5CWAA

Structure of anthranilate synthase component i (trpe) from mycobacterium tuberculosis with inhibitor bound
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
509
structure length
505
Chain Sequence
ADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIVEYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEGRTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARAVLNAIAAAETLAAPGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase/lyase inhibitor
molecule keywords Anthranilate synthase component 1
publication title Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
total genus 159
structure length 505
sequence length 509
ec nomenclature ec 4.1.3.27: Anthranilate synthase.
pdb deposition date 2015-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00425 Chorismate_bind chorismate binding enzyme
A PF04715 Anth_synt_I_N Anthranilate synthase component I, N terminal region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.120.10 Alpha Beta 4-Layer Sandwich Anthranilate synthase Anthranilate synthase 5cwaA00
3LOGA 3GSEA 5JY8A 3VEHA 3ST6A 3HWOA 1I7SA 3R74A 2I6YA 1I1QA 1I7QA 2FN1A 3BZMA 5JY4B 5JY4A 2G5FA 5CWAA 1K0EA 3RV6A 5JY9A 2EUAA 2FN0A 1QDLA 4GRHA 5JXZA 3RV8A 5JZDA 3OS6A 3R75A 3RV7A 3RV9A 5KCKA 3H9MA 1K0GA 3BZNA 3R76A
chains in the Genus database with same CATH superfamily
3LOGA 3GSEA 5JY8A 3VEHA 3ST6A 3HWOA 1I7SA 3R74A 2I6YA 1I1QA 1I7QA 2FN1A 3BZMA 5JY4B 5JY4A 2G5FA 5CWAA 1K0EA 3RV6A 5JY9A 2EUAA 2FN0A 1QDLA 4GRHA 5JXZA 3RV8A 5JZDA 3OS6A 3R75A 3RV7A 3RV9A 5KCKA 3H9MA 1K0GA 3BZNA 3R76A
chains in the Genus database with same CATH topology
3LOGA 3GSEA 5JY8A 3VEHA 3ST6A 3HWOA 1I7SA 3R74A 2I6YA 1I1QA 1I7QA 2FN1A 3BZMA 5JY4B 5JY4A 2G5FA 5CWAA 1K0EA 3RV6A 5JY9A 2EUAA 2FN0A 1QDLA 4GRHA 5JXZA 3RV8A 5JZDA 3OS6A 3R75A 3RV7A 3RV9A 5KCKA 3H9MA 1K0GA 3BZNA 3R76A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LOG A;  3GSE A;  5JY8 A;  3VEH A;  3ST6 A;  3HWO A;  1I7S A;  3R74 A;  2I6Y A;  1I1Q A;  1I7Q A;  2FN1 A;  3BZM A;  5JY4 B;  5JY4 A;  2G5F A;  5CWA A;  1K0E A;  3RV6 A;  5JY9 A;  2EUA A;  2FN0 A;  1QDL A;  4GRH A;  5JXZ A;  3RV8 A;  5JZD A;  3OS6 A;  3R75 A;  3RV7 A;  3RV9 A;  5KCK A;  3H9M A;  1K0G A;  3BZN A;  3R76 A; 
#chains in the Genus database with same CATH topology
 3LOG A;  3GSE A;  5JY8 A;  3VEH A;  3ST6 A;  3HWO A;  1I7S A;  3R74 A;  2I6Y A;  1I1Q A;  1I7Q A;  2FN1 A;  3BZM A;  5JY4 B;  5JY4 A;  2G5F A;  5CWA A;  1K0E A;  3RV6 A;  5JY9 A;  2EUA A;  2FN0 A;  1QDL A;  4GRH A;  5JXZ A;  3RV8 A;  5JZD A;  3OS6 A;  3R75 A;  3RV7 A;  3RV9 A;  5KCK A;  3H9M A;  1K0G A;  3BZN A;  3R76 A; 
#chains in the Genus database with same CATH homology
 3LOG A;  3GSE A;  5JY8 A;  3VEH A;  3ST6 A;  3HWO A;  1I7S A;  3R74 A;  2I6Y A;  1I1Q A;  1I7Q A;  2FN1 A;  3BZM A;  5JY4 B;  5JY4 A;  2G5F A;  5CWA A;  1K0E A;  3RV6 A;  5JY9 A;  2EUA A;  2FN0 A;  1QDL A;  4GRH A;  5JXZ A;  3RV8 A;  5JZD A;  3OS6 A;  3R75 A;  3RV7 A;  3RV9 A;  5KCK A;  3H9M A;  1K0G A;  3BZN A;  3R76 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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