5EQIA

Mfs transporter in complex with cytochalasin b
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
sequence length
447
structure length
447
Chain Sequence
TGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPET
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
pubmed doi rcsb
molecule keywords Solute carrier family 2, facilitated glucose transporter mem
molecule tags Transport protein/inhibitor
source organism Homo sapiens
total genus 161
structure length 447
sequence length 447
ec nomenclature
pdb deposition date 2015-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00083 Sugar_tr Sugar (and other) transporter
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.20 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; MFS general substrate transporter like domains 5eqiA00
4OAAA 4APSA 5C65A 3O7PA 3O7QA 2XUTA 4GC0A 4IU9A 4IKVA 4ZW9A 4UVMA 1PV6A 4IKZA 2V8NA 4LDSA 4U4TA 4XNJA 4ZWCA 2CFQA 4PYPA 5EQIA 5EQHA 4YB9D 4XNIA 4JA3A 4IKYA 4YBQA 1PV7A 4U4WA 4JR9A 4JREA 5D58A 4GBZA 3WDOA 4TPHA 5A2NA 4IKWA 4Q65A 4IKXA 4TPJA 4J05A 4U4VA 2CFPA 2Y5YA 4GBYA 4TPGA 4D2DA 4ZYRA 4D2BA 5GXBA 5D6KA 4QIQA 4W6VA 4D2CA 4IU8A 4LEPA 4OH3A 5EQGA 5A2OA 5D59A 1PW4A 4ZWBA
chains in the Genus database with same CATH superfamily
4BY7D 3MZGA 2D48A 3BPNA 1CN4C 2L3YA 3IRHA 5D22A 1M4AA 4NN5A 3DGCL 4TPJA 3HOUD 4U4VA 5E4EA 1ITFA 3NCBA 2Z3QA 4NN6A 3QAZA 1VLKA 3EW3A 5IP9D 1BGDA 4DKEA 4IKZA 1Z7CA 1HIKA 1Y1VD 1Y1WD 2VUMD 4BY1D 1M48A 5D58A 4A3CD 4DKDA 4EXPA 2ILKA 2E9WC 3Q1SI 5IYBD 2R92D 4OAAA 3AYHA 5C65A 1HWGA 5IYCD 4ZS7A 4YUEC 5EQHA 3N0PA 4NEJA 1BCNA 3EJJA 5C44D 1LKIA 4Q65A 4D2DA 1HWHA 3PO2D 3H0GD 1JLIA 5C3ED 1HUWA 5FHXA 3FKID 4ZW9A 3UX9A 3HMXB 4XNIA 2JA6D 4YBQA 4JREA 4PS4A 4NN7A 1M47A 4IKXA 4J05A 1CD9A 2R93D 3DUHC 4IU8A 3DLQI 5EQGA 3NCCA 3HOXD 1PVHB 4UVMA 1ALUA 1EKUA 3HHCA 4GRWA 2HYMB 4LDSA 5EQIA 3TGXB 1IRLA 4A3ED 4LRLA 3BPOA 4U4WA 4GBZA 1V7NV 3OG6A 5D6KA 4A3KD 1INRA 3B5KA 5FLMD 4A3LD 5KNHI 2B8UA 1PV6A 1Z92A 2V8NA 4U4TA 4XNJA 1Y6KL 4RS1A 4A3MD 4EXNA 3H3VE 1M4BA 2B8YA 1GA3A 1FYHA 1HULA 2Y5YA 4GBYA 3D85C 5IYDD 3SE4B 3L5XA 4ZWBA 1A22A 