5FSVA

Crystal structure of trypanosoma brucei macrodomain (crystal form 2)
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
249
structure length
232
Chain Sequence
EFVTYSGEESPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
molecule tags Hydrolase
source organism Trypanosoma brucei
molecule keywords MACRODOMAIN
total genus 86
structure length 232
sequence length 249
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsvA00
3KQZA 2BFQA 4JCAA 4K0CA 3GPQA 4X2TA 5DUSA 4JVVA 1BLLE 4R6TA 3GQEA 1BPMA 2EEEA 1GYTA 2FG1A 3IIFA 4JGKA 2BFRA 3EKEA 3SIHA 3SIGA 2L8RA 4J4ZA 5CMSA 3IIDA 5CB3A 4ZY1A 4ABKA 3V2BA 3EJGA 4J5RA 4R76A 3Q71A 1NJRA 3EWRA 4ZX8A 5HOLA 1BPNA 3IJ3A 3JZTA 1ZR5A 4K3NA 4GUAA 3KQXA 5CBMA 4TU0A 3EW5A 4IQYA 2ACFA 2FXKA 4GVVA 4ZI6A 2AFCA 4KYBA 3EWPA 4ESSA 2J9AA 2LGRA 5E3BA 2XD7A 5HIHA 5CB5A 3Q6ZA 4R7MA 5FSVA 4ZY0A 5FSZA 3KZWA 4ZYQA 4ZY2A 3SIJA 2VRIA 1YD9A 1VHUA 1LCPA 1LANA 2DX6A 1ZR3A 2EWBA 4ETKA 3KR4A 3JRUA 3KR5A 2X47A 3GQOA 3GPGA 4GVWA 4J5SA 3V45A 3VFQA 4ABLA 3EJFA 5FSYA 3ETIA 3EWQA 2FAVA 4ZX9A 1LAPA 3EWOA 5FSXA 3SIIA 4ETJA 3PEIA 5D8NA 5FSUA 4D86A 3H8FA 4J5QA 1LAMA 4JLLA 4KSIA 1TY8A 3T8WA 4UMLA 1SPVA 5AILA 3GPOA 1TXZA 1HJZA 3H8EA 3H8GA
chains in the Genus database with same CATH superfamily
3KQZA 2BFQA 2JZEA 4JCAA 4K0CA 3GPQA 4X2TA 5DUSA 4JVVA 2KQVA 1BLLE 4R6TA 3GQEA 1BPMA 2EEEA 1GYTA 2FG1A 3IIFA 4JGKA 2BFRA 3EKEA 3SIHA 3SIGA 2L8RA 4J4ZA 5CMSA 3IIDA 5CB3A 4ZY1A 4ABKA 3V2BA 3EJGA 4J5RA 4R76A 3Q71A 1NJRA 3EWRA 4ZX8A 5HOLA 1BPNA 3IJ3A 3JZTA 1ZR5A 4K3NA 4GUAA 3KQXA 5CBMA 4TU0A 3EW5A 4IQYA 2ACFA 2FXKA 4GVVA 4ZI6A 2AFCA 4KYBA 3EWPA 4ESSA 2J9AA 2LGRA 5E3BA 2JZDA 2XD7A 5HIHA 5CB5A 3Q6ZA 4R7MA 5FSVA 4ZY0A 5FSZA 3KZWA 4ZYQA 4ZY2A 3SIJA 2VRIA 1YD9A 1VHUA 1LCPA 1LANA 2DX6A 1ZR3A 2EWBA 4ETKA 3KR4A 3JRUA 3KR5A 2X47A 3GQOA 3GPGA 4GVWA 4J5SA 3V45A 3VFQA 2WCTA 4ABLA 3EJFA 5FSYA 3ETIA 3EWQA 2FAVA 4ZX9A 1LAPA 3EWOA 5FSXA 2RNKA 3SIIA 2JZFA 4ETJA 3PEIA 5D8NA 5FSUA 4D86A 3H8FA 4J5QA 1LAMA 2W2GA 4JLLA 4KSIA 1TY8A 3T8WA 4UMLA 1SPVA 5AILA 3GPOA 1TXZA 1HJZA 3H8EA 3H8GA
chains in the Genus database with same CATH topology
