5EFJD

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with hc toxin
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
357
structure length
356
Chain Sequence
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase/hydrolase inhibitor
total genus 147
structure length 356
sequence length 357
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5efjD00
5EEMA 3ZNSA 5FCWA 3Q9BA 4QA5A 5DC7A 5D1DA 3RQDA 5G11A 4ZUNA 4BZ5A 5EEIA 5LI3A 4QA4A 4RN1A 4ZUQA 3MZ3A 4LXZA 4RN2A 4LY1A 2VQMA 5G0GA 4ZURA 1VKGA 5G12A 5ICNB 1ZZ1A 2VQWG 5G10A 4ZUMA 5EF7A 5G3WA 2VQQA 5IWGA 5THUA 4BZ7A 5EFKB 3EW8A 5THVA 5BWZA 3SFHA 5G13A 5EFHA 5THSA 3ZNRA 3EWFA 5EFNA 4CQFA 5G1BA 5G0XA 5D1BA 3EZPA 2VQVA 1ZZ3A 4A69A 4ZUPA 4QA2A 1W22A 3MZ6A 3MZ4A 4BZ8A 3EZTA 5THTA 4BZ9A 1ZZ0A 4BZ6A 4QA7A 3C10A 5A2SA 1T69A 5EENA 3Q9CA 1C3SA 5IX0A 5EFGA 5EEKA 1C3RA 4QA0A 3Q9EA 5DC6A 1C3PA 5G0HA 3F07A 5EF8A 3F0RA 2GH6A 5D1CA 1T67A 4ZUOA 5DC5A 2V5WA 5DC8A 2VCGA 3MENA 5EFJD 4CBTA 3MZ7A 4QA6A 5G0JA 3C0YA 4QA1A 2VQOA 1T64A 5G17A 3C0ZA 2V5XA 4RN0A 3F06A 5EEFA 5EFBD 4BKXB 3MAXA 4QA3A 5G0IA 5FUEA 5G1AA 3SFFA 5G1CA 5JI5A 3Q9FA 4CBYA 5G0YA 2VQJA
chains in the Genus database with same CATH superfamily
5EEMA 2EF4A 3ZNSA 5CEVA 4IE2A 5FCWA 1P8SA 1GQ7A 4Q3QA 2AEBA 2PHAA 4Q3RC 4I06A 3Q9BA 4RHLA 3SL1A 4QA5A 1RLAA 5DC7A 1T5GA 4IU5A 3LP4A 3E9BA 5D1DA 3RQDA 1TBLA 5G11A 4Q41A 4RHQA 4Q3TA 4ZUNA 3SL0A 4FCKA 3KV2A 4MXRA 4BZ5A 3E6KA 5EEIA 5RLAA 4QA4A 4RN1A 3SKKA 5G0YA 3MZ3A 4MYFA 4ZUQA 5LI3A 4LXZA 4RN2A 3SJTA 3GMZA 4LY1A 3MMRA 1PQ3A 2VQMA 4IU1A 4ZURA 5G0GA 1VKGA 3TH7A 4Q3UA 5G12A 5ICNB 1ZZ1A 3E6VA 4IXUA 2VQWG 4MYNA 4RHIA 3DJ8A 5G10A 4ZUMA 5EF7A 5G3WA 2VQQA 5IWGA 5THUA 2EIVA 1ZPGA 4MYLA 4BZ7A 5EFKB 4RHJA 3NIPA 3EW8A 5THVA 2CEVA 3RLAA 5BWZA 3SFHA 5G13A 1WOHA 1P8NA 4Q42A 5EFHA 4RHMA 5THSA 3ZNRA 1T4TA 3EWFA 5EFNA 4CQFA 5G1BA 5G0XA 3LP7A 5D1BA 1T4RA 4IU4A 3EZPA 2VQVA 1HQXA 1ZZ3A 4ZUPA 2ZAVA 4GSMA 4A69A 4QA2A 3TF3A 1W22A 3MZ6A 4GWCA 3THEA 1T4PA 1WOGA 4GWDA 3MZ4A 1WVBA 4BZ8A 4Q3PA 4IU0A 3GN0A 1P8RA 2RLAA 4GSVA 3EZTA 1CEVA 4CEVA 5THTA 4BZ9A 1ZZ0A 4BZ6A 4QA7A 3C10A 4Q3VA 5A2SA 3NIOA 1T69A 1HQ5A 1HQFA 5EENA 3NIQA 