5EXAA

Small-molecule stabilization of the 14-3-3/gab2 ppi interface
Total Genus 103
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
229
structure length
229
Chain Sequence
DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Signaling protein
molecule keywords 14-3-3 protein zeta/delta
publication title Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
pubmed doi rcsb
source organism Homo sapiens
total genus 103
structure length 229
sequence length 229
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 5exaA00
4J6SA 4HKCA 3SMLA 4DHSA 5LU2A 4BG6A 2O02A 4DHUA 4N7GA 4N84A 4ZDRA 4N7YA 4Y3BA 2NPMA 4Y5IA 5LX2A 2V7DA 1QJAA 1YZ5A 3P1RA 3T0MA 2WH0A 4Y32A 3EFZA 4O46A 1O9EA 1A4OA 4JDDA 2C1JA 5LVZA 3SP5A 3UBWA 4DHMA 3SMKA 5EXAA 3P1SA 4WRQA 5F74A 2C74A 3T0LA 4QLIA 5IQPA 3CU8A 1O9CA 4IEAA 2C63A 2O98A 4GNTA 5LU1A 2BR9A 4FJ3A 1IB1A 4E2EA 4FR3A 4DX0A 3IQJA 5EWZA 3NKXA 5D2DA 1QJBA 5BTVA 1A37A 3E6YA 4FL5A 3UZDA 3U9XA 4F7RA 3M50A 4JC3A 1O9FA 4IHLA 2C23A 4DHTA 1A38A 3SMOA 3LW1A 3SMMA 4DHRA 4ZQ0A 3P1OA 4DHQA 3IQVA 2C1NA 1YWTA 2O8PA 3MHRA 3UX0A 4DHPA 5J31A 5BY9A 1O9DA 3IQUA 3RDHA 3M51A 3AXYC 4DATA 2B05A 3SMNA 5LHOA 2BTPA 5HF3A 3O8IA 4DHNA 3SPRA 4DAUA 3UALA 3P1PA 5D3FA 3P1QA 5D3EA 3P1NA 4DHOA 4DNKA 2BQ0A
chains in the Genus database with same CATH superfamily
4J6SA 4HKCA 3SMLA 4DHSA 5LU2A 4BG6A 2O02A 4DHUA 4N7GA 4N84A 4ZDRA 4N7YA 4Y3BA 2NPMA 4Y5IA 5LX2A 2V7DA 1QJAA 1YZ5A 3P1RA 4W8JA 3T0MA 2WH0A 4Y32A 3EFZA 4D8MA 4O46A 1O9EA 1A4OA 4JDDA 2C1JA 5LVZA 3SP5A 3UBWA 4QX2A 4DHMA 5EXAA 3SMKA 4QX3A 3P1SA 4WRQA 5F74A 2C74A 3T0LA 4QLIA 2C9KA 5IQPA 3CU8A 1O9CA 1CIYA 4IEAA 2C63A 2O98A 4GNTA 5LU1A 2BR9A 4FJ3A 1IB1A 4E2EA 4FR3A 4DX0A 3IQJA 5EWZA 3NKXA 5D2DA 1QJBA 1DLCA 5BTVA 1A37A 3E6YA 4FL5A 3UZDA 3U9XA 4F7RA 3M50A 4JC3A 1O9FA 1JI6A 4IHLA 2C23A 4DHTA 1A38A 3CQCA 3SMOA 1URJA 3LW1A 3SMMA 3CQGA 3I4RA 4DHRA 4ZQ0A 3P1OA 4DHQA 3IQVA 2C1NA 1YWTA 4ARXA 2O8PA 3MHRA 3UX0A 4DHPA 5J31A 5BY9A 1O9DA 3IQUA 3RDHA 3M51A 4QX1A 3AXYC 1W99A 4DATA 2B05A 4ARYA 3SMNA 5LHOA 2BTPA 5HF3A 3O8IA 4QX0A 3X0UA 1S2XA 4DHNA 1I5PA 3SPRA 4DAUA 3UALA 3ZHEB 3P1PA 5D3FA 3P1QA 5D3EA 4MOAA 3P1NA 4DHOA 3EB7A 4DNKA 2BQ0A
