5DV4A

Crystal structure of human cnot6l in complex with neomycin
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
372
structure length
344
Chain Sequence
LPPRPWITLKERDQSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for inhibition of the deadenylase activity of human CNOT6L
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords CCR4-NOT transcription complex subunit 6-like
total genus 119
structure length 344
sequence length 372
ec nomenclature ec 3.1.13.4: Poly(A)-specific ribonuclease.
pdb deposition date 2015-09-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 5dv4A00
2O3CA 5J3PA 1I9ZA 1I9YA 1Y21A 3G0AA 5INQA 2O3HA 2JC5A 4K6LF 4F1HA 1DNKA 4L1YA 2A3ZB 1SR4B 4GYZA 4QHEA 2XSWA 3NGNA 3I46A 3I48A 4QH9A 5A7IA 3G2DA 3U8UA 2A42B 2DDTA 5INNA 5HT2A 5EWTA 4A9CA 1SI6X 3WCXA 4FVAA 4B5MA 4B5HA 2JC4A 3G91A 3I5VA 4GEWA 3MTCA 4CMNA 1HD7A 4L21A 3MPRA 1VYBA 3I41A 3G6SA 4F1RA 3G0RA 5J3ZA 2J63A 2V0RA 5DV4A 5INMA 5CFGA 3GA6A 4FPVA 5INPA 4B5FA 3NR8A 3K55A 3W2XA 1WDUA 3DNIA 1DE8A 2A41B 2DDRA 4AWNA 3G3YA 3G38A 5DFIA 1DEWA 2A40B 3G8VA 4F1IA 5J8NA 4RUWA 5J42A 5J3SA 3G4TA 3W2YA 3FZIA 4B5IA 2V0SA 3NGOA 2EI9A 2UYRX 2F2FB 2IMQX 4F1HB 5DFHA 3G3CA 5DFJA 4GZ1A 5DFFA 2DNJA 1BIXA 1ATND 2VOAA 2F1NA 5INKA 4GZ2A 4JG3A 1YJHA 4L20A 5DV2A 4L1ZA 5CFEA 3W3DB 2DDSA 3G1KA 5A7JA 3G00A 3NGQA 2ISIA 4CMLA 1AKOA 4PUQA 4IEMA 3TEBA 5INOA 4C1RA 1DE9A 5INLA 4GZ0A 4B5JA 3L1WA 3G2CA 2D1KB 3N9VA 4QHDA 5DG0A 1NTFA 3CJCD 1E9NA 1ZWXA 4B5GA 4LNDA
chains in the Genus database with same CATH superfamily
2O3CA 5J3PA 1I9ZA 1I9YA 1Y21A 3G0AA 5INQA 2O3HA 2JC5A 4K6LF 4F1HA 1DNKA 4L1YA 2A3ZB 1SR4B 4GYZA 4QHEA 2XSWA 3NGNA 3I46A 3I48A 4QH9A 5A7IA 3G2DA 3U8UA 2A42B 2DDTA 5INNA 5HT2A 5EWTA 4A9CA 1SI6X 3WCXA 4FVAA 4B5MA 4B5HA 2JC4A 3G91A 3I5VA 4GEWA 3MTCA 4CMNA 1HD7A 4L21A 3MPRA 1VYBA 3I41A 3G6SA 4F1RA 3G0RA 5J3ZA 2J63A 2V0RA 5DV4A 5INMA 5CFGA 3GA6A 4FPVA 5INPA 4B5FA 3NR8A 3K55A 3W2XA 1WDUA 3DNIA 1DE8A 2A41B 2DDRA 4AWNA 3G3YA 3G38A 5DFIA 1DEWA 2A40B 3G8VA 4F1IA 5J8NA 4RUWA 5J42A 5J3SA 3G4TA 3W2YA 3FZIA 4B5IA 2V0SA 3NGOA 2EI9A 2UYRX 2F2FB 2IMQX 4F1HB 5DFHA 3G3CA 5DFJA 4GZ1A 5DFFA 2DNJA 1BIXA 1ATND 2VOAA 2F1NA 5INKA 4GZ2A 4JG3A 1YJHA 4L20A 5DV2A 4L1ZA 5CFEA 3W3DB 2DDSA 3G1KA 5A7JA 3G00A 3NGQA 2ISIA 4CMLA 1AKOA 4PUQA 4IEMA 3TEBA 5INOA 4C1RA 1DE9A 5INLA 4GZ0A 4B5JA 3L1WA 3G2CA 2D1KB 3N9VA 4QHDA 5DG0A 1NTFA 3CJCD 1E9NA 1ZWXA 4B5GA 4LNDA
chains in the Genus database with same CATH topology
