5EFKB

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 (y745f mutant) in complex with alpha tubulin k40 tripeptide substrate
Total Genus 146
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
146
sequence length
356
structure length
355
Chain Sequence
ITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGFNLTSISESMSMCTSMLLGDSPPSLHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
molecule tags Hydrolase
total genus 146
structure length 355
sequence length 356
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5efkB00
5G0IA 4BZ5A 4CBTA 3SFHA 2VQMA 1C3SA 1T64A 3C10A 4RN0A 5LI3A 2VQJA 3F07A 3MENA 4CBYA 4ZUMA 5G0JA 4LXZA 5D1CA 3MZ4A 5G13A 2GH6A 1T67A 5DC8A 5DC5A 4BKXB 5ICNB 1W22A 3F06A 2VQVA 4A69A 5IWGA 2V5XA 5G0YA 5A2SA 4QA2A 2VQOA 5IX0A 5THSA 5EF8A 5THTA 1VKGA 3EZPA 1ZZ1A 5DC7A 4BZ6A 2VQWG 4ZUNA 3EW8A 3MAXA 5EFKB 4RN2A 5EF7A 5D1DA 3Q9BA 5EEFA 3C0ZA 3ZNSA 5EFBD 3EWFA 4QA6A 5FUEA 5JI5A 4BZ9A 4QA7A 4QA5A 4QA4A 5G11A 3SFFA 1C3RA 4BZ8A 4ZUQA 1ZZ0A 4RN1A 5G1AA 3MZ7A 5EEMA 3MZ6A 5G0XA 3C0YA 5THUA 4CQFA 5G1CA 5DC6A 5D1BA 5EFHA 4QA0A 5EENA 4ZUPA 5G3WA 5EFNA 3Q9FA 5EEIA 2V5WA 4BZ7A 4QA3A 3EZTA 5G10A 2VCGA 5G17A 2VQQA 5G0HA 5G12A 3ZNRA 4ZURA 5G1BA 4LY1A 3MZ3A 5FCWA 5EFGA 1ZZ3A 5G0GA 3RQDA 5EFJD 5BWZA 4ZUOA 1T69A 3Q9CA 4QA1A 5THVA 3Q9EA 5EEKA 1C3PA 3F0RA
chains in the Genus database with same CATH superfamily
5G0IA 3SKKA 4MYFA 1CEVA 4Q3TA 1WOGA 3THJA 3GMZA 5EFNA 4BZ5A 4GSMA 4Q3QA 1TBHA 4CBTA 3SFHA 1WVBA 2VQMA 1C3SA 1T64A 3C10A 4RN0A 3THEA 3MJLA 5LI3A 2VQJA 3F07A 4GSZA 1ZPGA 3MENA 4RHKA 3MFWA 4CBYA 4ZUMA 5G0JA 4LXZA 5D1CA 3MZ4A 4IU1A 5G13A 3TF3A 2GH6A 1TBJA 1T67A 1P8PA 5DC8A 3DJ8A 3E6VA 3E8QA 5DC5A 4BKXB 5ICNB 1GQ6A 4IE3A 1P8MA 1W22A 1HQ5A 3F06A 2VQVA 4A69A 5IWGA 2PLLA 2V5XA 5RLAA 4GWCA 2PHAA 3GN0A 4FCKA 5G0YA 3E9BA 5A2SA 1HQHA 4QA2A 2ZAVA 2VQOA 5IX0A 5THSA 1WOHA 5EF8A 3KV2A 5THTA 1VKGA 3NIQA 1T4SA 3EZPA 1ZZ1A 5DC7A 1P8NA 2EF5A 4MYLA 4BZ6A 2VQWG 3M1RA 4ZUNA 3EW8A 3LP7A 4Q42A 3MAXA 4Q3SA 4RN2A 5EF7A 5D1DA 5EFKB 1P8SA 3Q9BA 4CEVA 5EEFA 4IE2A 4IU5A 3C0ZA 4MYNA 3ZNSA 5EFBD 2EIVA 3THHA 4DZ4A 1T4TA 4I06A 1WOIA 3EWFA 2CEVA 4QA6A 5FUEA 4BZ9A 5JI5A 1TA1A 4IE1A 1T4RA 4QA7A 4QA5A 