5F72C

De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
rcsb
molecule tags De novo protein
source organism Homo sapiens
molecule keywords Kelch-like ECH-associated protein 1
total genus 62
structure length 285
sequence length 285
chains with identical sequence K
ec nomenclature
pdb deposition date 2015-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5f72C00
5FNRA 1ZGKA 4N1BA 2Z32A 4IFLX 2ZZKA 1U6DX 4IN4A 5FZNA 3ZGDA 5FNUA 1X2JA 1X2RA 3ADEA 4XMBA 4L7CA 5FZJA 3WN7A 2XN4A 2FLUX 2WOZA 5CGJA 2VPJA 3WDZA 2ZW9A 4CHBA 4L7BA 2ZWAA 4IFNX 2DYHA 4IQKA 5FNQA 3VNGA 3VNHA 4IFJA 5F72C 3ZGCA 4ZGCA 4ZY3A 5FNTA 4L7DA 4CH9A 4ASCA 5FNSA 4YY8A 3II7A
chains in the Genus database with same CATH superfamily
4K1IA 4MWLA 2X9MA 1W21A 1DILA 3S2KA 2HT8A 4XILA 3CKZA 1NMAN 2VW2A 2IAXA 1NMBN 4MWJA 2GHSA 2W5OA 4GZPA 3A9GA 4MX0A 1ZI0A 4IFNX 3O9JA 1MWEA 4YW4A 3B69A 4FZHA 1INYA 2W20A 4M4UA 2ZB5A 1CRZA 1INVA 2P4OA 4K1HA 1B9SA 4B7QA 4FOYA 2Z32A 1QBIA 1XOGA 3NO0A 2DSOA 4MWUA 1W8OA 2IAVA 3HLIA 5HUNA 1Z4WA 2JKBA 4YZ2A 4XIKA 2W8BB 3D11A 4B7NA 5GX4A 4QNPA 1IUBA 4FPJA 4FPEA 5FNQA 2QWFA 3VNHA 1Z4XA 3ZGCA 1C9UA 3G4HA 1Z4YA 3GVLA 4X47A 4YW5A 5H47A 4BBWA 3SLIA 2QWCA 2F28A 2AH2A 4GZTA 4FJ6A 1V3BA 1SLLA 4N1BA 2YA6A 2QWEA 1NSCA 3TICA 1S0IA 4MWXA 4HW6A 5HUGA 1Q7FA 1F8CA 2IAOA 4MWQA 4QN3A 4GN8A 4NN9A 1A4GA 4WEFA 4XHBA 2IAPA 4CPMA 3TI3A 2YA5A 5F72C 4ZGCA 1W0OA 2QWGA 5NN9A 2HTUA 4SLIA 4L7DA 3W09A 4XJUA 5EO8A 2F11A 7NN9A 1V0ZA 2FHRA 1N7DA 4FPHA 4B7JA 2DG0A 3A72A 2YA7A 4IFLX 3IAXA 3B7EA 1RWLA 1S18A 4IN4A 4FPLA 1NPEA 1IVGA 1X2RA 5FWWA 2HU0A 4ZLRA 1A14N 3KGGA 4XMAA 3KYAA 2GVUA 1F8DA 1V3DA 1POOA 4D52B 4GJTA 4XHXA 1W1XA 3CL0A 2F26A 1EUTA 2F24A 4MC7A 2F0ZA 4G3NA 1NNCA 1XOEA 5GX3A 3WWAA 2HT7A 1INWA 2F29A 4HHQA 3SOVA 1NCBN 1WCSA 4H53A 4X6KA 2BZDA 1E8UA 3A9HA 1EUUA 4CPYA 4Q6KA 2XZJA 3GVJA 1IVDA 3D12A 1INHA 4DGRA 1Z4ZA 2SILA 3TI6A 2QWIA 1NCAN 4GDJA 5FNSA 1MZ6A 1MS9A 2F13A 4FOWA 4HZZA 4AGIA 4CPZA 5F9TA 2YDTA 4D4UA 1V0EA 4UOUA 2VW0A 2HTYA 5HUMA 4B7RA 2DG1A 3K39A 3ZGDA 3H71A 4MWVA 4XMBA 1DIMA 2VK5A 1IVCA 4XJAA 5EX7A 2XCYA 4MZAA 1MS4A 4WA5A 3K38A 1H6LA 5HX0A 1L7HA 1USRA 1MS8A 4HIZA 4M4VA 1MR5A 2BERA 1V3EA 2QWHA 2F27A 2YA4A 4FP3A 1A4QA 2QWJA 5JYYA 3PJQA 2VW1A 2FLUX 3HLHA 2ISMA 4O5TA 2ZW9A 