5FNQA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
source organism Mus musculus
total genus 70
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fnqA00
3ZGDA 3VNGA 4L7DA 4L7BA 4IFNX 3WN7A 5FNSA 3VNHA 3ZGCA 4ZGCA 3WDZA 4YY8A 4CHBA 5FNTA 1X2JA 1X2RA 5FZJA 2ZW9A 5CGJA 3ADEA 2VPJA 4N1BA 4IQKA 4L7CA 4XMBA 1ZGKA 5F72C 2ZZKA 5FZNA 2WOZA 2DYHA 2ZWAA 5FNUA 4IFLX 5FNQA 2FLUX 1U6DX 2Z32A 4ZY3A 4IN4A 5FNRA 3II7A 2XN4A 4CH9A 4ASCA 4IFJA
chains in the Genus database with same CATH superfamily
4UOUA 2H2NA 2ZB5A 4FOYA 4GJTA 1DIMA 3SANA 3S2KA 2YA6A 4MWXA 4FJ6A 5D9BA 3ADEA 5F9TA 2WOZA 2FP8A 2VAQA 1NCDN 4R40A 3ALXA 4XIKA 1NCBN 1NMBN 3DR2A 3WWAA 4CH9A 2GVXA 1W0PA 7NN9A 1F8BA 2XZJA 4O5SA 4K1HA 2W38A 2XZKA 1N1TA 4AGTA 4KS4A 1EUTA 4MJVA 1NNCA 2F26A 4B7MA 4MC7A 4MWRA 4J9TA 4MZEA 5HUGA 3I1CA 1EUSA 1ZI0A 4XMAA 1E8VA 4B7JA 5GX4A 4IYGA 5M1ZA 2F0ZA 2G8SA 3NSSA 2ISMA 4YW3A 2SILA 2HTVA 2YA4A 4M4UA 1W1XA 2HTWA 1W8NA 2FPCA 3G4HA 4YZ2A 2ZB6A 4YZ5A 1MZ5A 1DILA 4FPLA 2F13A 4FPHA 4YZ3A 1W0OA 4YW1A 2DYHA 4IFLX 2FLUX 1U6DX 4C1YA 5EO8A 4FPEA 2F10A 3CL0A 2AEPA 4FPKA 4GZXA 2W8BA 1F8EA 3ZGDA 3LI5A 3VNHA 4B7NA 4D52C 4B7QA 1INFA 3UC1A 1X2RA 5FZJA 3K36A 4XOGA 1NMAN 3W09A 3SRGA 1NSDA 3TC9A 1RWIA 3FW0A 5F72C 2BERA 1CRZA 3E5ZA 4GZTA 3GVJA 3SOVA 2OJHA 2VVZA 2QE8A 1IUCA 4X6KA 4PWZA 4KS3A 1POOA 4MZAA 2HU4A 1Z4ZA 2IATA 2QWAA 2F12A 4QN5A 1IVEA 1SO7A 2YA7A 3Q6KA 4Q1UA 4D52A 3TI8A 2F11A 4GDIA 4CPOA 1OFZA 2IASA 1L7GA 4GN9A 4GDJA 4IN4A 1V04A 1CQ1A 3SLIA 4H52A 1NCAN 3H72A 1MS8A 1MS9A 2QWKA 2A75A 4GEZA 1NN2A 1RWLA 5GTQA 4GZQA 1Z50A 4JF7A 4NN9A 4AH4A 4AGIA 1PJXA 4CHBA 1WCSA 2ZW9A 1MS1A 2YDPA 4N1BA 1VCUA 4XJZA 4FP3A 4GNCA 4FVKA 1MS0A 2YDTA 2HTRA 3O9JA 2FHRA 1L7FA 2HT5A 4CPYA 2GHSA 4ZY3A 3BYCA 3TICA 5GX1A 4K3YA 4MJUA 4ASCA 5EX7A 4CSDA 3SOQA 4GZOA 1C9UA 1INWA 3Q6PA 3WN7A 1F8DA 3JU4A 4C1YB 1SNTA 1S0JA 3S8ZA 2FP9A 2VW1A 2W8BB 4HZVA 4L7CA 4BBWA 4DG6A 2YA8A 2ZZKA 3V65B 1W8OA 3LI4A 1WP5A 4XMIA 4XJRA 2QWIA 1B9SA 2W20A 3B7EA 4CPNA 4X49A 1S0IA 2JKBA 4FZHA 1MS3A 2QWDA 4XILA 2VW0A 2HT8A 1MZ6A 1IVGA 2F25A 4MWYA 5FNTA 1X2JA 4XYXA 2AH2A 2VSMA 5CGJA 2RKCA 1XOGA 2VK7A 3TI3A 4FPGA 3BEQA 3H71A 1SLLA 2QWFA 2Z32A 1V3BA 4FPYA 5NN9A 1MS5A 2QWJA 5D9CA 5FNRA 2C4LA 