5FNUA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 74
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
288
structure length
288
Chain Sequence
RLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
source organism Mus musculus
total genus 74
structure length 288
sequence length 288
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fnuA00
2DYHA 2FLUX 4L7DA 2ZZKA 3ADEA 5CGJA 4IQKA 5F72C 4IFJA 3VNHA 5FNQA 4ZGCA 1X2JA 2XN4A 3II7A 5FZJA 5FNTA 4IN4A 4IFNX 2ZW9A 4L7BA 5FNRA 3WDZA 4CHBA 1ZGKA 5FNSA 2WOZA 1U6DX 2VPJA 4L7CA 4YY8A 1X2RA 3VNGA 4CH9A 2ZWAA 4XMBA 3ZGDA 4ASCA 5FZNA 3WN7A 3ZGCA 4N1BA 4IFLX 4ZY3A 5FNUA 2Z32A
chains in the Genus database with same CATH superfamily
1NCCN 4MWUA 4D52B 4FVKA 1NN2A 3SOBB 5NN9A 1V0EA 1MWEA 2HU4A 4HZYA 3HRPA 2JKBA 1OFZA 7NN9A 1BJIA 1DIMA 2HU0A 2HTYA 4XJUA 2VAQA 2HTWA 3B7EA 1MS4A 4XMBA 3ZGDA 1ZI0A 2POOA 1E1AA 2ISMA 4NCSA 1N7DA 3S8ZA 1W8NA 4WA3A 3KYAA 2F25A 1W21A 1W1XA 1INWA 3GVLA 4FPYA 4B7QA 3TI3A 4JMLA 6NN9A 1N6FA 5HX0A 2QWAA 2QWHA 4XJAA 4GEZA 4XJWA 1V3DA 4YW2A 2ZW9A 3H72A 4MC7A 4AHAA 4D8SA 4KS5A 2DSOA 1L7HA 4M4VA 1Z50A 2P4OA 4AGIA 4FPCA 4K3YA 4X49A 4A0PA 1EUTA 4HW6A 3TI5A 5D9CA 3A9GA 3D11A 3Q6TA 2QWJA 4K1KA 2OJHA 3DR2A 5FNTA 1K32A 2YDTA 4K1JA 4GZWA 4YZ4A 5EO7A 1IVGA 4L7BA 4QN6A 5HUMA 1SLLA 3SRGA 2XCYA 1EUSA 1E8UA 4R40A 1E8TA 2BERA 4GZXA 3G4EA 5GX2A 4XJ8A 3TI4A 3I1CA 4HZWA 1VCJA 2H2UA 4N1BA 5GX1A 5FNUA 1IUCA 5GX4A 2VW0A 4ZLRA 3ALXA 5B2DA 4YZ1A 4CPMA 2X9MA 4XMAA 4CPYA 5JYYA 4HZXA 1A4GA 1F8BA 4ZGCA 4XHBA 4D4UA 2AH2A 4FJ6A 3CKZA 3TICA 3W09A 1F8CA 4FOYA 4MWLA 4MWWA 4K1IA 2AGSA 4FZHA 1SNTA 3TC9A 3K36A 1QLGA 2F10A 3Q6PA 2F24A 4ZY3A 1CQ1A 4GZOA 4DG6A 2QWCA 4GZPA 5D9BA 4FPFA 4XMIA 1MS8A 5F72C 4IFJA 4XJ9A 4O5SA 2XN4A 4CSDA 4YZ2A 3KGGA 4MWVA 1IVDA 1MS3A 3U0SA 2VK5A 3JU4A 1B9SA 4XHXA 1IUBA 4GN9A 3VNGA 3CYEA 3HLIA 4HIZA 5EO8A 1MS1A 4K1HA 4C1YB 2QWKA 4C1YA 2A75A 3S8VA 3SOVA 1NCDN 4H53A 2XZIA 2DYHA 3GVKA 4DGRA 5CGJA 4GN7A 4GDIA 2DG1A 4IQKA 1MS0A 3S94A 2C4LA 2B8HA 2FP9A 4FPEA 1CRUA 4IN4A 4B7NA 1INYA 4YW4A 1MZ6A 5FNSA 4HZZA 1USXA 1MZ5A 3GVJA 3O9KA 4XYXA 4WA4A 1W0OA 1RWIA 1B9TA 2SIMA 3WN7A 2HTQA 3BYCA 1SO7A 3V1SA 4YW3A 3V64C 2DG0A 4UF7A 2YA6A 4MWXA 1CRZA 1Z4VA 3FVZA 3AMRA 2BZDA 1IVEA 1NPEA 3K3AA 