2F10A 3TI4A 2POOA 5B2DA 2W5NA 4FP2A 4GZXA 3NN9A 2VK6A 4H52A 3JU4A 1IVEA 3SREA 4CH9A 5GTQA 3O9KA 4IYGA 1CVMA 4XJRA 3FW0A 1S1DA 4XJ8A 3ADEA 1S0JA 3SRGA 2IAQA 4GNAA 4GDIA 1MS5A 5CGJA 2IAUA 3Q6TA 4FVKA 4L7BA 3TIBA 2AGSA 4IQKA 2W38A 2YDPA 2AEQA 4YY8A 4CPOA 3II7A 1N1SA 1NSBA 1NCDN 3ALWA 5B2CA 2B8HA 1EUSA 3TIAA 1E8TA 1WCQA 2F12A 2QWKA 2HTWA 3SOQA 2WOZA 4D52C 4M3MA 2QWAA 2H2NA 3HRPA 1N6DA 3WW9A 4GN9A 2VSMA 2YA8A 1IJQA 4GN7A 2W8BA 4FPFA 1KITA 4YW1A 4D8SA 2XZKA 2XZIA 4YZ3A 2IATA 2HT5A 4QN6A 1OFZA 4FPGA 3H6JA 2FPBA 4C1YA 4QN4A 3OPZA 4DG6A 1F8EA 2H2UA 2VSKA 4YZ5A 4CPNA 4AH4A 2GVXA 3DASA 4FPCA 1C5KA 4PWZA 4K1KA 1N1VA 3E5ZA 5GX1A 5D9BA 3K37A 1MZ5A 1F8BA 2VK7A 4FOVA 1SNTA 2VAQA 3P5BL 2BATA 4FPKA 3K36A 1INXA 4XOGA 4MWYA 4XIOA 4MWRA 2C4LA 1N6EA 1CQ1A 3Q6PA 3K3AA 4AHAA 4XMIA 5FZJA 4QN7A 4GZQA 4GZOA 3A71A 4HZWA 1E8VA 5GX5A 2ZWAA 3AMSA 6NN9A 3S94A 4FPOB 3CYEA 4GZWA 4D52A 1CRUA 4WEGA 4A0PA 3CL2A 1W8NA 3BYCA 3SOBB 4XJQA 3WN7A 4HZYA 4L7CA 2BF6A 2XN4A 1W0PA 2V91A 4WA4A 1V3CA 1NNBA 1E1AA 3ALXA 2DYHA 4YZ1A 4GB1A 4I00A 2QWBA 2FP8A 4J9TA 2ZB6A 5FNTA 5M1ZA 3S8ZA 1X2JA 1SLIA 4IMBA 2F25A 2SLIA 1N1TA 3BEQA 2IVZA 4KS1A 4Q1UA 4NCSA 3G4EA 4YW2A 3U0SA 2A75A 4K3YA 1V04A 4GNBA 4R40A 3SANA 1V2IA 4B7MA 2FP9A 4XE9A 1MS3A 1BJIA 1INGA 4M4NA 2VPJA 4CHBA 2IAWA 4C1YB 3V64C 4ZY3A 3L6VA 3LI5A 1V0FA 4XJ9A 3LI4A 4JMLA 4FQ4A 2OJHA 4FOQA 4YW3A 3TC9A 4XJWA 4WA3A 2GVWA 3UC1A 4UF7A 2C4AA 2ZZKA 3NSSA 5HUKA 4GNCA 1MS1A 4KS4A 3SALA 3FVZA 4X4AA 1SUUA 3LI3A 2QWDA 2HTQA 4MWWA 2IASA 4NC5A 4KS3A 4GEZA 1EURA 1Z50A 2CMLA 4XYXA 1NSDA 3V65B 4X49A 3T1EA 3V1SA 1NCCN 3VNGA 1B9TA 4QN5A 1L7FA 1VCUA 2SIMA 1L7GA 4HHOA 2HTVA 2IARA 4MJUA 4JF7A 3Q6KA 3S8VA 4AGTA 1WP5A 2HTRA 5FNRA 4XJZA 4CPLA 3TI5A 1N1YA 4K1JA 1K32A 4MJVA 1U6DX 1NNAA 1W20A 1PJXA 2VWDA 2QE8A 5GX2A 2VVZA 1B9VA 3DR2A 3TI8A 5EO7A 3WDZA 3H72A 3AMRA 2HU4A 4MZEA 1IVBA 3I1CA 3GVKA 4IFJA 2G8SA 1RWIA 3INBA 1SO7A 4O5SA 4CSDA 1Z4VA 1ZGKA 4YZ4A 4HZXA 3SILA 5FZNA 5FNUA 1USXA 1NN2A 4KS5A 4KS2A 5D9CA 3H73A 4FPYA 2RKCA 1INFA 1N6FA 4HZVA 1IUCA 1MS0A 1NMCA 1QLGA 2GVVA 4GZSA 3O4PA 5D9DA 2AEPA 2FPCA 1VCJA 2HQSA 4ASCA 1IVFA
chains in the Genus database with same CATH topology
