5FSXA

Crystal structure of trypanosoma brucei macrodomain in complex with adp
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
249
structure length
233
Chain Sequence
EFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords MACRODOMAIN
publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
source organism Trypanosoma brucei
molecule tags Hydrolase
total genus 79
structure length 233
sequence length 249
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsxA00
1BPNA 4ABKA 1LANA 5FSUA 1TXZA 4GVVA 3KR5A 4ZX8A 3V45A 4GVWA 1NJRA 4R76A 1GYTA 1VHUA 3SIHA 4UMLA 1LAMA 3IJ3A 3EJFA 5AILA 4ETKA 4ABLA 5D8NA 5CB3A 2BFRA 4J4ZA 1ZR5A 2AFCA 3ETIA 3EWPA 5FSXA 1LCPA 4R6TA 4JCAA 3GPQA 3IIDA 4JGKA 4J5QA 4ETJA 4ZYQA 1HJZA 4TU0A 3KZWA 2LGRA 2XD7A 4R7MA 3H8EA 1SPVA 3V2BA 2FXKA 4ZY1A 3EKEA 4ZY0A 2EWBA 4J5SA 1TY8A 3SIJA 3JRUA 4X2TA 2FG1A 4KSIA 4IQYA 4JLLA 5FSYA 3KQXA 2DX6A 3EWOA 3H8FA 3KQZA 3KR4A 4ZX9A 4K3NA 4ZI6A 3GQOA 4J5RA 4ESSA 4ZY2A 4K0CA 2VRIA 3SIIA 5E3BA 3Q71A 2J9AA 3EWRA 2X47A 4D86A 3T8WA 4KYBA 3H8GA 3VFQA 1BPMA 1BLLE 3IIFA 5CB5A 3PEIA 3GPGA 3EWQA 3Q6ZA 1YD9A 3GQEA 3EJGA 5HIHA 5FSVA 4JVVA 5CMSA 3EW5A 2BFQA 1LAPA 1ZR3A 2L8RA 2ACFA 3GPOA 3SIGA 5DUSA 2EEEA 3JZTA 2FAVA 5HOLA 4GUAA 5FSZA 5CBMA
chains in the Genus database with same CATH superfamily
1BPNA 4ABKA 1LANA 2JZFA 5FSUA 1TXZA 4GVVA 3KR5A 4ZX8A 3V45A 4GVWA 1NJRA 4R76A 1GYTA 1VHUA 3SIHA 4UMLA 1LAMA 3IJ3A 3EJFA 5AILA 4ETKA 4ABLA 5D8NA 5CB3A 2BFRA 4J4ZA 1ZR5A 2AFCA 3ETIA 3EWPA 5FSXA 1LCPA 4R6TA 4JCAA 3GPQA 3IIDA 4JGKA 4J5QA 4ETJA 4ZYQA 1HJZA 4TU0A 3KZWA 2LGRA 2XD7A 4R7MA 3H8EA 1SPVA 3V2BA 2FXKA 4ZY1A 3EKEA 4ZY0A 2EWBA 4J5SA 2JZDA 1TY8A 3SIJA 3JRUA 4X2TA 2FG1A 4KSIA 4IQYA 4JLLA 5FSYA 3KQXA 2DX6A 3EWOA 3H8FA 3KQZA 3KR4A 4ZX9A 2RNKA 4K3NA 4ZI6A 3GQOA 4J5RA 4ESSA 4ZY2A 4K0CA 2VRIA 3SIIA 5E3BA 3Q71A 2J9AA 3EWRA 2X47A 4D86A 3T8WA 4KYBA 3H8GA 3VFQA 1BPMA 1BLLE 3IIFA 5CB5A 3PEIA 3GPGA 3EWQA 3Q6ZA 1YD9A 3GQEA 3EJGA 5HIHA 5FSVA 4JVVA 5CMSA 3EW5A 2WCTA 2BFQA 2W2GA 1LAPA 1ZR3A 2L8RA 2ACFA 2KQVA 3GPOA 5DUSA 3SIGA 2EEEA 3JZTA 2JZEA 2FAVA 5HOLA 4GUAA 5FSZA 5CBMA
chains in the Genus database with same CATH topology
