5cm9A02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 5cm9A01
4F7ZA 4MGYE 4URWS 3T6AA 1XD2C 2IJES 5CM9A 4MGKE 4MH0E 1NVVS 2II0A 4NYMS 4US0S 2BYVE 4MGIE 4US2S 4JGWA 1NVWS 4NYJS 1NVUS 4URYS 4URXS 3KSYA 3QXLA 1BKDS 4MGZE 4US1S 3T6GA 1NVXS 4NYIS 4URZS 4URUS 1XD4A 4URVS 5CM8A 4L9MA 3CF6E
chains in the Genus database with same CATH superfamily
4F7ZA 4MGYE 4URWS 3T6AA 1XD2C 2IJES 5CM9A 4MGKE 4MH0E 1NVVS 2II0A 4NYMS 4US0S 2BYVE 4MGIE 4US2S 4JGWA 1NVWS 4NYJS 1NVUS 4URYS 4URXS 3KSYA 3QXLA 1BKDS 4MGZE 4US1S 3T6GA 1NVXS 4NYIS 4URZS 4URUS 1XD4A 4URVS 5CM8A 4L9MA 3CF6E
chains in the Genus database with same CATH topology
4F7ZA 4MGYE 4URWS 3T6AA 1XD2C 2IJES 5CM9A 4MGKE 4MH0E 1NVVS 2II0A 4NYMS 4US0S 2BYVE 4MGIE 4US2S 4JGWA 1NVWS 4NYJS 1NVUS 4URYS 4URXS 3KSYA 3QXLA 1BKDS 4MGZE 4US1S 3T6GA 1NVXS 4NYIS 4URZS 4URUS 1XD4A 4URVS 5CM8A 4L9MA 3CF6E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F7Z A;  4MGY E;  4URW S;  3T6A A;  1XD2 C;  2IJE S;  5CM9 A;  4MGK E;  4MH0 E;  1NVV S;  2II0 A;  4NYM S;  4US0 S;  2BYV E;  4MGI E;  4US2 S;  4JGW A;  1NVW S;  4NYJ S;  1NVU S;  4URY S;  4URX S;  3KSY A;  3QXL A;  1BKD S;  4MGZ E;  4US1 S;  3T6G A;  1NVX S;  4NYI S;  4URZ S;  4URU S;  1XD4 A;  4URV S;  5CM8 A;  4L9M A;  3CF6 E; 
#chains in the Genus database with same CATH topology
 4F7Z A;  4MGY E;  4URW S;  3T6A A;  1XD2 C;  2IJE S;  5CM9 A;  4MGK E;  4MH0 E;  1NVV S;  2II0 A;  4NYM S;  4US0 S;  2BYV E;  4MGI E;  4US2 S;  4JGW A;  1NVW S;  4NYJ S;  1NVU S;  4URY S;  4URX S;  3KSY A;  3QXL A;  1BKD S;  4MGZ E;  4US1 S;  3T6G A;  1NVX S;  4NYI S;  4URZ S;  4URU S;  1XD4 A;  4URV S;  5CM8 A;  4L9M A;  3CF6 E; 
#chains in the Genus database with same CATH homology
 4F7Z A;  4MGY E;  4URW S;  3T6A A;  1XD2 C;  2IJE S;  5CM9 A;  4MGK E;  4MH0 E;  1NVV S;  2II0 A;  4NYM S;  4US0 S;  2BYV E;  4MGI E;  4US2 S;  4JGW A;  1NVW S;  4NYJ S;  1NVU S;  4URY S;  4URX S;  3KSY A;  3QXL A;  1BKD S;  4MGZ E;  4US1 S;  3T6G A;  1NVX S;  4NYI S;  4URZ S;  4URU S;  1XD4 A;  4URV S;  5CM8 A;  4L9M A;  3CF6 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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