4Q3RA 3Q9CA 3THJA 1C3SA 4Q3SA 3THHA 1T4SA 3PZLA 5IX0A 4IE3A 4ITYA 3M1RA 5EFGA 5EEKA 1TBJA 1C3RA 3F80A 4QA0A 1T5FA 1TBHA 3Q9EA 5DC6A 5HJ9A 1C3PA 5G0HA 3F07A 5EF8A 1P8OA 3F0RA 1TA1A 2GH6A 1P8MA 2PLLA 3MJLA 5D1CA 1T67A 4IE1A 4ZUOA 1D3VA 1GQ6A 3MFVA 3E8QA 4HZEA 5DC5A 2V5WA 5DC8A 3LHLA 2VCGA 1P8PA 4IXVA 3MENA 5EFJD 4CBTA 3MZ7A 4QA6A 1WVAA 1HQHA 4HWWA 5G0JA 3C0YA 4QA1A 4DZ4A 1ZPEA 2VQOA 3MFWA 4RHKA 3E8ZA 1HQGA 1T64A 5G17A 4RLAA 5HJAA 2A0MA 3C0ZA 3CEVA 2V5XA 4RN0A 3F06A 4HXQA 4G3HA 5EEFA 5EFBD 4BKXB 2EF5A 3MAXA 4QA3A 5G0IA 1R1OA 4GSZA 5FUEA 5G1AA 4FCIA 3SFFA 4Q40A 5G1CA 1P8QA 1XFKA 5JI5A 2PHOA 3Q9FA 4CBYA 1WOIA 4MYKA 2VQJA
chains in the Genus database with same CATH topology
5EEMA 3ZNSA 5FCWA 3Q9BA 4QA5A 5DC7A 5D1DA 3RQDA 5G11A 4ZUNA 4BZ5A 5EEIA 5LI3A 4QA4A 4RN1A 4ZUQA 3MZ3A 4LXZA 4RN2A 4LY1A 2VQMA 5G0GA 4ZURA 1VKGA 5G12A 5ICNB 1ZZ1A 2VQWG 5G10A 4ZUMA 5EF7A 5G3WA 2VQQA 5IWGA 5THUA 4BZ7A 5EFKB 3EW8A 5THVA 5BWZA 3SFHA 5G13A 5EFHA 5THSA 3ZNRA 3EWFA 5EFNA 4CQFA 5G1BA 5G0XA 5D1BA 3EZPA 2VQVA 1ZZ3A 4A69A 4ZUPA 4QA2A 1W22A 3MZ6A 3MZ4A 4BZ8A 3EZTA 5THTA 4BZ9A 1ZZ0A 4BZ6A 4QA7A 3C10A 5A2SA 1T69A 5EENA 3Q9CA 1C3SA 5IX0A 5EFGA 5EEKA 1C3RA 4QA0A 3Q9EA 5DC6A 1C3PA 5G0HA 3F07A 5EF8A 3F0RA 2GH6A 5D1CA 1T67A 4ZUOA 5DC5A 2V5WA 5DC8A 2VCGA 3MENA 5EFJD 4CBTA 3MZ7A 4QA6A 5G0JA 3C0YA 4QA1A 2VQOA 1T64A 5G17A 3C0ZA 2V5XA 4RN0A 3F06A 5EEFA 5EFBD 4BKXB 3MAXA 4QA3A 5G0IA 5FUEA 5G1AA 3SFFA 5G1CA 5JI5A 3Q9FA 4CBYA 5G0YA 2VQJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EEM A;  3ZNS A;  5FCW A;  3Q9B A;  4QA5 A;  5DC7 A;  5D1D A;  3RQD A;  5G11 A;  4ZUN A;  4BZ5 A;  5EEI A;  5LI3 A;  4QA4 A;  4RN1 A;  4ZUQ A;  3MZ3 A;  4LXZ A;  4RN2 A;  4LY1 A;  2VQM A;  5G0G A;  4ZUR A;  1VKG A;  5G12 A;  5ICN B;  1ZZ1 A;  2VQW G;  5G10 A;  4ZUM A;  5EF7 A;  5G3W A;  2VQQ A;  5IWG A;  5THU A;  4BZ7 A;  5EFK B;  3EW8 A;  5THV A;  5BWZ A;  3SFH A;  5G13 A;  5EFH A;  5THS A;  3ZNR A;  3EWF A;  5EFN A;  4CQF A;  5G1B A;  5G0X A;  5D1B A;  3EZP A;  2VQV A;  1ZZ3 A;  4A69 A;  4ZUP A;  4QA2 A;  1W22 A;  3MZ6 A;  3MZ4 A;  4BZ8 A;  3EZT A;  5THT A;  4BZ9 A;  1ZZ0 A;  4BZ6 A;  