5FSUA

Crystal structure of trypanosoma brucei macrodomain (crystal form 1)
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
251
structure length
235
Chain Sequence
PFEFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
source organism Trypanosoma brucei
molecule tags Hydrolase
molecule keywords MACRODOMAIN
total genus 77
structure length 235
sequence length 251
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsuA00
4KYBA 3V2BA 3H8EA 5FSYA 3IIDA 2FXKA 1BPNA 3VFQA 1VHUA 2DX6A 4ETJA 2FAVA 5FSVA 4ESSA 4ZYQA 5AILA 3KQZA 4R7MA 5D8NA 5FSZA 2BFRA 4ETKA 1NJRA 4JGKA 3Q6ZA 4JCAA 2BFQA 1LANA 5CBMA 4ZY2A 4K0CA 5HIHA 2EWBA 5DUSA 3GPQA 1YD9A 4UMLA 4ZY1A 3EWPA 3GQOA 4TU0A 1SPVA 3T8WA 2ACFA 3KQXA 1ZR3A 3H8GA 5FSUA 3ETIA 4ZX8A 1LAMA 3EW5A 3V45A 3SIJA 3GPOA 1LCPA 3KZWA 2FG1A 3EWOA 5CMSA 2LGRA 4J5RA 4JLLA 4J5QA 2X47A 2L8RA 3KR4A 4X2TA 1GYTA 1TXZA 4GUAA 2VRIA 3IIFA 4J4ZA 3GQEA 4R76A 1BLLE 4IQYA 4ZX9A 3IJ3A 5HOLA 3SIIA 4D86A 2AFCA 2XD7A 5E3BA 3SIGA 4JVVA 4GVVA 3H8FA 4ZY0A 5CB5A 3SIHA 4J5SA 4ABLA 3EKEA 4GVWA 3GPGA 1ZR5A 1HJZA 4KSIA 3EWQA 4K3NA 3Q71A 3JZTA 1TY8A 1BPMA 3JRUA 5FSXA 2J9AA 1LAPA 4ABKA 3PEIA 3EWRA 2EEEA 4ZI6A 4R6TA 3EJFA 3EJGA 3KR5A 5CB3A
chains in the Genus database with same CATH superfamily
4KYBA 3V2BA 3H8EA 5FSYA 3IIDA 2FXKA 1BPNA 2W2GA 3VFQA 1VHUA 2DX6A 4ETJA 2KQVA 2FAVA 5FSVA 4ESSA 4ZYQA 5AILA 3KQZA 4R7MA 5D8NA 5FSZA 2BFRA 4ETKA 1NJRA 4JGKA 3Q6ZA 4JCAA 2BFQA 1LANA 5CBMA 4ZY2A 4K0CA 5HIHA 2EWBA 5DUSA 3GPQA 1YD9A 4UMLA 4ZY1A 2WCTA 3EWPA 3GQOA 4TU0A 1SPVA 2RNKA 3T8WA 2ACFA 3KQXA 1ZR3A 3H8GA 5FSUA 3ETIA 4ZX8A 1LAMA 3EW5A 3V45A 3SIJA 3GPOA 1LCPA 3KZWA 2FG1A 3EWOA 5CMSA 2LGRA 4J5RA 4JLLA 4J5QA 2X47A 2L8RA 3KR4A 4X2TA 1GYTA 1TXZA 4GUAA 2VRIA 3IIFA 4J4ZA 3GQEA 2JZDA 4R76A 1BLLE 2JZFA 4IQYA 4ZX9A 3IJ3A 5HOLA 3SIIA 4D86A 2AFCA 2XD7A 5E3BA 3SIGA 4JVVA 4GVVA 3H8FA 4ZY0A 5CB5A 3SIHA 4J5SA 4ABLA 3EKEA 4GVWA 3GPGA 1ZR5A 1HJZA 4KSIA 3EWQA 4K3NA 3Q71A 3JZTA 2JZEA 1TY8A 1BPMA 3JRUA 5FSXA 2J9AA 1LAPA 4ABKA 3PEIA 3EWRA 2EEEA 4ZI6A 4R6TA 3EJFA 3EJGA 3KR5A 5CB3A
chains in the Genus database with same CATH topology
