The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
193
|
sequence length |
596
|
structure length |
596
|
Chain Sequence |
MVHYYRLSLKSRQKAPKIVNSKYNSILNIALKNFRLCKKHKTKKPVQILALLQEIIPKSYFGTTTNLKRFYKVVEKILTQSSFECIHLSVLHKCYDYDAIPWLQNVEPNLRPKLLLKHNLFLLDNIVKPIIAFYYKPIKTLNGHEIKFIRKEEYISFESKVFHKLKKMKYLVEVQDEVKPRGVLNIIPKQDNFRAIVSIFPDSARKPFFKLLTSKIYKVLEEKYKTSGSLYTCWSEFTQKTQGQIYGIKVDIRDAYGNVKIPVLCKLIQSIPTHLLDSEKKNFIVDHISNQFVAFRRKIYKWNHGLLQGDPLSGCLCELYMAFMDRLYFSNLDKDAFIHRTVDDYFFCSPHPHKVYDFELLIKGVYQVNPTKTRTNLPTHRHPQDEIPYCGKIFNLTTRQVRTLYKLPPNYEIRHKFKLWNFNNQISDDNPARFLQKAMDFPFICNSFTKFEFNTVFNDQRTVFANFYDAMICVAYKFDAAMMALRTSFLVNDFGFIWLVLSSTVRAYASRAFKKIVTYKGGKYRKVTFQCLKSIAWRAFLAVLKRRTEIYKGLIDRIKSREKLTMKFHDGEVDASYFCKLPEKFRFVKINRKASI
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532.
pubmed doi rcsb |
| molecule keywords |
Telomerase reverse transcriptase
|
| source organism |
Tribolium castaneum
|
| molecule tags |
Transferase/transferase inhibitor
|
| total genus |
193
|
| structure length |
596
|
| sequence length |
596
|
| chains with identical sequence |
B
|
| ec nomenclature | |
| pdb deposition date | 2015-07-21 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00078 | RVT_1 | Reverse transcriptase (RNA-dependent DNA polymerase) |
| A | PF12009 | Telomerase_RBD | Telomerase ribonucleoprotein complex - RNA binding domain |
| A | PF17984 | TERT_thumb | Telomerase reverse transcriptase thumb DNA binding domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Arc Repressor Mutant, subunit A | Arc Repressor Mutant, subunit A | ||
| Mainly Alpha | Orthogonal Bundle | Topoisomerase I; Chain A, domain 4 | Topoisomerase I; Chain A, domain 4 | ||
| Mainly Alpha | Orthogonal Bundle | Tetracycline Repressor; domain 2 | Tetracycline Repressor; domain 2 | ||
| Alpha Beta | Roll | HIV Type 1 Reverse Transcriptase; Chain A, domain 1 | HIV Type 1 Reverse Transcriptase; Chain A, domain 1 | ||
| Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | Alpha-Beta Plaits |
