5F72C

De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags De novo protein
molecule keywords Kelch-like ECH-associated protein 1
publication title De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
rcsb
source organism Homo sapiens
total genus 62
structure length 285
sequence length 285
chains with identical sequence K
ec nomenclature
pdb deposition date 2015-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5f72C00
3WN7A 3WDZA 4CH9A 5FZNA 4N1BA 1U6DX 4IFNX 4YY8A 5FNQA 3VNGA 2XN4A 4L7CA 4IFLX 4CHBA 2FLUX 4L7DA 2VPJA 5F72C 5FNSA 3II7A 3ZGDA 2ZW9A 4IFJA 4IQKA 5CGJA 2WOZA 4L7BA 5FNUA 3ADEA 3ZGCA 1X2JA 2DYHA 5FZJA 1X2RA 2ZWAA 1ZGKA 3VNHA 4ZGCA 4ZY3A 4IN4A 5FNTA 2ZZKA 4XMBA 2Z32A 4ASCA 5FNRA
chains in the Genus database with same CATH superfamily
1RWLA 3K3AA 4G3NA 2V91A 1E8VA 1S0JA 2VK6A 2AGSA 3TI5A 4FZHA 2VSKA 1RWIA 3SRGA 4IFLX 5HUNA 4MWUA 1K32A 1DILA 4GN8A 4MWJA 1NCBN 2F28A 1MS9A 4K1HA 1SO7A 2YDPA 4IFJA 2FP8A 1EUTA 4YW4A 3KYAA 4FP2A 2W20A 2HT7A 4MWVA 2IAWA 4GDIA 5B2DA 2GVWA 1Q7FA 4DG6A 2C4LA 1SLLA 1W0OA 2VWDA 1S0IA 1F8BA 3WWAA 1H6LA 1N1VA 4D52C 1NMAN 2W38A 2B8HA 4XIOA 2FLUX 2QWFA 3GVKA 2ISMA 2QWBA 4FPLA 3V64C 6NN9A 3H6JA 1S1DA 4GZQA 5FNUA 3P5BL 4WEFA 2QE8A 2IAQA 1DIMA 2IAXA 2DYHA 2F10A 5B2CA 2HTWA 1INHA 2X9MA 2HT8A 3Q6KA 1A4QA 3B7EA 5FNTA 3TI4A 3V65B 1XOEA 4Q6KA 4XYXA 1NPEA 3WDZA 1NMCA 3TICA 2GVXA 4YZ2A 1WCSA 1Z4XA 4MWRA 4O5TA 2IAVA 4NN9A 4FPOB 4FJ6A 2W8BB 4K1KA 2VW0A 1N7DA 2F26A 2BATA 2VSMA 1V2IA 2ZW9A 5EX7A 5CGJA 4QN4A 1IVEA 3G4EA 4ZY3A 1A4GA 1INFA 4J9TA 4M4NA 4ASCA 1NCDN 4X49A 3ZGDA 4XJZA 1A14N 4GEZA 1W1XA 2DG1A 3H72A 4WA5A 1SNTA 1USXA 4PWZA 4HZXA 4FPJA 4UF7A 3LI5A 3BYCA 2YA7A 1EUSA 3HLHA 1INYA 1QLGA 1ZI0A 4FOVA 1E1AA 4GB1A 2F25A 1MS3A 4M4UA 1W8NA 3S8ZA 4GZXA 5M1ZA 2VAQA 2F29A 3SOQA 1L7FA 1NN2A 5FZNA 4FPYA 3TI3A 3SLIA 1W0PA 4IFNX 3TI6A 4MX0A 1E8UA 3ALWA 1CQ1A 3DASA 2C4AA 4XIKA 3NSSA 2RKCA 4MC7A 4WA3A 2AH2A 4FPEA 2YA6A 1B9TA 1V04A 4XMAA 1ZGKA 3PJQA 4CPMA 4SLIA 2JKBA 4GNAA 4QN7A 1MS5A 1NSDA 2SLIA 1C5KA 1IUBA 5EO7A 3AMSA 1U6DX 3SREA 7NN9A 3UC1A 1USRA 2P4OA 4CSDA 4XJAA 4KS4A 2F13A 2VW1A 1F8EA 1INVA 2QWKA 2F12A 1MZ5A 4XJWA 4D52A 2GVVA 4L7BA 4AGIA 3D11A 1F8CA 4HHQA 4R40A 1CRZA 3JU4A 3HLIA 3KGGA 5GX4A 4C1YA 1WCQA 2F24A 3AMRA 1KITA 4AGTA 