4D52B 4QN3A 2IARA 2IAQA 4QN6A 5FNSA 3WDZA 4YZ4A 2VW2A 4FPJA 4WEFA 4XJWA 3WW9A 2HQSA 4CPMA 3Q6TA 4CPLA 1EUUA 4Q6KA 3U0SA 1V3DA 3GVLA 4HZYA 4MWUA 5D9DA 1Z4WA 2ZWAA 3KGGA 1EURA 1V3EA 2W5NA 2VK6A 5JYYA 4XE9A 3K39A 4FPFA 4HHOA 1XOEA 1F8CA 3HLIA 1NSCA 3INBA 4I00A 2QWHA 3CL2A 4IFNX 2HU0A 2POOA 1KITA 1Q7FA 3A9HA 2SLIA 3TI5A 4X4AA 1SLIA 4XMBA 5HX0A 2IAWA 4GZPA 4K1KA 1H6LA 4GB1A 4KS5A 2HTQA 6NN9A 3A9GA 4ZLRA 3II7A 4FPCA 5GX5A 2BF6A 4HHQA 4CPZA 1N6EA 1IVBA 4FOVA 2F29A 2AGSA 1USRA 2XZIA 3VNGA 4WA4A 3V1SA 4HW6A 1NNBA 2XCYA 4XJQA 4FOQA 2IAVA 4GZSA 1N6DA 1NPEA 1IJQA 4JMLA 1E8UA 1INGA 3D12A 1IVFA 4D8SA 2C4AA 4HZWA 3AMSA 4AHAA 2B8HA 4X47A 5GX2A 1QLGA 3L6VA 1MS4A 1E1AA 3O9KA 1E8TA 4DGRA 2F27A 2QWEA 1Z4YA 4XJUA 4YW2A 1N1VA 1B9VA 2QWCA 4WA3A 4XJ9A 2VSKA 4L7DA 5H47A 3SILA 3G4EA 2QWGA 1Z4XA 1A14N 4HZXA 1CVMA 1V0EA 3S94A 2DG1A 3TI4A 3NN9A 1A4QA 4MX0A 1ZGKA 4QN4A 1S18A 4M4VA 4SLIA 4HZZA 2GVWA 4YW4A 1IUBA 3TIBA 1K32A 1MWEA 3T1EA 4G3NA 2DG0A 2AEQA 1VCJA 4QNPA 3A71A 3ZGCA 4ZGCA 1L7HA 4GNAA 2BATA 2IVZA 1V0FA 3TI6A 2BZDA 1CRUA 3SALA 3H6JA 4M3MA 2VK5A 2F28A 4YZ1A 1MR5A 5FWWA 3CKZA 1N6FA 3A72A 2H2UA 5FNUA 4A0PA 4UF7A 3V64C 4FPOB 2V91A 1INVA 3ALWA 3HLHA 3O4PA 1B9TA 2GVUA 1USXA 4MWWA 1W20A 3B69A 3LI3A 4XHXA 3OPZA 3H73A 4MWLA 2FPBA 1NCCN 1NMCA 2P4OA 4L7BA 4B7RA 5B2DA 1NNAA 4O5TA 3K3AA 4D4UA 4XJAA 4MWVA 2QWBA 5FZNA 2W5OA 1WCQA 3CYEA 4QN7A 3SOBB 4MWQA 4KS2A 2IAUA 4XIOA 5HUNA 3K37A 1INHA 2F24A 4GNBA 4GZWA 4FP2A 1Z4VA 1V0ZA 1IVCA 4FQ4A 4WA5A 3TIAA 2IAOA 3KYAA 4KS1A 4M4NA 1INXA 5HUMA 4IMBA 2CMLA 1C5KA 3PJQA 3FVZA 2DSOA 1SUUA 4K1IA 1N1YA 1V3CA 4H53A 5EO7A 1S1DA 1N7DA 4HIZA 4GN8A 4WEGA 2IAPA 3P5BL 4MWJA 2HTUA 2VWDA 4GN7A 4IFJA 4K1JA 4NCSA 2X9MA 4XJ8A 5HUKA 3AMRA 4NC5A 3NO0A 1BJIA 3D11A 3K38A 4XHBA 4YY8A 1V2IA 1A4GA 2SIMA 2HT7A 2IAXA 1W21A 1NSBA 4FOWA 3GVKA 3DASA 2VPJA 4IQKA 1N1SA 5GX3A 5FNQA 1INYA 3S8VA 2YA5A 3IAXA 3SREA 2XN4A 2HTYA 1QBIA 1IVDA 2GVVA 3HRPA 5B2CA 4YW5A
chains in the Genus database with same CATH topology
