5FAFA

N184k pathological variant of gelsolin domain 2 (orthorhombic form)
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
113
structure length
113
Chain Sequence
GSHHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFKNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Structural protein
molecule keywords Gelsolin
total genus 33
structure length 113
sequence length 113
ec nomenclature
pdb deposition date 2015-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 5fafA00
1DEJS 1NLVG 3TU5B 3EG9A 1D0NA 1M4JA 1TMWA 1QPVA 1RGIG 2NUPA 3FG7A 1PCXA 5L6WC 1CFYA 2FF6G 5KYUA 3EFOA 1HQZ1 4KEDA 1JHWA 2LLFA 3EGDB 5KYWA 5DD2A 1M2VB 1C0FS 1NPHA 2FGHA 1J72A 3A5LS 4KEFA 1T3YA 1SVRA 1COFA 1SVYA 3Q2BA 2KVKA 1ESVS 3EH2A 3A5MS 3CJCG 3EGXA 1VFQA 2FF3A 5KYXB 2NUTA 1WNJA 5FAEA 1TVJA 2MV2A 1UDMA 2FH1A 3EGDA 3EH1A 5HVKB 1D4XG 3L50A 2L72A 3FFNA 4CBUG 2FH3A 1WFSA 2MP4A 1PD0A 1Q8XA 1T3XA 5IVUA 1YAGG 3EFOB 2LXXA 2NUTB 1CNUA 2VILA 1SVQA 3CIPG 5KYNA 2W0IA 1M2VA 1AK7A 1X67A 2HD7A 4CBXG 5HVKD 2QTVA 2I2QA 3FG6A 1KCQA 1AK6A 1EQYS 1Q8GA 3A5OS 1AHQA 1NMDG 5FAFA 5KYUB 2MOTA 1P8ZG 1P8XA 3EGXB 5KYYB 1F7SA 2FH2A 1T2LA 1NM1G 3CJBG 2FH4A 2D8BA 4PKIG 5KYXA 4PKGG 5KYWB 1MDUA 2LJ8A 1M2OA 1T44G 2VIKA 4JD2H 3EG9B 4LIZA 3CI5G 3A5NS 1PD1A 1YVNG 3FFKA 4CBWG 1WM4A 2NUPB 3DAWB 1V6FA 5A1MA 4PKHB 2XFAA 2VACA 4S10C 4KEEA 1VKKA 5KYYA 4Z94G 1H1VG 1C0GS 2XF1A 4BEX1
chains in the Genus database with same CATH superfamily
1DEJS 1NLVG 3TU5B 3EG9A 1D0NA 1M4JA 1TMWA 1QPVA 1RGIG 2NUPA 3FG7A 1PCXA 5L6WC 1CFYA 2FF6G 5KYUA 3EFOA 1HQZ1 4KEDA 1JHWA 2LLFA 3EGDB 5KYWA 5DD2A 1M2VB 1C0FS 1NPHA 2FGHA 1J72A 3A5LS 4KEFA 1T3YA 1SVRA 1COFA 1SVYA 3Q2BA 2KVKA 1ESVS 3EH2A 3A5MS 3CJCG 3EGXA 1VFQA 2FF3A 5KYXB 2NUTA 1WNJA 5FAEA 1TVJA 2MV2A 1UDMA 2FH1A 3EGDA 3EH1A 5HVKB 1D4XG 3L50A 2L72A 3FFNA 4CBUG 2FH3A 1WFSA 2MP4A 1PD0A 1Q8XA 1T3XA 5IVUA 1YAGG 3EFOB 2LXXA 2NUTB 1CNUA 2VILA 1SVQA 3CIPG 5KYNA 2W0IA 1M2VA 1AK7A 1X67A 2HD7A 4CBXG 5HVKD 2QTVA 2I2QA 3FG6A 3DA7A 1KCQA 1AK6A 1EQYS 1Q8GA 3A5OS 1AHQA 1NMDG 5FAFA 5KYUB 2MOTA 1P8ZG 1P8XA 3EGXB 5KYYB 1F7SA 2FH2A 1T2LA 1NM1G 3CJBG 2FH4A 2D8BA 4PKIG 5KYXA 4PKGG 5KYWB 1MDUA 2LJ8A 1M2OA 1T44G 2VIKA 4JD2H 3EG9B 4LIZA 3CI5G 3A5NS 1PD1A 1YVNG 3FFKA 4CBWG 1WM4A 2NUPB 3DAWB 1V6FA 5A1MA 4PKHB 2XFAA 2VACA 4S10C 4KEEA 1VKKA 5KYYA 4Z94G 1H1VG 1C0GS 2XF1A 4BEX1
chains in the Genus database with same CATH topology