4KS5A 3CYEA 4B7QA 5FNQA 3CL2A 2FP9A 4MWLA 4GNCA 4L7CA 2DSOA 3NN9A 1IVDA 4HIZA 5JYYA 5GX1A 2BF6A 4IQKA 1XOGA 2QWHA 1W8OA 4GN9A 4K1JA 1X2JA 5D9DA 1IJQA 4GJTA 1INWA 5FZJA 1MS0A 4GZOA 4FP3A 3SANA 5HUKA 4YZ5A 2VK7A 3Q6PA 4FPGA 2YA8A 4CPZA 4B7RA 4ZLRA 4YY8A 2GVUA 2XN4A 2XZIA 1V3CA 2HTUA 4XOGA 1IUCA 2YA4A 4KS2A 2QWDA 5FNSA 4FPHA 3L6VA 3Q6TA 2SILA 4CPNA 1N1YA 1Z50A 3SOBB 4B7NA 1B9SA 4QN5A 1V3BA 4KS3A 5FNRA 4WA4A 3K39A 4D52B 1N6EA 3W09A 4QN6A 4XHXA 4XE9A 3H73A 4FPCA 3CKZA 1V3EA 4C1YB 3IAXA 4FQ4A 2ZB5A 1N6FA 2XZKA 4XJRA 2ZB6A 2F11A 5GX2A 1IVCA 3O9JA 3CL0A 2H2NA 4GZTA 3FVZA 1E8TA 4GNBA 1Z4YA 4AH4A 2IATA 2A75A 2QWCA 3TC9A 1C9UA 4N1BA 1NMBN 2IASA 2YA5A 4X47A 3SOVA 2H2UA 1INGA 1MZ6A 2IARA 2HU4A 4H53A 1OFZA 3T1EA 1IVBA 2POOA 3ALXA 4M3MA 3K38A 5FWWA 4HZWA 2F0ZA 3A9GA 2HQSA 1W20A 1Z4ZA 2IAOA 1X2RA 3K37A 4X4AA 4IN4A 3WW9A 2BERA 1VCJA 2Z32A 2QWJA 3OPZA 1MR5A 3WN7A 2W5OA 4MJVA 2HU0A 1Z4VA 1QBIA 3O4PA 4YW2A 3E5ZA 3GVJA 4L7DA 2IVZA 5F72C 3U0SA 4FPKA 2OJHA 3SILA 5GX3A 3LI3A 4IMBA 1MS8A 1N1TA 4KS1A 4FOWA 5GX5A 4GDJA 4HZYA 3VNGA 3B69A 2VK5A 2GHSA 2XZJA 4FPFA 4K1IA 1L7GA 3TIBA 4HZZA 4YW1A 2QWGA 4WEGA 1PJXA 4CHBA 4GZSA 2HTRA 3S8VA 2VPJA 3S2KA 3BEQA 3H71A 3II7A 4GZPA 2YDTA 3D12A 5HUMA 4H52A 1V0ZA 2HTVA 1MWEA 4ZGCA 2SIMA 1POOA 4XJ8A 4BBWA 4HW6A 3SALA 4B7MA 4MZAA 1V0EA 1W21A 1BJIA 1EURA 2AEQA 1NNAA 1NNCA 1CVMA 2VW2A 4CPLA 5GTQA 4GZWA 1INXA 4XJQA 5D9BA 4HHOA 1B9VA 4A0PA 2FHRA 1IVGA 4JMLA 4GN7A 2QWIA 4X6KA 3FW0A 3K36A 5F9TA 4XMBA 4D8SA 3TI8A 4M4VA 4CH9A 4B7JA 4DGRA 4HZVA 4YW3A 1MS4A 4QN3A 4XJ9A 1Z4WA 1MS1A 2FPCA 1F8DA 4JF7A 4NC5A 2F27A 1S18A 3HRPA 3INBA 2WOZA 4YZ3A 3ADEA 4MWQA 3DR2A 2QWAA 2HTYA 4YZ1A 5HUGA 4MWXA 1CRUA 4Q1UA 4UOUA 4YZ4A 3VNHA 4XHBA 2DG0A 1IVFA 2G8SA 2XCYA 3A72A 2ZZKA 4YW5A 1NSBA 5NN9A 5HX0A 3A9HA 4CPOA 4XMIA 3NO0A 4MJUA 3S94A 5D9CA 2VVZA 3G4HA 1VCUA 5H47A 1SLIA 4K3YA 1NCAN 3O9KA 2IAUA 4XJUA 1N1SA 1V0FA 2W5NA 2CMLA 1SUUA 3I1CA 1EUUA 4I00A 4D4UA 1V3DA 2IAPA 4MZEA 4FOQA 1NCCN 4AHAA 4NCSA 1N6DA 1L7HA 3TIAA 3A71A 2HTQA 3V1SA 4CPYA 2QWEA 3LI4A 1NSCA 2AEPA 1NNBA 2BZDA 5EO8A 2FPBA 4IYGA 4FVKA 4MWYA 4XILA 3ZGCA 4FOYA 2HT5A 4O5SA 2ZWAA 2W8BA 4QNPA 1WP5A 3GVLA 4MWWA
chains in the Genus database with same CATH topology