3ZGDA 3VNGA 4L7DA 4L7BA 4IFNX 3WN7A 5FNSA 3VNHA 3ZGCA 4ZGCA 3WDZA 4YY8A 4CHBA 5FNTA 1X2JA 1X2RA 5FZJA 2ZW9A 5CGJA 3ADEA 2VPJA 4N1BA 4IQKA 4L7CA 4XMBA 1ZGKA 5F72C 2ZZKA 5FZNA 2WOZA 2DYHA 2ZWAA 5FNUA 4IFLX 5FNQA 2FLUX 1U6DX 2Z32A 4ZY3A 4IN4A 5FNRA 3II7A 2XN4A 4CH9A 4ASCA 4IFJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZGD A;  3VNG A;  4L7D A;  4L7B A;  4IFN X;  3WN7 A;  5FNS A;  3VNH A;  3ZGC A;  4ZGC A;  3WDZ A;  4YY8 A;  4CHB A;  5FNT A;  1X2J A;  1X2R A;  5FZJ A;  2ZW9 A;  5CGJ A;  3ADE A;  2VPJ A;  4N1B A;  4IQK A;  4L7C A;  4XMB A;  1ZGK A;  5F72 C;  2ZZK A;  5FZN A;  2WOZ A;  2DYH A;  2ZWA A;  5FNU A;  4IFL X;  5FNQ A;  2FLU X;  1U6D X;  2Z32 A;  4ZY3 A;  4IN4 A;  5FNR A;  3II7 A;  2XN4 A;  4CH9 A;  4ASC A;  4IFJ A; 
#chains in the Genus database with same CATH topology
 4UOU A;  2H2N A;  2ZB5 A;  4FOY A;  4GJT A;  1DIM A;  3SAN A;  3S2K A;  2YA6 A;  4MWX A;  4FJ6 A;  5D9B A;  3ADE A;  5F9T A;  2WOZ A;  2FP8 A;  2VAQ A;  1NCD N;  4R40 A;  3ALX A;  4XIK A;  1NCB N;  1NMB N;  3DR2 A;  3WWA A;  4CH9 A;  2GVX A;  1W0P A;  7NN9 A;  1F8B A;  2XZJ A;  4O5S A;  4K1H A;  2W38 A;  2XZK A;  1N1T A;  4AGT A;  4KS4 A;  1EUT A;  4MJV A;  1NNC A;  2F26 A;  4B7M A;  4MC7 A;  4MWR A;  4J9T A;  4MZE A;  5HUG A;  3I1C A;  1EUS A;  1ZI0 A;  4XMA A;  1E8V A;  4B7J A;  5GX4 A;  4IYG A;  5M1Z A;  2F0Z A;  2G8S A;  3NSS A;  2ISM A;  4YW3 A;  2SIL A;  2HTV A;  2YA4 A;  4M4U A;  1W1X A;  2HTW A;  1W8N A;  2FPC A;  3G4H A;  4YZ2 A;  2ZB6 A;  4YZ5 A;  1MZ5 A;  1DIL A;  4FPL A;  2F13 A;  4FPH A;  4YZ3 A;  1W0O A;  4YW1 A;  2DYH A;  4IFL X;  2FLU X;  1U6D X;  4C1Y A;  5EO8 A;  4FPE A;  2F10 A;  3CL0 A;  2AEP A;  4FPK A;  4GZX A;  2W8B A;  1F8E A;  3ZGD A;  3LI5 A;  3VNH A;  4B7N A;  4D52 C;  4B7Q A;  1INF A;  3UC1 A;  1X2R A;  5FZJ A;  3K36 A;  4XOG A;  1NMA N;  3W09 A;  3SRG A;  1NSD A;  3TC9 A;  1RWI A;  3FW0 A;  5F72 C;  2BER A;  1CRZ A;  3E5Z A;  4GZT A;  3GVJ A;  3SOV A;  2OJH A;  2VVZ A;  2QE8 A;  1IUC A;  4X6K A;  4PWZ A;  4KS3 A;  1POO A;  4MZA A;  2HU4 A;  1Z4Z A;  2IAT A;  2QWA A;  2F12 A;  4QN5 A;  1IVE A;  1SO7 A;  2YA7 A;  3Q6K A;  4Q1U A;  4D52 A;  3TI8 A;  2F11 A;  4GDI A;  4CPO A;  1OFZ A;  2IAS A;  1L7G A;  4GN9 A;  4GDJ A;  4IN4 A;  1V04 A;  1CQ1 A;  3SLI A;  4H52 A;  1NCA N;  3H72 A;  1MS8 A;  1MS9 A;  2QWK A;  2A75 A;  4GEZ A;  1NN2 A;  1RWL A;  5GTQ A;  4GZQ A;  1Z50 A;  4JF7 A;  4NN9 A;  4AH4 A;  4AGI