1DEJS 1NLVG 3TU5B 3EG9A 1D0NA 1M4JA 1TMWA 1QPVA 1RGIG 2NUPA 3FG7A 1PCXA 5L6WC 1CFYA 2FF6G 5KYUA 3EFOA 1HQZ1 4KEDA 1JHWA 2LLFA 3EGDB 5KYWA 5DD2A 1M2VB 1C0FS 1NPHA 2FGHA 1J72A 3A5LS 4KEFA 1T3YA 1SVRA 1COFA 1SVYA 3Q2BA 2KVKA 1ESVS 3EH2A 3A5MS 3CJCG 3EGXA 1VFQA 2FF3A 5KYXB 2NUTA 1WNJA 5FAEA 1TVJA 2MV2A 1UDMA 2FH1A 3EGDA 3EH1A 5HVKB 1D4XG 3L50A 2L72A 3FFNA 4CBUG 2FH3A 1WFSA 2MP4A 1PD0A 1Q8XA 1T3XA 5IVUA 1YAGG 3EFOB 2LXXA 2NUTB 1CNUA 2VILA 1SVQA 3CIPG 5KYNA 2W0IA 1M2VA 1AK7A 1X67A 2HD7A 4CBXG 5HVKD 2QTVA 2I2QA 3FG6A 3DA7A 1KCQA 1AK6A 1EQYS 1Q8GA 3A5OS 1AHQA 1NMDG 5FAFA 5KYUB 2MOTA 1P8ZG 1P8XA 3EGXB 5KYYB 1F7SA 2FH2A 1T2LA 1NM1G 3CJBG 2FH4A 2D8BA 4PKIG 5KYXA 4PKGG 5KYWB 1MDUA 2LJ8A 1M2OA 1T44G 2VIKA 4JD2H 3EG9B 4LIZA 3CI5G 3A5NS 1PD1A 1YVNG 3FFKA 4CBWG 1WM4A 2NUPB 3DAWB 1V6FA 5A1MA 4PKHB 2XFAA 2VACA 4S10C 4KEEA 1VKKA 5KYYA 4Z94G 1H1VG 1C0GS 2XF1A 4BEX1
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DEJ S;  1NLV G;  3TU5 B;  3EG9 A;  1D0N A;  1M4J A;  1TMW A;  1QPV A;  1RGI G;  2NUP A;  3FG7 A;  1PCX A;  5L6W C;  1CFY A;  2FF6 G;  5KYU A;  3EFO A;  1HQZ 1;  4KED A;  1JHW A;  2LLF A;  3EGD B;  5KYW A;  5DD2 A;  1M2V B;  1C0F S;  1NPH A;  2FGH A;  1J72 A;  3A5L S;  4KEF A;  1T3Y A;  1SVR A;  1COF A;  1SVY A;  3Q2B A;  2KVK A;  1ESV S;  3EH2 A;  3A5M S;  3CJC G;  3EGX A;  1VFQ A;  2FF3 A;  5KYX B;  2NUT A;  1WNJ A;  5FAE A;  1TVJ A;  2MV2 A;  1UDM A;  2FH1 A;  3EGD A;  3EH1 A;  5HVK B;  1D4X G;  3L50 A;  2L72 A;  3FFN A;  4CBU G;  2FH3 A;  1WFS A;  2MP4 A;  1PD0 A;  1Q8X A;  1T3X A;  5IVU A;  1YAG G;  3EFO B;  2LXX A;  2NUT B;  1CNU A;  2VIL A;  1SVQ A;  3CIP G;  5KYN A;  2W0I A;  1M2V A;  1AK7 A;  1X67 A;  2HD7 A;  4CBX G;  5HVK D;  2QTV A;  2I2Q A;  3FG6 A;  1KCQ A;  1AK6 A;  1EQY S;  1Q8G A;  3A5O S;  1AHQ A;  1NMD G;  5FAF A;  5KYU B;  2MOT A;  1P8Z G;  1P8X A;  3EGX B;  5KYY B;  1F7S A;  2FH2 A;  1T2L A;  1NM1 G;  3CJB G;  2FH4 A;  2D8B A;  4PKI G;  5KYX A;  4PKG G;  5KYW B;  1MDU A;  2LJ8 A;  1M2O A;  1T44 G;  2VIK A;  4JD2 H;  3EG9 B;  4LIZ A;  3CI5 G;  3A5N S;  1PD1 A;  1YVN G;  3FFK A;  4CBW G;  1WM4 A;  2NUP B;  3DAW B;  1V6F A;  5A1M A;  4PKH B;  2XFA A;  2VAC A;  4S10 C;  4KEE A;  1VKK A;  5KYY A;  4Z94 G;  1H1V G;  1C0G S;  2XF1 A;  4BEX 1; 
#chains in the Genus database with same CATH topology