1W8OA 2FHRA 4XIKA 2V91A 1A14N 2IAOA 4MZEA 1H6LA 3Q6KA 2YA5A 3SILA 2GHSA 1VCUA 3HLHA 3NN9A 1NMBN 2BF6A 1E8VA 1SUUA 5FNQA 4O5TA 2QWIA 2VWDA 4G3NA 3WDZA 2IASA 2QWEA 5M1ZA 1IVCA 2FPBA 1S0JA 1V0FA 3TIAA 2ZB6A 4M4NA 3TI8A 4CH9A 5B2CA 4QN4A 2ZWAA 3K38A 2HTRA 1V0ZA 3DASA 2XZJA 4GN8A 4XJRA 1V3BA 1L7GA 5EX7A 1NCAN 2IAXA 4YZ5A 1IVFA 2IAQA 2W5NA 1S18A 4YZ3A 3V65B 1MS5A 1F8EA 4IFNX 3WW9A 2H2NA 2RKCA 4B7MA 1INFA 3LI3A 3FW0A 1N6DA 1INGA 3P5BL 2C4AA 3K39A 2QE8A 1V3CA 4XJZA 3H73A 2QWGA 2CMLA 5FWWA 2ZB5A 2SLIA 4XOGA 4XJQA 2F13A 4GZQA 4FOWA 4B7RA 4IMBA 1V2IA 2HT5A 2QWDA 4MJVA 4BBWA 3E5ZA 2HT7A 3BEQA 3D12A 4MX0A 3INBA 4AH4A 4CPZA 3S2KA 2IARA 1NSBA 4GZSA 4WA5A 4QN5A 5GX3A 4I00A 2HT8A 1MR5A 1Z4YA 4KS2A 3WWAA 2YDPA 3TIBA 3ADEA 3TI6A 1NNBA 4MZAA 1WCQA 2FP8A 3VNHA 1N1YA 4MWRA 3SALA 4CPLA 4MWJA 4YW1A 1USRA 1NMAN 4JF7A 1NMCA 4X47A 1INHA 2YA7A 2VVZA 2IAWA 4HHQA 4Q6KA 4CPNA 4CPOA 4QN3A 2W20A 5F9TA 3AMSA 1XOEA 2VSMA 2F27A 3A9HA 1MS9A 2FLUX 4FP3A 3CL0A 2VW1A 1B9VA 4SLIA 4PWZA 4D52A 1POOA 1W20A 4FP2A 2GVWA 1V3EA 5GX5A 2VK7A 4XILA 4FQ4A 1S0IA 3SREA 2HQSA 5GTQA 4L7CA 4YY8A 3SOQA 1A4QA 1NSCA 2GVVA 3A72A 1QBIA 2AEQA 1EUUA 1INVA 4NN9A 4FOQA 3OPZA 4FPOB 1Q7FA 3LI4A 1Z4WA 4L7DA 4GZTA 4QN7A 3CL2A 1INXA 2F28A 2IAUA 5FZJA 1XOGA 4HHOA 2F11A 2GVXA 3SANA 4FPKA 2F29A 2VPJA 2G8SA 4HZVA 4XIOA 1C9UA 4QNPA 2AEPA 3K37A 2W38A 3NSSA 3L6VA 3ZGCA 4MWQA 2IAVA 2F12A 2GVUA 2YA8A 4D52C 1L7FA 4GNBA 1Z4XA 1WCSA 2ZZKA 3LI5A 4FPGA 1NNAA 1N1TA 2F0ZA 1RWLA 4MWYA 1X2JA 3A71A 3SLIA 3PJQA 1CVMA 3ALWA 4KS1A 2QWFA 2VK6A 4GJTA 1C5KA 1ZGKA 1S1DA 5H47A 1W0PA 4MJUA 1U6DX 2W8BB 3B69A 3H71A 4GDJA 2W8BA 1WP5A 1EURA 1PJXA 2BATA 5D9DA 2YA4A 4AGTA 1NNCA 4ASCA 5FZNA 1N6EA 4X6KA 1IJQA 4X4AA 2QWBA 4FOVA 4XE9A 2F26A 4UOUA 4M4UA 4YW5A 5HUGA 4WEFA 3H6JA 5HUKA 3UC1A 4FPHA 1NSDA 2FPCA 3O9JA 1N1SA 2W5OA 4M3MA 4CHBA 4KS3A 4GB1A 4J9TA 1Z4ZA 2WOZA 3T1EA 3G4HA 4KS4A 4FPJA 2IATA 4H52A 1IVBA 3NO0A 2SILA 4B7JA 3O4PA 1NCBN 1F8DA 4NC5A 2Z32A 2HTUA 2XZKA 1SLIA 2VW2A 1V04A 2IAPA 1N1VA 3II7A 4WEGA 1KITA 5FNRA 2HTVA 4GNAA 4Q1UA 2VSKA 1X2RA 4IYGA 2IVZA 4GNCA 1DILA 4FPLA 4IFLX 5HUNA 3IAXA
chains in the Genus database with same CATH topology