A;  1PJX A;  4CHB A;  1WCS A;  2ZW9 A;  1MS1 A;  2YDP A;  4N1B A;  1VCU A;  4XJZ A;  4FP3 A;  4GNC A;  4FVK A;  1MS0 A;  2YDT A;  2HTR A;  3O9J A;  2FHR A;  1L7F A;  2HT5 A;  4CPY A;  2GHS A;  4ZY3 A;  3BYC A;  3TIC A;  5GX1 A;  4K3Y A;  4MJU A;  4ASC A;  5EX7 A;  4CSD A;  3SOQ A;  4GZO A;  1C9U A;  1INW A;  3Q6P A;  3WN7 A;  1F8D A;  3JU4 A;  4C1Y B;  1SNT A;  1S0J A;  3S8Z A;  2FP9 A;  2VW1 A;  2W8B B;  4HZV A;  4L7C A;  4BBW A;  4DG6 A;  2YA8 A;  2ZZK A;  3V65 B;  1W8O A;  3LI4 A;  1WP5 A;  4XMI A;  4XJR A;  2QWI A;  1B9S A;  2W20 A;  3B7E A;  4CPN A;  4X49 A;  1S0I A;  2JKB A;  4FZH A;  1MS3 A;  2QWD A;  4XIL A;  2VW0 A;  2HT8 A;  1MZ6 A;  1IVG A;  2F25 A;  4MWY A;  5FNT A;  1X2J A;  4XYX A;  2AH2 A;  2VSM A;  5CGJ A;  2RKC A;  1XOG A;  2VK7 A;  3TI3 A;  4FPG A;  3BEQ A;  3H71 A;  1SLL A;  2QWF A;  2Z32 A;  1V3B A;  4FPY A;  5NN9 A;  1MS5 A;  2QWJ A;  5D9C A;  5FNR A;  2C4L A;  4D52 B;  4QN3 A;  2IAR A;  2IAQ A;  4QN6 A;  5FNS A;  3WDZ A;  4YZ4 A;  2VW2 A;  4FPJ A;  4WEF A;  4XJW A;  3WW9 A;  2HQS A;  4CPM A;  3Q6T A;  4CPL A;  1EUU A;  4Q6K A;  3U0S A;  1V3D A;  3GVL A;  4HZY A;  4MWU A;  5D9D A;  1Z4W A;  2ZWA A;  3KGG A;  1EUR A;  1V3E A;  2W5N A;  2VK6 A;  5JYY A;  4XE9 A;  3K39 A;  4FPF A;  4HHO A;  1XOE A;  1F8C A;  3HLI A;  1NSC A;  3INB A;  4I00 A;  2QWH A;  3CL2 A;  4IFN X;  2HU0 A;  2POO A;  1KIT A;  1Q7F A;  3A9H A;  2SLI A;  3TI5 A;  4X4A A;  1SLI A;  4XMB A;  5HX0 A;  2IAW A;  4GZP A;  4K1K A;  1H6L A;  4GB1 A;  4KS5 A;  2HTQ A;  6NN9 A;  3A9G A;  4ZLR A;  3II7 A;  4FPC A;  5GX5 A;  2BF6 A;  4HHQ A;  4CPZ A;  1N6E A;  1IVB A;  4FOV A;  2F29 A;  2AGS A;  1USR A;  2XZI A;  3VNG A;  4WA4 A;  3V1S A;  4HW6 A;  1NNB A;  2XCY A;  4XJQ A;  4FOQ A;  2IAV A;  4GZS A;  1N6D A;  1NPE A;  1IJQ A;  4JML A;  1E8U A;  1ING A;  3D12 A;  1IVF A;  4D8S A;  2C4A A;  4HZW A;  3AMS A;  4AHA A;  2B8H A;  4X47 A;  5GX2 A;  1QLG A;  3L6V A;  1MS4 A;  1E1A A;  3O9K A;  1E8T A;  4DGR A;  2F27 A;  2QWE A;  1Z4Y A;  4XJU A;  4YW2 A;  1N1V A;  1B9V A;  2QWC A;  4WA3 A;  4XJ9 A;  2VSK A;  4L7D A;  5H47 A;  3SIL A;  3G4E A;  2QWG A;  1Z4X A;  1A14 N;  4HZX A;  1CVM A;  1V0E A;  3S94 A;  2DG1 A;  3TI4 A;  