5EF8A

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
357
structure length
357
Chain Sequence
b'PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 143
structure length 357
sequence length 357
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5ef8A00
5D1CA 5A2SA 4BZ7A 1C3PA 3RQDA 3SFFA 3Q9EA 5EFBD 5G0JA 4BZ6A 3MENA 5DC7A 5EFHA 5G1AA 4ZUQA 1T64A 2VQMA 5LI3A 4CBTA 2GH6A 5G12A 3SFHA 5EFJD 5DC6A 2V5WA 5G11A 5G17A 5EEKA 3MZ7A 3MZ6A 5DC5A 2VQOA 4ZUPA 5D1DA 4QA1A 1ZZ1A 2VCGA 5G1BA 4QA0A 5THTA 4A69A 3Q9BA 1C3SA 5EFNA 4RN0A 5D1BA 2VQVA 3MAXA 2V5XA 4QA3A 4ZURA 5IWGA 4LY1A 5G0XA 5G0IA 5THUA 5G13A 4QA6A 5G0YA 1VKGA 5EF7A 5EF8A 5JI5A 3EZTA 5DC8A 5G10A 4BKXB 5G0GA 4BZ5A 4QA4A 3EZPA 1ZZ3A 3C0ZA 3MZ3A 1C3RA 4BZ9A 4LXZA 5BWZA 5THVA 5IX0A 3ZNSA 4CBYA 5G3WA 5EEMA 5ICNB 5EEFA 3F0RA 2VQWG 3MZ4A 5G1CA 4RN1A 1ZZ0A 5THSA 4BZ8A 4RN2A 1W22A 4QA7A 1T69A 5FCWA 2VQJA 3C10A 3F06A 3EWFA 5G0HA 3F07A 2VQQA 3EW8A 4QA5A 5FUEA 5EEIA 4ZUOA 4ZUNA 5EFGA 4ZUMA 5EENA 3Q9FA 3C0YA 3Q9CA 5EFKB 1T67A 4CQFA 4QA2A 3ZNRA
chains in the Genus database with same CATH superfamily
5D1CA 1P8RA 1T5GA 2PHOA 3MJLA 4Q40A 4DZ4A 4MYLA 3GMZA 4BZ7A 5A2SA 1C3PA 4IU4A 3RQDA 3SFFA 3MFWA 3Q9EA 5EFBD 5G0JA 4ITYA 4BZ6A 4RHLA 1WOHA 3MENA 1WOGA 3MFVA 5DC7A 5EFHA 5CEVA 5G1AA 4ZUQA 1T64A 4RHQA 2VQMA 4CEVA 4RHJA 5LI3A 3MMRA 4Q3UA 4GWDA 4CBTA 2GH6A 3PZLA 1P8SA 5G12A 3SFHA 5EFJD 5DC6A 3NIPA 2EIVA 3M1RA 4IE1A 3THJA 4Q41A 2V5WA 4FCKA 5G11A 5G17A 2CEVA 5EEKA 1WOIA 4RHIA 4HWWA 5RLAA 3THHA 3MZ7A 1P8PA 1WVAA 3MZ6A 1P8QA 5DC5A 3THEA 2VQOA 4IE2A 4MYKA 5D1DA 4ZUPA 4QA1A 1ZZ1A 2VCGA 5G1BA 4QA0A 3LHLA 5THTA 4A69A 3Q9BA 1C3SA 5EFNA 3SKKA 3E8QA 4RN0A 5D1BA 3KV2A 1TBLA 2VQVA 3MAXA 3NIQA 4Q42A 3NIOA 1R1OA 4MYFA 2V5XA 2ZAVA 4HZEA 4QA3A 4ZURA 5HJ9A 1GQ7A 1WVBA 4MXRA 5IWGA 4LY1A 5G0XA 2PLLA 4IU5A 5G0IA 5THUA 5G13A 1T4TA 4QA6A 5G0YA 1HQ5A 1VKGA 2A0MA 1PQ3A 2RLAA 1T5FA 4GSZA 4GSMA 4RHMA 1T4RA 4GSVA 5EF7A 1ZPEA 3EZTA 5DC8A 1TA1A 4G3HA 5EF8A 5G10A 3SL1A 4BKXB 1HQXA 1P8OA 5G0GA 1XFKA 4BZ5A 4QA4A 4IXVA 3EZPA 3E6VA 1T4PA 1ZZ3A 3C0ZA 3MZ3A 3TH7A 1C3RA 4BZ9A 3E6KA 4LXZA 4RLAA 3CEVA 1TBJA 