5EEFA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 in complex with trichostatin a
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
359
structure length
354
Chain Sequence
SATGTGLVYVDAFTRFHSHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HDAC6
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 144
structure length 354
sequence length 359
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-10-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5eefA00
3Q9EA 3MAXA 5IX0A 4BZ9A 4CBTA 3Q9FA 3C0ZA 5D1CA 5JI5A 4BZ6A 5G0HA 2V5WA 3Q9BA 3Q9CA 3MZ3A 3MZ6A 5D1DA 3EW8A 4QA1A 5EFBD 2V5XA 5G1AA 5THUA 4RN2A 3C10A 5THSA 3F06A 1C3PA 5EEFA 5EFJD 4CBYA 1C3SA 4QA3A 3EZTA 5D1BA 1T67A 5EENA 3F07A 4QA5A 4ZUOA 5G13A 5G3WA 5G0JA 1ZZ3A 5DC6A 5DC8A 2VQMA 5EEIA 5EF8A 4BZ7A 3MZ4A 5G1BA 3EZPA 5G17A 2VQWG 4ZUMA 5G10A 4QA7A 4ZURA 5G0GA 4QA2A 3MZ7A 4RN1A 5EFNA 3RQDA 5EEKA 1T64A 3MENA 4BZ5A 5G0XA 5LI3A 3EWFA 4A69A 5BWZA 3F0RA 1ZZ1A 2VQQA 1W22A 5G11A 4CQFA 4ZUQA 3SFHA 1VKGA 5FUEA 5A2SA 5IWGA 5DC5A 4QA4A 5EF7A 5EFKB 2VQJA 4LY1A 2VQOA 1C3RA 5EFHA 5THTA 4BKXB 3SFFA 4QA6A 3C0YA 5EFGA 4ZUPA 3ZNRA 5FCWA 2GH6A 5G0YA 4QA0A 4RN0A 3ZNSA 2VQVA 5ICNB 1T69A 5EEMA 5DC7A 1ZZ0A 5G12A 2VCGA 5G1CA 5G0IA 4ZUNA 4BZ8A 5THVA 4LXZA
chains in the Genus database with same CATH superfamily
4Q3UA 3Q9EA 3MAXA 5IX0A 4BZ9A 4CBTA 4RHMA 3Q9FA 3C0ZA 5D1CA 4Q3SA 5JI5A 1ZPEA 4RHLA 5G0HA 4BZ6A 1TBHA 2V5WA 3Q9BA 1P8OA 3RLAA 1T4PA 3Q9CA 3MZ3A 1HQXA 3MZ6A 1HQHA 1WVBA 5D1DA 4IU4A 4CEVA 3EW8A 4QA1A 1P8SA 5EFBD 2V5XA 3M1RA 4FCKA 5G1AA 5THUA 4GSZA 4RN2A 4FCIA 1XFKA 1CEVA 4Q3RA 3C10A 2PLLA 3E9BA 1GQ7A 4RLAA 5THSA 3F06A 5CEVA 1C3PA 5EEFA 5EFJD 4GWDA 4IE3A 4CBYA 1HQFA 1C3SA 4QA3A 3EZTA 5D1BA 3F80A 1T67A 4IU5A 3E8ZA 1T5GA 5EENA 3GN0A 1PQ3A 3F07A 4HZEA 4QA5A 4RHKA 4ZUOA 5G13A 5G3WA 5G0JA 2AEBA 4Q41A 1ZZ3A 4IE1A 2ZAVA 5DC6A 1P8RA 3SJTA 1R1OA 5DC8A 4MYLA 2VQMA 5EEIA 5EF8A 3E6KA 3NIPA 4Q40A 1P8MA 4BZ7A 3MZ4A 5HJ9A 1TBLA 3MFWA 3MMRA 3E6VA 5G1BA 3EZPA 4ITYA 5G17A 4Q3TA 1T4RA 1WOIA 3CEVA 2VQWG 1WVAA 4ZUMA 5G10A 4MYNA 4QA7A 1RLAA 4GSVA 4MXRA 4ZURA 5G0GA 4QA2A 3KV2A 3MZ7A 4RN1A 5EFNA 3RQDA 5EEKA 1T64A 3MENA 2PHAA 4RHIA 