5EEFA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 in complex with trichostatin a
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
359
structure length
354
Chain Sequence
b'SATGTGLVYVDAFTRFHSHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HDAC6
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 144
structure length 354
sequence length 359
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-10-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5eefA00
4BZ5A 3F0RA 5EEFA 4ZUPA 3MZ3A 4ZUMA 4A69A 4QA1A 4BZ6A 3EZTA 3EZPA 3MZ7A 4QA2A 4CBTA 4QA5A 4QA7A 3F06A 3RQDA 3EW8A 3Q9FA 3Q9CA 5G13A 4RN0A 5G1BA 3ZNRA 5EFNA 5THTA 1ZZ0A 3EWFA 4BKXB 4LXZA 5EFHA 1C3RA 3C0YA 2VQMA 5A2SA 3SFHA 4QA3A 4RN2A 5G1AA 5G0YA 5THUA 2VQWG 5G0HA 4BZ7A 5EF8A 5G11A 3MZ6A 5THSA 4CQFA 5IX0A 4QA4A 4CBYA 5IWGA 5EEMA 3C10A 4RN1A 5EF7A 5DC5A 3Q9BA 4ZURA 3MENA 5LI3A 5EFBD 5G12A 2V5XA 2VCGA 3C0ZA 4ZUOA 4ZUQA 5EENA 1C3SA 4ZUNA 5THVA 5EFGA 5D1DA 5DC6A 5DC8A 5G10A 4BZ8A 1VKGA 5BWZA 5EFKB 1W22A 5EEKA 2V5WA 2VQJA 4QA0A 5G0IA 5FCWA 5EFJD 5ICNB 5FUEA 2VQQA 1T69A 1T64A 3SFFA 5G17A 4LY1A 3MAXA 5D1BA 2VQOA 5G3WA 3ZNSA 1T67A 5G0XA 5D1CA 5JI5A 2VQVA 5G0JA 5DC7A 2GH6A 4QA6A 5G1CA 5G0GA 1C3PA 4BZ9A 1ZZ3A 1ZZ1A 3Q9EA 5EEIA 3F07A 3MZ4A
chains in the Genus database with same CATH superfamily
4BZ5A 3F0RA 1T4PA 5EEFA 4RHLA 1WOIA 3NIQA 2EF4A 2AEBA 2PHAA 3MZ3A 4ZUPA 4ZUMA 4IXVA 4A69A 4IE3A 4QA1A 3THEA 4BZ6A 4IU5A 3EZTA 2EF5A 4Q42A 4Q3UA 1WOGA 1WVAA 3EZPA 1P8NA 4Q40A 5HJ9A 5RLAA 3E6VA 3MZ7A 4QA2A 4Q3SA 4QA5A 4QA7A 3F06A 4CBTA 1T4TA 4GSVA 3EW8A 3PZLA 3Q9FA 2CEVA 4GSMA 1T5GA 3Q9CA 5G13A 4RN0A 1P8QA 4IE1A 5G1BA 4GSZA 3ZNRA 1TBHA 4Q3RA 1P8PA 4I06A 5EFNA 5THTA 1WVBA 1ZZ0A 2ZAVA 3EWFA 4RLAA 4DZ4A 4BKXB 4LXZA 3E8QA 4GWDA 5EFHA 3E9BA 1D3VA 1C3RA 1ZPEA 2VQMA 3C0YA 3RQDA 5A2SA 3SFHA 4QA3A 3THJA 4RN2A 4HWWA 5G1AA 5G0YA 4MYKA 5THUA 2VQWG 3KV2A 5G0HA 4BZ7A 5EF8A 4HXQA 5G11A 3MZ6A 1R1OA 5THSA 5IX0A 4CQFA 1HQ5A 4QA4A 4RHKA 4RHQA 4GWCA 4Q41A 4CBYA 3LP7A 5IWGA 4ITYA 3C10A 3DJ8A 4RN1A 5EEMA 1WOHA 5EF7A 4Q3PA 5DC5A 4IE2A 5CEVA 1P8RA 3Q9BA 3LP4A 2RLAA 3MENA 4Q3QA 4ZURA 3RLAA 4IU0A 5LI3A 3GMZA 4IU4A 2PLLA 4FCKA 5EFBD 