chains in the Genus database with same CATH topology
4J6SA 4HKCA 3SMLA 4DHSA 5LU2A 4BG6A 2O02A 4DHUA 4N7GA 4N84A 4ZDRA 4N7YA 4Y3BA 2NPMA 4Y5IA 5LX2A 2V7DA 1QJAA 1YZ5A 3P1RA 3T0MA 2WH0A 4Y32A 3EFZA 4O46A 1O9EA 1A4OA 4JDDA 2C1JA 5LVZA 3SP5A 3UBWA 4DHMA 3SMKA 5EXAA 3P1SA 4WRQA 5F74A 2C74A 3T0LA 4QLIA 5IQPA 3CU8A 1O9CA 4IEAA 2C63A 2O98A 4GNTA 5LU1A 2BR9A 4FJ3A 1IB1A 4E2EA 4FR3A 4DX0A 3IQJA 5EWZA 3NKXA 5D2DA 1QJBA 5BTVA 1A37A 3E6YA 4FL5A 3UZDA 3U9XA 4F7RA 3M50A 4JC3A 1O9FA 4IHLA 2C23A 4DHTA 1A38A 3SMOA 3LW1A 3SMMA 4DHRA 4ZQ0A 3P1OA 4DHQA 3IQVA 2C1NA 1YWTA 2O8PA 3MHRA 3UX0A 4DHPA 5J31A 5BY9A 1O9DA 3IQUA 3RDHA 3M51A 3AXYC 4DATA 2B05A 3SMNA 5LHOA 2BTPA 5HF3A 3O8IA 4DHNA 3SPRA 4DAUA 3UALA 3P1PA 5D3FA 3P1QA 5D3EA 3P1NA 4DHOA 4DNKA 2BQ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J6S A;  4HKC A;  3SML A;  4DHS A;  5LU2 A;  4BG6 A;  2O02 A;  4DHU A;  4N7G A;  4N84 A;  4ZDR A;  4N7Y A;  4Y3B A;  2NPM A;  4Y5I A;  5LX2 A;  2V7D A;  1QJA A;  1YZ5 A;  3P1R A;  3T0M A;  2WH0 A;  4Y32 A;  3EFZ A;  4O46 A;  1O9E A;  1A4O A;  4JDD A;  2C1J A;  5LVZ A;  3SP5 A;  3UBW A;  4DHM A;  3SMK A;  5EXA A;  3P1S A;  4WRQ A;  5F74 A;  2C74 A;  3T0L A;  4QLI A;  5IQP A;  3CU8 A;  1O9C A;  4IEA A;  2C63 A;  2O98 A;  4GNT A;  5LU1 A;  2BR9 A;  4FJ3 A;  1IB1 A;  4E2E A;  4FR3 A;  4DX0 A;  3IQJ A;  5EWZ A;  3NKX A;  5D2D A;  1QJB A;  5BTV A;  1A37 A;  3E6Y A;  4FL5 A;  3UZD A;  3U9X A;  4F7R A;  3M50 A;  4JC3 A;  1O9F A;  4IHL A;  2C23 A;  4DHT A;  1A38 A;  3SMO A;  3LW1 A;  3SMM A;  4DHR A;  4ZQ0 A;  3P1O A;  4DHQ A;  3IQV A;  2C1N A;  1YWT A;  2O8P A;  3MHR A;  3UX0 A;  4DHP A;  5J31 A;  5BY9 A;  1O9D A;  3IQU A;  3RDH A;  3M51 A;  3AXY C;  4DAT A;  2B05 A;  3SMN A;  5LHO A;  2BTP A;  5HF3 A;  3O8I A;  4DHN A;  3SPR A;  4DAU A;  3UAL A;  3P1P A;  5D3F A;  3P1Q A;  5D3E A;  3P1N A;  4DHO A;  4DNK A;  2BQ0 A; 
#chains in the Genus database with same CATH topology