4BZ5A 5G0XA 5LI3A 3EWFA 1T4TA 4A69A 5BWZA 3MJLA 2PHOA 3F0RA 1ZZ1A 2VQQA 1W22A 4IU1A 5G11A 3SL0A 4CQFA 3LHLA 4ZUQA 3NIOA 3SFHA 1TBJA 1D3VA 1P8PA 1VKGA 3DJ8A 5FUEA 5A2SA 2RLAA 5IWGA 1WOHA 3THJA 3LP7A 3MFVA 5DC5A 2EF5A 3E8QA 4Q3QA 4QA4A 3TH7A 5EF7A 4GSMA 4MYFA 5EFKB 2VQJA 4LY1A 4IU0A 2VQOA 1WOGA 1T5FA 2A0MA 2CEVA 1C3RA 4LXZA 1ZPGA 4I06A 4Q3RC 1HQGA 3PZLA 5EFHA 3GMZA 5THTA 2EF4A 4HWWA 4BKXB 3SFFA 4QA6A 4HXQA 3LP4A 4RHJA 3SKKA 3C0YA 4IXVA 5EFGA 3THHA 4RHQA 4ZUPA 3NIQA 5HJAA 3ZNRA 5FCWA 2GH6A 4MYKA 1P8NA 4IE2A 4Q42A 5G0YA 4QA0A 4RN0A 3ZNSA 3SL1A 4GWCA 4Q3PA 2VQVA 3TF3A 5ICNB 1T69A 4G3HA 5EEMA 5DC7A 1TA1A 1ZZ0A 5G12A 1HQ5A 2VCGA 5G1CA 5G0IA 2EIVA 3THEA 4ZUNA 4IXUA 4DZ4A 5RLAA 4BZ8A 1T4SA 1P8QA 4Q3VA 5THVA 1GQ6A
chains in the Genus database with same CATH topology
3Q9EA 3MAXA 5IX0A 4BZ9A 4CBTA 3Q9FA 3C0ZA 5D1CA 5JI5A 4BZ6A 5G0HA 2V5WA 3Q9BA 3Q9CA 3MZ3A 3MZ6A 5D1DA 3EW8A 4QA1A 5EFBD 2V5XA 5G1AA 5THUA 4RN2A 3C10A 5THSA 3F06A 1C3PA 5EEFA 5EFJD 4CBYA 1C3SA 4QA3A 3EZTA 5D1BA 1T67A 5EENA 3F07A 4QA5A 4ZUOA 5G13A 5G3WA 5G0JA 1ZZ3A 5DC6A 5DC8A 2VQMA 5EEIA 5EF8A 4BZ7A 3MZ4A 5G1BA 3EZPA 5G17A 2VQWG 4ZUMA 5G10A 4QA7A 4ZURA 5G0GA 4QA2A 3MZ7A 4RN1A 5EFNA 3RQDA 5EEKA 1T64A 3MENA 4BZ5A 5G0XA 5LI3A 3EWFA 4A69A 5BWZA 3F0RA 1ZZ1A 2VQQA 1W22A 5G11A 4CQFA 4ZUQA 3SFHA 1VKGA 5FUEA 5A2SA 5IWGA 5DC5A 4QA4A 5EF7A 5EFKB 2VQJA 4LY1A 2VQOA 1C3RA 5EFHA 5THTA 4BKXB 3SFFA 4QA6A 3C0YA 5EFGA 4ZUPA 3ZNRA 5FCWA 2GH6A 5G0YA 4QA0A 4RN0A 3ZNSA 2VQVA 5ICNB 1T69A 5EEMA 5DC7A 1ZZ0A 5G12A 2VCGA 5G1CA 5G0IA 4ZUNA 4BZ8A 5THVA 4LXZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q9E A;  3MAX A;  5IX0 A;  4BZ9 A;  4CBT A;  3Q9F A;  3C0Z A;  5D1C A;  5JI5 A;  4BZ6 A;  5G0H A;  2V5W A;  3Q9B A;  3Q9C A;  3MZ3 A;  3MZ6 A;  5D1D A;  3EW8 A;  4QA1 A;  5EFB D;  2V5X A;  5G1A A;  5THU A;  4RN2 A;  3C10 A;  5THS A;  3F06 A;  1C3P A;  5EEF A;  5EFJ D;  4CBY A;  1C3S A;  4QA3 A;  3EZT A;  5D1B A;  1T67 A;  5EEN A;  3F07 A;  4QA5 A;  4ZUO A;  5G13 A;  5G3W A;  5G0J A;  1ZZ3 A;  5DC6 A;  5DC8 A;  2VQM A;  5EEI A;  5EF8 A;  4BZ7 A;  3MZ4 A;  5G1B A;  3EZP A;  5G17 A;  2VQW G;  4ZUM A;  5G10 A;  4QA7 A;  4ZUR A;  5G0G