4KYBA 3V2BA 3H8EA 5FSYA 3IIDA 2FXKA 1BPNA 3VFQA 1VHUA 2DX6A 4ETJA 2FAVA 5FSVA 4ESSA 4ZYQA 5AILA 3KQZA 4R7MA 5D8NA 5FSZA 2BFRA 4ETKA 1NJRA 4JGKA 3Q6ZA 4JCAA 2BFQA 1LANA 5CBMA 4ZY2A 4K0CA 5HIHA 2EWBA 5DUSA 3GPQA 1YD9A 4UMLA 4ZY1A 3EWPA 3GQOA 4TU0A 1SPVA 3T8WA 2ACFA 3KQXA 1ZR3A 3H8GA 5FSUA 3ETIA 4ZX8A 1LAMA 3EW5A 3V45A 3SIJA 3GPOA 1LCPA 3KZWA 2FG1A 3EWOA 5CMSA 2LGRA 4J5RA 4JLLA 4J5QA 2X47A 2L8RA 3KR4A 4X2TA 1GYTA 1TXZA 4GUAA 2VRIA 3IIFA 4J4ZA 3GQEA 4R76A 1BLLE 4IQYA 4ZX9A 3IJ3A 5HOLA 3SIIA 4D86A 2AFCA 2XD7A 5E3BA 3SIGA 4JVVA 4GVVA 3H8FA 4ZY0A 5CB5A 3SIHA 4J5SA 4ABLA 3EKEA 4GVWA 3GPGA 1ZR5A 1HJZA 4KSIA 3EWQA 4K3NA 3Q71A 3JZTA 1TY8A 1BPMA 3JRUA 5FSXA 2J9AA 1LAPA 4ABKA 3PEIA 3EWRA 2EEEA 4ZI6A 4R6TA 3EJFA 3EJGA 3KR5A 5CB3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KYB A;  3V2B A;  3H8E A;  5FSY A;  3IID A;  2FXK A;  1BPN A;  3VFQ A;  1VHU A;  2DX6 A;  4ETJ A;  2FAV A;  5FSV A;  4ESS A;  4ZYQ A;  5AIL A;  3KQZ A;  4R7M A;  5D8N A;  5FSZ A;  2BFR A;  4ETK A;  1NJR A;  4JGK A;  3Q6Z A;  4JCA A;  2BFQ A;  1LAN A;  5CBM A;  4ZY2 A;  4K0C A;  5HIH A;  2EWB A;  5DUS A;  3GPQ A;  1YD9 A;  4UML A;  4ZY1 A;  3EWP A;  3GQO A;  4TU0 A;  1SPV A;  3T8W A;  2ACF A;  3KQX A;  1ZR3 A;  3H8G A;  5FSU A;  3ETI A;  4ZX8 A;  1LAM A;  3EW5 A;  3V45 A;  3SIJ A;  3GPO A;  1LCP A;  3KZW A;  2FG1 A;  3EWO A;  5CMS A;  2LGR A;  4J5R A;  4JLL A;  4J5Q A;  2X47 A;  2L8R A;  3KR4 A;  4X2T A;  1GYT A;  1TXZ A;  4GUA A;  2VRI A;  3IIF A;  4J4Z A;  3GQE A;  4R76 A;  1BLL E;  4IQY A;  4ZX9 A;  3IJ3 A;  5HOL A;  3SII A;  4D86 A;  2AFC A;  2XD7 A;  5E3B A;  3SIG A;  4JVV A;  4GVV A;  3H8F A;  4ZY0 A;  5CB5 A;  3SIH A;  4J5S A;  4ABL A;  3EKE A;  4GVW A;  3GPG A;  1ZR5 A;  1HJZ A;  4KSI A;  3EWQ A;  4K3N A;  3Q71 A;  3JZT A;  1TY8 A;  1BPM A;  3JRU A;  5FSX A;  2J9A A;  1LAP A;  4ABK A;  3PEI A;  3EWR A;  2EEE A;  4ZI6 A;  4R6T A;  3EJF A;  3EJG A;  3KR5 A;  5CB3 A; 
#chains in the Genus database with same CATH topology