5FNRA 1ZGKA 4N1BA 2Z32A 4IFLX 2ZZKA 1U6DX 4IN4A 5FZNA 3ZGDA 5FNUA 1X2JA 1X2RA 3ADEA 4XMBA 4L7CA 5FZJA 3WN7A 2XN4A 2FLUX 2WOZA 5CGJA 2VPJA 3WDZA 2ZW9A 4CHBA 4L7BA 2ZWAA 4IFNX 2DYHA 4IQKA 5FNQA 3VNGA 3VNHA 4IFJA 5F72C 3ZGCA 4ZGCA 4ZY3A 5FNTA 4L7DA 4CH9A 4ASCA 5FNSA 4YY8A 3II7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FNR A;  1ZGK A;  4N1B A;  2Z32 A;  4IFL X;  2ZZK A;  1U6D X;  4IN4 A;  5FZN A;  3ZGD A;  5FNU A;  1X2J A;  1X2R A;  3ADE A;  4XMB A;  4L7C A;  5FZJ A;  3WN7 A;  2XN4 A;  2FLU X;  2WOZ A;  5CGJ A;  2VPJ A;  3WDZ A;  2ZW9 A;  4CHB A;  4L7B A;  2ZWA A;  4IFN X;  2DYH A;  4IQK A;  5FNQ A;  3VNG A;  3VNH A;  4IFJ A;  5F72 C;  3ZGC A;  4ZGC A;  4ZY3 A;  5FNT A;  4L7D A;  4CH9 A;  4ASC A;  5FNS A;  4YY8 A;  3II7 A; 
#chains in the Genus database with same CATH topology
 4K1I A;  4MWL A;  2X9M A;  1W21 A;  1DIL A;  3S2K A;  2HT8 A;  4XIL A;  3CKZ A;  1NMA N;  2VW2 A;  2IAX A;  1NMB N;  4MWJ A;  2GHS A;  2W5O A;  4GZP A;  3A9G A;  4MX0 A;  1ZI0 A;  4IFN X;  3O9J A;  1MWE A;  4YW4 A;  3B69 A;  4FZH A;  1INY A;  2W20 A;  4M4U A;  2ZB5 A;  1CRZ A;  1INV A;  2P4O A;  4K1H A;  1B9S A;  4B7Q A;  4FOY A;  2Z32 A;  1QBI A;  1XOG A;  3NO0 A;  2DSO A;  4MWU A;  1W8O A;  2IAV A;  3HLI A;  5HUN A;  1Z4W A;  2JKB A;  4YZ2 A;  4XIK A;  2W8B B;  3D11 A;  4B7N A;  5GX4 A;  4QNP A;  1IUB A;  4FPJ A;  4FPE A;  5FNQ A;  2QWF A;  3VNH A;  1Z4X A;  3ZGC A;  1C9U A;  3G4H A;  1Z4Y A;  3GVL A;  4X47 A;  4YW5 A;  5H47 A;  4BBW A;  3SLI A;  2QWC A;  2F28 A;  2AH2 A;  4GZT A;  4FJ6 A;  1V3B A;  1SLL A;  4N1B A;  2YA6 A;  2QWE A;  1NSC A;  3TIC A;  1S0I A;  4MWX A;  4HW6 A;  5HUG A;  1Q7F A;  1F8C A;  2IAO A;  4MWQ A;  4QN3 A;  4GN8 A;  4NN9 A;  1A4G A;  4WEF A;  4XHB A;  2IAP A;  4CPM A;  3TI3 A;  2YA5 A;  5F72 C;  4ZGC A;  1W0O A;  2QWG A;  5NN9 A;  2HTU A;  4SLI A;  4L7D A;  3W09 A;  4XJU A;  5EO8 A;  2F11 A;  7NN9 A;  1V0Z A;  2FHR A;  1N7D A;  4FPH A;  4B7J A;  2DG0 A;  3A72 A;  2YA7 A;  4IFL X;  3IAX A;  3B7E A;  1RWL A;  1S18 A;  4IN4 A;  4FPL A;  1NPE A;  1IVG A;  1X2R A;  5FWW A;  2HU0 A;  4ZLR A;  1A14 N;  3KGG A;  4XMA A;  3KYA A;  2GVU A;  1F8D A;  1V3D A;  1POO A;  4D52 B;  4GJT A;  4XHX A;  1W1X A;  3CL0 A;  2F26 A;  1EUT A;  2F24 A;  4MC7 A;  2F0Z A;  4G3N A;  1NNC A;  1XOE A;  5GX3 A;  3WWA A;  2HT7 A;  1INW A;  2F29 A;  