5F9CA

Crystal structure of the g121r mutant of human phosphoglucomutase 1
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
562
structure length
550
Chain Sequence
MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNPRGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Phosphoglucomutase-1
publication title Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Isomerase
total genus 176
structure length 550
sequence length 562
chains with identical sequence B
ec nomenclature ec 5.4.2.2: Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00408 PGM_PMM_IV Phosphoglucomutase/phosphomannomutase, C-terminal domain
A PF02878 PGM_PMM_I Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
A PF02879 PGM_PMM_II Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
A PF02880 PGM_PMM_III Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.50 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Alpha-D-phosphohexomutase, C-terminal domain 5f9cA04
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5f9cA02
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5f9cA03
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5f9cA01
4QG5A 2FKFA 5BMNA 1LXTA 1P5DX 2EHPA 1C4GA 1VKLA 4WX8A 3BKQX 3UW2A 2DKDA 2DKCA 1P5GX 2DKAA 2FUVA 1KFQA 5HSHA 2H4LX 2H5AX 2EIUA 5JMVD 3RSMA 3PMGA 4HJHA 3I3WA 5BMPA 5EPCA 1C47A 4BJUA 5JN5A 2JPIA 1WJWA 1KFIA 1K2YX 3NA5A 1PCJX 3PDKA 4MRQA 1WQAA 4IL8A 3C04A 1TUOA 2Z0FA 5F9CA 1K35A 3OLPA 1JDYA 3ENOC 5KL0A 3ENCA 2FKMX 2F7LA 4WXAA 1PCMX
chains in the Genus database with same CATH superfamily
1UL7A 1NH2A 2HZMA 4QG5A 2FKFA 1V5SA 2IV8A 4B0AA 4EAKA 2HL9A 1NGMA 2R5XA 2DKDA 2DKCA 1P5GX 1KYDA 3KTUA 1EUVA 2DKAA 3VN5A 2PWWA 5IYCP 5HSHA 3I0XA 1M3HA 1KY6A 2EIUA 5JMVD 3RSMA 3OSMA 3PMGA 4HJHA 3D7QA 1QN4A 2NOLA 1C47A 3I0WA 5JN5A 1VTLE 3OSTA 1YTFA 2G30A 3OH9A 1CDWA 4EJYA 3NA5A 4MRQA 2QR1A 3CVSA 3DPTA 4EALA 5F9CA 4PY5A 1QNEA 1K35A 2Y8QA 1YTBA 3EAYA 3OLPA 3ULXA 2NOIA 1RM1A 3OC3C 3OH6A 3ENCA 1LWYA 2F7LA 4WXAA 1PCMX 2MJ7A 5IYDP 2QRCA 1FN7A 2MZ8A 1QN9A 3F10A 1VKLA 1YQRA 1NVPA 1M5Q1 5IYBP 2NWVA 2QRDA 2HL8A 2YA3A 2ZFDB 3ASMA 3RPJA 1KFQA 1QN8A 2H4LX 1UT4A 1TGHA 3I3WA 5BMPA 1AISA 1C9BB 1YQLA 1Q9UA 2NOZA 2JPIA 2V92A 1QN7A 1J3MA 1QNAA 1T6AA 3TDHA 1WQAA 4EAIA 3C04A 1TUOA 2Z0FA 4RODB 1YQKA 1LWWA 1QNCA 1XSZA 2Z8UA 3OSEA 2NOEA 3TE5A 1M3QA 2NOFA 2OOYA 