2O3CA 5J3PA 1I9ZA 1I9YA 1Y21A 3G0AA 5INQA 2O3HA 2JC5A 4K6LF 4F1HA 1DNKA 4L1YA 2A3ZB 1SR4B 4GYZA 4QHEA 2XSWA 3NGNA 3I46A 3I48A 4QH9A 5A7IA 3G2DA 3U8UA 2A42B 2DDTA 5INNA 5HT2A 5EWTA 4A9CA 1SI6X 3WCXA 4FVAA 4B5MA 4B5HA 2JC4A 3G91A 3I5VA 4GEWA 3MTCA 4CMNA 1HD7A 4L21A 3MPRA 1VYBA 3I41A 3G6SA 4F1RA 3G0RA 5J3ZA 2J63A 2V0RA 5DV4A 5INMA 5CFGA 3GA6A 4FPVA 5INPA 4B5FA 3NR8A 3K55A 3W2XA 1WDUA 3DNIA 1DE8A 2A41B 2DDRA 4AWNA 3G3YA 3G38A 5DFIA 1DEWA 2A40B 3G8VA 4F1IA 5J8NA 4RUWA 5J42A 5J3SA 3G4TA 3W2YA 3FZIA 4B5IA 2V0SA 3NGOA 2EI9A 2UYRX 2F2FB 2IMQX 4F1HB 5DFHA 3G3CA 5DFJA 4GZ1A 5DFFA 2DNJA 1BIXA 1ATND 2VOAA 2F1NA 5INKA 4GZ2A 4JG3A 1YJHA 4L20A 5DV2A 4L1ZA 5CFEA 3W3DB 2DDSA 3G1KA 5A7JA 3G00A 3NGQA 2ISIA 4CMLA 1AKOA 4PUQA 4IEMA 3TEBA 5INOA 4C1RA 1DE9A 5INLA 4GZ0A 4B5JA 3L1WA 3G2CA 2D1KB 3N9VA 4QHDA 5DG0A 1NTFA 3CJCD 1E9NA 1ZWXA 4B5GA 4LNDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O3C A;  5J3P A;  1I9Z A;  1I9Y A;  1Y21 A;  3G0A A;  5INQ A;  2O3H A;  2JC5 A;  4K6L F;  4F1H A;  1DNK A;  4L1Y A;  2A3Z B;  1SR4 B;  4GYZ A;  4QHE A;  2XSW A;  3NGN A;  3I46 A;  3I48 A;  4QH9 A;  5A7I A;  3G2D A;  3U8U A;  2A42 B;  2DDT A;  5INN A;  5HT2 A;  5EWT A;  4A9C A;  1SI6 X;  3WCX A;  4FVA A;  4B5M A;  4B5H A;  2JC4 A;  3G91 A;  3I5V A;  4GEW A;  3MTC A;  4CMN A;  1HD7 A;  4L21 A;  3MPR A;  1VYB A;  3I41 A;  3G6S A;  4F1R A;  3G0R A;  5J3Z A;  2J63 A;  2V0R A;  5DV4 A;  5INM A;  5CFG A;  3GA6 A;  4FPV A;  5INP A;  4B5F A;  3NR8 A;  3K55 A;  3W2X A;  1WDU A;  3DNI A;  1DE8 A;  2A41 B;  2DDR A;  4AWN A;  3G3Y A;  3G38 A;  5DFI A;  1DEW A;  2A40 B;  3G8V A;  4F1I A;  5J8N A;  4RUW A;  5J42 A;  5J3S A;  3G4T A;  3W2Y A;  3FZI A;  4B5I A;  2V0S A;  3NGO A;  2EI9 A;  2UYR X;  2F2F B;  2IMQ X;  4F1H B;  5DFH A;  3G3C A;  5DFJ A;  4GZ1 A;  5DFF A;  2DNJ A;  1BIX A;  1ATN D;  2VOA A;  2F1N A;  5INK A;  4GZ2 A;  4JG3 A;  1YJH A;  4L20 A;  5DV2 A;  4L1Z A;  5CFE A;  3W3D B;  2DDS A;  3G1K A;  5A7J A;  3G00 A;  3NGQ A;  2ISI A;  4CML A;  1AKO A;  4PUQ A;  4IEM A;  3TEB A;  5INO A;  4C1R A;  1DE9 A;  5INL A;  4GZ0 A;  4B5J A;  3L1W A;  3G2C A;  2D1K B;  3N9V A;  4QHD A;  5DG0 A;  1NTF A;  3CJC D;  1E9N A;  1ZWX A;  4B5G A;  4LND A; 
#chains in the Genus database with same CATH topology