 1DEJ S;  1NLV G;  3TU5 B;  3EG9 A;  1D0N A;  1M4J A;  1TMW A;  1QPV A;  1RGI G;  2NUP A;  3FG7 A;  1PCX A;  5L6W C;  1CFY A;  2FF6 G;  5KYU A;  3EFO A;  1HQZ 1;  4KED A;  1JHW A;  2LLF A;  3EGD B;  5KYW A;  5DD2 A;  1M2V B;  1C0F S;  1NPH A;  2FGH A;  1J72 A;  3A5L S;  4KEF A;  1T3Y A;  1SVR A;  1COF A;  1SVY A;  3Q2B A;  2KVK A;  1ESV S;  3EH2 A;  3A5M S;  3CJC G;  3EGX A;  1VFQ A;  2FF3 A;  5KYX B;  2NUT A;  1WNJ A;  5FAE A;  1TVJ A;  2MV2 A;  1UDM A;  2FH1 A;  3EGD A;  3EH1 A;  5HVK B;  1D4X G;  3L50 A;  2L72 A;  3FFN A;  4CBU G;  2FH3 A;  1WFS A;  2MP4 A;  1PD0 A;  1Q8X A;  1T3X A;  5IVU A;  1YAG G;  3EFO B;  2LXX A;  2NUT B;  1CNU A;  2VIL A;  1SVQ A;  3CIP G;  5KYN A;  2W0I A;  1M2V A;  1AK7 A;  1X67 A;  2HD7 A;  4CBX G;  5HVK D;  2QTV A;  2I2Q A;  3FG6 A;  3DA7 A;  1KCQ A;  1AK6 A;  1EQY S;  1Q8G A;  3A5O S;  1AHQ A;  1NMD G;  5FAF A;  5KYU B;  2MOT A;  1P8Z G;  1P8X A;  3EGX B;  5KYY B;  1F7S A;  2FH2 A;  1T2L A;  1NM1 G;  3CJB G;  2FH4 A;  2D8B A;  4PKI G;  5KYX A;  4PKG G;  5KYW B;  1MDU A;  2LJ8 A;  1M2O A;  1T44 G;  2VIK A;  4JD2 H;  3EG9 B;  4LIZ A;  3CI5 G;  3A5N S;  1PD1 A;  1YVN G;  3FFK A;  4CBW G;  1WM4 A;  2NUP B;  3DAW B;  1V6F A;  5A1M A;  4PKH B;  2XFA A;  2VAC A;  4S10 C;  4KEE A;  1VKK A;  5KYY A;  4Z94 G;  1H1V G;  1C0G S;  2XF1 A;  4BEX 1; 
#chains in the Genus database with same CATH homology
 1DEJ S;  1NLV G;  3TU5 B;  3EG9 A;  1D0N A;  1M4J A;  1TMW A;  1QPV A;  1RGI G;  2NUP A;  3FG7 A;  1PCX A;  5L6W C;  1CFY A;  2FF6 G;  5KYU A;  3EFO A;  1HQZ 1;  4KED A;  1JHW A;  2LLF A;  3EGD B;  5KYW A;  5DD2 A;  1M2V B;  1C0F S;  1NPH A;  2FGH A;  1J72 A;  3A5L S;  4KEF A;  1T3Y A;  1SVR A;  1COF A;  1SVY A;  3Q2B A;  2KVK A;  1ESV S;  3EH2 A;  3A5M S;  3CJC G;  3EGX A;  1VFQ A;  2FF3 A;  5KYX B;  2NUT A;  1WNJ A;  5FAE A;  1TVJ A;  2MV2 A;  1UDM A;  2FH1 A;  3EGD A;  3EH1 A;  5HVK B;  1D4X G;  3L50 A;  2L72 A;  3FFN A;  4CBU G;  2FH3 A;  1WFS A;  2MP4 A;  1PD0 A;  1Q8X A;  1T3X A;  5IVU A;  1YAG G;  3EFO B;  2LXX A;  2NUT B;  1CNU A;  2VIL A;  1SVQ A;  3CIP G;  5KYN A;  2W0I A;  1M2V A;  1AK7 A;  1X67 A;  2HD7 A;  4CBX G;  5HVK D;  2QTV A;  2I2Q A;  3FG6 A;  3DA7 A;  1KCQ A;  1AK6 A;  1EQY S;  1Q8G A;  3A5O S;  1AHQ A;  1NMD G;  5FAF A;  5KYU B;  2MOT A;  1P8Z G;  1P8X A;  3EGX B;  5KYY B;  1F7S A;  2FH2 A;  1T2L A;  1NM1 G;  3CJB G;  2FH4 A;  2D8B A;  4PKI G;  5KYX A;  4PKG G;  5KYW B;  1MDU A;  2LJ8 A;  1M2O A;  1T44 G;  2VIK A;  4JD2 H;  3EG9 B;  4LIZ A;  3CI5 G;  3A5N S;  1PD1 A;  1YVN G;  3FFK A;  4CBW G;  1WM4 A;  2NUP B;  3DAW B;  1V6F A;  5A1M A;  4PKH B;  2XFA A;  2VAC A;  4S10 C;  4KEE A;  1VKK A;  5KYY A;  4Z94 G;  1H1V G;  1C0G S;  2XF1 A;  4BEX 1; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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