A;  4QA2 A;  3MZ7 A;  4RN1 A;  5EFN A;  3RQD A;  5EEK A;  1T64 A;  3MEN A;  4BZ5 A;  5G0X A;  5LI3 A;  3EWF A;  4A69 A;  5BWZ A;  3F0R A;  1ZZ1 A;  2VQQ A;  1W22 A;  5G11 A;  4CQF A;  4ZUQ A;  3SFH A;  1VKG A;  5FUE A;  5A2S A;  5IWG A;  5DC5 A;  4QA4 A;  5EF7 A;  5EFK B;  2VQJ A;  4LY1 A;  2VQO A;  1C3R A;  5EFH A;  5THT A;  4BKX B;  3SFF A;  4QA6 A;  3C0Y A;  5EFG A;  4ZUP A;  3ZNR A;  5FCW A;  2GH6 A;  5G0Y A;  4QA0 A;  4RN0 A;  3ZNS A;  2VQV A;  5ICN B;  1T69 A;  5EEM A;  5DC7 A;  1ZZ0 A;  5G12 A;  2VCG A;  5G1C A;  5G0I A;  4ZUN A;  4BZ8 A;  5THV A;  4LXZ A; 
#chains in the Genus database with same CATH topology
 4Q3U A;  3Q9E A;  3MAX A;  5IX0 A;  4BZ9 A;  4CBT A;  4RHM A;  3Q9F A;  3C0Z A;  5D1C A;  4Q3S A;  5JI5 A;  1ZPE A;  4RHL A;  5G0H A;  4BZ6 A;  1TBH A;  2V5W A;  3Q9B A;  1P8O A;  3RLA A;  1T4P A;  3Q9C A;  3MZ3 A;  1HQX A;  3MZ6 A;  1HQH A;  1WVB A;  5D1D A;  4IU4 A;  4CEV A;  3EW8 A;  4QA1 A;  1P8S A;  5EFB D;  2V5X A;  3M1R A;  4FCK A;  5G1A A;  5THU A;  4GSZ A;  4RN2 A;  4FCI A;  1XFK A;  1CEV A;  4Q3R A;  3C10 A;  2PLL A;  3E9B A;  1GQ7 A;  4RLA A;  5THS A;  3F06 A;  5CEV A;  1C3P A;  5EEF A;  5EFJ D;  4GWD A;  4IE3 A;  4CBY A;  1HQF A;  1C3S A;  4QA3 A;  3EZT A;  5D1B A;  3F80 A;  1T67 A;  4IU5 A;  3E8Z A;  1T5G A;  5EEN A;  3GN0 A;  1PQ3 A;  3F07 A;  4HZE A;  4QA5 A;  4RHK A;  4ZUO A;  5G13 A;  5G3W A;  5G0J A;  2AEB A;  4Q41 A;  1ZZ3 A;  4IE1 A;  2ZAV A;  5DC6 A;  1P8R A;  3SJT A;  1R1O A;  5DC8 A;  4MYL A;  2VQM A;  5EEI A;  5EF8 A;  3E6K A;  3NIP A;  4Q40 A;  1P8M A;  4BZ7 A;  3MZ4 A;  5HJ9 A;  1TBL A;  3MFW A;  3MMR A;  3E6V A;  5G1B A;  3EZP A;  4ITY A;  5G17 A;  4Q3T A;  1T4R A;  1WOI A;  3CEV A;  2VQW G;  1WVA A;  4ZUM A;  5G10 A;  4MYN A;  4QA7 A;  1RLA A;  4GSV A;  4MXR A;  4ZUR A;  5G0G A;  4QA2 A;  3KV2 A;  3MZ7 A;  4RN1 A;  5EFN A;  3RQD A;  5EEK A;  1T64 A;  3MEN A;  2PHA A;  4RHI A;  4BZ5 A;  5G0X A;  5LI3 A;  3EWF A;  1T4T A;  4A69 A;  5BWZ A;  3MJL A;  2PHO A;  3F0R A;  1ZZ1 A;  2VQQ A;  1W22 A;  4IU1 A;  5G11 A;  3SL0 A;  4CQF A;  3LHL A;  4ZUQ A;  3NIO A;  3SFH A;  1TBJ A;  1D3V A;  1P8P A;  1VKG A;  3DJ8 A;  5FUE A;  