3QB1A 2B8XA 3G9VB 4A3BD 3L5WI 1BBNA 4A3ID 3NCFA 4J4LC 5LQBA 1Y6ML 1IK0A 1GNCA 1HGUA 2Q7NB 5D59A 1V7MV 4NI7A 4DOHA 4APSA 4GC0A 4IKVA 3LB6B 1BGEA 1F45B 4TPHA 2PSMA 1AU1A 1ITLA 4CNIC 5L6YC 1PGRA 1M49A 1M4RA 1CYLA 2Q14A 3OG4A 3I4ND 3O7QA 1Y14A 1EXZA 3QB7A 3HOVD 4FA8E 3VA2A 5GXBA 4O9HA 2B90A 1HIJA 2LMSA 5C7XA 2KZ1A 2JA8D 1EMRA 1FG9A 1I1RB 2CFPA 4X51A 1ILKA 4W6VA 5D28B 4LEPA 4BBSD 1PW4A 4ZF7A 1RW5A 2B8ZA 1IJZA 4WRLB 4ZWCA 1ITIA 3D48P 4NEMA 1BUYA 1ITMA 2L3OA 5D71A 2ERJD 4DKCA 3BPLA 4A3GD 2JA5D 4TPGA 4ZYRA 3DI3A 5A2OA 3PIWA 1IARA 4A3JD 3D87A 4DKFA 3HOYD 1AXIA 2IL6A 1RFBA 1PV7A 1A7MA 3PO3D 3NPZA 3UEZE 1IL6A 3WCYI 4D2CA 1EERA 1M4CA 3BESL 1BGCA 2INTA 4OH3A 3I4MD 2O27A 1NBPA 3SE3B 3HHRA 2B5IA 2B63D 4YQXA 3UF5A 2O6IA 4I77Z 2Z3RA 5A2NA 4JR9A 1D9CA 4IKWA 3QWRB 5C4XD 3INKC 2Q98A 4QIQA 3S9DA 4NI9A 5TS9A 4NKQC 4BBRD 3N06A 2H24A 4BXXD 2XUTA 1HZIA 1J7VL 1B5LA 4PYPA 5D72A 4YDYI 4YB9D 4MHLA 1WU3I 1QVNA 4O6KA 1WCMD 1LQSL 1RCBA 1P9MB 2GMFA 2LAGA 1D9GA 2R7ZD 1CSGA 5IP7D 4A93D 1YKBA 4IU9A 4A3FD 3UF2A 4JA3A 2C35A 2B91A 4IKYA 3QT2C 4YPGC 4GS7A 1RHGA 3HOWD 5D70A 1LK3A 1CNT1 1Y6NL 3OQ3A 2CYKA 2D9QA 3LB6A 2JA7D 5FUCA 1ETEA 3O7PA 1SCFA 1BP3A 1F6FA 2O26A 3NCEA 2CFQA 3DI2A 3WDOA 4A3DD 1N1FA 1PW6A 1AX8A 3PIVA 4Z5RD 1PY2A 4D2BA 2OQPA 2XQBA 1EVSA 1KF9A 3HOZD 3G6DA
chains in the Genus database with same CATH topology
4OAAA 4APSA 5C65A 3O7PA 3O7QA 2XUTA 4GC0A 4IU9A 4IKVA 4ZW9A 4UVMA 1PV6A 4IKZA 2V8NA 4LDSA 4U4TA 4XNJA 4ZWCA 2CFQA 4PYPA 5EQIA 5EQHA 4YB9D 4XNIA 4JA3A 4IKYA 4YBQA 1PV7A 4U4WA 4JR9A 4JREA 5D58A 4GBZA 3WDOA 4TPHA 5A2NA 4IKWA 4Q65A 4IKXA 4TPJA 4J05A 4U4VA 2CFPA 2Y5YA 4GBYA 4TPGA 4D2DA 4ZYRA 4D2BA 5GXBA 5D6KA 4QIQA 4W6VA 4D2CA 4IU8A 4LEPA 4OH3A 5EQGA 5A2OA 5D59A 1PW4A 4ZWBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OAA A;  4APS A;  5C65 A;  3O7P A;  3O7Q A;  2XUT A;  4GC0 A;  4IU9 A;  4IKV A;  4ZW9 A;  4UVM A;  1PV6 A;  4IKZ A;  2V8N A;  4LDS A;  4U4T A;  4XNJ A;  4ZWC A;  2CFQ A;  4PYP A;  5EQI A;  5EQH A;  4YB9 D;  4XNI A;  4JA3 A;  4IKY A;  4YBQ A;  1PV7 A;  4U4W A;  4JR9 A;  4JRE A;  5D58 A;  4GBZ A;  3WDO A;  4TPH A;  5A2N A;  4IKW A;  4Q65 A;  4IKX A;  4TPJ A;  4J05 A;  4U4V A;  2CFP A;  2Y5Y A;  4GBY A;  4TPG A;  4D2D A;  4ZYR A;  4D2B A;  5GXB A;  5D6K A;  4QIQ A;  4W6V A;  4D2C A;  4IU8 A;  4LEP A;  4OH3 A;  5EQG A;  5A2O A;  5D59 A;  1PW4 A;  4ZWB A; 