4IXUA 4QA4A 1P8OA 4Q3PA 1C3RA 5G11A 3SFFA 4BZ8A 3TH7A 3RLAA 1P8QA 4ZUQA 3MMRA 5CEVA 1ZZ0A 4RN1A 4RHMA 3MZ7A 4RHJA 5EEMA 5G1AA 1R1OA 4GSVA 1HQGA 3LP4A 4RLAA 3MZ6A 4IU0A 3C0YA 4RHQA 5G0XA 5THUA 4CQFA 5G1CA 2RLAA 5DC6A 5HJAA 5D1BA 5EFHA 2EF4A 4IU4A 3SL1A 1WVAA 4QA0A 1GQ7A 5EENA 4MXRA 4ZUPA 4ITYA 1RLAA 3E6KA 5G3WA 4GWDA 1TBLA 3LHLA 4Q3RA 3Q9FA 1ZPEA 4RHIA 1PQ3A 2V5WA 5EEIA 4BZ7A 4HWWA 2PHOA 4QA3A 3PZLA 4RHLA 3EZTA 3SJTA 4FCIA 4Q3RC 3F80A 4G3HA 4MYKA 5G10A 5HJ9A 1P8RA 1HQFA 2VCGA 5G17A 4Q3VA 2VQQA 5G0HA 5G12A 4IXVA 3ZNRA 4ZURA 5G1BA 2AEBA 4LY1A 3MZ3A 3NIOA 5FCWA 1T5FA 4Q41A 5EFGA 1HQXA 1ZZ3A 3SL0A 3NIPA 4Q40A 4Q3UA 5G0GA 5EFJD 3RQDA 2A0MA 4HZEA 1T4PA 1T5GA 4HXQA 5BWZA 1D3VA 4ZUOA 3CEVA 1T69A 1XFKA 3Q9CA 4QA1A 3Q9EA 5THVA 3MFVA 5EEKA 1C3PA 3E8ZA 3F0RA
chains in the Genus database with same CATH topology
5G0IA 4BZ5A 4CBTA 3SFHA 2VQMA 1C3SA 1T64A 3C10A 4RN0A 5LI3A 2VQJA 3F07A 3MENA 4CBYA 4ZUMA 5G0JA 4LXZA 5D1CA 3MZ4A 5G13A 2GH6A 1T67A 5DC8A 5DC5A 4BKXB 5ICNB 1W22A 3F06A 2VQVA 4A69A 5IWGA 2V5XA 5G0YA 5A2SA 4QA2A 2VQOA 5IX0A 5THSA 5EF8A 5THTA 1VKGA 3EZPA 1ZZ1A 5DC7A 4BZ6A 2VQWG 4ZUNA 3EW8A 3MAXA 5EFKB 4RN2A 5EF7A 5D1DA 3Q9BA 5EEFA 3C0ZA 3ZNSA 5EFBD 3EWFA 4QA6A 5FUEA 5JI5A 4BZ9A 4QA7A 4QA5A 4QA4A 5G11A 3SFFA 1C3RA 4BZ8A 4ZUQA 1ZZ0A 4RN1A 5G1AA 3MZ7A 5EEMA 3MZ6A 5G0XA 3C0YA 5THUA 4CQFA 5G1CA 5DC6A 5D1BA 5EFHA 4QA0A 5EENA 4ZUPA 5G3WA 5EFNA 3Q9FA 5EEIA 2V5WA 4BZ7A 4QA3A 3EZTA 5G10A 2VCGA 5G17A 2VQQA 5G0HA 5G12A 3ZNRA 4ZURA 5G1BA 4LY1A 3MZ3A 5FCWA 5EFGA 1ZZ3A 5G0GA 3RQDA 5EFJD 5BWZA 4ZUOA 1T69A 3Q9CA 4QA1A 5THVA 3Q9EA 5EEKA 1C3PA 3F0RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G0I A;  4BZ5 A;  4CBT A;  3SFH A;  2VQM A;  1C3S A;  1T64 A;  3C10 A;  4RN0 A;  5LI3 A;  2VQJ A;  3F07 A;  3MEN A;  4CBY A;  4ZUM A;  5G0J A;  4LXZ A;  5D1C A;  3MZ4 A;  5G13 A;  2GH6 A;  1T67 A;  5DC8 A;  5DC5 A;  4BKX B;  5ICN B;  1W22 A;  3F06 A;  2VQV A;  4A69 A;  5IWG A;  2V5X A;  5G0Y A;  5A2S A;  4QA2 A;  2VQO A;  5IX0 A;  5THS A;  5EF8 A;  5THT A;  1VKG A;  3EZP A;  1ZZ1 A;  5DC7 A;  4BZ6 A;  2VQW G;  4ZUN A;  3EW8 A;  3MAX A;  5EFK B;  4RN2 A;  5EF7 A;  5D1D A;  3Q9B A;  5EEF A;  3C0Z A;  3ZNS