5EWZA

Small-molecule stabilization of the 14-3-3/gab2 ppi interface
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
229
structure length
229
Chain Sequence
DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords 14-3-3 protein zeta/delta
publication title Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
pubmed doi rcsb
source organism Homo sapiens
total genus 94
structure length 229
sequence length 229
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 5ewzA00
2BQ0A 3UZDA 2O98A 3CU8A 3IQJA 2BR9A 4DAUA 2B05A 3P1NA 5HF3A 2C1JA 1A38A 4FJ3A 2V7DA 3SP5A 2WH0A 3P1QA 1A4OA 4DHQA 3EFZA 4N7YA 3P1OA 4E2EA 4DHNA 4J6SA 4O46A 3RDHA 5D3EA 4Y32A 1O9DA 4N7GA 4JC3A 5EWZA 4DNKA 4DHPA 4Y5IA 3P1RA 3P1PA 4JDDA 4GNTA 2C63A 5LHOA 4IHLA 4DHSA 3M51A 2C74A 3UALA 5EXAA 3SMOA 3M50A 3SPRA 4IEAA 3SMNA 4DATA 5IQPA 3LW1A 5BY9A 5J31A 1O9CA 4Y3BA 5D2DA 1O9FA 3SMLA 2C1NA 4FR3A 1YWTA 4N84A 1QJBA 5D3FA 3IQUA 1IB1A 3MHRA 1O9EA 3UBWA 5LU1A 3U9XA 4ZQ0A 3O8IA 4DHRA 4HKCA 2C23A 5F74A 4BG6A 4WRQA 3NKXA 3T0LA 3SMMA 4DX0A 2O8PA 3SMKA 4DHUA 2NPMA 3UX0A 3IQVA 1YZ5A 3T0MA 1A37A 5LVZA 5LU2A 3P1SA 2BTPA 4DHOA 4F7RA 4DHMA 2O02A 1QJAA 3E6YA 5BTVA 4ZDRA 4DHTA 4FL5A 3AXYC 5LX2A 4QLIA
chains in the Genus database with same CATH superfamily
2BQ0A 3CQGA 3UZDA 2O98A 3CU8A 3EB7A 3IQJA 2BR9A 4DAUA 4W8JA 1I5PA 2B05A 3P1NA 5HF3A 2C1JA 1A38A 4FJ3A 2V7DA 3SP5A 2WH0A 3P1QA 1A4OA 4DHQA 3EFZA 4N7YA 3P1OA 4E2EA 4DHNA 4QX0A 4J6SA 4O46A 3CQCA 3RDHA 5D3EA 1URJA 4Y32A 1O9DA 4N7GA 4JC3A 5EWZA 4DNKA 4DHPA 4QX2A 4Y5IA 3P1RA 3P1PA 4JDDA 4GNTA 2C63A 5LHOA 4MOAA 4IHLA 4DHSA 3M51A 2C74A 3UALA 5EXAA 3SMOA 1DLCA 3M50A 3SPRA 4IEAA 3SMNA 4DATA 5IQPA 3LW1A 5BY9A 5J31A 1S2XA 1O9CA 4Y3BA 5D2DA 1O9FA 4QX3A 3SMLA 2C1NA 4FR3A 4ARYA 1CIYA 1YWTA 4N84A 1QJBA 5D3FA 3IQUA 1IB1A 3MHRA 3I4RA 1O9EA 3UBWA 1W99A 4D8MA 5LU1A 3U9XA 4ZQ0A 3O8IA 4ARXA 4DHRA 4QX1A 4HKCA 2C23A 5F74A 4BG6A 4WRQA 3NKXA 3T0LA 3SMMA 4DX0A 2O8PA 3SMKA 4DHUA 2C9KA 2NPMA 3UX0A 3IQVA 1YZ5A 3T0MA 1A37A 5LVZA 5LU2A 3P1SA 2BTPA 1JI6A 4DHOA 3ZHEB 4F7RA 4DHMA 2O02A 1QJAA 3E6YA 5BTVA 4ZDRA 3X0UA 4FL5A 4DHTA 3AXYC 5LX2A 4QLIA
chains in the Genus database with same CATH topology
