5EF8A

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
357
structure length
357
Chain Sequence
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
total genus 143
structure length 357
sequence length 357
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5ef8A00
3Q9BA 3SFFA 1T67A 3C0ZA 2GH6A 5IX0A 5IWGA 2VCGA 4QA2A 3Q9CA 2VQWG 5D1DA 3F0RA 4ZUPA 4QA5A 3MZ6A 5A2SA 5THUA 4CBYA 3MZ7A 5THSA 3MZ3A 3EZTA 3ZNRA 5LI3A 3SFHA 4CBTA 1VKGA 4BZ5A 2VQVA 2VQMA 5EF8A 1ZZ3A 5EFNA 5EFJD 1W22A 5G10A 5D1BA 1C3PA 4ZUOA 3Q9EA 4QA7A 1C3RA 2V5XA 4A69A 5DC5A 5FUEA 4RN1A 5G1AA 5EEIA 4ZUQA 3F07A 4QA0A 5FCWA 1ZZ1A 5EFGA 5G3WA 4QA3A 5D1CA 5G0GA 5G1CA 5EF7A 3MAXA 1ZZ0A 3Q9FA 2VQQA 5THVA 4CQFA 4QA4A 3C0YA 4BZ7A 5G13A 5THTA 5G0XA 5JI5A 5ICNB 3EWFA 4BZ9A 3F06A 5G0JA 5EFBD 2V5WA 4RN2A 5BWZA 4ZURA 4LY1A 3MZ4A 4ZUNA 5G0HA 5G1BA 5G0IA 5EFHA 5EENA 4QA6A 4BZ8A 5DC8A 3RQDA 3C10A 3EW8A 2VQJA 4ZUMA 4QA1A 3MENA 3ZNSA 5G17A 5G12A 5DC6A 1C3SA 4LXZA 5G0YA 5EEFA 1T69A 5EEKA 4BKXB 5G11A 1T64A 5EEMA 5DC7A 3EZPA 2VQOA 4BZ6A 4RN0A 5EFKB
chains in the Genus database with same CATH superfamily
3Q9BA 1P8PA 1T4SA 1RLAA 4I06A 4Q3TA 3SFFA 4RHKA 1T67A 4Q3SA 2AEBA 1HQGA 3C0ZA 3SJTA 2GH6A 4ITYA 5IX0A 5IWGA 2VCGA 3RLAA 4QA2A 1R1OA 3Q9CA 2VQWG 5D1DA 4IU4A 4IE1A 3F0RA 4ZUPA 3F80A 4MXRA 4QA5A 3MZ6A 5A2SA 5THUA 4CBYA 3NIPA 1P8RA 3MZ7A 2CEVA 5THSA 1WVAA 1TBHA 3EZTA 3MZ3A 3NIOA 1P8QA 3ZNRA 5LI3A 3SFHA 1TA1A 4CBTA 3SL0A 3LP4A 4IE3A 1P8MA 1VKGA 1P8OA 4BZ5A 2VQVA 3E6VA 2VQMA 1WOIA 3THHA 1ZZ3A 5EF8A 5EFNA 5EFJD 5RLAA 1T5FA 1W22A 4MYNA 3GN0A 3E8ZA 5G10A 5D1BA 4Q3VA 1WOGA 1C3PA 3NIQA 3SL1A 5CEVA 4ZUOA 3Q9EA 4QA7A 1C3RA 1TBLA 1GQ6A 2A0MA 2PHAA 2V5XA 5HJ9A 4GSMA 4A69A 1HQXA 4IU5A 3KV2A 5DC5A 1D3VA 5FUEA 4RN1A 4Q40A 5G1AA 5EEIA 4ZUQA 3MJLA 3F07A 4QA0A 4FCIA 1HQFA 1ZZ1A 5EFGA 5FCWA 3SKKA 5G3WA 4MYFA 4QA3A 5D1CA 1T5GA 3MFWA 5G1CA 4FCKA 5G0GA 4CEVA 2PLLA 3DJ8A 5EF7A 3MAXA 1ZZ0A 1HQ5A 3Q9FA 4IU1A 4RHLA 2VQQA 3MMRA 5THVA 3E6KA 4GSVA 1T4TA 1ZPGA 4CQFA 4QA4A 1CEVA 3C0YA 4RHIA 4BZ7A 3LP7A 3M1RA 5G13A 5THTA 4HZEA 5G0XA 5JI5A 3THEA 2RLAA 5ICNB 3EWFA 4BZ9A 1P8SA 2ZAVA 3F06A 4Q42A 