A;  5EFB D;  3EWF A;  4QA6 A;  5FUE A;  5JI5 A;  4BZ9 A;  4QA7 A;  4QA5 A;  4QA4 A;  5G11 A;  3SFF A;  1C3R A;  4BZ8 A;  4ZUQ A;  1ZZ0 A;  4RN1 A;  5G1A A;  3MZ7 A;  5EEM A;  3MZ6 A;  5G0X A;  3C0Y A;  5THU A;  4CQF A;  5G1C A;  5DC6 A;  5D1B A;  5EFH A;  4QA0 A;  5EEN A;  4ZUP A;  5G3W A;  5EFN A;  3Q9F A;  5EEI A;  2V5W A;  4BZ7 A;  4QA3 A;  3EZT A;  5G10 A;  2VCG A;  5G17 A;  2VQQ A;  5G0H A;  5G12 A;  3ZNR A;  4ZUR A;  5G1B A;  4LY1 A;  3MZ3 A;  5FCW A;  5EFG A;  1ZZ3 A;  5G0G A;  3RQD A;  5EFJ D;  5BWZ A;  4ZUO A;  1T69 A;  3Q9C A;  4QA1 A;  5THV A;  3Q9E A;  5EEK A;  1C3P A;  3F0R A; 
#chains in the Genus database with same CATH topology
 5G0I A;  3SKK A;  4MYF A;  1CEV A;  4Q3T A;  1WOG A;  3THJ A;  3GMZ A;  5EFN A;  4BZ5 A;  4GSM A;  4Q3Q A;  1TBH A;  4CBT A;  3SFH A;  1WVB A;  2VQM A;  1C3S A;  1T64 A;  3C10 A;  4RN0 A;  3THE A;  3MJL A;  5LI3 A;  2VQJ A;  3F07 A;  4GSZ A;  1ZPG A;  3MEN A;  4RHK A;  3MFW A;  4CBY A;  4ZUM A;  5G0J A;  4LXZ A;  5D1C A;  3MZ4 A;  4IU1 A;  5G13 A;  3TF3 A;  2GH6 A;  1TBJ A;  1T67 A;  1P8P A;  5DC8 A;  3DJ8 A;  3E6V A;  3E8Q A;  5DC5 A;  4BKX B;  5ICN B;  1GQ6 A;  4IE3 A;  1P8M A;  1W22 A;  1HQ5 A;  3F06 A;  2VQV A;  4A69 A;  5IWG A;  2PLL A;  2V5X A;  5RLA A;  4GWC A;  2PHA A;  3GN0 A;  4FCK A;  5G0Y A;  3E9B A;  5A2S A;  1HQH A;  4QA2 A;  2ZAV A;  2VQO A;  5IX0 A;  5THS A;  1WOH A;  5EF8 A;  3KV2 A;  5THT A;  1VKG A;  3NIQ A;  1T4S A;  3EZP A;  1ZZ1 A;  5DC7 A;  1P8N A;  2EF5 A;  4MYL A;  4BZ6 A;  2VQW G;  3M1R A;  4ZUN A;  3EW8 A;  3LP7 A;  4Q42 A;  3MAX A;  4Q3S A;  4RN2 A;  5EF7 A;  5D1D A;  5EFK B;  1P8S A;  3Q9B A;  4CEV A;  5EEF A;  4IE2 A;  4IU5 A;  3C0Z A;  4MYN A;  3ZNS A;  5EFB D;  2EIV A;  3THH A;  4DZ4 A;  1T4T A;  4I06 A;  1WOI A;  3EWF A;  2CEV A;  4QA6 A;  5FUE A;  4BZ9 A;  5JI5 A;  1TA1 A;  4IE1 A;  1T4R A;  4QA7 A;  4QA5 A;  4IXU A;  4QA4 A;  1P8O A;  4Q3P A;  1C3R A;  5G11 A;  3SFF A;  4BZ8 A;  3TH7 A;  3RLA A;  1P8Q A;  4ZUQ A;  3MMR A;  5CEV A;  1ZZ0 A;  4RN1 A;  4RHM A;  3MZ7 A;  4RHJ A;  5EEM A;  5G1A A;  1R1O A;  4GSV A;  1HQG A;  3LP4 A;  4RLA A;  3MZ6 A;  4IU0 A;  3C0Y A;  4RHQ A;  5G0X A;  5THU A;  4CQF