The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
105
|
sequence length |
313
|
structure length |
313
|
Chain Sequence |
MCLKLNLLDHVFANPFMNAAGVLCSTEEDLRCMTASSSGALVSKSCTSAPRDGNPEPRYMAFPLGSINSMGLPNLGFDFYLKYASDLHDYSKKPLFLSISGLSVEENVAMVRRLAPVAQEKGVLLELNLSCPNVPGKPQVAYDFEAMRTYLQQVSLAYGLPFGVKMPPYFDIAHFDTAAAVLNEFPLVKFVTCVNSVGNGLVIDAESESVVIKPKQGFGGLGGKYILPTALANVNAFYRRCPDKLVFGCGGVYSGEDAFLHILAGASMVQVGTALQEEGPGIFTRLEDELLEIMARKGYRTLEEFRGRVKTIE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| molecule keywords |
Dihydroorotate dehydrogenase (fumarate)
|
| publication title |
Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity
rcsb |
| source organism |
Trypanosoma cruzi strain cl brener
|
| molecule tags |
Oxidoreductase/oxidoreductase inhibitor
|
| total genus |
105
|
| structure length |
313
|
| sequence length |
313
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
1.3.98.1: Dihydroorotate oxidase (fumarate). |
| pdb deposition date | 2015-10-15 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01180 | DHO_dh | Dihydroorotate dehydrogenase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Roll | Dihydroorotate Dehydrogenase A; chain A, domain 2 | Dihydroorotate Dehydrogenase A, chain A, domain 2 | ||
| Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I |
