5FSUA

Crystal structure of trypanosoma brucei macrodomain (crystal form 1)
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
251
structure length
235
Chain Sequence
PFEFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords MACRODOMAIN
publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
source organism Trypanosoma brucei
molecule tags Hydrolase
total genus 77
structure length 235
sequence length 251
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsuA00
5D8NA 3GQOA 3EW5A 3Q71A 2AFCA 4ZI6A 1LAPA 4ZY1A 4ABKA 2VRIA 1LAMA 3T8WA 3PEIA 4ETJA 3H8FA 3IJ3A 3JZTA 4JCAA 2BFQA 5CB3A 2L8RA 1ZR5A 3H8GA 3KQXA 5CBMA 3KZWA 3V45A 5FSUA 3VFQA 2X47A 1VHUA 5HIHA 3GPGA 5E3BA 3EWPA 1LCPA 1BPNA 4TU0A 1GYTA 4GVWA 4GVVA 3ETIA 5FSZA 4R7MA 4X2TA 1SPVA 2ACFA 4ZYQA 2FXKA 2LGRA 4KYBA 3KQZA 3IIDA 4J5SA 3Q6ZA 4R6TA 5CB5A 5CMSA 4J5QA 2J9AA 1YD9A 4GUAA 2EWBA 4J5RA 3EJFA 1TXZA 4R76A 3EWOA 1HJZA 1LANA 3SIJA 4ZX8A 4KSIA 5FSYA 3SIGA 4D86A 4IQYA 3GPOA 4J4ZA 3KR4A 4K3NA 4JLLA 4JVVA 5FSXA 2FAVA 5AILA 4ETKA 3KR5A 5FSVA 1TY8A 3SIHA 1NJRA 4K0CA 3GPQA 2BFRA 3EWRA 3V2BA 3JRUA 4ZY2A 3EKEA 3EWQA 4UMLA 5DUSA 3IIFA 2EEEA 3EJGA 3GQEA 1ZR3A 5HOLA 1BPMA 4JGKA 4ZY0A 3H8EA 4ESSA 2FG1A 2DX6A 1BLLE 2XD7A 4ZX9A 4ABLA 3SIIA
chains in the Genus database with same CATH superfamily
5D8NA 3GQOA 3EW5A 3Q71A 2JZDA 2AFCA 4ZI6A 1LAPA 4ZY1A 4ABKA 2VRIA 1LAMA 3T8WA 3PEIA 4ETJA 3H8FA 3IJ3A 3JZTA 4JCAA 2BFQA 5CB3A 2L8RA 1ZR5A 3H8GA 3KQXA 5CBMA 3KZWA 3V45A 5FSUA 3VFQA 2X47A 1VHUA 5HIHA 3GPGA 5E3BA 2WCTA 3EWPA 1LCPA 1BPNA 4TU0A 1GYTA 4GVWA 4GVVA 3ETIA 5FSZA 4R7MA 4X2TA 1SPVA 2ACFA 4ZYQA 2FXKA 2LGRA 4KYBA 3KQZA 3IIDA 4J5SA 3Q6ZA 4R6TA 5CB5A 5CMSA 4J5QA 2J9AA 1YD9A 4GUAA 2EWBA 4J5RA 3EJFA 1TXZA 4R76A 3EWOA 1HJZA 1LANA 3SIJA 4ZX8A 4KSIA 5FSYA 3SIGA 4D86A 4IQYA 2RNKA 3GPOA 4J4ZA 2KQVA 3KR4A 4K3NA 4JLLA 4JVVA 5FSXA 2FAVA 5AILA 4ETKA 3KR5A 5FSVA 1TY8A 3SIHA 1NJRA 4K0CA 3GPQA 2BFRA 3EWRA 3V2BA 3JRUA 4ZY2A 3EKEA 3EWQA 2JZEA 4UMLA 5DUSA 3IIFA 2EEEA 3EJGA 3GQEA 1ZR3A 5HOLA 1BPMA 4JGKA 4ZY0A 3H8EA 4ESSA 2FG1A 2DX6A 2JZFA 1BLLE 2XD7A 4ZX9A 2W2GA 4ABLA 3SIIA
chains in the Genus database with same CATH topology