5G12A 2V5XA 3CEVA 2VCGA 3NIPA 3MMRA 3SJTA 3C0ZA 3MJLA 4ZUOA 3GN0A 1HQFA 4ZUQA 1PQ3A 5EENA 1C3SA 4G3HA 4ZUNA 5THVA 5EFGA 3SL1A 5D1DA 4CEVA 5DC6A 4Q3VA 5DC8A 5G10A 4BZ8A 1T5FA 3TH7A 1VKGA 5BWZA 1TA1A 3MFWA 5EFKB 1P8SA 1W22A 5EEKA 4Q3RC 2V5WA 2VQJA 1CEVA 1RLAA 4QA0A 5G0IA 1TBJA 5FCWA 3F80A 5EFJD 3SL0A 5ICNB 5FUEA 2VQQA 1T69A 1GQ6A 4IU1A 3NIOA 1T4RA 1P8OA 1GQ7A 4RHIA 1T64A 4MYNA 3SFFA 3E8ZA 3SKKA 5G17A 4MYLA 4LY1A 3E6KA 4MXRA 4RHMA 3MAXA 5D1BA 2VQOA 3THHA 1TBLA 4IXUA 5G3WA 3MFVA 4Q3TA 4FCIA 1ZPGA 3ZNSA 1T67A 1XFKA 5G0XA 3LHLA 5D1CA 5HJAA 5JI5A 2VQVA 5G0JA 2A0MA 1HQGA 2EIVA 5DC7A 3TF3A 2PHOA 1HQHA 2GH6A 4QA6A 1P8MA 3M1RA 5G1CA 5G0GA 1HQXA 1C3PA 4HZEA 1ZZ3A 4BZ9A 4MYFA 1T4SA 1ZZ1A 3Q9EA 4RHJA 5EEIA 3F07A 3MZ4A
chains in the Genus database with same CATH topology
4BZ5A 3F0RA 5EEFA 4ZUPA 3MZ3A 4ZUMA 4A69A 4QA1A 4BZ6A 3EZTA 3EZPA 3MZ7A 4QA2A 4CBTA 4QA5A 4QA7A 3F06A 3RQDA 3EW8A 3Q9FA 3Q9CA 5G13A 4RN0A 5G1BA 3ZNRA 5EFNA 5THTA 1ZZ0A 3EWFA 4BKXB 4LXZA 5EFHA 1C3RA 3C0YA 2VQMA 5A2SA 3SFHA 4QA3A 4RN2A 5G1AA 5G0YA 5THUA 2VQWG 5G0HA 4BZ7A 5EF8A 5G11A 3MZ6A 5THSA 4CQFA 5IX0A 4QA4A 4CBYA 5IWGA 5EEMA 3C10A 4RN1A 5EF7A 5DC5A 3Q9BA 4ZURA 3MENA 5LI3A 5EFBD 5G12A 2V5XA 2VCGA 3C0ZA 4ZUOA 4ZUQA 5EENA 1C3SA 4ZUNA 5THVA 5EFGA 5D1DA 5DC6A 5DC8A 5G10A 4BZ8A 1VKGA 5BWZA 5EFKB 1W22A 5EEKA 2V5WA 2VQJA 4QA0A 5G0IA 5FCWA 5EFJD 5ICNB 5FUEA 2VQQA 1T69A 1T64A 3SFFA 5G17A 4LY1A 3MAXA 5D1BA 2VQOA 5G3WA 3ZNSA 1T67A 5G0XA 5D1CA 5JI5A 2VQVA 5G0JA 5DC7A 2GH6A 4QA6A 5G1CA 5G0GA 1C3PA 4BZ9A 1ZZ3A 1ZZ1A 3Q9EA 5EEIA 3F07A 3MZ4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BZ5 A;  3F0R A;  5EEF A;  4ZUP A;  3MZ3 A;  4ZUM A;  4A69 A;  4QA1 A;  4BZ6 A;  3EZT A;  3EZP A;  3MZ7 A;  4QA2 A;  4CBT A;  4QA5 A;  4QA7 A;  3F06 A;  3RQD A;  3EW8 A;  3Q9F A;  3Q9C A;  5G13 A;  4RN0 A;  5G1B A;  3ZNR A;  5EFN A;  5THT A;  1ZZ0 A;  3EWF A;  4BKX B;  4LXZ A;  5EFH A;  1C3R A;  3C0Y A;  2VQM A;  5A2S A;  3SFH A;  4QA3 A;  4RN2 A;  5G1A A;  5G0Y A;  5THU A;  2VQW G;  5G0H A;  4BZ7 A;  5EF8 A;  5G11 A;  3MZ6 A;  5THS A;  4CQF A;  5IX0 A;  4QA4 A;  4CBY A;  5IWG A;  5EEM A;  3C10 A;  4RN1 A;  5EF7 A;  5DC5 A;  3Q9B