1ZPEA 5EFBD 1GQ7A 1TBJA 1WOHA 2V5WA 4RN2A 5G0JA 5BWZA 1HQHA 4ZURA 4Q3RC 4LY1A 3MZ4A 4ZUNA 5G0HA 5G1BA 1PQ3A 1T4RA 4RHMA 5G0IA 5EFHA 5EENA 3TF3A 4IXVA 3MFVA 4QA6A 4RHJA 4Q41A 4Q3UA 2EF4A 4BZ8A 5DC8A 4IE2A 3RQDA 3CEVA 3C10A 3TH7A 3EW8A 2VQJA 1WVBA 4QA1A 4ZUMA 3THJA 2EIVA 4GSZA 3MENA 1XFKA 4G3HA 4IXUA 3ZNSA 3PZLA 1P8NA 4Q3RA 5G17A 5G12A 5DC6A 4MYLA 1C3SA 3GMZA 4LXZA 5G0YA 5EEFA 1T69A 5EEKA 4MYKA 4BKXB 5G11A 1T64A 5EEMA 5DC7A 3EZPA 4Q3PA 2VQOA 4IU0A 2PHOA 4BZ6A 1T4PA 4HWWA 3LHLA 4RN0A 4GWDA 3E9BA 4GWCA 5HJAA 4HXQA 5EFKB 3E8QA 4Q3QA 4RLAA 4DZ4A 4RHQA 2EF5A
chains in the Genus database with same CATH topology
3Q9BA 3SFFA 1T67A 3C0ZA 2GH6A 5IX0A 5IWGA 2VCGA 4QA2A 3Q9CA 2VQWG 5D1DA 3F0RA 4ZUPA 4QA5A 3MZ6A 5A2SA 5THUA 4CBYA 3MZ7A 5THSA 3MZ3A 3EZTA 3ZNRA 5LI3A 3SFHA 4CBTA 1VKGA 4BZ5A 2VQVA 2VQMA 5EF8A 1ZZ3A 5EFNA 5EFJD 1W22A 5G10A 5D1BA 1C3PA 4ZUOA 3Q9EA 4QA7A 1C3RA 2V5XA 4A69A 5DC5A 5FUEA 4RN1A 5G1AA 5EEIA 4ZUQA 3F07A 4QA0A 5FCWA 1ZZ1A 5EFGA 5G3WA 4QA3A 5D1CA 5G0GA 5G1CA 5EF7A 3MAXA 1ZZ0A 3Q9FA 2VQQA 5THVA 4CQFA 4QA4A 3C0YA 4BZ7A 5G13A 5THTA 5G0XA 5JI5A 5ICNB 3EWFA 4BZ9A 3F06A 5G0JA 5EFBD 2V5WA 4RN2A 5BWZA 4ZURA 4LY1A 3MZ4A 4ZUNA 5G0HA 5G1BA 5G0IA 5EFHA 5EENA 4QA6A 4BZ8A 5DC8A 3RQDA 3C10A 3EW8A 2VQJA 4ZUMA 4QA1A 3MENA 3ZNSA 5G17A 5G12A 5DC6A 1C3SA 4LXZA 5G0YA 5EEFA 1T69A 5EEKA 4BKXB 5G11A 1T64A 5EEMA 5DC7A 3EZPA 2VQOA 4BZ6A 4RN0A 5EFKB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q9B A;  3SFF A;  1T67 A;  3C0Z A;  2GH6 A;  5IX0 A;  5IWG A;  2VCG A;  4QA2 A;  3Q9C A;  2VQW G;  5D1D A;  3F0R A;  4ZUP A;  4QA5 A;  3MZ6 A;  5A2S A;  5THU A;  4CBY A;  3MZ7 A;  5THS A;  3MZ3 A;  3EZT A;  3ZNR A;  5LI3 A;  3SFH A;  4CBT A;  1VKG A;  4BZ5 A;  2VQV A;  2VQM A;  5EF8 A;  1ZZ3 A;  5EFN A;  5EFJ D;  1W22 A;  5G10 A;  5D1B A;  1C3P A;  4ZUO A;  3Q9E A;  4QA7 A;  1C3R A;  2V5X A;  4A69 A;  5DC5 A;  5FUE A;  4RN1 A;  5G1A A;  5EEI A;  4ZUQ A;  3F07 A;  4QA0 A;  5FCW A;  1ZZ1 A;  5EFG A;  5G3W A;  4QA3 A;  5D1C A;  5G0G A;  5G1C A;  5EF7 A;  3MAX A;  1ZZ0 A;  3Q9F A;  2VQQ A;  5THV A;  4CQF A;  4QA4 A;  3C0Y A;  4BZ7 A;  