 2O3C A;  5J3P A;  1I9Z A;  1I9Y A;  1Y21 A;  3G0A A;  5INQ A;  2O3H A;  2JC5 A;  4K6L F;  4F1H A;  1DNK A;  4L1Y A;  2A3Z B;  1SR4 B;  4GYZ A;  4QHE A;  2XSW A;  3NGN A;  3I46 A;  3I48 A;  4QH9 A;  5A7I A;  3G2D A;  3U8U A;  2A42 B;  2DDT A;  5INN A;  5HT2 A;  5EWT A;  4A9C A;  1SI6 X;  3WCX A;  4FVA A;  4B5M A;  4B5H A;  2JC4 A;  3G91 A;  3I5V A;  4GEW A;  3MTC A;  4CMN A;  1HD7 A;  4L21 A;  3MPR A;  1VYB A;  3I41 A;  3G6S A;  4F1R A;  3G0R A;  5J3Z A;  2J63 A;  2V0R A;  5DV4 A;  5INM A;  5CFG A;  3GA6 A;  4FPV A;  5INP A;  4B5F A;  3NR8 A;  3K55 A;  3W2X A;  1WDU A;  3DNI A;  1DE8 A;  2A41 B;  2DDR A;  4AWN A;  3G3Y A;  3G38 A;  5DFI A;  1DEW A;  2A40 B;  3G8V A;  4F1I A;  5J8N A;  4RUW A;  5J42 A;  5J3S A;  3G4T A;  3W2Y A;  3FZI A;  4B5I A;  2V0S A;  3NGO A;  2EI9 A;  2UYR X;  2F2F B;  2IMQ X;  4F1H B;  5DFH A;  3G3C A;  5DFJ A;  4GZ1 A;  5DFF A;  2DNJ A;  1BIX A;  1ATN D;  2VOA A;  2F1N A;  5INK A;  4GZ2 A;  4JG3 A;  1YJH A;  4L20 A;  5DV2 A;  4L1Z A;  5CFE A;  3W3D B;  2DDS A;  3G1K A;  5A7J A;  3G00 A;  3NGQ A;  2ISI A;  4CML A;  1AKO A;  4PUQ A;  4IEM A;  3TEB A;  5INO A;  4C1R A;  1DE9 A;  5INL A;  4GZ0 A;  4B5J A;  3L1W A;  3G2C A;  2D1K B;  3N9V A;  4QHD A;  5DG0 A;  1NTF A;  3CJC D;  1E9N A;  1ZWX A;  4B5G A;  4LND A; 
#chains in the Genus database with same CATH homology
 2O3C A;  5J3P A;  1I9Z A;  1I9Y A;  1Y21 A;  3G0A A;  5INQ A;  2O3H A;  2JC5 A;  4K6L F;  4F1H A;  1DNK A;  4L1Y A;  2A3Z B;  1SR4 B;  4GYZ A;  4QHE A;  2XSW A;  3NGN A;  3I46 A;  3I48 A;  4QH9 A;  5A7I A;  3G2D A;  3U8U A;  2A42 B;  2DDT A;  5INN A;  5HT2 A;  5EWT A;  4A9C A;  1SI6 X;  3WCX A;  4FVA A;  4B5M A;  4B5H A;  2JC4 A;  3G91 A;  3I5V A;  4GEW A;  3MTC A;  4CMN A;  1HD7 A;  4L21 A;  3MPR A;  1VYB A;  3I41 A;  3G6S A;  4F1R A;  3G0R A;  5J3Z A;  2J63 A;  2V0R A;  5DV4 A;  5INM A;  5CFG A;  3GA6 A;  4FPV A;  5INP A;  4B5F A;  3NR8 A;  3K55 A;  3W2X A;  1WDU A;  3DNI A;  1DE8 A;  2A41 B;  2DDR A;  4AWN A;  3G3Y A;  3G38 A;  5DFI A;  1DEW A;  2A40 B;  3G8V A;  4F1I A;  5J8N A;  4RUW A;  5J42 A;  5J3S A;  3G4T A;  3W2Y A;  3FZI A;  4B5I A;  2V0S A;  3NGO A;  2EI9 A;  2UYR X;  2F2F B;  2IMQ X;  4F1H B;  5DFH A;  3G3C A;  5DFJ A;  4GZ1 A;  5DFF A;  2DNJ A;  1BIX A;  1ATN D;  2VOA A;  2F1N A;  5INK A;  4GZ2 A;  4JG3 A;  1YJH A;  4L20 A;  5DV2 A;  4L1Z A;  5CFE A;  3W3D B;  2DDS A;  3G1K A;  5A7J A;  3G00 A;  3NGQ A;  2ISI A;  4CML A;  1AKO A;  4PUQ A;  4IEM A;  3TEB A;  5INO A;  4C1R A;  1DE9 A;  5INL A;  4GZ0 A;  4B5J A;  3L1W A;  3G2C A;  2D1K B;  3N9V A;  4QHD A;  5DG0 A;  1NTF A;  3CJC D;  1E9N A;  1ZWX A;  4B5G A;  4LND A; 
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