A;  4ZUR A;  3MEN A;  5LI3 A;  5EFB D;  5G12 A;  2V5X A;  2VCG A;  3C0Z A;  4ZUO A;  4ZUQ A;  5EEN A;  1C3S A;  4ZUN A;  5THV A;  5EFG A;  5D1D A;  5DC6 A;  5DC8 A;  5G10 A;  4BZ8 A;  1VKG A;  5BWZ A;  5EFK B;  1W22 A;  5EEK A;  2V5W A;  2VQJ A;  4QA0 A;  5G0I A;  5FCW A;  5EFJ D;  5ICN B;  5FUE A;  2VQQ A;  1T69 A;  1T64 A;  3SFF A;  5G17 A;  4LY1 A;  3MAX A;  5D1B A;  2VQO A;  5G3W A;  3ZNS A;  1T67 A;  5G0X A;  5D1C A;  5JI5 A;  2VQV A;  5G0J A;  5DC7 A;  2GH6 A;  4QA6 A;  5G1C A;  5G0G A;  1C3P A;  4BZ9 A;  1ZZ3 A;  1ZZ1 A;  3Q9E A;  5EEI A;  3F07 A;  3MZ4 A; 
#chains in the Genus database with same CATH topology
 4BZ5 A;  3F0R A;  1T4P A;  5EEF A;  4RHL A;  1WOI A;  3NIQ A;  2EF4 A;  2AEB A;  2PHA A;  3MZ3 A;  4ZUP A;  4ZUM A;  4IXV A;  4A69 A;  4IE3 A;  4QA1 A;  3THE A;  4BZ6 A;  4IU5 A;  3EZT A;  2EF5 A;  4Q42 A;  4Q3U A;  1WOG A;  1WVA A;  3EZP A;  1P8N A;  4Q40 A;  5HJ9 A;  5RLA A;  3E6V A;  3MZ7 A;  4QA2 A;  4Q3S A;  4QA5 A;  4QA7 A;  3F06 A;  4CBT A;  1T4T A;  4GSV A;  3EW8 A;  3PZL A;  3Q9F A;  2CEV A;  4GSM A;  1T5G A;  3Q9C A;  5G13 A;  4RN0 A;  1P8Q A;  4IE1 A;  5G1B A;  4GSZ A;  3ZNR A;  1TBH A;  4Q3R A;  1P8P A;  4I06 A;  5EFN A;  5THT A;  1WVB A;  1ZZ0 A;  2ZAV A;  3EWF A;  4RLA A;  4DZ4 A;  4BKX B;  4LXZ A;  3E8Q A;  4GWD A;  5EFH A;  3E9B A;  1D3V A;  1C3R A;  1ZPE A;  2VQM A;  3C0Y A;  3RQD A;  5A2S A;  3SFH A;  4QA3 A;  3THJ A;  4RN2 A;  4HWW A;  5G1A A;  5G0Y A;  4MYK A;  5THU A;  2VQW G;  3KV2 A;  5G0H A;  4BZ7 A;  5EF8 A;  4HXQ A;  5G11 A;  3MZ6 A;  1R1O A;  5THS A;  5IX0 A;  4CQF A;  1HQ5 A;  4QA4 A;  4RHK A;  4RHQ A;  4GWC A;  4Q41 A;  4CBY A;  3LP7 A;  5IWG A;  4ITY A;  3C10 A;  3DJ8 A;  4RN1 A;  5EEM A;  1WOH A;  5EF7 A;  4Q3P A;  5DC5 A;  4IE2 A;  5CEV A;  1P8R A;  3Q9B A;  3LP4 A;  2RLA A;  3MEN A;  4Q3Q A;  4ZUR A;  3RLA A;  4IU0 A;  5LI3 A;  3GMZ A;  4IU4 A;  2PLL A;  4FCK A;  5EFB D;  5G12 A;  2V5X A;  3CEV A;  2VCG A;  3NIP A;  3MMR A;  3SJT A;  3C0Z A;  3MJL A;  4ZUO A;  3GN0 A;  1HQF A;  4ZUQ A;  1PQ3 A;  5EEN A;  1C3S A;  4G3H A;  4ZUN A;  5THV A;  5EFG A;  3SL1 A;  5D1D A;  4CEV A;  5DC6 A;  4Q3V A;  5DC8 A;  5G10 A;  