3WN7A 3WDZA 4CH9A 5FZNA 4N1BA 1U6DX 4IFNX 4YY8A 5FNQA 3VNGA 2XN4A 4L7CA 4IFLX 4CHBA 2FLUX 4L7DA 2VPJA 5F72C 5FNSA 3II7A 3ZGDA 2ZW9A 4IFJA 4IQKA 5CGJA 2WOZA 4L7BA 5FNUA 3ADEA 3ZGCA 1X2JA 2DYHA 5FZJA 1X2RA 2ZWAA 1ZGKA 3VNHA 4ZGCA 4ZY3A 4IN4A 5FNTA 2ZZKA 4XMBA 2Z32A 4ASCA 5FNRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WN7 A;  3WDZ A;  4CH9 A;  5FZN A;  4N1B A;  1U6D X;  4IFN X;  4YY8 A;  5FNQ A;  3VNG A;  2XN4 A;  4L7C A;  4IFL X;  4CHB A;  2FLU X;  4L7D A;  2VPJ A;  5F72 C;  5FNS A;  3II7 A;  3ZGD A;  2ZW9 A;  4IFJ A;  4IQK A;  5CGJ A;  2WOZ A;  4L7B A;  5FNU A;  3ADE A;  3ZGC A;  1X2J A;  2DYH A;  5FZJ A;  1X2R A;  2ZWA A;  1ZGK A;  3VNH A;  4ZGC A;  4ZY3 A;  4IN4 A;  5FNT A;  2ZZK A;  4XMB A;  2Z32 A;  4ASC A;  5FNR A; 
#chains in the Genus database with same CATH topology
 1RWL A;  3K3A A;  4G3N A;  2V91 A;  1E8V A;  1S0J A;  2VK6 A;  2AGS A;  3TI5 A;  4FZH A;  2VSK A;  1RWI A;  3SRG A;  4IFL X;  5HUN A;  4MWU A;  1K32 A;  1DIL A;  4GN8 A;  4MWJ A;  1NCB N;  2F28 A;  1MS9 A;  4K1H A;  1SO7 A;  2YDP A;  4IFJ A;  2FP8 A;  1EUT A;  4YW4 A;  3KYA A;  4FP2 A;  2W20 A;  2HT7 A;  4MWV A;  2IAW A;  4GDI A;  5B2D A;  2GVW A;  1Q7F A;  4DG6 A;  2C4L A;  1SLL A;  1W0O A;  2VWD A;  1S0I A;  1F8B A;  3WWA A;  1H6L A;  1N1V A;  4D52 C;  1NMA N;  2W38 A;  2B8H A;  4XIO A;  2FLU X;  2QWF A;  3GVK A;  2ISM A;  2QWB A;  4FPL A;  3V64 C;  6NN9 A;  3H6J A;  1S1D A;  4GZQ A;  5FNU A;  3P5B L;  4WEF A;  2QE8 A;  2IAQ A;  1DIM A;  2IAX A;  2DYH A;  2F10 A;  5B2C A;  2HTW A;  1INH A;  2X9M A;  2HT8 A;  3Q6K A;  1A4Q A;  3B7E A;  5FNT A;  3TI4 A;  3V65 B;  1XOE A;  4Q6K A;  4XYX A;  1NPE A;  3WDZ A;  1NMC A;  3TIC A;  2GVX A;  4YZ2 A;  1WCS A;  1Z4X A;  4MWR A;  4O5T A;  2IAV A;  4NN9 A;  4FPO B;  4FJ6 A;  2W8B B;  4K1K A;  2VW0 A;  1N7D A;  2F26 A;  2BAT A;  2VSM A;  1V2I A;  2ZW9 A;  5EX7 A;  5CGJ A;  4QN4 A;  1IVE A;  3G4E A;  4ZY3 A;  1A4G A;  1INF A;  4J9T A;  4M4N A;  4ASC A;  1NCD N;  4X49 A;  3ZGD A;  4XJZ A;  1A14 N;  4GEZ A;  1W1X A;  2DG1 A;  3H72 A;  4WA5 A;  1SNT A;  1USX A;  4PWZ A;  4HZX A;  4FPJ A;  4UF7 A;  3LI5 A;  3BYC A;  2YA7 A;  1EUS A;  3HLH A;  1INY A;  1QLG A;  1ZI0 A;  4FOV A;  1E1A A;  4GB1 A;  2F25 A;  1MS3 A;  4M4U A;  1W8N A;  3S8Z A;  4GZX A;  5M1Z A;  2VAQ A;  2F29 A;  3SOQ A;  