5D8NA 3GQOA 3EW5A 3Q71A 2AFCA 4ZI6A 1LAPA 4ZY1A 4ABKA 2VRIA 1LAMA 3T8WA 3PEIA 4ETJA 3H8FA 3IJ3A 3JZTA 4JCAA 2BFQA 5CB3A 2L8RA 1ZR5A 3H8GA 3KQXA 5CBMA 3KZWA 3V45A 5FSUA 3VFQA 2X47A 1VHUA 5HIHA 3GPGA 5E3BA 3EWPA 1LCPA 1BPNA 4TU0A 1GYTA 4GVWA 4GVVA 3ETIA 5FSZA 4R7MA 4X2TA 1SPVA 2ACFA 4ZYQA 2FXKA 2LGRA 4KYBA 3KQZA 3IIDA 4J5SA 3Q6ZA 4R6TA 5CB5A 5CMSA 4J5QA 2J9AA 1YD9A 4GUAA 2EWBA 4J5RA 3EJFA 1TXZA 4R76A 3EWOA 1HJZA 1LANA 3SIJA 4ZX8A 4KSIA 5FSYA 3SIGA 4D86A 4IQYA 3GPOA 4J4ZA 3KR4A 4K3NA 4JLLA 4JVVA 5FSXA 2FAVA 5AILA 4ETKA 3KR5A 5FSVA 1TY8A 3SIHA 1NJRA 4K0CA 3GPQA 2BFRA 3EWRA 3V2BA 3JRUA 4ZY2A 3EKEA 3EWQA 4UMLA 5DUSA 3IIFA 2EEEA 3EJGA 3GQEA 1ZR3A 5HOLA 1BPMA 4JGKA 4ZY0A 3H8EA 4ESSA 2FG1A 2DX6A 1BLLE 2XD7A 4ZX9A 4ABLA 3SIIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D8N A;  3GQO A;  3EW5 A;  3Q71 A;  2AFC A;  4ZI6 A;  1LAP A;  4ZY1 A;  4ABK A;  2VRI A;  1LAM A;  3T8W A;  3PEI A;  4ETJ A;  3H8F A;  3IJ3 A;  3JZT A;  4JCA A;  2BFQ A;  5CB3 A;  2L8R A;  1ZR5 A;  3H8G A;  3KQX A;  5CBM A;  3KZW A;  3V45 A;  5FSU A;  3VFQ A;  2X47 A;  1VHU A;  5HIH A;  3GPG A;  5E3B A;  3EWP A;  1LCP A;  1BPN A;  4TU0 A;  1GYT A;  4GVW A;  4GVV A;  3ETI A;  5FSZ A;  4R7M A;  4X2T A;  1SPV A;  2ACF A;  4ZYQ A;  2FXK A;  2LGR A;  4KYB A;  3KQZ A;  3IID A;  4J5S A;  3Q6Z A;  4R6T A;  5CB5 A;  5CMS A;  4J5Q A;  2J9A A;  1YD9 A;  4GUA A;  2EWB A;  4J5R A;  3EJF A;  1TXZ A;  4R76 A;  3EWO A;  1HJZ A;  1LAN A;  3SIJ A;  4ZX8 A;  4KSI A;  5FSY A;  3SIG A;  4D86 A;  4IQY A;  3GPO A;  4J4Z A;  3KR4 A;  4K3N A;  4JLL A;  4JVV A;  5FSX A;  2FAV A;  5AIL A;  4ETK A;  3KR5 A;  5FSV A;  1TY8 A;  3SIH A;  1NJR A;  4K0C A;  3GPQ A;  2BFR A;  3EWR A;  3V2B A;  3JRU A;  4ZY2 A;  3EKE A;  3EWQ A;  4UML A;  5DUS A;  3IIF A;  2EEE A;  3EJG A;  3GQE A;  1ZR3 A;  5HOL A;  1BPM A;  4JGK A;  4ZY0 A;  3H8E A;  4ESS A;  2FG1 A;  2DX6 A;  1BLL E;  2XD7 A;  4ZX9 A;  4ABL A;  3SII A; 
#chains in the Genus database with same CATH topology