2BQ0A 3UZDA 2O98A 3CU8A 3IQJA 2BR9A 4DAUA 2B05A 3P1NA 5HF3A 2C1JA 1A38A 4FJ3A 2V7DA 3SP5A 2WH0A 3P1QA 1A4OA 4DHQA 3EFZA 4N7YA 3P1OA 4E2EA 4DHNA 4J6SA 4O46A 3RDHA 5D3EA 4Y32A 1O9DA 4N7GA 4JC3A 5EWZA 4DNKA 4DHPA 4Y5IA 3P1RA 3P1PA 4JDDA 4GNTA 2C63A 5LHOA 4IHLA 4DHSA 3M51A 2C74A 3UALA 5EXAA 3SMOA 3M50A 3SPRA 4IEAA 3SMNA 4DATA 5IQPA 3LW1A 5BY9A 5J31A 1O9CA 4Y3BA 5D2DA 1O9FA 3SMLA 2C1NA 4FR3A 1YWTA 4N84A 1QJBA 5D3FA 3IQUA 1IB1A 3MHRA 1O9EA 3UBWA 5LU1A 3U9XA 4ZQ0A 3O8IA 4DHRA 4HKCA 2C23A 5F74A 4BG6A 4WRQA 3NKXA 3T0LA 3SMMA 4DX0A 2O8PA 3SMKA 4DHUA 2NPMA 3UX0A 3IQVA 1YZ5A 3T0MA 1A37A 5LVZA 5LU2A 3P1SA 2BTPA 4DHOA 4F7RA 4DHMA 2O02A 1QJAA 3E6YA 5BTVA 4ZDRA 4DHTA 4FL5A 3AXYC 5LX2A 4QLIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BQ0 A;  3UZD A;  2O98 A;  3CU8 A;  3IQJ A;  2BR9 A;  4DAU A;  2B05 A;  3P1N A;  5HF3 A;  2C1J A;  1A38 A;  4FJ3 A;  2V7D A;  3SP5 A;  2WH0 A;  3P1Q A;  1A4O A;  4DHQ A;  3EFZ A;  4N7Y A;  3P1O A;  4E2E A;  4DHN A;  4J6S A;  4O46 A;  3RDH A;  5D3E A;  4Y32 A;  1O9D A;  4N7G A;  4JC3 A;  5EWZ A;  4DNK A;  4DHP A;  4Y5I A;  3P1R A;  3P1P A;  4JDD A;  4GNT A;  2C63 A;  5LHO A;  4IHL A;  4DHS A;  3M51 A;  2C74 A;  3UAL A;  5EXA A;  3SMO A;  3M50 A;  3SPR A;  4IEA A;  3SMN A;  4DAT A;  5IQP A;  3LW1 A;  5BY9 A;  5J31 A;  1O9C A;  4Y3B A;  5D2D A;  1O9F A;  3SML A;  2C1N A;  4FR3 A;  1YWT A;  4N84 A;  1QJB A;  5D3F A;  3IQU A;  1IB1 A;  3MHR A;  1O9E A;  3UBW A;  5LU1 A;  3U9X A;  4ZQ0 A;  3O8I A;  4DHR A;  4HKC A;  2C23 A;  5F74 A;  4BG6 A;  4WRQ A;  3NKX A;  3T0L A;  3SMM A;  4DX0 A;  2O8P A;  3SMK A;  4DHU A;  2NPM A;  3UX0 A;  3IQV A;  1YZ5 A;  3T0M A;  1A37 A;  5LVZ A;  5LU2 A;  3P1S A;  2BTP A;  4DHO A;  4F7R A;  4DHM A;  2O02 A;  1QJA A;  3E6Y A;  5BTV A;  4ZDR A;  4DHT A;  4FL5 A;  3AXY C;  5LX2 A;  4QLI A; 
#chains in the Genus database with same CATH topology