5G13 A;  5THT A;  5G0X A;  5JI5 A;  5ICN B;  3EWF A;  4BZ9 A;  3F06 A;  5G0J A;  5EFB D;  2V5W A;  4RN2 A;  5BWZ A;  4ZUR A;  4LY1 A;  3MZ4 A;  4ZUN A;  5G0H A;  5G1B A;  5G0I A;  5EFH A;  5EEN A;  4QA6 A;  4BZ8 A;  5DC8 A;  3RQD A;  3C10 A;  3EW8 A;  2VQJ A;  4ZUM A;  4QA1 A;  3MEN A;  3ZNS A;  5G17 A;  5G12 A;  5DC6 A;  1C3S A;  4LXZ A;  5G0Y A;  5EEF A;  1T69 A;  5EEK A;  4BKX B;  5G11 A;  1T64 A;  5EEM A;  5DC7 A;  3EZP A;  2VQO A;  4BZ6 A;  4RN0 A;  5EFK B; 
#chains in the Genus database with same CATH topology
 3Q9B A;  1P8P A;  1T4S A;  1RLA A;  4I06 A;  4Q3T A;  3SFF A;  4RHK A;  1T67 A;  4Q3S A;  2AEB A;  1HQG A;  3C0Z A;  3SJT A;  2GH6 A;  4ITY A;  5IX0 A;  5IWG A;  2VCG A;  3RLA A;  4QA2 A;  1R1O A;  3Q9C A;  2VQW G;  5D1D A;  4IU4 A;  4IE1 A;  3F0R A;  4ZUP A;  3F80 A;  4MXR A;  4QA5 A;  3MZ6 A;  5A2S A;  5THU A;  4CBY A;  3NIP A;  1P8R A;  3MZ7 A;  2CEV A;  5THS A;  1WVA A;  1TBH A;  3EZT A;  3MZ3 A;  3NIO A;  1P8Q A;  3ZNR A;  5LI3 A;  3SFH A;  1TA1 A;  4CBT A;  3SL0 A;  3LP4 A;  4IE3 A;  1P8M A;  1VKG A;  1P8O A;  4BZ5 A;  2VQV A;  3E6V A;  2VQM A;  1WOI A;  3THH A;  1ZZ3 A;  5EF8 A;  5EFN A;  5EFJ D;  5RLA A;  1T5F A;  1W22 A;  4MYN A;  3GN0 A;  3E8Z A;  5G10 A;  5D1B A;  4Q3V A;  1WOG A;  1C3P A;  3NIQ A;  3SL1 A;  5CEV A;  4ZUO A;  3Q9E A;  4QA7 A;  1C3R A;  1TBL A;  1GQ6 A;  2A0M A;  2PHA A;  2V5X A;  5HJ9 A;  4GSM A;  4A69 A;  1HQX A;  4IU5 A;  3KV2 A;  5DC5 A;  1D3V A;  5FUE A;  4RN1 A;  4Q40 A;  5G1A A;  5EEI A;  4ZUQ A;  3MJL A;  3F07 A;  4QA0 A;  4FCI A;  1HQF A;  1ZZ1 A;  5EFG A;  5FCW A;  3SKK A;  5G3W A;  4MYF A;  4QA3 A;  5D1C A;  1T5G A;  3MFW A;  5G1C A;  4FCK A;  5G0G A;  4CEV A;  2PLL A;  3DJ8 A;  5EF7 A;  3MAX A;  1ZZ0 A;  1HQ5 A;  3Q9F A;  4IU1 A;  4RHL A;  2VQQ A;  3MMR A;  5THV A;  3E6K A;  4GSV A;  1T4T A;  1ZPG A;  4CQF A;  4QA4 A;  1CEV A;  3C0Y A;  4RHI A;  4BZ7 A;  3LP7 A;  3M1R A;  5G13 A;  5THT A;  4HZE A;  5G0X A;  5JI5 A;  3THE A;  2RLA A;  5ICN B;  3EWF A;  4BZ9 A;  1P8S A;  2ZAV A;  3F06 A;  4Q42 A;  1ZPE A;  5EFB D;  1GQ7 A;  1TBJ A;  1WOH A;  2V5W A;  4RN2 A;  