5BWZA 5THVA 5IX0A 1HQFA 3SJTA 3ZNSA 1D3VA 3GN0A 1T4SA 5G3WA 4CBYA 5EEMA 5ICNB 5EEFA 1GQ6A 4Q3SA 1TBHA 4IU0A 3F0RA 2VQWG 3MZ4A 4Q3PA 1P8MA 5G1CA 3SL0A 4IU1A 3TF3A 2AEBA 4RN1A 2EF4A 1ZPGA 4Q3QA 4I06A 1ZZ0A 3E9BA 5THSA 1CEVA 4MYNA 1RLAA 4BZ8A 4RN2A 1W22A 4QA7A 1T69A 4Q3VA 4IE3A 2PHAA 1HQGA 4Q3RA 4Q3TA 2VQJA 4GWCA 5FCWA 2EF5A 3RLAA 3C10A 4FCIA 3F06A 3F80A 3ZNRA 5HJAA 3LP7A 3EWFA 3E8ZA 5G0HA 3F07A 4HXQA 1P8NA 2VQQA 3EW8A 3LP4A 4QA5A 4RHKA 1HQHA 5FUEA 4IXUA 5EEIA 4ZUOA 4ZUNA 5EFGA 4ZUMA 5EENA 3Q9FA 5JI5A 3C0YA 3DJ8A 3Q9CA 1T67A 5EFKB 4CQFA 4QA2A 4Q3RC
chains in the Genus database with same CATH topology
5D1CA 5A2SA 4BZ7A 1C3PA 3RQDA 3SFFA 3Q9EA 5EFBD 5G0JA 4BZ6A 3MENA 5DC7A 5EFHA 5G1AA 4ZUQA 1T64A 2VQMA 5LI3A 4CBTA 2GH6A 5G12A 3SFHA 5EFJD 5DC6A 2V5WA 5G11A 5G17A 5EEKA 3MZ7A 3MZ6A 5DC5A 2VQOA 4ZUPA 5D1DA 4QA1A 1ZZ1A 2VCGA 5G1BA 4QA0A 5THTA 4A69A 3Q9BA 1C3SA 5EFNA 4RN0A 5D1BA 2VQVA 3MAXA 2V5XA 4QA3A 4ZURA 5IWGA 4LY1A 5G0XA 5G0IA 5THUA 5G13A 4QA6A 5G0YA 1VKGA 5EF7A 5EF8A 5JI5A 3EZTA 5DC8A 5G10A 4BKXB 5G0GA 4BZ5A 4QA4A 3EZPA 1ZZ3A 3C0ZA 3MZ3A 1C3RA 4BZ9A 4LXZA 5BWZA 5THVA 5IX0A 3ZNSA 4CBYA 5G3WA 5EEMA 5ICNB 5EEFA 3F0RA 2VQWG 3MZ4A 5G1CA 4RN1A 1ZZ0A 5THSA 4BZ8A 4RN2A 1W22A 4QA7A 1T69A 5FCWA 2VQJA 3C10A 3F06A 3EWFA 5G0HA 3F07A 2VQQA 3EW8A 4QA5A 5FUEA 5EEIA 4ZUOA 4ZUNA 5EFGA 4ZUMA 5EENA 3Q9FA 3C0YA 3Q9CA 5EFKB 1T67A 4CQFA 4QA2A 3ZNRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D1C A;  5A2S A;  4BZ7 A;  1C3P A;  3RQD A;  3SFF A;  3Q9E A;  5EFB D;  5G0J A;  4BZ6 A;  3MEN A;  5DC7 A;  5EFH A;  5G1A A;  4ZUQ A;  1T64 A;  2VQM A;  5LI3 A;  4CBT A;  2GH6 A;  5G12 A;  3SFH A;  5EFJ D;  5DC6 A;  2V5W A;  5G11 A;  5G17 A;  5EEK A;  3MZ7 A;  3MZ6 A;  5DC5 A;  2VQO A;  4ZUP A;  5D1D A;  4QA1 A;  1ZZ1 A;  2VCG A;  5G1B A;  4QA0 A;  5THT A;  4A69 A;  3Q9B A;  1C3S A;  5EFN A;  4RN0 A;  5D1B A;  2VQV A;  3MAX A;  2V5X A;  4QA3 A;  4ZUR A;  5IWG A;  4LY1 A;  5G0X A;  5G0I A;  5THU A;  5G13 A;  4QA6 A;  5G0Y A;  1VKG A;  5EF7 A;  5EF8 A;  5JI5 A;  3EZT A;  5DC8 A;  5G10 A;  4BKX B;  5G0G A;  4BZ5 A;  4QA4 A;  3EZP A;  1ZZ3 