A;  5G1C A;  2RLA A;  5DC6 A;  5HJA A;  5D1B A;  5EFH A;  2EF4 A;  4IU4 A;  3SL1 A;  1WVA A;  4QA0 A;  1GQ7 A;  5EEN A;  4MXR A;  4ZUP A;  4ITY A;  1RLA A;  3E6K A;  5G3W A;  4GWD A;  1TBL A;  3LHL A;  4Q3R A;  3Q9F A;  1ZPE A;  4RHI A;  1PQ3 A;  2V5W A;  5EEI A;  4BZ7 A;  4HWW A;  2PHO A;  4QA3 A;  3PZL A;  4RHL A;  3EZT A;  3SJT A;  4FCI A;  4Q3R C;  3F80 A;  4G3H A;  4MYK A;  5G10 A;  5HJ9 A;  1P8R A;  1HQF A;  2VCG A;  5G17 A;  4Q3V A;  2VQQ A;  5G0H A;  5G12 A;  4IXV A;  3ZNR A;  4ZUR A;  5G1B A;  2AEB A;  4LY1 A;  3MZ3 A;  3NIO A;  5FCW A;  1T5F A;  4Q41 A;  5EFG A;  1HQX A;  1ZZ3 A;  3SL0 A;  3NIP A;  4Q40 A;  4Q3U A;  5G0G A;  5EFJ D;  3RQD A;  2A0M A;  4HZE A;  1T4P A;  1T5G A;  4HXQ A;  5BWZ A;  1D3V A;  4ZUO A;  3CEV A;  1T69 A;  1XFK A;  3Q9C A;  4QA1 A;  3Q9E A;  5THV A;  3MFV A;  5EEK A;  1C3P A;  3E8Z A;  3F0R A; 
#chains in the Genus database with same CATH homology
 5G0I A;  4BZ5 A;  4CBT A;  3SFH A;  2VQM A;  1C3S A;  1T64 A;  3C10 A;  4RN0 A;  5LI3 A;  2VQJ A;  3F07 A;  3MEN A;  4CBY A;  4ZUM A;  5G0J A;  4LXZ A;  5D1C A;  3MZ4 A;  5G13 A;  2GH6 A;  1T67 A;  5DC8 A;  5DC5 A;  4BKX B;  5ICN B;  1W22 A;  3F06 A;  2VQV A;  4A69 A;  5IWG A;  2V5X A;  5G0Y A;  5A2S A;  4QA2 A;  2VQO A;  5IX0 A;  5THS A;  5EF8 A;  5THT A;  1VKG A;  3EZP A;  1ZZ1 A;  5DC7 A;  4BZ6 A;  2VQW G;  4ZUN A;  3EW8 A;  3MAX A;  5EFK B;  4RN2 A;  5EF7 A;  5D1D A;  3Q9B A;  5EEF A;  3C0Z A;  3ZNS A;  5EFB D;  3EWF A;  4QA6 A;  5FUE A;  5JI5 A;  4BZ9 A;  4QA7 A;  4QA5 A;  4QA4 A;  5G11 A;  3SFF A;  1C3R A;  4BZ8 A;  4ZUQ A;  1ZZ0 A;  4RN1 A;  5G1A A;  3MZ7 A;  5EEM A;  3MZ6 A;  5G0X A;  3C0Y A;  5THU A;  4CQF A;  5G1C A;  5DC6 A;  5D1B A;  5EFH A;  4QA0 A;  5EEN A;  4ZUP A;  5G3W A;  5EFN A;  3Q9F A;  5EEI A;  2V5W A;  4BZ7 A;  4QA3 A;  3EZT A;  5G10 A;  2VCG A;  5G17 A;  2VQQ A;  5G0H A;  5G12 A;  3ZNR A;  4ZUR A;  5G1B A;  4LY1 A;  3MZ3 A;  5FCW A;  5EFG A;  1ZZ3 A;  5G0G A;  3RQD A;  5EFJ D;  5BWZ A;  4ZUO A;  1T69 A;  3Q9C A;  4QA1 A;  5THV A;  3Q9E A;  5EEK A;  1C3P A;  3F0R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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