5FSUA

Crystal structure of trypanosoma brucei macrodomain (crystal form 1)
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
251
structure length
235
Chain Sequence
PFEFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
source organism Trypanosoma brucei
molecule tags Hydrolase
molecule keywords MACRODOMAIN
total genus 77
structure length 235
sequence length 251
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsuA00
4ZYQA 3KR4A 5CMSA 4J5QA 4K3NA 3EWPA 1BPMA 2BFRA 5FSUA 1TXZA 1LCPA 2BFQA 3EKEA 1ZR5A 5AILA 1ZR3A 2FAVA 4K0CA 3EJGA 1BPNA 3PEIA 4JCAA 5FSVA 1GYTA 5HIHA 4ZY0A 1NJRA 3GPQA 5FSXA 3EWOA 3SIJA 2X47A 1YD9A 4J5SA 4J5RA 3EWQA 2FXKA 4ETKA 3Q71A 3GPGA 4ABLA 5FSYA 3ETIA 4X2TA 3JRUA 5D8NA 4ESSA 2AFCA 3H8FA 3V2BA 4ZX9A 3GQEA 3GQOA 2ACFA 5CB5A 5CBMA 1LANA 4GUAA 5DUSA 2DX6A 4ZY2A 5E3BA 4R7MA 2J9AA 1SPVA 2EEEA 3KR5A 3VFQA 3EW5A 3IJ3A 4ZI6A 3H8EA 3KZWA 4JGKA 2LGRA 3JZTA 1TY8A 3KQZA 1HJZA 4KYBA 4GVVA 1VHUA 2EWBA 3SIIA 4KSIA 4JVVA 4J4ZA 4UMLA 4R6TA 4R76A 1LAPA 5CB3A 3GPOA 4JLLA 3Q6ZA 5HOLA 1BLLE 5FSZA 3IIFA 3KQXA 3SIHA 2VRIA 4ABKA 2FG1A 2XD7A 4ZX8A 4TU0A 4IQYA 3V45A 3H8GA 1LAMA 3T8WA 4GVWA 4D86A 3SIGA 3EJFA 3IIDA 4ZY1A 3EWRA 2L8RA 4ETJA
chains in the Genus database with same CATH superfamily
4ZYQA 3KR4A 5CMSA 4J5QA 4K3NA 3EWPA 1BPMA 2BFRA 5FSUA 1TXZA 1LCPA 2BFQA 3EKEA 1ZR5A 5AILA 1ZR3A 2FAVA 4K0CA 3EJGA 1BPNA 3PEIA 2WCTA 4JCAA 5FSVA 1GYTA 5HIHA 4ZY0A 1NJRA 3GPQA 5FSXA 2RNKA 3EWOA 3SIJA 2X47A 1YD9A 4J5SA 4J5RA 2W2GA 3EWQA 2FXKA 4ETKA 2JZDA 3Q71A 3GPGA 4ABLA 5FSYA 3ETIA 4X2TA 3JRUA 5D8NA 4ESSA 2AFCA 3H8FA 3V2BA 4ZX9A 3GQEA 3GQOA 2ACFA 5CB5A 5CBMA 1LANA 4GUAA 5DUSA 2DX6A 4ZY2A 5E3BA 4R7MA 2J9AA 1SPVA 2EEEA 2JZFA 3KR5A 3VFQA 3EW5A 3IJ3A 2KQVA 4ZI6A 3H8EA 3KZWA 4JGKA 2LGRA 3JZTA 1TY8A 3KQZA 1HJZA 4KYBA 4GVVA 1VHUA 2EWBA 3SIIA 4KSIA 4JVVA 4J4ZA 4UMLA 4R6TA 4R76A 1LAPA 5CB3A 2JZEA 3GPOA 4JLLA 3Q6ZA 5HOLA 1BLLE 5FSZA 3IIFA 3KQXA 3SIHA 2VRIA 4ABKA 2FG1A 2XD7A 4ZX8A 4TU0A 4IQYA 3V45A 3H8GA 1LAMA 3T8WA 4GVWA 4D86A 3SIGA 3EJFA 3IIDA 4ZY1A 3EWRA 2L8RA 4ETJA
chains in the Genus database with same CATH topology