 5D8N A;  3GQO A;  3EW5 A;  3Q71 A;  2JZD A;  2AFC A;  4ZI6 A;  1LAP A;  4ZY1 A;  4ABK A;  2VRI A;  1LAM A;  3T8W A;  3PEI A;  4ETJ A;  3H8F A;  3IJ3 A;  3JZT A;  4JCA A;  2BFQ A;  5CB3 A;  2L8R A;  1ZR5 A;  3H8G A;  3KQX A;  5CBM A;  3KZW A;  3V45 A;  5FSU A;  3VFQ A;  2X47 A;  1VHU A;  5HIH A;  3GPG A;  5E3B A;  2WCT A;  3EWP A;  1LCP A;  1BPN A;  4TU0 A;  1GYT A;  4GVW A;  4GVV A;  3ETI A;  5FSZ A;  4R7M A;  4X2T A;  1SPV A;  2ACF A;  4ZYQ A;  2FXK A;  2LGR A;  4KYB A;  3KQZ A;  3IID A;  4J5S A;  3Q6Z A;  4R6T A;  5CB5 A;  5CMS A;  4J5Q A;  2J9A A;  1YD9 A;  4GUA A;  2EWB A;  4J5R A;  3EJF A;  1TXZ A;  4R76 A;  3EWO A;  1HJZ A;  1LAN A;  3SIJ A;  4ZX8 A;  4KSI A;  5FSY A;  3SIG A;  4D86 A;  4IQY A;  2RNK A;  3GPO A;  4J4Z A;  2KQV A;  3KR4 A;  4K3N A;  4JLL A;  4JVV A;  5FSX A;  2FAV A;  5AIL A;  4ETK A;  3KR5 A;  5FSV A;  1TY8 A;  3SIH A;  1NJR A;  4K0C A;  3GPQ A;  2BFR A;  3EWR A;  3V2B A;  3JRU A;  4ZY2 A;  3EKE A;  3EWQ A;  2JZE A;  4UML A;  5DUS A;  3IIF A;  2EEE A;  3EJG A;  3GQE A;  1ZR3 A;  5HOL A;  1BPM A;  4JGK A;  4ZY0 A;  3H8E A;  4ESS A;  2FG1 A;  2DX6 A;  2JZF A;  1BLL E;  2XD7 A;  4ZX9 A;  2W2G A;  4ABL A;  3SII A; 
#chains in the Genus database with same CATH homology
 5D8N A;  3GQO A;  3EW5 A;  3Q71 A;  2AFC A;  4ZI6 A;  1LAP A;  4ZY1 A;  4ABK A;  2VRI A;  1LAM A;  3T8W A;  3PEI A;  4ETJ A;  3H8F A;  3IJ3 A;  3JZT A;  4JCA A;  2BFQ A;  5CB3 A;  2L8R A;  1ZR5 A;  3H8G A;  3KQX A;  5CBM A;  3KZW A;  3V45 A;  5FSU A;  3VFQ A;  2X47 A;  1VHU A;  5HIH A;  3GPG A;  5E3B A;  3EWP A;  1LCP A;  1BPN A;  4TU0 A;  1GYT A;  4GVW A;  4GVV A;  3ETI A;  5FSZ A;  4R7M A;  4X2T A;  1SPV A;  2ACF A;  4ZYQ A;  2FXK A;  2LGR A;  4KYB A;  3KQZ A;  3IID A;  4J5S A;  3Q6Z A;  4R6T A;  5CB5 A;  5CMS A;  4J5Q A;  2J9A A;  1YD9 A;  4GUA A;  2EWB A;  4J5R A;  3EJF A;  1TXZ A;  4R76 A;  3EWO A;  1HJZ A;  1LAN A;  3SIJ A;  4ZX8 A;  4KSI A;  5FSY A;  3SIG A;  4D86 A;  4IQY A;  3GPO A;  4J4Z A;  3KR4 A;  4K3N A;  4JLL A;  4JVV A;  5FSX A;  2FAV A;  5AIL A;  4ETK A;  3KR5 A;  5FSV A;  1TY8 A;  3SIH A;  1NJR A;  4K0C A;  3GPQ A;  2BFR A;  3EWR A;  3V2B A;  3JRU A;  4ZY2 A;  3EKE A;  3EWQ A;  4UML A;  5DUS A;  3IIF A;  2EEE A;  3EJG A;  3GQE A;  1ZR3 A;  5HOL A;  1BPM A;  4JGK A;  4ZY0 A;  3H8E A;  4ESS A;  2FG1 A;  2DX6 A;  1BLL E;  2XD7 A;  4ZX9 A;  4ABL A;  3SII A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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