1L7F A;  1NN2 A;  5FZN A;  4FPY A;  3TI3 A;  3SLI A;  1W0P A;  4IFN X;  3TI6 A;  4MX0 A;  1E8U A;  3ALW A;  1CQ1 A;  3DAS A;  2C4A A;  4XIK A;  3NSS A;  2RKC A;  4MC7 A;  4WA3 A;  2AH2 A;  4FPE A;  2YA6 A;  1B9T A;  1V04 A;  4XMA A;  1ZGK A;  3PJQ A;  4CPM A;  4SLI A;  2JKB A;  4GNA A;  4QN7 A;  1MS5 A;  1NSD A;  2SLI A;  1C5K A;  1IUB A;  5EO7 A;  3AMS A;  1U6D X;  3SRE A;  7NN9 A;  3UC1 A;  1USR A;  2P4O A;  4CSD A;  4XJA A;  4KS4 A;  2F13 A;  2VW1 A;  1F8E A;  1INV A;  2QWK A;  2F12 A;  1MZ5 A;  4XJW A;  4D52 A;  2GVV A;  4L7B A;  4AGI A;  3D11 A;  1F8C A;  4HHQ A;  4R40 A;  1CRZ A;  3JU4 A;  3HLI A;  3KGG A;  5GX4 A;  4C1Y A;  1WCQ A;  2F24 A;  3AMR A;  1KIT A;  4AGT A;  4KS5 A;  3CYE A;  4B7Q A;  5FNQ A;  3CL2 A;  2FP9 A;  4MWL A;  4GNC A;  4L7C A;  2DSO A;  3NN9 A;  1IVD A;  4HIZ A;  5JYY A;  5GX1 A;  2BF6 A;  4IQK A;  1XOG A;  2QWH A;  1W8O A;  4GN9 A;  4K1J A;  1X2J A;  5D9D A;  1IJQ A;  4GJT A;  1INW A;  5FZJ A;  1MS0 A;  4GZO A;  4FP3 A;  3SAN A;  5HUK A;  4YZ5 A;  2VK7 A;  3Q6P A;  4FPG A;  2YA8 A;  4CPZ A;  4B7R A;  4ZLR A;  4YY8 A;  2GVU A;  2XN4 A;  2XZI A;  1V3C A;  2HTU A;  4XOG A;  1IUC A;  2YA4 A;  4KS2 A;  2QWD A;  5FNS A;  4FPH A;  3L6V A;  3Q6T A;  2SIL A;  4CPN A;  1N1Y A;  1Z50 A;  3SOB B;  4B7N A;  1B9S A;  4QN5 A;  1V3B A;  4KS3 A;  5FNR A;  4WA4 A;  3K39 A;  4D52 B;  1N6E A;  3W09 A;  4QN6 A;  4XHX A;  4XE9 A;  3H73 A;  4FPC A;  3CKZ A;  1V3E A;  4C1Y B;  3IAX A;  4FQ4 A;  2ZB5 A;  1N6F A;  2XZK A;  4XJR A;  2ZB6 A;  2F11 A;  5GX2 A;  1IVC A;  3O9J A;  3CL0 A;  2H2N A;  4GZT A;  3FVZ A;  1E8T A;  4GNB A;  1Z4Y A;  4AH4 A;  2IAT A;  2A75 A;  2QWC A;  3TC9 A;  1C9U A;  4N1B A;  1NMB N;  2IAS A;  2YA5 A;  4X47 A;  3SOV A;  2H2U A;  1ING A;  1MZ6 A;  2IAR A;  2HU4 A;  4H53 A;  1OFZ A;  3T1E A;  1IVB A;  2POO A;  3ALX A;  4M3M A;  3K38 A;  5FWW A;  4HZW A;  2F0Z A;  3A9G A;  2HQS A;  1W20 A;  1Z4Z A;  2IAO A;  1X2R A;  3K37 A;  4X4A A;  4IN4 A;  3WW9 A;  2BER A;  1VCJ A;  2Z32 A;  2QWJ A;  3OPZ A;  1MR5 A;  3WN7 A;  2W5O A;  4MJV A;  2HU0 A;  1Z4V A;  1QBI A;  3O4P A;  4YW2 A;  3E5Z A;  3GVJ A;  4L7D A;  2IVZ A;  5F72 C;  3U0S A;  4FPK A;  2OJH A;  3SIL A;  5GX3 A;  3LI3 A;  4IMB A;  1MS8 A;  1N1T A;  4KS1 A;  4FOW A;  5GX5 