#chains in the Genus database with same CATH topology
 4BY7 D;  3MZG A;  2D48 A;  3BPN A;  1CN4 C;  2L3Y A;  3IRH A;  5D22 A;  1M4A A;  4NN5 A;  3DGC L;  4TPJ A;  3HOU D;  4U4V A;  5E4E A;  1ITF A;  3NCB A;  2Z3Q A;  4NN6 A;  3QAZ A;  1VLK A;  3EW3 A;  5IP9 D;  1BGD A;  4DKE A;  4IKZ A;  1Z7C A;  1HIK A;  1Y1V D;  1Y1W D;  2VUM D;  4BY1 D;  1M48 A;  5D58 A;  4A3C D;  4DKD A;  4EXP A;  2ILK A;  2E9W C;  3Q1S I;  5IYB D;  2R92 D;  4OAA A;  3AYH A;  5C65 A;  1HWG A;  5IYC D;  4ZS7 A;  4YUE C;  5EQH A;  3N0P A;  4NEJ A;  1BCN A;  3EJJ A;  5C44 D;  1LKI A;  4Q65 A;  4D2D A;  1HWH A;  3PO2 D;  3H0G D;  1JLI A;  5C3E D;  1HUW A;  5FHX A;  3FKI D;  4ZW9 A;  3UX9 A;  3HMX B;  4XNI A;  2JA6 D;  4YBQ A;  4JRE A;  4PS4 A;  4NN7 A;  1M47 A;  4IKX A;  4J05 A;  1CD9 A;  2R93 D;  3DUH C;  4IU8 A;  3DLQ I;  5EQG A;  3NCC A;  3HOX D;  1PVH B;  4UVM A;  1ALU A;  1EKU A;  3HHC A;  4GRW A;  2HYM B;  4LDS A;  5EQI A;  3TGX B;  1IRL A;  4A3E D;  4LRL A;  3BPO A;  4U4W A;  4GBZ A;  1V7N V;  3OG6 A;  5D6K A;  4A3K D;  1INR A;  3B5K A;  5FLM D;  4A3L D;  5KNH I;  2B8U A;  1PV6 A;  1Z92 A;  2V8N A;  4U4T A;  4XNJ A;  1Y6K L;  4RS1 A;  4A3M D;  4EXN A;  3H3V E;  1M4B A;  2B8Y A;  1GA3 A;  1FYH A;  1HUL A;  2Y5Y A;  4GBY A;  3D85 C;  5IYD D;  3SE4 B;  3L5X A;  4ZWB A;  1A22 A;  3QB1 A;  2B8X A;  3G9V B;  4A3B D;  3L5W I;  1BBN A;  4A3I D;  3NCF A;  4J4L C;  5LQB A;  1Y6M L;  1IK0 A;  1GNC A;  1HGU A;  2Q7N B;  5D59 A;  1V7M V;  4NI7 A;  4DOH A;  4APS A;  4GC0 A;  4IKV A;  3LB6 B;  1BGE A;  1F45 B;  4TPH A;  2PSM A;  1AU1 A;  1ITL A;  4CNI C;  5L6Y C;  1PGR A;  1M49 A;  1M4R A;  1CYL A;  2Q14 A;  3OG4 A;  3I4N D;  3O7Q A;  1Y14 A;  1EXZ A;  3QB7 A;  3HOV D;  4FA8 E;  3VA2 A;  5GXB A;  4O9H A;  2B90 A;  1HIJ A;  2LMS A;  5C7X A;  2KZ1 A;  2JA8 D;  1EMR A;  1FG9 A;  1I1R B;  2CFP A;  4X51 A;  1ILK A;  4W6V A;  