2DYHA 2FLUX 4L7DA 2ZZKA 3ADEA 5CGJA 4IQKA 5F72C 4IFJA 3VNHA 5FNQA 4ZGCA 1X2JA 2XN4A 3II7A 5FZJA 5FNTA 4IN4A 4IFNX 2ZW9A 4L7BA 5FNRA 3WDZA 4CHBA 1ZGKA 5FNSA 2WOZA 1U6DX 2VPJA 4L7CA 4YY8A 1X2RA 3VNGA 4CH9A 2ZWAA 4XMBA 3ZGDA 4ASCA 5FZNA 3WN7A 3ZGCA 4N1BA 4IFLX 4ZY3A 5FNUA 2Z32A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DYH A;  2FLU X;  4L7D A;  2ZZK A;  3ADE A;  5CGJ A;  4IQK A;  5F72 C;  4IFJ A;  3VNH A;  5FNQ A;  4ZGC A;  1X2J A;  2XN4 A;  3II7 A;  5FZJ A;  5FNT A;  4IN4 A;  4IFN X;  2ZW9 A;  4L7B A;  5FNR A;  3WDZ A;  4CHB A;  1ZGK A;  5FNS A;  2WOZ A;  1U6D X;  2VPJ A;  4L7C A;  4YY8 A;  1X2R A;  3VNG A;  4CH9 A;  2ZWA A;  4XMB A;  3ZGD A;  4ASC A;  5FZN A;  3WN7 A;  3ZGC A;  4N1B A;  4IFL X;  4ZY3 A;  5FNU A;  2Z32 A; 
#chains in the Genus database with same CATH topology
 1NCC N;  4MWU A;  4D52 B;  4FVK A;  1NN2 A;  3SOB B;  5NN9 A;  1V0E A;  1MWE A;  2HU4 A;  4HZY A;  3HRP A;  2JKB A;  1OFZ A;  7NN9 A;  1BJI A;  1DIM A;  2HU0 A;  2HTY A;  4XJU A;  2VAQ A;  2HTW A;  3B7E A;  1MS4 A;  4XMB A;  3ZGD A;  1ZI0 A;  2POO A;  1E1A A;  2ISM A;  4NCS A;  1N7D A;  3S8Z A;  1W8N A;  4WA3 A;  3KYA A;  2F25 A;  1W21 A;  1W1X A;  1INW A;  3GVL A;  4FPY A;  4B7Q A;  3TI3 A;  4JML A;  6NN9 A;  1N6F A;  5HX0 A;  2QWA A;  2QWH A;  4XJA A;  4GEZ A;  4XJW A;  1V3D A;  4YW2 A;  2ZW9 A;  3H72 A;  4MC7 A;  4AHA A;  4D8S A;  4KS5 A;  2DSO A;  1L7H A;  4M4V A;  1Z50 A;  2P4O A;  4AGI A;  4FPC A;  4K3Y A;  4X49 A;  4A0P A;  1EUT A;  4HW6 A;  3TI5 A;  5D9C A;  3A9G A;  3D11 A;  3Q6T A;  2QWJ A;  4K1K A;  2OJH A;  3DR2 A;  5FNT A;  1K32 A;  2YDT A;  4K1J A;  4GZW A;  4YZ4 A;  5EO7 A;  1IVG A;  4L7B A;  4QN6 A;  5HUM A;  1SLL A;  3SRG A;  2XCY A;  1EUS A;  1E8U A;  4R40 A;  1E8T A;  2BER A;  4GZX A;  3G4E A;  5GX2 A;  4XJ8 A;  3TI4 A;  3I1C A;  4HZW A;  1VCJ A;  2H2U A;  4N1B A;  5GX1 A;  5FNU A;  1IUC A;  5GX4 A;  2VW0 A;  4ZLR A;  3ALX A;  5B2D A;  4YZ1 A;  4CPM A;  2X9M A;  4XMA A;  4CPY A;  5JYY A;  4HZX A;  1A4G A;  1F8B A;  4ZGC A;  4XHB A;  4D4U A;  2AH2 A;  4FJ6 A;  3CKZ A;  3TIC A;  3W09 A;  1F8C A;  4FOY A;  4MWL A;  4MWW A;  4K1I A;  2AGS A;  4FZH A;  1SNT A;  3TC9 A;  3K36 A;  1QLG A;  2F10 A;  3Q6P A;  2F24 A;  4ZY3 A;  1CQ1 A;  4GZO A;  4DG6 A;  2QWC A;  4GZP A;  5D9B A;  4FPF A;  4XMI A;  1MS8 A;  5F72 