3KQZA 2BFQA 4JCAA 4K0CA 3GPQA 4X2TA 5DUSA 4JVVA 1BLLE 4R6TA 3GQEA 1BPMA 2EEEA 1GYTA 2FG1A 3IIFA 4JGKA 2BFRA 3EKEA 3SIHA 3SIGA 2L8RA 4J4ZA 5CMSA 3IIDA 5CB3A 4ZY1A 4ABKA 3V2BA 3EJGA 4J5RA 4R76A 3Q71A 1NJRA 3EWRA 4ZX8A 5HOLA 1BPNA 3IJ3A 3JZTA 1ZR5A 4K3NA 4GUAA 3KQXA 5CBMA 4TU0A 3EW5A 4IQYA 2ACFA 2FXKA 4GVVA 4ZI6A 2AFCA 4KYBA 3EWPA 4ESSA 2J9AA 2LGRA 5E3BA 2XD7A 5HIHA 5CB5A 3Q6ZA 4R7MA 5FSVA 4ZY0A 5FSZA 3KZWA 4ZYQA 4ZY2A 3SIJA 2VRIA 1YD9A 1VHUA 1LCPA 1LANA 2DX6A 1ZR3A 2EWBA 4ETKA 3KR4A 3JRUA 3KR5A 2X47A 3GQOA 3GPGA 4GVWA 4J5SA 3V45A 3VFQA 4ABLA 3EJFA 5FSYA 3ETIA 3EWQA 2FAVA 4ZX9A 1LAPA 3EWOA 5FSXA 3SIIA 4ETJA 3PEIA 5D8NA 5FSUA 4D86A 3H8FA 4J5QA 1LAMA 4JLLA 4KSIA 1TY8A 3T8WA 4UMLA 1SPVA 5AILA 3GPOA 1TXZA 1HJZA 3H8EA 3H8GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KQZ A;  2BFQ A;  4JCA A;  4K0C A;  3GPQ A;  4X2T A;  5DUS A;  4JVV A;  1BLL E;  4R6T A;  3GQE A;  1BPM A;  2EEE A;  1GYT A;  2FG1 A;  3IIF A;  4JGK A;  2BFR A;  3EKE A;  3SIH A;  3SIG A;  2L8R A;  4J4Z A;  5CMS A;  3IID A;  5CB3 A;  4ZY1 A;  4ABK A;  3V2B A;  3EJG A;  4J5R A;  4R76 A;  3Q71 A;  1NJR A;  3EWR A;  4ZX8 A;  5HOL A;  1BPN A;  3IJ3 A;  3JZT A;  1ZR5 A;  4K3N A;  4GUA A;  3KQX A;  5CBM A;  4TU0 A;  3EW5 A;  4IQY A;  2ACF A;  2FXK A;  4GVV A;  4ZI6 A;  2AFC A;  4KYB A;  3EWP A;  4ESS A;  2J9A A;  2LGR A;  5E3B A;  2XD7 A;  5HIH A;  5CB5 A;  3Q6Z A;  4R7M A;  5FSV A;  4ZY0 A;  5FSZ A;  3KZW A;  4ZYQ A;  4ZY2 A;  3SIJ A;  2VRI A;  1YD9 A;  1VHU A;  1LCP A;  1LAN A;  2DX6 A;  1ZR3 A;  2EWB A;  4ETK A;  3KR4 A;  3JRU A;  3KR5 A;  2X47 A;  3GQO A;  3GPG A;  4GVW A;  4J5S A;  3V45 A;  3VFQ A;  4ABL A;  3EJF A;  5FSY A;  3ETI A;  3EWQ A;  2FAV A;  4ZX9 A;  1LAP A;  3EWO A;  5FSX A;  3SII A;  4ETJ A;  3PEI A;  5D8N A;  5FSU A;  4D86 A;  3H8F A;  4J5Q A;  1LAM A;  4JLL A;  4KSI A;  1TY8 A;  3T8W A;  4UML A;  1SPV A;  5AIL A;  3GPO A;  1TXZ A;  1HJZ A;  3H8E A;  3H8G A; 
#chains in the Genus database with same CATH topology