4ZYQA 3KR4A 5CMSA 4J5QA 4K3NA 3EWPA 1BPMA 2BFRA 5FSUA 1TXZA 1LCPA 2BFQA 3EKEA 1ZR5A 5AILA 1ZR3A 2FAVA 4K0CA 3EJGA 1BPNA 3PEIA 4JCAA 5FSVA 1GYTA 5HIHA 4ZY0A 1NJRA 3GPQA 5FSXA 3EWOA 3SIJA 2X47A 1YD9A 4J5SA 4J5RA 3EWQA 2FXKA 4ETKA 3Q71A 3GPGA 4ABLA 5FSYA 3ETIA 4X2TA 3JRUA 5D8NA 4ESSA 2AFCA 3H8FA 3V2BA 4ZX9A 3GQEA 3GQOA 2ACFA 5CB5A 5CBMA 1LANA 4GUAA 5DUSA 2DX6A 4ZY2A 5E3BA 4R7MA 2J9AA 1SPVA 2EEEA 3KR5A 3VFQA 3EW5A 3IJ3A 4ZI6A 3H8EA 3KZWA 4JGKA 2LGRA 3JZTA 1TY8A 3KQZA 1HJZA 4KYBA 4GVVA 1VHUA 2EWBA 3SIIA 4KSIA 4JVVA 4J4ZA 4UMLA 4R6TA 4R76A 1LAPA 5CB3A 3GPOA 4JLLA 3Q6ZA 5HOLA 1BLLE 5FSZA 3IIFA 3KQXA 3SIHA 2VRIA 4ABKA 2FG1A 2XD7A 4ZX8A 4TU0A 4IQYA 3V45A 3H8GA 1LAMA 3T8WA 4GVWA 4D86A 3SIGA 3EJFA 3IIDA 4ZY1A 3EWRA 2L8RA 4ETJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZYQ A;  3KR4 A;  5CMS A;  4J5Q A;  4K3N A;  3EWP A;  1BPM A;  2BFR A;  5FSU A;  1TXZ A;  1LCP A;  2BFQ A;  3EKE A;  1ZR5 A;  5AIL A;  1ZR3 A;  2FAV A;  4K0C A;  3EJG A;  1BPN A;  3PEI A;  4JCA A;  5FSV A;  1GYT A;  5HIH A;  4ZY0 A;  1NJR A;  3GPQ A;  5FSX A;  3EWO A;  3SIJ A;  2X47 A;  1YD9 A;  4J5S A;  4J5R A;  3EWQ A;  2FXK A;  4ETK A;  3Q71 A;  3GPG A;  4ABL A;  5FSY A;  3ETI A;  4X2T A;  3JRU A;  5D8N A;  4ESS A;  2AFC A;  3H8F A;  3V2B A;  4ZX9 A;  3GQE A;  3GQO A;  2ACF A;  5CB5 A;  5CBM A;  1LAN A;  4GUA A;  5DUS A;  2DX6 A;  4ZY2 A;  5E3B A;  4R7M A;  2J9A A;  1SPV A;  2EEE A;  3KR5 A;  3VFQ A;  3EW5 A;  3IJ3 A;  4ZI6 A;  3H8E A;  3KZW A;  4JGK A;  2LGR A;  3JZT A;  1TY8 A;  3KQZ A;  1HJZ A;  4KYB A;  4GVV A;  1VHU A;  2EWB A;  3SII A;  4KSI A;  4JVV A;  4J4Z A;  4UML A;  4R6T A;  4R76 A;  1LAP A;  5CB3 A;  3GPO A;  4JLL A;  3Q6Z A;  5HOL A;  1BLL E;  5FSZ A;  3IIF A;  3KQX A;  3SIH A;  2VRI A;  4ABK A;  2FG1 A;  2XD7 A;  4ZX8 A;  4TU0 A;  4IQY A;  3V45 A;  3H8G A;  1LAM A;  3T8W A;  4GVW A;  4D86 A;  3SIG A;  3EJF A;  3IID A;  4ZY1 A;  3EWR A;  2L8R A;  4ETJ A; 
#chains in the Genus database with same CATH topology