4QA7 A;  3C10 A;  5A2S A;  1T69 A;  5EEN A;  3Q9C A;  1C3S A;  5IX0 A;  5EFG A;  5EEK A;  1C3R A;  4QA0 A;  3Q9E A;  5DC6 A;  1C3P A;  5G0H A;  3F07 A;  5EF8 A;  3F0R A;  2GH6 A;  5D1C A;  1T67 A;  4ZUO A;  5DC5 A;  2V5W A;  5DC8 A;  2VCG A;  3MEN A;  5EFJ D;  4CBT A;  3MZ7 A;  4QA6 A;  5G0J A;  3C0Y A;  4QA1 A;  2VQO A;  1T64 A;  5G17 A;  3C0Z A;  2V5X A;  4RN0 A;  3F06 A;  5EEF A;  5EFB D;  4BKX B;  3MAX A;  4QA3 A;  5G0I A;  5FUE A;  5G1A A;  3SFF A;  5G1C A;  5JI5 A;  3Q9F A;  4CBY A;  5G0Y A;  2VQJ A; 
#chains in the Genus database with same CATH topology
 5EEM A;  2EF4 A;  3ZNS A;  5CEV A;  4IE2 A;  5FCW A;  1P8S A;  1GQ7 A;  4Q3Q A;  2AEB A;  2PHA A;  4Q3R C;  4I06 A;  3Q9B A;  4RHL A;  3SL1 A;  4QA5 A;  1RLA A;  5DC7 A;  1T5G A;  4IU5 A;  3LP4 A;  3E9B A;  5D1D A;  3RQD A;  1TBL A;  5G11 A;  4Q41 A;  4RHQ A;  4Q3T A;  4ZUN A;  3SL0 A;  4FCK A;  3KV2 A;  4MXR A;  4BZ5 A;  3E6K A;  5EEI A;  5RLA A;  4QA4 A;  4RN1 A;  3SKK A;  5G0Y A;  3MZ3 A;  4MYF A;  4ZUQ A;  5LI3 A;  4LXZ A;  4RN2 A;  3SJT A;  3GMZ A;  4LY1 A;  3MMR A;  1PQ3 A;  2VQM A;  4IU1 A;  4ZUR A;  5G0G A;  1VKG A;  3TH7 A;  4Q3U A;  5G12 A;  5ICN B;  1ZZ1 A;  3E6V A;  4IXU A;  2VQW G;  4MYN A;  4RHI A;  3DJ8 A;  5G10 A;  4ZUM A;  5EF7 A;  5G3W A;  2VQQ A;  5IWG A;  5THU A;  2EIV A;  1ZPG A;  4MYL A;  4BZ7 A;  5EFK B;  4RHJ A;  3NIP A;  3EW8 A;  5THV A;  2CEV A;  3RLA A;  5BWZ A;  3SFH A;  5G13 A;  1WOH A;  1P8N A;  4Q42 A;  5EFH A;  4RHM A;  5THS A;  3ZNR A;  1T4T A;  3EWF A;  5EFN A;  4CQF A;  5G1B A;  5G0X A;  3LP7 A;  5D1B A;  1T4R A;  4IU4 A;  3EZP A;  2VQV A;  1HQX A;  1ZZ3 A;  4ZUP A;  2ZAV A;  4GSM A;  4A69 A;  4QA2 A;  3TF3 A;  1W22 A;  3MZ6 A;  4GWC A;  3THE A;  1T4P A;  1WOG A;  4GWD A;  3MZ4 A;  1WVB A;  4BZ8 A;  4Q3P A;  4IU0 A;  3GN0 A;  1P8R A;  2RLA A;  4GSV A;  3EZT A;  1CEV A;  4CEV A;  5THT A;  4BZ9 A;  1ZZ0 A;  4BZ6 A;  4QA7 A;  3C10 A;  4Q3V A;  5A2S A;  3NIO A;  1T69 A;  1HQ5 A;  1HQF A;  5EEN A;  3NIQ A;  4Q3R A;  3Q9C A;  3THJ A;  1C3S A;  4Q3S A;  3THH A;  1T4S A;  3PZL A;  5IX0 A;  4IE3 A;  4ITY A;  3M1R A;  5EFG A;  5EEK A;  1TBJ A;  