C;  4IFJ A;  4XJ9 A;  4O5S A;  2XN4 A;  4CSD A;  4YZ2 A;  3KGG A;  4MWV A;  1IVD A;  1MS3 A;  3U0S A;  2VK5 A;  3JU4 A;  1B9S A;  4XHX A;  1IUB A;  4GN9 A;  3VNG A;  3CYE A;  3HLI A;  4HIZ A;  5EO8 A;  1MS1 A;  4K1H A;  4C1Y B;  2QWK A;  4C1Y A;  2A75 A;  3S8V A;  3SOV A;  1NCD N;  4H53 A;  2XZI A;  2DYH A;  3GVK A;  4DGR A;  5CGJ A;  4GN7 A;  4GDI A;  2DG1 A;  4IQK A;  1MS0 A;  3S94 A;  2C4L A;  2B8H A;  2FP9 A;  4FPE A;  1CRU A;  4IN4 A;  4B7N A;  1INY A;  4YW4 A;  1MZ6 A;  5FNS A;  4HZZ A;  1USX A;  1MZ5 A;  3GVJ A;  3O9K A;  4XYX A;  4WA4 A;  1W0O A;  1RWI A;  1B9T A;  2SIM A;  3WN7 A;  2HTQ A;  3BYC A;  1SO7 A;  3V1S A;  4YW3 A;  3V64 C;  2DG0 A;  4UF7 A;  2YA6 A;  4MWX A;  1CRZ A;  1Z4V A;  3FVZ A;  3AMR A;  2BZD A;  1IVE A;  1NPE A;  3K3A A;  1W8O A;  2FHR A;  4XIK A;  2V91 A;  1A14 N;  2IAO A;  4MZE A;  1H6L A;  3Q6K A;  2YA5 A;  3SIL A;  2GHS A;  1VCU A;  3HLH A;  3NN9 A;  1NMB N;  2BF6 A;  1E8V A;  1SUU A;  5FNQ A;  4O5T A;  2QWI A;  2VWD A;  4G3N A;  3WDZ A;  2IAS A;  2QWE A;  5M1Z A;  1IVC A;  2FPB A;  1S0J A;  1V0F A;  3TIA A;  2ZB6 A;  4M4N A;  3TI8 A;  4CH9 A;  5B2C A;  4QN4 A;  2ZWA A;  3K38 A;  2HTR A;  1V0Z A;  3DAS A;  2XZJ A;  4GN8 A;  4XJR A;  1V3B A;  1L7G A;  5EX7 A;  1NCA N;  2IAX A;  4YZ5 A;  1IVF A;  2IAQ A;  2W5N A;  1S18 A;  4YZ3 A;  3V65 B;  1MS5 A;  1F8E A;  4IFN X;  3WW9 A;  2H2N A;  2RKC A;  4B7M A;  1INF A;  3LI3 A;  3FW0 A;  1N6D A;  1ING A;  3P5B L;  2C4A A;  3K39 A;  2QE8 A;  1V3C A;  4XJZ A;  3H73 A;  2QWG A;  2CML A;  5FWW A;  2ZB5 A;  2SLI A;  4XOG A;  4XJQ A;  2F13 A;  4GZQ A;  4FOW A;  4B7R A;  4IMB A;  1V2I A;  2HT5 A;  2QWD A;  4MJV A;  4BBW A;  3E5Z A;  2HT7 A;  3BEQ A;  3D12 A;  4MX0 A;  3INB A;  4AH4 A;  4CPZ A;  3S2K A;  2IAR A;  1NSB A;  4GZS A;  4WA5 A;  4QN5 A;  5GX3 A;  4I00 A;  2HT8 A;  1MR5 A;  1Z4Y A;  4KS2 A;  3WWA A;  2YDP A;  3TIB A;  3ADE A;  3TI6 A;  1NNB A;  4MZA A;  1WCQ A;  2FP8 A;  3VNH A;  1N1Y A;  4MWR A;  3SAL A;  4CPL A;  4MWJ A;  4YW1 A;  1USR A;  1NMA N;  4JF7 A;  1NMC A;  4X47 A;  1INH A;  2YA7 A;  2VVZ A;  2IAW A;  4HHQ A;  4Q6K A;  4CPN A;  4CPO A;  4QN3 A;  2W20 A;  5F9T A;  3AMS A;  1XOE A;  2VSM A;  2F27 A;  3A9H A;  1MS9 A;  2FLU X;  4FP3 A;  