 4ZYQ A;  3KR4 A;  5CMS A;  4J5Q A;  4K3N A;  3EWP A;  1BPM A;  2BFR A;  5FSU A;  1TXZ A;  1LCP A;  2BFQ A;  3EKE A;  1ZR5 A;  5AIL A;  1ZR3 A;  2FAV A;  4K0C A;  3EJG A;  1BPN A;  3PEI A;  2WCT A;  4JCA A;  5FSV A;  1GYT A;  5HIH A;  4ZY0 A;  1NJR A;  3GPQ A;  5FSX A;  2RNK A;  3EWO A;  3SIJ A;  2X47 A;  1YD9 A;  4J5S A;  4J5R A;  2W2G A;  3EWQ A;  2FXK A;  4ETK A;  2JZD A;  3Q71 A;  3GPG A;  4ABL A;  5FSY A;  3ETI A;  4X2T A;  3JRU A;  5D8N A;  4ESS A;  2AFC A;  3H8F A;  3V2B A;  4ZX9 A;  3GQE A;  3GQO A;  2ACF A;  5CB5 A;  5CBM A;  1LAN A;  4GUA A;  5DUS A;  2DX6 A;  4ZY2 A;  5E3B A;  4R7M A;  2J9A A;  1SPV A;  2EEE A;  2JZF A;  3KR5 A;  3VFQ A;  3EW5 A;  3IJ3 A;  2KQV A;  4ZI6 A;  3H8E A;  3KZW A;  4JGK A;  2LGR A;  3JZT A;  1TY8 A;  3KQZ A;  1HJZ A;  4KYB A;  4GVV A;  1VHU A;  2EWB A;  3SII A;  4KSI A;  4JVV A;  4J4Z A;  4UML A;  4R6T A;  4R76 A;  1LAP A;  5CB3 A;  2JZE A;  3GPO A;  4JLL A;  3Q6Z A;  5HOL A;  1BLL E;  5FSZ A;  3IIF A;  3KQX A;  3SIH A;  2VRI A;  4ABK A;  2FG1 A;  2XD7 A;  4ZX8 A;  4TU0 A;  4IQY A;  3V45 A;  3H8G A;  1LAM A;  3T8W A;  4GVW A;  4D86 A;  3SIG A;  3EJF A;  3IID A;  4ZY1 A;  3EWR A;  2L8R A;  4ETJ A; 
#chains in the Genus database with same CATH homology
 4ZYQ A;  3KR4 A;  5CMS A;  4J5Q A;  4K3N A;  3EWP A;  1BPM A;  2BFR A;  5FSU A;  1TXZ A;  1LCP A;  2BFQ A;  3EKE A;  1ZR5 A;  5AIL A;  1ZR3 A;  2FAV A;  4K0C A;  3EJG A;  1BPN A;  3PEI A;  4JCA A;  5FSV A;  1GYT A;  5HIH A;  4ZY0 A;  1NJR A;  3GPQ A;  5FSX A;  3EWO A;  3SIJ A;  2X47 A;  1YD9 A;  4J5S A;  4J5R A;  3EWQ A;  2FXK A;  4ETK A;  3Q71 A;  3GPG A;  4ABL A;  5FSY A;  3ETI A;  4X2T A;  3JRU A;  5D8N A;  4ESS A;  2AFC A;  3H8F A;  3V2B A;  4ZX9 A;  3GQE A;  3GQO A;  2ACF A;  5CB5 A;  5CBM A;  1LAN A;  4GUA A;  5DUS A;  2DX6 A;  4ZY2 A;  5E3B A;  4R7M A;  2J9A A;  1SPV A;  2EEE A;  3KR5 A;  3VFQ A;  3EW5 A;  3IJ3 A;  4ZI6 A;  3H8E A;  3KZW A;  4JGK A;  2LGR A;  3JZT A;  1TY8 A;  3KQZ A;  1HJZ A;  4KYB A;  4GVV A;  1VHU A;  2EWB A;  3SII A;  4KSI A;  4JVV A;  4J4Z A;  4UML A;  4R6T A;  4R76 A;  1LAP A;  5CB3 A;  3GPO A;  4JLL A;  3Q6Z A;  5HOL A;  1BLL E;  5FSZ A;  3IIF A;  3KQX A;  3SIH A;  2VRI A;  4ABK A;  2FG1 A;  2XD7 A;  4ZX8 A;  4TU0 A;  4IQY A;  3V45 A;  3H8G A;  1LAM A;  3T8W A;  4GVW A;  4D86 A;  3SIG A;  3EJF A;  3IID A;  4ZY1 A;  3EWR A;  2L8R A;  4ETJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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