 2BQ0 A;  3CQG A;  3UZD A;  2O98 A;  3CU8 A;  3EB7 A;  3IQJ A;  2BR9 A;  4DAU A;  4W8J A;  1I5P A;  2B05 A;  3P1N A;  5HF3 A;  2C1J A;  1A38 A;  4FJ3 A;  2V7D A;  3SP5 A;  2WH0 A;  3P1Q A;  1A4O A;  4DHQ A;  3EFZ A;  4N7Y A;  3P1O A;  4E2E A;  4DHN A;  4QX0 A;  4J6S A;  4O46 A;  3CQC A;  3RDH A;  5D3E A;  1URJ A;  4Y32 A;  1O9D A;  4N7G A;  4JC3 A;  5EWZ A;  4DNK A;  4DHP A;  4QX2 A;  4Y5I A;  3P1R A;  3P1P A;  4JDD A;  4GNT A;  2C63 A;  5LHO A;  4MOA A;  4IHL A;  4DHS A;  3M51 A;  2C74 A;  3UAL A;  5EXA A;  3SMO A;  1DLC A;  3M50 A;  3SPR A;  4IEA A;  3SMN A;  4DAT A;  5IQP A;  3LW1 A;  5BY9 A;  5J31 A;  1S2X A;  1O9C A;  4Y3B A;  5D2D A;  1O9F A;  4QX3 A;  3SML A;  2C1N A;  4FR3 A;  4ARY A;  1CIY A;  1YWT A;  4N84 A;  1QJB A;  5D3F A;  3IQU A;  1IB1 A;  3MHR A;  3I4R A;  1O9E A;  3UBW A;  1W99 A;  4D8M A;  5LU1 A;  3U9X A;  4ZQ0 A;  3O8I A;  4ARX A;  4DHR A;  4QX1 A;  4HKC A;  2C23 A;  5F74 A;  4BG6 A;  4WRQ A;  3NKX A;  3T0L A;  3SMM A;  4DX0 A;  2O8P A;  3SMK A;  4DHU A;  2C9K A;  2NPM A;  3UX0 A;  3IQV A;  1YZ5 A;  3T0M A;  1A37 A;  5LVZ A;  5LU2 A;  3P1S A;  2BTP A;  1JI6 A;  4DHO A;  3ZHE B;  4F7R A;  4DHM A;  2O02 A;  1QJA A;  3E6Y A;  5BTV A;  4ZDR A;  3X0U A;  4FL5 A;  4DHT A;  3AXY C;  5LX2 A;  4QLI A; 
#chains in the Genus database with same CATH homology
 2BQ0 A;  3UZD A;  2O98 A;  3CU8 A;  3IQJ A;  2BR9 A;  4DAU A;  2B05 A;  3P1N A;  5HF3 A;  2C1J A;  1A38 A;  4FJ3 A;  2V7D A;  3SP5 A;  2WH0 A;  3P1Q A;  1A4O A;  4DHQ A;  3EFZ A;  4N7Y A;  3P1O A;  4E2E A;  4DHN A;  4J6S A;  4O46 A;  3RDH A;  5D3E A;  4Y32 A;  1O9D A;  4N7G A;  4JC3 A;  5EWZ A;  4DNK A;  4DHP A;  4Y5I A;  3P1R A;  3P1P A;  4JDD A;  4GNT A;  2C63 A;  5LHO A;  4IHL A;  4DHS A;  3M51 A;  2C74 A;  3UAL A;  5EXA A;  3SMO A;  3M50 A;  3SPR A;  4IEA A;  3SMN A;  4DAT A;  5IQP A;  3LW1 A;  5BY9 A;  5J31 A;  1O9C A;  4Y3B A;  5D2D A;  1O9F A;  3SML A;  2C1N A;  4FR3 A;  1YWT A;  4N84 A;  1QJB A;  5D3F A;  3IQU A;  1IB1 A;  3MHR A;  1O9E A;  3UBW A;  5LU1 A;  3U9X A;  4ZQ0 A;  3O8I A;  4DHR A;  4HKC A;  2C23 A;  5F74 A;  4BG6 A;  4WRQ A;  3NKX A;  3T0L A;  3SMM A;  4DX0 A;  2O8P A;  3SMK A;  4DHU A;  2NPM A;  3UX0 A;  3IQV A;  1YZ5 A;  3T0M A;  1A37 A;  5LVZ A;  5LU2 A;  3P1S A;  2BTP A;  4DHO A;  4F7R A;  4DHM A;  2O02 A;  1QJA A;  3E6Y A;  5BTV A;  4ZDR A;  4DHT A;  4FL5 A;  3AXY C;  5LX2 A;  4QLI A; 
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