5EXRA

Crystal structure of human primosome
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
412
structure length
389
Chain Sequence
METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIGPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
pubmed doi rcsb
molecule tags Replication
source organism Homo sapiens
molecule keywords DNA primase small subunit
total genus 98
structure length 389
sequence length 412
chains with identical sequence E
ec nomenclature
pdb deposition date 2015-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 5exrA00
2FAQA 1ZT2A 5EXRA 4LIMA 2FARA 4BPWA 4MM2A 4BPXA 4LILA 4BPUA 4MHQA 2FAOA 4RR2A 4LIKA
chains in the Genus database with same CATH superfamily
2FAQA 1G71A 1ZT2A 5EXRA 4LIMA 2FARA 4MHQA 4BPWA 4MM2A 4BPXA 4LILA 1V33A 4BPUA 2ATZA 2FAOA 4RR2A 1V34A 4LIKA
chains in the Genus database with same CATH topology
2FAQA 1G71A 1ZT2A 5EXRA 4LIMA 2FARA 4BPWA 4MM2A 4BPXA 4LILA 1V33A 4BPUA 4MHQA 2FAOA 4RR2A 1V34A 4LIKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FAQ A;  1ZT2 A;  5EXR A;  4LIM A;  2FAR A;  4BPW A;  4MM2 A;  4BPX A;  4LIL A;  4BPU A;  4MHQ A;  2FAO A;  4RR2 A;  4LIK A; 
#chains in the Genus database with same CATH topology
 2FAQ A;  1G71 A;  1ZT2 A;  5EXR A;  4LIM A;  2FAR A;  4MHQ A;  4BPW A;  4MM2 A;  4BPX A;  4LIL A;  1V33 A;  4BPU A;  2ATZ A;  2FAO A;  4RR2 A;  1V34 A;  4LIK A; 
#chains in the Genus database with same CATH homology
 2FAQ A;  1G71 A;  1ZT2 A;  5EXR A;  4LIM A;  2FAR A;  4BPW A;  4MM2 A;  4BPX A;  4LIL A;  1V33 A;  4BPU A;  4MHQ A;  2FAO A;  4RR2 A;  1V34 A;  4LIK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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