2FKMX 2Y8LA 1UT7A 2VJ0A 4EAJA 1KYUA 4EAGA 1DIZA 2QREA 1R4XA 3D4VA 1P5DX 2EHPA 3IH7A 1VOKA 2EHBD 2OOXA 3UW2A 3HS8A 1JFIC 2V8QA 2YH5A 3T4NA 1QNBA 1N3CA 1PZDA 2FUVA 4EJZA 1QN5A 4Q11A 3H1ZA 5AN4A 4C7PA 1TBAB 1KY7A 5EPCA 4BJUA 2XHIA 1QN3A 1WJWA 4D7QA 1VTOA 3PDKA 1N39A 3HS9A 3CWTA 3CWUA 3F0ZA 1PVSA 4I8OA 4D7RA 2JHJA 1MP9A 2NLVA 5KL0A 3N89A 3CW7A 1HU0A 2LAEA 2O3OA 1KO9A 3OCIA 1YQMA 5BMNA 2NOBA 1LXTA 1LWVA 1C4GA 1TBPA 1B9KA 4WX8A 3SNSA 3BKQX 3DPUA 1E42A 2I5WA 1QTSA 2D0AA 1VOLB 2JHNA 2H5AX 4CFFA 1KYFA 3CVTA 2IV9A 2QLVA 2V9JA 2D0BA 2JOIA 2NVMA 1D3UA 1PCZA 2HZSA 3KRMA 3CWAA 3CWSA 1KFIA 1K2YX 4WZSD 1PCJX 4ROEB 4IL8A 1QN6A 1EBMA 4TPSA 3OGDA 2FGTA 2HKPA 4ROCB 1QTPA 1JDYA 3ENOC 1N3AA 4DULA 2D0CA 1W80A 1MPGA 3EIKA 2NOHA
chains in the Genus database with same CATH topology
4QG5A 2FKFA 5BMNA 1LXTA 1P5DX 2EHPA 1C4GA 1VKLA 4WX8A 3BKQX 3UW2A 2DKDA 2DKCA 1P5GX 2DKAA 2FUVA 1KFQA 5HSHA 2H4LX 2H5AX 2EIUA 5JMVD 3RSMA 3PMGA 4HJHA 3I3WA 5BMPA 5EPCA 1C47A 4BJUA 5JN5A 2JPIA 1WJWA 1KFIA 1K2YX 3NA5A 1PCJX 3PDKA 4MRQA 1WQAA 4IL8A 3C04A 1TUOA 2Z0FA 5F9CA 1K35A 3OLPA 1JDYA 3ENOC 5KL0A 3ENCA 2FKMX 2F7LA 4WXAA 1PCMX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QG5 A;  2FKF A;  5BMN A;  1LXT A;  1P5D X;  2EHP A;  1C4G A;  1VKL A;  4WX8 A;  3BKQ X;  3UW2 A;  2DKD A;  2DKC A;  1P5G X;  2DKA A;  2FUV A;  1KFQ A;  5HSH A;  2H4L X;  2H5A X;  2EIU A;  5JMV D;  3RSM A;  3PMG A;  4HJH A;  3I3W A;  5BMP A;  5EPC A;  1C47 A;  4BJU A;  5JN5 A;  2JPI A;  1WJW A;  1KFI A;  1K2Y X;  3NA5 A;  1PCJ X;  3PDK A;  4MRQ A;  1WQA A;  4IL8 A;  3C04 A;  1TUO A;  2Z0F A;  5F9C A;  1K35 A;  3OLP A;  1JDY A;  3ENO C;  5KL0 A;  3ENC A;  2FKM X;  2F7L A;  4WXA A;  1PCM X; 
#chains in the Genus database with same CATH topology
 1UL7 A;  1NH2 A;  2HZM A;  4QG5 A;  2FKF A;  1V5S A;  2IV8 A;  4B0A A;  4EAK A;  2HL9 A;  1NGM A;  2R5X A;  2DKD A;  2DKC A;  1P5G X;  1KYD A;  3KTU A;  1EUV A;  2DKA A;  3VN5 A;  2PWW A;  5IYC P;  5HSH A;  3I0X A;  1M3H A;  1KY6 A;  2EIU A;  5JMV D;  3RSM A;  3OSM A;  3PMG A;  4HJH A;  3D7Q A;  1QN4 A;  2NOL A;  1C47 A;  3I0W A;  5JN5 A;  1VTL E;  3OST A;  1YTF A;  2G30 A;  3OH9 A;  1CDW A;  4EJY A;  3NA5 A;  4MRQ A;  2QR1 A;  3CVS A;  3DPT A;  4EAL A;  5F9C A;  4PY5 A;  1QNE A;  1K35 A;  2Y8Q A;  1YTB A;  3EAY A;  3OLP A;  3ULX A;  2NOI A;  1RM1 A;  3OC3 C;  3OH6 