4HHQ A;  3SOV A;  1NCB N;  1WCS A;  4H53 A;  4X6K A;  2BZD A;  1E8U A;  3A9H A;  1EUU A;  4CPY A;  4Q6K A;  2XZJ A;  3GVJ A;  1IVD A;  3D12 A;  1INH A;  4DGR A;  1Z4Z A;  2SIL A;  3TI6 A;  2QWI A;  1NCA N;  4GDJ A;  5FNS A;  1MZ6 A;  1MS9 A;  2F13 A;  4FOW A;  4HZZ A;  4AGI A;  4CPZ A;  5F9T A;  2YDT A;  4D4U A;  1V0E A;  4UOU A;  2VW0 A;  2HTY A;  5HUM A;  4B7R A;  2DG1 A;  3K39 A;  3ZGD A;  3H71 A;  4MWV A;  4XMB A;  1DIM A;  2VK5 A;  1IVC A;  4XJA A;  5EX7 A;  2XCY A;  4MZA A;  1MS4 A;  4WA5 A;  3K38 A;  1H6L A;  5HX0 A;  1L7H A;  1USR A;  1MS8 A;  4HIZ A;  4M4V A;  1MR5 A;  2BER A;  1V3E A;  2QWH A;  2F27 A;  2YA4 A;  4FP3 A;  1A4Q A;  2QWJ A;  5JYY A;  3PJQ A;  2VW1 A;  2FLU X;  3HLH A;  2ISM A;  4O5T A;  2ZW9 A;  2F10 A;  3TI4 A;  2POO A;  5B2D A;  2W5N A;  4FP2 A;  4GZX A;  3NN9 A;  2VK6 A;  4H52 A;  3JU4 A;  1IVE A;  3SRE A;  4CH9 A;  5GTQ A;  3O9K A;  4IYG A;  1CVM A;  4XJR A;  3FW0 A;  1S1D A;  4XJ8 A;  3ADE A;  1S0J A;  3SRG A;  2IAQ A;  4GNA A;  4GDI A;  1MS5 A;  5CGJ A;  2IAU A;  3Q6T A;  4FVK A;  4L7B A;  3TIB A;  2AGS A;  4IQK A;  2W38 A;  2YDP A;  2AEQ A;  4YY8 A;  4CPO A;  3II7 A;  1N1S A;  1NSB A;  1NCD N;  3ALW A;  5B2C A;  2B8H A;  1EUS A;  3TIA A;  1E8T A;  1WCQ A;  2F12 A;  2QWK A;  2HTW A;  3SOQ A;  2WOZ A;  4D52 C;  4M3M A;  2QWA A;  2H2N A;  3HRP A;  1N6D A;  3WW9 A;  4GN9 A;  2VSM A;  2YA8 A;  1IJQ A;  4GN7 A;  2W8B A;  4FPF A;  1KIT A;  4YW1 A;  4D8S A;  2XZK A;  2XZI A;  4YZ3 A;  2IAT A;  2HT5 A;  4QN6 A;  1OFZ A;  4FPG A;  3H6J A;  2FPB A;  4C1Y A;  4QN4 A;  3OPZ A;  4DG6 A;  1F8E A;  2H2U A;  2VSK A;  4YZ5 A;  4CPN A;  4AH4 A;  2GVX A;  3DAS A;  4FPC A;  1C5K A;  4PWZ A;  4K1K A;  1N1V A;  3E5Z A;  5GX1 A;  5D9B A;  3K37 A;  1MZ5 A;  1F8B A;  2VK7 A;  4FOV A;  1SNT A;  2VAQ A;  3P5B L;  2BAT A;  4FPK A;  3K36 A;  1INX A;  4XOG A;  4MWY A;  4XIO A;  4MWR A;  2C4L A;  1N6E A;  1CQ1 A;  3Q6P A;  3K3A A;  4AHA A;  4XMI A;  5FZJ A;  4QN7 A;  4GZQ A;  4GZO A;  3A71 A;  4HZW A;  1E8V A;  5GX5 A;  2ZWA A;  3AMS A;  6NN9 A;  3S94 A;  4FPO B;  3CYE A;  4GZW A;  4D52 A;  1CRU A;  4WEG A;  4A0P A;  3CL2 A;  1W8N A;  3BYC A;  3SOB B;  4XJQ A;  3WN7 A;  4HZY A;  4L7C A;  2BF6 A;  2XN4 A;  1W0P A;  2V91 A;  4WA4 A;  