 4KYB A;  3V2B A;  3H8E A;  5FSY A;  3IID A;  2FXK A;  1BPN A;  2W2G A;  3VFQ A;  1VHU A;  2DX6 A;  4ETJ A;  2KQV A;  2FAV A;  5FSV A;  4ESS A;  4ZYQ A;  5AIL A;  3KQZ A;  4R7M A;  5D8N A;  5FSZ A;  2BFR A;  4ETK A;  1NJR A;  4JGK A;  3Q6Z A;  4JCA A;  2BFQ A;  1LAN A;  5CBM A;  4ZY2 A;  4K0C A;  5HIH A;  2EWB A;  5DUS A;  3GPQ A;  1YD9 A;  4UML A;  4ZY1 A;  2WCT A;  3EWP A;  3GQO A;  4TU0 A;  1SPV A;  2RNK A;  3T8W A;  2ACF A;  3KQX A;  1ZR3 A;  3H8G A;  5FSU A;  3ETI A;  4ZX8 A;  1LAM A;  3EW5 A;  3V45 A;  3SIJ A;  3GPO A;  1LCP A;  3KZW A;  2FG1 A;  3EWO A;  5CMS A;  2LGR A;  4J5R A;  4JLL A;  4J5Q A;  2X47 A;  2L8R A;  3KR4 A;  4X2T A;  1GYT A;  1TXZ A;  4GUA A;  2VRI A;  3IIF A;  4J4Z A;  3GQE A;  2JZD A;  4R76 A;  1BLL E;  2JZF A;  4IQY A;  4ZX9 A;  3IJ3 A;  5HOL A;  3SII A;  4D86 A;  2AFC A;  2XD7 A;  5E3B A;  3SIG A;  4JVV A;  4GVV A;  3H8F A;  4ZY0 A;  5CB5 A;  3SIH A;  4J5S A;  4ABL A;  3EKE A;  4GVW A;  3GPG A;  1ZR5 A;  1HJZ A;  4KSI A;  3EWQ A;  4K3N A;  3Q71 A;  3JZT A;  2JZE A;  1TY8 A;  1BPM A;  3JRU A;  5FSX A;  2J9A A;  1LAP A;  4ABK A;  3PEI A;  3EWR A;  2EEE A;  4ZI6 A;  4R6T A;  3EJF A;  3EJG A;  3KR5 A;  5CB3 A; 
#chains in the Genus database with same CATH homology
 4KYB A;  3V2B A;  3H8E A;  5FSY A;  3IID A;  2FXK A;  1BPN A;  3VFQ A;  1VHU A;  2DX6 A;  4ETJ A;  2FAV A;  5FSV A;  4ESS A;  4ZYQ A;  5AIL A;  3KQZ A;  4R7M A;  5D8N A;  5FSZ A;  2BFR A;  4ETK A;  1NJR A;  4JGK A;  3Q6Z A;  4JCA A;  2BFQ A;  1LAN A;  5CBM A;  4ZY2 A;  4K0C A;  5HIH A;  2EWB A;  5DUS A;  3GPQ A;  1YD9 A;  4UML A;  4ZY1 A;  3EWP A;  3GQO A;  4TU0 A;  1SPV A;  3T8W A;  2ACF A;  3KQX A;  1ZR3 A;  3H8G A;  5FSU A;  3ETI A;  4ZX8 A;  1LAM A;  3EW5 A;  3V45 A;  3SIJ A;  3GPO A;  1LCP A;  3KZW A;  2FG1 A;  3EWO A;  5CMS A;  2LGR A;  4J5R A;  4JLL A;  4J5Q A;  2X47 A;  2L8R A;  3KR4 A;  4X2T A;  1GYT A;  1TXZ A;  4GUA A;  2VRI A;  3IIF A;  4J4Z A;  3GQE A;  4R76 A;  1BLL E;  4IQY A;  4ZX9 A;  3IJ3 A;  5HOL A;  3SII A;  4D86 A;  2AFC A;  2XD7 A;  5E3B A;  3SIG A;  4JVV A;  4GVV A;  3H8F A;  4ZY0 A;  5CB5 A;  3SIH A;  4J5S A;  4ABL A;  3EKE A;  4GVW A;  3GPG A;  1ZR5 A;  1HJZ A;  4KSI A;  3EWQ A;  4K3N A;  3Q71 A;  3JZT A;  1TY8 A;  1BPM A;  3JRU A;  5FSX A;  2J9A A;  1LAP A;  4ABK A;  3PEI A;  3EWR A;  2EEE A;  4ZI6 A;  4R6T A;  3EJF A;  3EJG A;  3KR5 A;  5CB3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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