3CL0 A;  2VW1 A;  1B9V A;  4SLI A;  4PWZ A;  4D52 A;  1POO A;  1W20 A;  4FP2 A;  2GVW A;  1V3E A;  5GX5 A;  2VK7 A;  4XIL A;  4FQ4 A;  1S0I A;  3SRE A;  2HQS A;  5GTQ A;  4L7C A;  4YY8 A;  3SOQ A;  1A4Q A;  1NSC A;  2GVV A;  3A72 A;  1QBI A;  2AEQ A;  1EUU A;  1INV A;  4NN9 A;  4FOQ A;  3OPZ A;  4FPO B;  1Q7F A;  3LI4 A;  1Z4W A;  4L7D A;  4GZT A;  4QN7 A;  3CL2 A;  1INX A;  2F28 A;  2IAU A;  5FZJ A;  1XOG A;  4HHO A;  2F11 A;  2GVX A;  3SAN A;  4FPK A;  2F29 A;  2VPJ A;  2G8S A;  4HZV A;  4XIO A;  1C9U A;  4QNP A;  2AEP A;  3K37 A;  2W38 A;  3NSS A;  3L6V A;  3ZGC A;  4MWQ A;  2IAV A;  2F12 A;  2GVU A;  2YA8 A;  4D52 C;  1L7F A;  4GNB A;  1Z4X A;  1WCS A;  2ZZK A;  3LI5 A;  4FPG A;  1NNA A;  1N1T A;  2F0Z A;  1RWL A;  4MWY A;  1X2J A;  3A71 A;  3SLI A;  3PJQ A;  1CVM A;  3ALW A;  4KS1 A;  2QWF A;  2VK6 A;  4GJT A;  1C5K A;  1ZGK A;  1S1D A;  5H47 A;  1W0P A;  4MJU A;  1U6D X;  2W8B B;  3B69 A;  3H71 A;  4GDJ A;  2W8B A;  1WP5 A;  1EUR A;  1PJX A;  2BAT A;  5D9D A;  2YA4 A;  4AGT A;  1NNC A;  4ASC A;  5FZN A;  1N6E A;  4X6K A;  1IJQ A;  4X4A A;  2QWB A;  4FOV A;  4XE9 A;  2F26 A;  4UOU A;  4M4U A;  4YW5 A;  5HUG A;  4WEF A;  3H6J A;  5HUK A;  3UC1 A;  4FPH A;  1NSD A;  2FPC A;  3O9J A;  1N1S A;  2W5O A;  4M3M A;  4CHB A;  4KS3 A;  4GB1 A;  4J9T A;  1Z4Z A;  2WOZ A;  3T1E A;  3G4H A;  4KS4 A;  4FPJ A;  2IAT A;  4H52 A;  1IVB A;  3NO0 A;  2SIL A;  4B7J A;  3O4P A;  1NCB N;  1F8D A;  4NC5 A;  2Z32 A;  2HTU A;  2XZK A;  1SLI A;  2VW2 A;  1V04 A;  2IAP A;  1N1V A;  3II7 A;  4WEG A;  1KIT A;  5FNR A;  2HTV A;  4GNA A;  4Q1U A;  2VSK A;  1X2R A;  4IYG A;  2IVZ A;  4GNC A;  1DIL A;  4FPL A;  4IFL X;  5HUN A;  3IAX A; 
#chains in the Genus database with same CATH homology
 2DYH A;  2FLU X;  4L7D A;  2ZZK A;  3ADE A;  5CGJ A;  4IQK A;  5F72 C;  4IFJ A;  3VNH A;  5FNQ A;  4ZGC A;  1X2J A;  2XN4 A;  3II7 A;  5FZJ A;  5FNT A;  4IN4 A;  4IFN X;  2ZW9 A;  4L7B A;  5FNR A;  3WDZ A;  4CHB A;  1ZGK A;  5FNS A;  2WOZ A;  1U6D X;  2VPJ A;  4L7C A;  4YY8 A;  1X2R A;  3VNG A;  4CH9 A;  2ZWA A;  4XMB A;  3ZGD A;  4ASC A;  5FZN A;  3WN7 A;  3ZGC A;  4N1B A;  4IFL X;  4ZY3 A;  5FNU A;  2Z32 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...