5G0J A;  5BWZ A;  1HQH A;  4ZUR A;  4Q3R C;  4LY1 A;  3MZ4 A;  4ZUN A;  5G0H A;  5G1B A;  1PQ3 A;  1T4R A;  4RHM A;  5G0I A;  5EFH A;  5EEN A;  3TF3 A;  4IXV A;  3MFV A;  4QA6 A;  4RHJ A;  4Q41 A;  4Q3U A;  2EF4 A;  4BZ8 A;  5DC8 A;  4IE2 A;  3RQD A;  3CEV A;  3C10 A;  3TH7 A;  3EW8 A;  2VQJ A;  1WVB A;  4QA1 A;  4ZUM A;  3THJ A;  2EIV A;  4GSZ A;  3MEN A;  1XFK A;  4G3H A;  4IXU A;  3ZNS A;  3PZL A;  1P8N A;  4Q3R A;  5G17 A;  5G12 A;  5DC6 A;  4MYL A;  1C3S A;  3GMZ A;  4LXZ A;  5G0Y A;  5EEF A;  1T69 A;  5EEK A;  4MYK A;  4BKX B;  5G11 A;  1T64 A;  5EEM A;  5DC7 A;  3EZP A;  4Q3P A;  2VQO A;  4IU0 A;  2PHO A;  4BZ6 A;  1T4P A;  4HWW A;  3LHL A;  4RN0 A;  4GWD A;  3E9B A;  4GWC A;  5HJA A;  4HXQ A;  5EFK B;  3E8Q A;  4Q3Q A;  4RLA A;  4DZ4 A;  4RHQ A;  2EF5 A; 
#chains in the Genus database with same CATH homology
 3Q9B A;  3SFF A;  1T67 A;  3C0Z A;  2GH6 A;  5IX0 A;  5IWG A;  2VCG A;  4QA2 A;  3Q9C A;  2VQW G;  5D1D A;  3F0R A;  4ZUP A;  4QA5 A;  3MZ6 A;  5A2S A;  5THU A;  4CBY A;  3MZ7 A;  5THS A;  3MZ3 A;  3EZT A;  3ZNR A;  5LI3 A;  3SFH A;  4CBT A;  1VKG A;  4BZ5 A;  2VQV A;  2VQM A;  5EF8 A;  1ZZ3 A;  5EFN A;  5EFJ D;  1W22 A;  5G10 A;  5D1B A;  1C3P A;  4ZUO A;  3Q9E A;  4QA7 A;  1C3R A;  2V5X A;  4A69 A;  5DC5 A;  5FUE A;  4RN1 A;  5G1A A;  5EEI A;  4ZUQ A;  3F07 A;  4QA0 A;  5FCW A;  1ZZ1 A;  5EFG A;  5G3W A;  4QA3 A;  5D1C A;  5G0G A;  5G1C A;  5EF7 A;  3MAX A;  1ZZ0 A;  3Q9F A;  2VQQ A;  5THV A;  4CQF A;  4QA4 A;  3C0Y A;  4BZ7 A;  5G13 A;  5THT A;  5G0X A;  5JI5 A;  5ICN B;  3EWF A;  4BZ9 A;  3F06 A;  5G0J A;  5EFB D;  2V5W A;  4RN2 A;  5BWZ A;  4ZUR A;  4LY1 A;  3MZ4 A;  4ZUN A;  5G0H A;  5G1B A;  5G0I A;  5EFH A;  5EEN A;  4QA6 A;  4BZ8 A;  5DC8 A;  3RQD A;  3C10 A;  3EW8 A;  2VQJ A;  4ZUM A;  4QA1 A;  3MEN A;  3ZNS A;  5G17 A;  5G12 A;  5DC6 A;  1C3S A;  4LXZ A;  5G0Y A;  5EEF A;  1T69 A;  5EEK A;  4BKX B;  5G11 A;  1T64 A;  5EEM A;  5DC7 A;  3EZP A;  2VQO A;  4BZ6 A;  4RN0 A;  5EFK B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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