5D28 B;  4LEP A;  4BBS D;  1PW4 A;  4ZF7 A;  1RW5 A;  2B8Z A;  1IJZ A;  4WRL B;  4ZWC A;  1ITI A;  3D48 P;  4NEM A;  1BUY A;  1ITM A;  2L3O A;  5D71 A;  2ERJ D;  4DKC A;  3BPL A;  4A3G D;  2JA5 D;  4TPG A;  4ZYR A;  3DI3 A;  5A2O A;  3PIW A;  1IAR A;  4A3J D;  3D87 A;  4DKF A;  3HOY D;  1AXI A;  2IL6 A;  1RFB A;  1PV7 A;  1A7M A;  3PO3 D;  3NPZ A;  3UEZ E;  1IL6 A;  3WCY I;  4D2C A;  1EER A;  1M4C A;  3BES L;  1BGC A;  2INT A;  4OH3 A;  3I4M D;  2O27 A;  1NBP A;  3SE3 B;  3HHR A;  2B5I A;  2B63 D;  4YQX A;  3UF5 A;  2O6I A;  4I77 Z;  2Z3R A;  5A2N A;  4JR9 A;  1D9C A;  4IKW A;  3QWR B;  5C4X D;  3INK C;  2Q98 A;  4QIQ A;  3S9D A;  4NI9 A;  5TS9 A;  4NKQ C;  4BBR D;  3N06 A;  2H24 A;  4BXX D;  2XUT A;  1HZI A;  1J7V L;  1B5L A;  4PYP A;  5D72 A;  4YDY I;  4YB9 D;  4MHL A;  1WU3 I;  1QVN A;  4O6K A;  1WCM D;  1LQS L;  1RCB A;  1P9M B;  2GMF A;  2LAG A;  1D9G A;  2R7Z D;  1CSG A;  5IP7 D;  4A93 D;  1YKB A;  4IU9 A;  4A3F D;  3UF2 A;  4JA3 A;  2C35 A;  2B91 A;  4IKY A;  3QT2 C;  4YPG C;  4GS7 A;  1RHG A;  3HOW D;  5D70 A;  1LK3 A;  1CNT 1;  1Y6N L;  3OQ3 A;  2CYK A;  2D9Q A;  3LB6 A;  2JA7 D;  5FUC A;  1ETE A;  3O7P A;  1SCF A;  1BP3 A;  1F6F A;  2O26 A;  3NCE A;  2CFQ A;  3DI2 A;  3WDO A;  4A3D D;  1N1F A;  1PW6 A;  1AX8 A;  3PIV A;  4Z5R D;  1PY2 A;  4D2B A;  2OQP A;  2XQB A;  1EVS A;  1KF9 A;  3HOZ D;  3G6D A; 
#chains in the Genus database with same CATH homology
 4OAA A;  4APS A;  5C65 A;  3O7P A;  3O7Q A;  2XUT A;  4GC0 A;  4IU9 A;  4IKV A;  4ZW9 A;  4UVM A;  1PV6 A;  4IKZ A;  2V8N A;  4LDS A;  4U4T A;  4XNJ A;  4ZWC A;  2CFQ A;  4PYP A;  5EQI A;  5EQH A;  4YB9 D;  4XNI A;  4JA3 A;  4IKY A;  4YBQ A;  1PV7 A;  4U4W A;  4JR9 A;  4JRE A;  5D58 A;  4GBZ A;  3WDO A;  4TPH A;  5A2N A;  4IKW A;  4Q65 A;  4IKX A;  4TPJ A;  4J05 A;  4U4V A;  2CFP A;  2Y5Y A;  4GBY A;  4TPG A;  4D2D A;  4ZYR A;  4D2B A;  5GXB A;  5D6K A;  4QIQ A;  4W6V A;  4D2C A;  4IU8 A;  4LEP A;  4OH3 A;  5EQG A;  5A2O A;  5D59 A;  1PW4 A;  4ZWB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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