 3KQZ A;  2BFQ A;  2JZE A;  4JCA A;  4K0C A;  3GPQ A;  4X2T A;  5DUS A;  4JVV A;  2KQV A;  1BLL E;  4R6T A;  3GQE A;  1BPM A;  2EEE A;  1GYT A;  2FG1 A;  3IIF A;  4JGK A;  2BFR A;  3EKE A;  3SIH A;  3SIG A;  2L8R A;  4J4Z A;  5CMS A;  3IID A;  5CB3 A;  4ZY1 A;  4ABK A;  3V2B A;  3EJG A;  4J5R A;  4R76 A;  3Q71 A;  1NJR A;  3EWR A;  4ZX8 A;  5HOL A;  1BPN A;  3IJ3 A;  3JZT A;  1ZR5 A;  4K3N A;  4GUA A;  3KQX A;  5CBM A;  4TU0 A;  3EW5 A;  4IQY A;  2ACF A;  2FXK A;  4GVV A;  4ZI6 A;  2AFC A;  4KYB A;  3EWP A;  4ESS A;  2J9A A;  2LGR A;  5E3B A;  2JZD A;  2XD7 A;  5HIH A;  5CB5 A;  3Q6Z A;  4R7M A;  5FSV A;  4ZY0 A;  5FSZ A;  3KZW A;  4ZYQ A;  4ZY2 A;  3SIJ A;  2VRI A;  1YD9 A;  1VHU A;  1LCP A;  1LAN A;  2DX6 A;  1ZR3 A;  2EWB A;  4ETK A;  3KR4 A;  3JRU A;  3KR5 A;  2X47 A;  3GQO A;  3GPG A;  4GVW A;  4J5S A;  3V45 A;  3VFQ A;  2WCT A;  4ABL A;  3EJF A;  5FSY A;  3ETI A;  3EWQ A;  2FAV A;  4ZX9 A;  1LAP A;  3EWO A;  5FSX A;  2RNK A;  3SII A;  2JZF A;  4ETJ A;  3PEI A;  5D8N A;  5FSU A;  4D86 A;  3H8F A;  4J5Q A;  1LAM A;  2W2G A;  4JLL A;  4KSI A;  1TY8 A;  3T8W A;  4UML A;  1SPV A;  5AIL A;  3GPO A;  1TXZ A;  1HJZ A;  3H8E A;  3H8G A; 
#chains in the Genus database with same CATH homology
 3KQZ A;  2BFQ A;  4JCA A;  4K0C A;  3GPQ A;  4X2T A;  5DUS A;  4JVV A;  1BLL E;  4R6T A;  3GQE A;  1BPM A;  2EEE A;  1GYT A;  2FG1 A;  3IIF A;  4JGK A;  2BFR A;  3EKE A;  3SIH A;  3SIG A;  2L8R A;  4J4Z A;  5CMS A;  3IID A;  5CB3 A;  4ZY1 A;  4ABK A;  3V2B A;  3EJG A;  4J5R A;  4R76 A;  3Q71 A;  1NJR A;  3EWR A;  4ZX8 A;  5HOL A;  1BPN A;  3IJ3 A;  3JZT A;  1ZR5 A;  4K3N A;  4GUA A;  3KQX A;  5CBM A;  4TU0 A;  3EW5 A;  4IQY A;  2ACF A;  2FXK A;  4GVV A;  4ZI6 A;  2AFC A;  4KYB A;  3EWP A;  4ESS A;  2J9A A;  2LGR A;  5E3B A;  2XD7 A;  5HIH A;  5CB5 A;  3Q6Z A;  4R7M A;  5FSV A;  4ZY0 A;  5FSZ A;  3KZW A;  4ZYQ A;  4ZY2 A;  3SIJ A;  2VRI A;  1YD9 A;  1VHU A;  1LCP A;  1LAN A;  2DX6 A;  1ZR3 A;  2EWB A;  4ETK A;  3KR4 A;  3JRU A;  3KR5 A;  2X47 A;  3GQO A;  3GPG A;  4GVW A;  4J5S A;  3V45 A;  3VFQ A;  4ABL A;  3EJF A;  5FSY A;  3ETI A;  3EWQ A;  2FAV A;  4ZX9 A;  1LAP A;  3EWO A;  5FSX A;  3SII A;  4ETJ A;  3PEI A;  5D8N A;  5FSU A;  4D86 A;  3H8F A;  4J5Q A;  1LAM A;  4JLL A;  4KSI A;  1TY8 A;  3T8W A;  4UML A;  1SPV A;  5AIL A;  3GPO A;  1TXZ A;  1HJZ A;  3H8E A;  3H8G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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