3NN9 A;  1A4Q A;  4MX0 A;  1ZGK A;  4QN4 A;  1S18 A;  4M4V A;  4SLI A;  4HZZ A;  2GVW A;  4YW4 A;  1IUB A;  3TIB A;  1K32 A;  1MWE A;  3T1E A;  4G3N A;  2DG0 A;  2AEQ A;  1VCJ A;  4QNP A;  3A71 A;  3ZGC A;  4ZGC A;  1L7H A;  4GNA A;  2BAT A;  2IVZ A;  1V0F A;  3TI6 A;  2BZD A;  1CRU A;  3SAL A;  3H6J A;  4M3M A;  2VK5 A;  2F28 A;  4YZ1 A;  1MR5 A;  5FWW A;  3CKZ A;  1N6F A;  3A72 A;  2H2U A;  5FNU A;  4A0P A;  4UF7 A;  3V64 C;  4FPO B;  2V91 A;  1INV A;  3ALW A;  3HLH A;  3O4P A;  1B9T A;  2GVU A;  1USX A;  4MWW A;  1W20 A;  3B69 A;  3LI3 A;  4XHX A;  3OPZ A;  3H73 A;  4MWL A;  2FPB A;  1NCC N;  1NMC A;  2P4O A;  4L7B A;  4B7R A;  5B2D A;  1NNA A;  4O5T A;  3K3A A;  4D4U A;  4XJA A;  4MWV A;  2QWB A;  5FZN A;  2W5O A;  1WCQ A;  3CYE A;  4QN7 A;  3SOB B;  4MWQ A;  4KS2 A;  2IAU A;  4XIO A;  5HUN A;  3K37 A;  1INH A;  2F24 A;  4GNB A;  4GZW A;  4FP2 A;  1Z4V A;  1V0Z A;  1IVC A;  4FQ4 A;  4WA5 A;  3TIA A;  2IAO A;  3KYA A;  4KS1 A;  4M4N A;  1INX A;  5HUM A;  4IMB A;  2CML A;  1C5K A;  3PJQ A;  3FVZ A;  2DSO A;  1SUU A;  4K1I A;  1N1Y A;  1V3C A;  4H53 A;  5EO7 A;  1S1D A;  1N7D A;  4HIZ A;  4GN8 A;  4WEG A;  2IAP A;  3P5B L;  4MWJ A;  2HTU A;  2VWD A;  4GN7 A;  4IFJ A;  4K1J A;  4NCS A;  2X9M A;  4XJ8 A;  5HUK A;  3AMR A;  4NC5 A;  3NO0 A;  1BJI A;  3D11 A;  3K38 A;  4XHB A;  4YY8 A;  1V2I A;  1A4G A;  2SIM A;  2HT7 A;  2IAX A;  1W21 A;  1NSB A;  4FOW A;  3GVK A;  3DAS A;  2VPJ A;  4IQK A;  1N1S A;  5GX3 A;  5FNQ A;  1INY A;  3S8V A;  2YA5 A;  3IAX A;  3SRE A;  2XN4 A;  2HTY A;  1QBI A;  1IVD A;  2GVV A;  3HRP A;  5B2C A;  4YW5 A; 
#chains in the Genus database with same CATH homology
 3ZGD A;  3VNG A;  4L7D A;  4L7B A;  4IFN X;  3WN7 A;  5FNS A;  3VNH A;  3ZGC A;  4ZGC A;  3WDZ A;  4YY8 A;  4CHB A;  5FNT A;  1X2J A;  1X2R A;  5FZJ A;  2ZW9 A;  5CGJ A;  3ADE A;  2VPJ A;  4N1B A;  4IQK A;  4L7C A;  4XMB A;  1ZGK A;  5F72 C;  2ZZK A;  5FZN A;  2WOZ A;  2DYH A;  2ZWA A;  5FNU A;  4IFL X;  5FNQ A;  2FLU X;  1U6D X;  2Z32 A;  4ZY3 A;  4IN4 A;  5FNR A;  3II7 A;  2XN4 A;  4CH9 A;  4ASC A;  4IFJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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