1C3R A;  3F80 A;  4QA0 A;  1T5F A;  1TBH A;  3Q9E A;  5DC6 A;  5HJ9 A;  1C3P A;  5G0H A;  3F07 A;  5EF8 A;  1P8O A;  3F0R A;  1TA1 A;  2GH6 A;  1P8M A;  2PLL A;  3MJL A;  5D1C A;  1T67 A;  4IE1 A;  4ZUO A;  1D3V A;  1GQ6 A;  3MFV A;  3E8Q A;  4HZE A;  5DC5 A;  2V5W A;  5DC8 A;  3LHL A;  2VCG A;  1P8P A;  4IXV A;  3MEN A;  5EFJ D;  4CBT A;  3MZ7 A;  4QA6 A;  1WVA A;  1HQH A;  4HWW A;  5G0J A;  3C0Y A;  4QA1 A;  4DZ4 A;  1ZPE A;  2VQO A;  3MFW A;  4RHK A;  3E8Z A;  1HQG A;  1T64 A;  5G17 A;  4RLA A;  5HJA A;  2A0M A;  3C0Z A;  3CEV A;  2V5X A;  4RN0 A;  3F06 A;  4HXQ A;  4G3H A;  5EEF A;  5EFB D;  4BKX B;  2EF5 A;  3MAX A;  4QA3 A;  5G0I A;  1R1O A;  4GSZ A;  5FUE A;  5G1A A;  4FCI A;  3SFF A;  4Q40 A;  5G1C A;  1P8Q A;  1XFK A;  5JI5 A;  2PHO A;  3Q9F A;  4CBY A;  1WOI A;  4MYK A;  2VQJ A; 
#chains in the Genus database with same CATH homology
 5EEM A;  3ZNS A;  5FCW A;  3Q9B A;  4QA5 A;  5DC7 A;  5D1D A;  3RQD A;  5G11 A;  4ZUN A;  4BZ5 A;  5EEI A;  5LI3 A;  4QA4 A;  4RN1 A;  4ZUQ A;  3MZ3 A;  4LXZ A;  4RN2 A;  4LY1 A;  2VQM A;  5G0G A;  4ZUR A;  1VKG A;  5G12 A;  5ICN B;  1ZZ1 A;  2VQW G;  5G10 A;  4ZUM A;  5EF7 A;  5G3W A;  2VQQ A;  5IWG A;  5THU A;  4BZ7 A;  5EFK B;  3EW8 A;  5THV A;  5BWZ A;  3SFH A;  5G13 A;  5EFH A;  5THS A;  3ZNR A;  3EWF A;  5EFN A;  4CQF A;  5G1B A;  5G0X A;  5D1B A;  3EZP A;  2VQV A;  1ZZ3 A;  4A69 A;  4ZUP A;  4QA2 A;  1W22 A;  3MZ6 A;  3MZ4 A;  4BZ8 A;  3EZT A;  5THT A;  4BZ9 A;  1ZZ0 A;  4BZ6 A;  4QA7 A;  3C10 A;  5A2S A;  1T69 A;  5EEN A;  3Q9C A;  1C3S A;  5IX0 A;  5EFG A;  5EEK A;  1C3R A;  4QA0 A;  3Q9E A;  5DC6 A;  1C3P A;  5G0H A;  3F07 A;  5EF8 A;  3F0R A;  2GH6 A;  5D1C A;  1T67 A;  4ZUO A;  5DC5 A;  2V5W A;  5DC8 A;  2VCG A;  3MEN A;  5EFJ D;  4CBT A;  3MZ7 A;  4QA6 A;  5G0J A;  3C0Y A;  4QA1 A;  2VQO A;  1T64 A;  5G17 A;  3C0Z A;  2V5X A;  4RN0 A;  3F06 A;  5EEF A;  5EFB D;  4BKX B;  3MAX A;  4QA3 A;  5G0I A;  5FUE A;  5G1A A;  3SFF A;  5G1C A;  5JI5 A;  3Q9F A;  4CBY A;  5G0Y A;  2VQJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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