A;  3ENC A;  1LWY A;  2F7L A;  4WXA A;  1PCM X;  2MJ7 A;  5IYD P;  2QRC A;  1FN7 A;  2MZ8 A;  1QN9 A;  3F10 A;  1VKL A;  1YQR A;  1NVP A;  1M5Q 1;  5IYB P;  2NWV A;  2QRD A;  2HL8 A;  2YA3 A;  2ZFD B;  3ASM A;  3RPJ A;  1KFQ A;  1QN8 A;  2H4L X;  1UT4 A;  1TGH A;  3I3W A;  5BMP A;  1AIS A;  1C9B B;  1YQL A;  1Q9U A;  2NOZ A;  2JPI A;  2V92 A;  1QN7 A;  1J3M A;  1QNA A;  1T6A A;  3TDH A;  1WQA A;  4EAI A;  3C04 A;  1TUO A;  2Z0F A;  4ROD B;  1YQK A;  1LWW A;  1QNC A;  1XSZ A;  2Z8U A;  3OSE A;  2NOE A;  3TE5 A;  1M3Q A;  2NOF A;  2OOY A;  2FKM X;  2Y8L A;  1UT7 A;  2VJ0 A;  4EAJ A;  1KYU A;  4EAG A;  1DIZ A;  2QRE A;  1R4X A;  3D4V A;  1P5D X;  2EHP A;  3IH7 A;  1VOK A;  2EHB D;  2OOX A;  3UW2 A;  3HS8 A;  1JFI C;  2V8Q A;  2YH5 A;  3T4N A;  1QNB A;  1N3C A;  1PZD A;  2FUV A;  4EJZ A;  1QN5 A;  4Q11 A;  3H1Z A;  5AN4 A;  4C7P A;  1TBA B;  1KY7 A;  5EPC A;  4BJU A;  2XHI A;  1QN3 A;  1WJW A;  4D7Q A;  1VTO A;  3PDK A;  1N39 A;  3HS9 A;  3CWT A;  3CWU A;  3F0Z A;  1PVS A;  4I8O A;  4D7R A;  2JHJ A;  1MP9 A;  2NLV A;  5KL0 A;  3N89 A;  3CW7 A;  1HU0 A;  2LAE A;  2O3O A;  1KO9 A;  3OCI A;  1YQM A;  5BMN A;  2NOB A;  1LXT A;  1LWV A;  1C4G A;  1TBP A;  1B9K A;  4WX8 A;  3SNS A;  3BKQ X;  3DPU A;  1E42 A;  2I5W A;  1QTS A;  2D0A A;  1VOL B;  2JHN A;  2H5A X;  4CFF A;  1KYF A;  3CVT A;  2IV9 A;  2QLV A;  2V9J A;  2D0B A;  2JOI A;  2NVM A;  1D3U A;  1PCZ A;  2HZS A;  3KRM A;  3CWA A;  3CWS A;  1KFI A;  1K2Y X;  4WZS D;  1PCJ X;  4ROE B;  4IL8 A;  1QN6 A;  1EBM A;  4TPS A;  3OGD A;  2FGT A;  2HKP A;  4ROC B;  1QTP A;  1JDY A;  3ENO C;  1N3A A;  4DUL A;  2D0C A;  1W80 A;  1MPG A;  3EIK A;  2NOH A; 
#chains in the Genus database with same CATH homology
 4QG5 A;  2FKF A;  5BMN A;  1LXT A;  1P5D X;  2EHP A;  1C4G A;  1VKL A;  4WX8 A;  3BKQ X;  3UW2 A;  2DKD A;  2DKC A;  1P5G X;  2DKA A;  2FUV A;  1KFQ A;  5HSH A;  2H4L X;  2H5A X;  2EIU A;  5JMV D;  3RSM A;  3PMG A;  4HJH A;  3I3W A;  5BMP A;  5EPC A;  1C47 A;  4BJU A;  5JN5 A;  2JPI A;  1WJW A;  1KFI A;  1K2Y X;  3NA5 A;  1PCJ X;  3PDK A;  4MRQ A;  1WQA A;  4IL8 A;  3C04 A;  1TUO A;  2Z0F A;  5F9C A;  1K35 A;  3OLP A;  1JDY A;  3ENO C;  5KL0 A;  3ENC A;  2FKM X;  2F7L A;  4WXA A;  1PCM X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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