4BZ8 A;  1T5F A;  3TH7 A;  1VKG A;  5BWZ A;  1TA1 A;  3MFW A;  5EFK B;  1P8S A;  1W22 A;  5EEK A;  4Q3R C;  2V5W A;  2VQJ A;  1CEV A;  1RLA A;  4QA0 A;  5G0I A;  1TBJ A;  5FCW A;  3F80 A;  5EFJ D;  3SL0 A;  5ICN B;  5FUE A;  2VQQ A;  1T69 A;  1GQ6 A;  4IU1 A;  3NIO A;  1T4R A;  1P8O A;  1GQ7 A;  4RHI A;  1T64 A;  4MYN A;  3SFF A;  3E8Z A;  3SKK A;  5G17 A;  4MYL A;  4LY1 A;  3E6K A;  4MXR A;  4RHM A;  3MAX A;  5D1B A;  2VQO A;  3THH A;  1TBL A;  4IXU A;  5G3W A;  3MFV A;  4Q3T A;  4FCI A;  1ZPG A;  3ZNS A;  1T67 A;  1XFK A;  5G0X A;  3LHL A;  5D1C A;  5HJA A;  5JI5 A;  2VQV A;  5G0J A;  2A0M A;  1HQG A;  2EIV A;  5DC7 A;  3TF3 A;  2PHO A;  1HQH A;  2GH6 A;  4QA6 A;  1P8M A;  3M1R A;  5G1C A;  5G0G A;  1HQX A;  1C3P A;  4HZE A;  1ZZ3 A;  4BZ9 A;  4MYF A;  1T4S A;  1ZZ1 A;  3Q9E A;  4RHJ A;  5EEI A;  3F07 A;  3MZ4 A; 
#chains in the Genus database with same CATH homology
 4BZ5 A;  3F0R A;  5EEF A;  4ZUP A;  3MZ3 A;  4ZUM A;  4A69 A;  4QA1 A;  4BZ6 A;  3EZT A;  3EZP A;  3MZ7 A;  4QA2 A;  4CBT A;  4QA5 A;  4QA7 A;  3F06 A;  3RQD A;  3EW8 A;  3Q9F A;  3Q9C A;  5G13 A;  4RN0 A;  5G1B A;  3ZNR A;  5EFN A;  5THT A;  1ZZ0 A;  3EWF A;  4BKX B;  4LXZ A;  5EFH A;  1C3R A;  3C0Y A;  2VQM A;  5A2S A;  3SFH A;  4QA3 A;  4RN2 A;  5G1A A;  5G0Y A;  5THU A;  2VQW G;  5G0H A;  4BZ7 A;  5EF8 A;  5G11 A;  3MZ6 A;  5THS A;  4CQF A;  5IX0 A;  4QA4 A;  4CBY A;  5IWG A;  5EEM A;  3C10 A;  4RN1 A;  5EF7 A;  5DC5 A;  3Q9B A;  4ZUR A;  3MEN A;  5LI3 A;  5EFB D;  5G12 A;  2V5X A;  2VCG A;  3C0Z A;  4ZUO A;  4ZUQ A;  5EEN A;  1C3S A;  4ZUN A;  5THV A;  5EFG A;  5D1D A;  5DC6 A;  5DC8 A;  5G10 A;  4BZ8 A;  1VKG A;  5BWZ A;  5EFK B;  1W22 A;  5EEK A;  2V5W A;  2VQJ A;  4QA0 A;  5G0I A;  5FCW A;  5EFJ D;  5ICN B;  5FUE A;  2VQQ A;  1T69 A;  1T64 A;  3SFF A;  5G17 A;  4LY1 A;  3MAX A;  5D1B A;  2VQO A;  5G3W A;  3ZNS A;  1T67 A;  5G0X A;  5D1C A;  5JI5 A;  2VQV A;  5G0J A;  5DC7 A;  2GH6 A;  4QA6 A;  5G1C A;  5G0G A;  1C3P A;  4BZ9 A;  1ZZ3 A;  1ZZ1 A;  3Q9E A;  5EEI A;  3F07 A;  3MZ4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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