1BPNA 4ABKA 1LANA 5FSUA 1TXZA 4GVVA 3KR5A 4ZX8A 3V45A 4GVWA 1NJRA 4R76A 1GYTA 1VHUA 3SIHA 4UMLA 1LAMA 3IJ3A 3EJFA 5AILA 4ETKA 4ABLA 5D8NA 5CB3A 2BFRA 4J4ZA 1ZR5A 2AFCA 3ETIA 3EWPA 5FSXA 1LCPA 4R6TA 4JCAA 3GPQA 3IIDA 4JGKA 4J5QA 4ETJA 4ZYQA 1HJZA 4TU0A 3KZWA 2LGRA 2XD7A 4R7MA 3H8EA 1SPVA 3V2BA 2FXKA 4ZY1A 3EKEA 4ZY0A 2EWBA 4J5SA 1TY8A 3SIJA 3JRUA 4X2TA 2FG1A 4KSIA 4IQYA 4JLLA 5FSYA 3KQXA 2DX6A 3EWOA 3H8FA 3KQZA 3KR4A 4ZX9A 4K3NA 4ZI6A 3GQOA 4J5RA 4ESSA 4ZY2A 4K0CA 2VRIA 3SIIA 5E3BA 3Q71A 2J9AA 3EWRA 2X47A 4D86A 3T8WA 4KYBA 3H8GA 3VFQA 1BPMA 1BLLE 3IIFA 5CB5A 3PEIA 3GPGA 3EWQA 3Q6ZA 1YD9A 3GQEA 3EJGA 5HIHA 5FSVA 4JVVA 5CMSA 3EW5A 2BFQA 1LAPA 1ZR3A 2L8RA 2ACFA 3GPOA 3SIGA 5DUSA 2EEEA 3JZTA 2FAVA 5HOLA 4GUAA 5FSZA 5CBMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BPN A;  4ABK A;  1LAN A;  5FSU A;  1TXZ A;  4GVV A;  3KR5 A;  4ZX8 A;  3V45 A;  4GVW A;  1NJR A;  4R76 A;  1GYT A;  1VHU A;  3SIH A;  4UML A;  1LAM A;  3IJ3 A;  3EJF A;  5AIL A;  4ETK A;  4ABL A;  5D8N A;  5CB3 A;  2BFR A;  4J4Z A;  1ZR5 A;  2AFC A;  3ETI A;  3EWP A;  5FSX A;  1LCP A;  4R6T A;  4JCA A;  3GPQ A;  3IID A;  4JGK A;  4J5Q A;  4ETJ A;  4ZYQ A;  1HJZ A;  4TU0 A;  3KZW A;  2LGR A;  2XD7 A;  4R7M A;  3H8E A;  1SPV A;  3V2B A;  2FXK A;  4ZY1 A;  3EKE A;  4ZY0 A;  2EWB A;  4J5S A;  1TY8 A;  3SIJ A;  3JRU A;  4X2T A;  2FG1 A;  4KSI A;  4IQY A;  4JLL A;  5FSY A;  3KQX A;  2DX6 A;  3EWO A;  3H8F A;  3KQZ A;  3KR4 A;  4ZX9 A;  4K3N A;  4ZI6 A;  3GQO A;  4J5R A;  4ESS A;  4ZY2 A;  4K0C A;  2VRI A;  3SII A;  5E3B A;  3Q71 A;  2J9A A;  3EWR A;  2X47 A;  4D86 A;  3T8W A;  4KYB A;  3H8G A;  3VFQ A;  1BPM A;  1BLL E;  3IIF A;  5CB5 A;  3PEI A;  3GPG A;  3EWQ A;  3Q6Z A;  1YD9 A;  3GQE A;  3EJG A;  5HIH A;  5FSV A;  4JVV A;  5CMS A;  3EW5 A;  2BFQ A;  1LAP A;  1ZR3 A;  2L8R A;  2ACF A;  3GPO A;  3SIG A;  5DUS A;  2EEE A;  3JZT A;  2FAV A;  5HOL A;  4GUA A;  5FSZ A;  5CBM A; 
#chains in the Genus database with same CATH topology