5A2S A;  2RLA A;  5IWG A;  1WOH A;  3THJ A;  3LP7 A;  3MFV A;  5DC5 A;  2EF5 A;  3E8Q A;  4Q3Q A;  4QA4 A;  3TH7 A;  5EF7 A;  4GSM A;  4MYF A;  5EFK B;  2VQJ A;  4LY1 A;  4IU0 A;  2VQO A;  1WOG A;  1T5F A;  2A0M A;  2CEV A;  1C3R A;  4LXZ A;  1ZPG A;  4I06 A;  4Q3R C;  1HQG A;  3PZL A;  5EFH A;  3GMZ A;  5THT A;  2EF4 A;  4HWW A;  4BKX B;  3SFF A;  4QA6 A;  4HXQ A;  3LP4 A;  4RHJ A;  3SKK A;  3C0Y A;  4IXV A;  5EFG A;  3THH A;  4RHQ A;  4ZUP A;  3NIQ A;  5HJA A;  3ZNR A;  5FCW A;  2GH6 A;  4MYK A;  1P8N A;  4IE2 A;  4Q42 A;  5G0Y A;  4QA0 A;  4RN0 A;  3ZNS A;  3SL1 A;  4GWC A;  4Q3P A;  2VQV A;  3TF3 A;  5ICN B;  1T69 A;  4G3H A;  5EEM A;  5DC7 A;  1TA1 A;  1ZZ0 A;  5G12 A;  1HQ5 A;  2VCG A;  5G1C A;  5G0I A;  2EIV A;  3THE A;  4ZUN A;  4IXU A;  4DZ4 A;  5RLA A;  4BZ8 A;  1T4S A;  1P8Q A;  4Q3V A;  5THV A;  1GQ6 A; 
#chains in the Genus database with same CATH homology
 3Q9E A;  3MAX A;  5IX0 A;  4BZ9 A;  4CBT A;  3Q9F A;  3C0Z A;  5D1C A;  5JI5 A;  4BZ6 A;  5G0H A;  2V5W A;  3Q9B A;  3Q9C A;  3MZ3 A;  3MZ6 A;  5D1D A;  3EW8 A;  4QA1 A;  5EFB D;  2V5X A;  5G1A A;  5THU A;  4RN2 A;  3C10 A;  5THS A;  3F06 A;  1C3P A;  5EEF A;  5EFJ D;  4CBY A;  1C3S A;  4QA3 A;  3EZT A;  5D1B A;  1T67 A;  5EEN A;  3F07 A;  4QA5 A;  4ZUO A;  5G13 A;  5G3W A;  5G0J A;  1ZZ3 A;  5DC6 A;  5DC8 A;  2VQM A;  5EEI A;  5EF8 A;  4BZ7 A;  3MZ4 A;  5G1B A;  3EZP A;  5G17 A;  2VQW G;  4ZUM A;  5G10 A;  4QA7 A;  4ZUR A;  5G0G A;  4QA2 A;  3MZ7 A;  4RN1 A;  5EFN A;  3RQD A;  5EEK A;  1T64 A;  3MEN A;  4BZ5 A;  5G0X A;  5LI3 A;  3EWF A;  4A69 A;  5BWZ A;  3F0R A;  1ZZ1 A;  2VQQ A;  1W22 A;  5G11 A;  4CQF A;  4ZUQ A;  3SFH A;  1VKG A;  5FUE A;  5A2S A;  5IWG A;  5DC5 A;  4QA4 A;  5EF7 A;  5EFK B;  2VQJ A;  4LY1 A;  2VQO A;  1C3R A;  5EFH A;  5THT A;  4BKX B;  3SFF A;  4QA6 A;  3C0Y A;  5EFG A;  4ZUP A;  3ZNR A;  5FCW A;  2GH6 A;  5G0Y A;  4QA0 A;  4RN0 A;  3ZNS A;  2VQV A;  5ICN B;  1T69 A;  5EEM A;  5DC7 A;  1ZZ0 A;  5G12 A;  2VCG A;  5G1C A;  5G0I A;  4ZUN A;  4BZ8 A;  5THV A;  4LXZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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