 4J6S A;  4HKC A;  3SML A;  4DHS A;  5LU2 A;  4BG6 A;  2O02 A;  4DHU A;  4N7G A;  4N84 A;  4ZDR A;  4N7Y A;  4Y3B A;  2NPM A;  4Y5I A;  5LX2 A;  2V7D A;  1QJA A;  1YZ5 A;  3P1R A;  4W8J A;  3T0M A;  2WH0 A;  4Y32 A;  3EFZ A;  4D8M A;  4O46 A;  1O9E A;  1A4O A;  4JDD A;  2C1J A;  5LVZ A;  3SP5 A;  3UBW A;  4QX2 A;  4DHM A;  5EXA A;  3SMK A;  4QX3 A;  3P1S A;  4WRQ A;  5F74 A;  2C74 A;  3T0L A;  4QLI A;  2C9K A;  5IQP A;  3CU8 A;  1O9C A;  1CIY A;  4IEA A;  2C63 A;  2O98 A;  4GNT A;  5LU1 A;  2BR9 A;  4FJ3 A;  1IB1 A;  4E2E A;  4FR3 A;  4DX0 A;  3IQJ A;  5EWZ A;  3NKX A;  5D2D A;  1QJB A;  1DLC A;  5BTV A;  1A37 A;  3E6Y A;  4FL5 A;  3UZD A;  3U9X A;  4F7R A;  3M50 A;  4JC3 A;  1O9F A;  1JI6 A;  4IHL A;  2C23 A;  4DHT A;  1A38 A;  3CQC A;  3SMO A;  1URJ A;  3LW1 A;  3SMM A;  3CQG A;  3I4R A;  4DHR A;  4ZQ0 A;  3P1O A;  4DHQ A;  3IQV A;  2C1N A;  1YWT A;  4ARX A;  2O8P A;  3MHR A;  3UX0 A;  4DHP A;  5J31 A;  5BY9 A;  1O9D A;  3IQU A;  3RDH A;  3M51 A;  4QX1 A;  3AXY C;  1W99 A;  4DAT A;  2B05 A;  4ARY A;  3SMN A;  5LHO A;  2BTP A;  5HF3 A;  3O8I A;  4QX0 A;  3X0U A;  1S2X A;  4DHN A;  1I5P A;  3SPR A;  4DAU A;  3UAL A;  3ZHE B;  3P1P A;  5D3F A;  3P1Q A;  5D3E A;  4MOA A;  3P1N A;  4DHO A;  3EB7 A;  4DNK A;  2BQ0 A; 
#chains in the Genus database with same CATH homology
 4J6S A;  4HKC A;  3SML A;  4DHS A;  5LU2 A;  4BG6 A;  2O02 A;  4DHU A;  4N7G A;  4N84 A;  4ZDR A;  4N7Y A;  4Y3B A;  2NPM A;  4Y5I A;  5LX2 A;  2V7D A;  1QJA A;  1YZ5 A;  3P1R A;  3T0M A;  2WH0 A;  4Y32 A;  3EFZ A;  4O46 A;  1O9E A;  1A4O A;  4JDD A;  2C1J A;  5LVZ A;  3SP5 A;  3UBW A;  4DHM A;  3SMK A;  5EXA A;  3P1S A;  4WRQ A;  5F74 A;  2C74 A;  3T0L A;  4QLI A;  5IQP A;  3CU8 A;  1O9C A;  4IEA A;  2C63 A;  2O98 A;  4GNT A;  5LU1 A;  2BR9 A;  4FJ3 A;  1IB1 A;  4E2E A;  4FR3 A;  4DX0 A;  3IQJ A;  5EWZ A;  3NKX A;  5D2D A;  1QJB A;  5BTV A;  1A37 A;  3E6Y A;  4FL5 A;  3UZD A;  3U9X A;  4F7R A;  3M50 A;  4JC3 A;  1O9F A;  4IHL A;  2C23 A;  4DHT A;  1A38 A;  3SMO A;  3LW1 A;  3SMM A;  4DHR A;  4ZQ0 A;  3P1O A;  4DHQ A;  3IQV A;  2C1N A;  1YWT A;  2O8P A;  3MHR A;  3UX0 A;  4DHP A;  5J31 A;  5BY9 A;  1O9D A;  3IQU A;  3RDH A;  3M51 A;  3AXY C;  4DAT A;  2B05 A;  3SMN A;  5LHO A;  2BTP A;  5HF3 A;  3O8I A;  4DHN A;  3SPR A;  4DAU A;  3UAL A;  3P1P A;  5D3F A;  3P1Q A;  5D3E A;  3P1N A;  4DHO A;  4DNK A;  2BQ0 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...