 1BPN A;  4ABK A;  1LAN A;  2JZF A;  5FSU A;  1TXZ A;  4GVV A;  3KR5 A;  4ZX8 A;  3V45 A;  4GVW A;  1NJR A;  4R76 A;  1GYT A;  1VHU A;  3SIH A;  4UML A;  1LAM A;  3IJ3 A;  3EJF A;  5AIL A;  4ETK A;  4ABL A;  5D8N A;  5CB3 A;  2BFR A;  4J4Z A;  1ZR5 A;  2AFC A;  3ETI A;  3EWP A;  5FSX A;  1LCP A;  4R6T A;  4JCA A;  3GPQ A;  3IID A;  4JGK A;  4J5Q A;  4ETJ A;  4ZYQ A;  1HJZ A;  4TU0 A;  3KZW A;  2LGR A;  2XD7 A;  4R7M A;  3H8E A;  1SPV A;  3V2B A;  2FXK A;  4ZY1 A;  3EKE A;  4ZY0 A;  2EWB A;  4J5S A;  2JZD A;  1TY8 A;  3SIJ A;  3JRU A;  4X2T A;  2FG1 A;  4KSI A;  4IQY A;  4JLL A;  5FSY A;  3KQX A;  2DX6 A;  3EWO A;  3H8F A;  3KQZ A;  3KR4 A;  4ZX9 A;  2RNK A;  4K3N A;  4ZI6 A;  3GQO A;  4J5R A;  4ESS A;  4ZY2 A;  4K0C A;  2VRI A;  3SII A;  5E3B A;  3Q71 A;  2J9A A;  3EWR A;  2X47 A;  4D86 A;  3T8W A;  4KYB A;  3H8G A;  3VFQ A;  1BPM A;  1BLL E;  3IIF A;  5CB5 A;  3PEI A;  3GPG A;  3EWQ A;  3Q6Z A;  1YD9 A;  3GQE A;  3EJG A;  5HIH A;  5FSV A;  4JVV A;  5CMS A;  3EW5 A;  2WCT A;  2BFQ A;  2W2G A;  1LAP A;  1ZR3 A;  2L8R A;  2ACF A;  2KQV A;  3GPO A;  5DUS A;  3SIG A;  2EEE A;  3JZT A;  2JZE A;  2FAV A;  5HOL A;  4GUA A;  5FSZ A;  5CBM A; 
#chains in the Genus database with same CATH homology
 1BPN A;  4ABK A;  1LAN A;  5FSU A;  1TXZ A;  4GVV A;  3KR5 A;  4ZX8 A;  3V45 A;  4GVW A;  1NJR A;  4R76 A;  1GYT A;  1VHU A;  3SIH A;  4UML A;  1LAM A;  3IJ3 A;  3EJF A;  5AIL A;  4ETK A;  4ABL A;  5D8N A;  5CB3 A;  2BFR A;  4J4Z A;  1ZR5 A;  2AFC A;  3ETI A;  3EWP A;  5FSX A;  1LCP A;  4R6T A;  4JCA A;  3GPQ A;  3IID A;  4JGK A;  4J5Q A;  4ETJ A;  4ZYQ A;  1HJZ A;  4TU0 A;  3KZW A;  2LGR A;  2XD7 A;  4R7M A;  3H8E A;  1SPV A;  3V2B A;  2FXK A;  4ZY1 A;  3EKE A;  4ZY0 A;  2EWB A;  4J5S A;  1TY8 A;  3SIJ A;  3JRU A;  4X2T A;  2FG1 A;  4KSI A;  4IQY A;  4JLL A;  5FSY A;  3KQX A;  2DX6 A;  3EWO A;  3H8F A;  3KQZ A;  3KR4 A;  4ZX9 A;  4K3N A;  4ZI6 A;  3GQO A;  4J5R A;  4ESS A;  4ZY2 A;  4K0C A;  2VRI A;  3SII A;  5E3B A;  3Q71 A;  2J9A A;  3EWR A;  2X47 A;  4D86 A;  3T8W A;  4KYB A;  3H8G A;  3VFQ A;  1BPM A;  1BLL E;  3IIF A;  5CB5 A;  3PEI A;  3GPG A;  3EWQ A;  3Q6Z A;  1YD9 A;  3GQE A;  3EJG A;  5HIH A;  5FSV A;  4JVV A;  5CMS A;  3EW5 A;  2BFQ A;  1LAP A;  1ZR3 A;  2L8R A;  2ACF A;  3GPO A;  3SIG A;  5DUS A;  2EEE A;  3JZT A;  2FAV A;  5HOL A;  4GUA A;  5FSZ A;  5CBM A; 
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similar chains in the Genus database (?% sequence similarity)
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