A;  4GDJ A;  4HZY A;  3VNG A;  3B69 A;  2VK5 A;  2GHS A;  2XZJ A;  4FPF A;  4K1I A;  1L7G A;  3TIB A;  4HZZ A;  4YW1 A;  2QWG A;  4WEG A;  1PJX A;  4CHB A;  4GZS A;  2HTR A;  3S8V A;  2VPJ A;  3S2K A;  3BEQ A;  3H71 A;  3II7 A;  4GZP A;  2YDT A;  3D12 A;  5HUM A;  4H52 A;  1V0Z A;  2HTV A;  1MWE A;  4ZGC A;  2SIM A;  1POO A;  4XJ8 A;  4BBW A;  4HW6 A;  3SAL A;  4B7M A;  4MZA A;  1V0E A;  1W21 A;  1BJI A;  1EUR A;  2AEQ A;  1NNA A;  1NNC A;  1CVM A;  2VW2 A;  4CPL A;  5GTQ A;  4GZW A;  1INX A;  4XJQ A;  5D9B A;  4HHO A;  1B9V A;  4A0P A;  2FHR A;  1IVG A;  4JML A;  4GN7 A;  2QWI A;  4X6K A;  3FW0 A;  3K36 A;  5F9T A;  4XMB A;  4D8S A;  3TI8 A;  4M4V A;  4CH9 A;  4B7J A;  4DGR A;  4HZV A;  4YW3 A;  1MS4 A;  4QN3 A;  4XJ9 A;  1Z4W A;  1MS1 A;  2FPC A;  1F8D A;  4JF7 A;  4NC5 A;  2F27 A;  1S18 A;  3HRP A;  3INB A;  2WOZ A;  4YZ3 A;  3ADE A;  4MWQ A;  3DR2 A;  2QWA A;  2HTY A;  4YZ1 A;  5HUG A;  4MWX A;  1CRU A;  4Q1U A;  4UOU A;  4YZ4 A;  3VNH A;  4XHB A;  2DG0 A;  1IVF A;  2G8S A;  2XCY A;  3A72 A;  2ZZK A;  4YW5 A;  1NSB A;  5NN9 A;  5HX0 A;  3A9H A;  4CPO A;  4XMI A;  3NO0 A;  4MJU A;  3S94 A;  5D9C A;  2VVZ A;  3G4H A;  1VCU A;  5H47 A;  1SLI A;  4K3Y A;  1NCA N;  3O9K A;  2IAU A;  4XJU A;  1N1S A;  1V0F A;  2W5N A;  2CML A;  1SUU A;  3I1C A;  1EUU A;  4I00 A;  4D4U A;  1V3D A;  2IAP A;  4MZE A;  4FOQ A;  1NCC N;  4AHA A;  4NCS A;  1N6D A;  1L7H A;  3TIA A;  3A71 A;  2HTQ A;  3V1S A;  4CPY A;  2QWE A;  3LI4 A;  1NSC A;  2AEP A;  1NNB A;  2BZD A;  5EO8 A;  2FPB A;  4IYG A;  4FVK A;  4MWY A;  4XIL A;  3ZGC A;  4FOY A;  2HT5 A;  4O5S A;  2ZWA A;  2W8B A;  4QNP A;  1WP5 A;  3GVL A;  4MWW A; 
#chains in the Genus database with same CATH homology
 3WN7 A;  3WDZ A;  4CH9 A;  5FZN A;  4N1B A;  1U6D X;  4IFN X;  4YY8 A;  5FNQ A;  3VNG A;  2XN4 A;  4L7C A;  4IFL X;  4CHB A;  2FLU X;  4L7D A;  2VPJ A;  5F72 C;  5FNS A;  3II7 A;  3ZGD A;  2ZW9 A;  4IFJ A;  4IQK A;  5CGJ A;  2WOZ A;  4L7B A;  5FNU A;  3ADE A;  3ZGC A;  1X2J A;  2DYH A;  5FZJ A;  1X2R A;  2ZWA A;  1ZGK A;  3VNH A;  4ZGC A;  4ZY3 A;  4IN4 A;  5FNT A;  2ZZK A;  4XMB A;  2Z32 A;  4ASC A;  5FNR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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