A;  3C0Z A;  3MZ3 A;  1C3R A;  4BZ9 A;  4LXZ A;  5BWZ A;  5THV A;  5IX0 A;  3ZNS A;  4CBY A;  5G3W A;  5EEM A;  5ICN B;  5EEF A;  3F0R A;  2VQW G;  3MZ4 A;  5G1C A;  4RN1 A;  1ZZ0 A;  5THS A;  4BZ8 A;  4RN2 A;  1W22 A;  4QA7 A;  1T69 A;  5FCW A;  2VQJ A;  3C10 A;  3F06 A;  3EWF A;  5G0H A;  3F07 A;  2VQQ A;  3EW8 A;  4QA5 A;  5FUE A;  5EEI A;  4ZUO A;  4ZUN A;  5EFG A;  4ZUM A;  5EEN A;  3Q9F A;  3C0Y A;  3Q9C A;  5EFK B;  1T67 A;  4CQF A;  4QA2 A;  3ZNR A; 
#chains in the Genus database with same CATH topology
 5D1C A;  1P8R A;  1T5G A;  2PHO A;  3MJL A;  4Q40 A;  4DZ4 A;  4MYL A;  3GMZ A;  4BZ7 A;  5A2S A;  1C3P A;  4IU4 A;  3RQD A;  3SFF A;  3MFW A;  3Q9E A;  5EFB D;  5G0J A;  4ITY A;  4BZ6 A;  4RHL A;  1WOH A;  3MEN A;  1WOG A;  3MFV A;  5DC7 A;  5EFH A;  5CEV A;  5G1A A;  4ZUQ A;  1T64 A;  4RHQ A;  2VQM A;  4CEV A;  4RHJ A;  5LI3 A;  3MMR A;  4Q3U A;  4GWD A;  4CBT A;  2GH6 A;  3PZL A;  1P8S A;  5G12 A;  3SFH A;  5EFJ D;  5DC6 A;  3NIP A;  2EIV A;  3M1R A;  4IE1 A;  3THJ A;  4Q41 A;  2V5W A;  4FCK A;  5G11 A;  5G17 A;  2CEV A;  5EEK A;  1WOI A;  4RHI A;  4HWW A;  5RLA A;  3THH A;  3MZ7 A;  1P8P A;  1WVA A;  3MZ6 A;  1P8Q A;  5DC5 A;  3THE A;  2VQO A;  4IE2 A;  4MYK A;  5D1D A;  4ZUP A;  4QA1 A;  1ZZ1 A;  2VCG A;  5G1B A;  4QA0 A;  3LHL A;  5THT A;  4A69 A;  3Q9B A;  1C3S A;  5EFN A;  3SKK A;  3E8Q A;  4RN0 A;  5D1B A;  3KV2 A;  1TBL A;  2VQV A;  3MAX A;  3NIQ A;  4Q42 A;  3NIO A;  1R1O A;  4MYF A;  2V5X A;  2ZAV A;  4HZE A;  4QA3 A;  4ZUR A;  5HJ9 A;  1GQ7 A;  1WVB A;  4MXR A;  5IWG A;  4LY1 A;  5G0X A;  2PLL A;  4IU5 A;  5G0I A;  5THU A;  5G13 A;  1T4T A;  4QA6 A;  5G0Y A;  1HQ5 A;  1VKG A;  2A0M A;  1PQ3 A;  2RLA A;  1T5F A;  4GSZ A;  4GSM A;  4RHM A;  1T4R A;  4GSV A;  5EF7 A;  1ZPE A;  3EZT A;  5DC8 A;  1TA1 A;  4G3H A;  5EF8 A;  5G10 A;  3SL1 A;  4BKX B;  1HQX A;  1P8O A;  5G0G A;  1XFK A;  4BZ5 A;  4QA4 A;  4IXV A;  3EZP A;  3E6V A;  1T4P A;  1ZZ3 A;  3C0Z A;  3MZ3 A;  3TH7 A;  1C3R A;  4BZ9 A;  3E6K A;  4LXZ A;  4RLA A;  3CEV A;  1TBJ A;  5BWZ A;  5THV A;  5IX0 A;  1HQF A;  3SJT A;  3ZNS A;  