1V3C A;  1NNB A;  1E1A A;  3ALX A;  2DYH A;  4YZ1 A;  4GB1 A;  4I00 A;  2QWB A;  2FP8 A;  4J9T A;  2ZB6 A;  5FNT A;  5M1Z A;  3S8Z A;  1X2J A;  1SLI A;  4IMB A;  2F25 A;  2SLI A;  1N1T A;  3BEQ A;  2IVZ A;  4KS1 A;  4Q1U A;  4NCS A;  3G4E A;  4YW2 A;  3U0S A;  2A75 A;  4K3Y A;  1V04 A;  4GNB A;  4R40 A;  3SAN A;  1V2I A;  4B7M A;  2FP9 A;  4XE9 A;  1MS3 A;  1BJI A;  1ING A;  4M4N A;  2VPJ A;  4CHB A;  2IAW A;  4C1Y B;  3V64 C;  4ZY3 A;  3L6V A;  3LI5 A;  1V0F A;  4XJ9 A;  3LI4 A;  4JML A;  4FQ4 A;  2OJH A;  4FOQ A;  4YW3 A;  3TC9 A;  4XJW A;  4WA3 A;  2GVW A;  3UC1 A;  4UF7 A;  2C4A A;  2ZZK A;  3NSS A;  5HUK A;  4GNC A;  1MS1 A;  4KS4 A;  3SAL A;  3FVZ A;  4X4A A;  1SUU A;  3LI3 A;  2QWD A;  2HTQ A;  4MWW A;  2IAS A;  4NC5 A;  4KS3 A;  4GEZ A;  1EUR A;  1Z50 A;  2CML A;  4XYX A;  1NSD A;  3V65 B;  4X49 A;  3T1E A;  3V1S A;  1NCC N;  3VNG A;  1B9T A;  4QN5 A;  1L7F A;  1VCU A;  2SIM A;  1L7G A;  4HHO A;  2HTV A;  2IAR A;  4MJU A;  4JF7 A;  3Q6K A;  3S8V A;  4AGT A;  1WP5 A;  2HTR A;  5FNR A;  4XJZ A;  4CPL A;  3TI5 A;  1N1Y A;  4K1J A;  1K32 A;  4MJV A;  1U6D X;  1NNA A;  1W20 A;  1PJX A;  2VWD A;  2QE8 A;  5GX2 A;  2VVZ A;  1B9V A;  3DR2 A;  3TI8 A;  5EO7 A;  3WDZ A;  3H72 A;  3AMR A;  2HU4 A;  4MZE A;  1IVB A;  3I1C A;  3GVK A;  4IFJ A;  2G8S A;  1RWI A;  3INB A;  1SO7 A;  4O5S A;  4CSD A;  1Z4V A;  1ZGK A;  4YZ4 A;  4HZX A;  3SIL A;  5FZN A;  5FNU A;  1USX A;  1NN2 A;  4KS5 A;  4KS2 A;  5D9C A;  3H73 A;  4FPY A;  2RKC A;  1INF A;  1N6F A;  4HZV A;  1IUC A;  1MS0 A;  1NMC A;  1QLG A;  2GVV A;  4GZS A;  3O4P A;  5D9D A;  2AEP A;  2FPC A;  1VCJ A;  2HQS A;  4ASC A;  1IVF A; 
#chains in the Genus database with same CATH homology
 5FNR A;  1ZGK A;  4N1B A;  2Z32 A;  4IFL X;  2ZZK A;  1U6D X;  4IN4 A;  5FZN A;  3ZGD A;  5FNU A;  1X2J A;  1X2R A;  3ADE A;  4XMB A;  4L7C A;  5FZJ A;  3WN7 A;  2XN4 A;  2FLU X;  2WOZ A;  5CGJ A;  2VPJ A;  3WDZ A;  2ZW9 A;  4CHB A;  4L7B A;  2ZWA A;  4IFN X;  2DYH A;  4IQK A;  5FNQ A;  3VNG A;  3VNH A;  4IFJ A;  5F72 C;  3ZGC A;  4ZGC A;  4ZY3 A;  5FNT A;  4L7D A;  4CH9 A;  4ASC A;  5FNS A;  4YY8 A;  3II7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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