1D3V A;  3GN0 A;  1T4S A;  5G3W A;  4CBY A;  5EEM A;  5ICN B;  5EEF A;  1GQ6 A;  4Q3S A;  1TBH A;  4IU0 A;  3F0R A;  2VQW G;  3MZ4 A;  4Q3P A;  1P8M A;  5G1C A;  3SL0 A;  4IU1 A;  3TF3 A;  2AEB A;  4RN1 A;  2EF4 A;  1ZPG A;  4Q3Q A;  4I06 A;  1ZZ0 A;  3E9B A;  5THS A;  1CEV A;  4MYN A;  1RLA A;  4BZ8 A;  4RN2 A;  1W22 A;  4QA7 A;  1T69 A;  4Q3V A;  4IE3 A;  2PHA A;  1HQG A;  4Q3R A;  4Q3T A;  2VQJ A;  4GWC A;  5FCW A;  2EF5 A;  3RLA A;  3C10 A;  4FCI A;  3F06 A;  3F80 A;  3ZNR A;  5HJA A;  3LP7 A;  3EWF A;  3E8Z A;  5G0H A;  3F07 A;  4HXQ A;  1P8N A;  2VQQ A;  3EW8 A;  3LP4 A;  4QA5 A;  4RHK A;  1HQH A;  5FUE A;  4IXU A;  5EEI A;  4ZUO A;  4ZUN A;  5EFG A;  4ZUM A;  5EEN A;  3Q9F A;  5JI5 A;  3C0Y A;  3DJ8 A;  3Q9C A;  1T67 A;  5EFK B;  4CQF A;  4QA2 A;  4Q3R C; 
#chains in the Genus database with same CATH homology
 5D1C A;  5A2S A;  4BZ7 A;  1C3P A;  3RQD A;  3SFF A;  3Q9E A;  5EFB D;  5G0J A;  4BZ6 A;  3MEN A;  5DC7 A;  5EFH A;  5G1A A;  4ZUQ A;  1T64 A;  2VQM A;  5LI3 A;  4CBT A;  2GH6 A;  5G12 A;  3SFH A;  5EFJ D;  5DC6 A;  2V5W A;  5G11 A;  5G17 A;  5EEK A;  3MZ7 A;  3MZ6 A;  5DC5 A;  2VQO A;  4ZUP A;  5D1D A;  4QA1 A;  1ZZ1 A;  2VCG A;  5G1B A;  4QA0 A;  5THT A;  4A69 A;  3Q9B A;  1C3S A;  5EFN A;  4RN0 A;  5D1B A;  2VQV A;  3MAX A;  2V5X A;  4QA3 A;  4ZUR A;  5IWG A;  4LY1 A;  5G0X A;  5G0I A;  5THU A;  5G13 A;  4QA6 A;  5G0Y A;  1VKG A;  5EF7 A;  5EF8 A;  5JI5 A;  3EZT A;  5DC8 A;  5G10 A;  4BKX B;  5G0G A;  4BZ5 A;  4QA4 A;  3EZP A;  1ZZ3 A;  3C0Z A;  3MZ3 A;  1C3R A;  4BZ9 A;  4LXZ A;  5BWZ A;  5THV A;  5IX0 A;  3ZNS A;  4CBY A;  5G3W A;  5EEM A;  5ICN B;  5EEF A;  3F0R A;  2VQW G;  3MZ4 A;  5G1C A;  4RN1 A;  1ZZ0 A;  5THS A;  4BZ8 A;  4RN2 A;  1W22 A;  4QA7 A;  1T69 A;  5FCW A;  2VQJ A;  3C10 A;  3F06 A;  3EWF A;  5G0H A;  3F07 A;  2VQQ A;  3EW8 A;  4QA5 A;  5FUE A;  5EEI A;  4ZUO A;  4ZUN A;  5EFG A;  4ZUM A;  5EEN A;  3Q9F A;  3C0Y A;  3Q9C A;  5EFK B;  1T67 A;  4CQF A;  4QA2 A;  3ZNR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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