5FSXA

Crystal structure of trypanosoma brucei macrodomain in complex with adp
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
249
structure length
233
Chain Sequence
EFVTYSGEESSPTRTRILSAALSPAERAIFDVPIEKWLSIDRSSLSGWKCAVPRPVTIEQLRPVDPSDAILRHIALYRGPVTDLQLDAIVNAANTRCLGGGGVDGAIHRVAGPLLLRECATFNGCQTGECRLTKGYQLPARYVLHTVGPVGERPDMLRKCYRSILSLALKNGLRSIGFCCVSTGVYGYPLLPATRIALGETRKFLEEHGGALDMCCFACFQEDEYKTYEKCVG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proximal Adp-Ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
pubmed doi rcsb
molecule keywords MACRODOMAIN
molecule tags Hydrolase
source organism Trypanosoma brucei
total genus 79
structure length 233
sequence length 249
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5fsxA00
3Q71A 5FSUA 1YD9A 1TY8A 2ACFA 3SIHA 2BFQA 5CB5A 3EW5A 1ZR5A 4IQYA 5FSZA 2AFCA 4ETKA 4TU0A 1SPVA 4ZY1A 2FXKA 4J4ZA 4ZX8A 2J9AA 4ZY0A 2FAVA 4ZX9A 3EWOA 3EWPA 3EJGA 4J5QA 5AILA 4K3NA 5FSXA 4JGKA 4X2TA 5FSYA 3EWRA 3H8GA 1ZR3A 4GVVA 3KR4A 4R7MA 3EKEA 3JZTA 3PEIA 3IIFA 4GVWA 2EWBA 1BPMA 5CMSA 3EJFA 4J5RA 3H8FA 2BFRA 3KR5A 3SIJA 1LAMA 4KYBA 3H8EA 3JRUA 4ZY2A 4ABKA 3GPOA 4K0CA 1HJZA 3EWQA 3GQEA 1BPNA 4JVVA 3Q6ZA 1LCPA 3GPGA 2L8RA 3V45A 4ABLA 4KSIA 3KQZA 4J5SA 5D8NA 3T8WA 4ESSA 4JLLA 3IJ3A 2FG1A 2DX6A 4R6TA 4UMLA 1NJRA 5CBMA 1TXZA 4D86A 3ETIA 4ZYQA 3V2BA 4R76A 1VHUA 4GUAA 4ETJA 2VRIA 5CB3A 4ZI6A 2LGRA 5HIHA 2XD7A 3KZWA 5DUSA 3IIDA 1LAPA 1BLLE 5E3BA 3SIIA 4JCAA 3GQOA 5FSVA 1GYTA 2EEEA 5HOLA 3VFQA 3GPQA 3SIGA 3KQXA 2X47A 1LANA
chains in the Genus database with same CATH superfamily
3Q71A 5FSUA 2WCTA 1YD9A 1TY8A 2ACFA 3SIHA 2BFQA 5CB5A 3EW5A 1ZR5A 4IQYA 5FSZA 2AFCA 4ETKA 4TU0A 1SPVA 4ZY1A 2FXKA 4J4ZA 4ZX8A 2J9AA 4ZY0A 2FAVA 4ZX9A 2JZFA 3EWOA 3EWPA 3EJGA 4J5QA 5AILA 4K3NA 5FSXA 4JGKA 4X2TA 5FSYA 3EWRA 3H8GA 1ZR3A 4GVVA 3KR4A 4R7MA 3EKEA 3JZTA 3PEIA 3IIFA 2JZEA 4GVWA 2EWBA 1BPMA 5CMSA 3EJFA 2W2GA 4J5RA 3H8FA 2JZDA 2BFRA 3KR5A 3SIJA 1LAMA 4KYBA 3H8EA 3JRUA 4ZY2A 4ABKA 3GPOA 4K0CA 1HJZA 3EWQA 3GQEA 1BPNA 4JVVA 3Q6ZA 1LCPA 3GPGA 2L8RA 3V45A 4ABLA 4KSIA 3KQZA 4J5SA 5D8NA 3T8WA 4ESSA 4JLLA 3IJ3A 2FG1A 2DX6A 4R6TA 4UMLA 1NJRA 5CBMA 1TXZA 4D86A 3ETIA 4ZYQA 3V2BA 4R76A 1VHUA 4GUAA 4ETJA 2VRIA 5CB3A 2KQVA 4ZI6A 2LGRA 5HIHA 2XD7A 3KZWA 5DUSA 3IIDA 1LAPA 1BLLE 2RNKA 5E3BA 3SIIA 4JCAA 3GQOA 5FSVA 1GYTA 2EEEA 5HOLA 3VFQA 3GPQA 3SIGA 3KQXA 2X47A 1LANA
chains in the Genus database with same CATH topology
3Q71A 5FSUA 1YD9A 1TY8A 2ACFA 3SIHA 2BFQA 5CB5A 3EW5A 1ZR5A 4IQYA 5FSZA 2AFCA 4ETKA 4TU0A 1SPVA 4ZY1A 2FXKA 4J4ZA 4ZX8A 2J9AA 4ZY0A 2FAVA 4ZX9A 3EWOA 3EWPA 3EJGA 4J5QA 5AILA 4K3NA 5FSXA 4JGKA 4X2TA 5FSYA 3EWRA 3H8GA 1ZR3A 4GVVA 3KR4A 4R7MA 3EKEA 3JZTA 3PEIA 3IIFA 4GVWA 2EWBA 1BPMA 5CMSA 3EJFA 4J5RA 3H8FA 2BFRA 3KR5A 3SIJA 1LAMA 4KYBA 3H8EA 3JRUA 4ZY2A 4ABKA 3GPOA 4K0CA 1HJZA 3EWQA 3GQEA 1BPNA 4JVVA 3Q6ZA 1LCPA 3GPGA 2L8RA 3V45A 4ABLA 4KSIA 3KQZA 4J5SA 5D8NA 3T8WA 4ESSA 4JLLA 3IJ3A 2FG1A 2DX6A 4R6TA 4UMLA 1NJRA 5CBMA 1TXZA 4D86A 3ETIA 4ZYQA 3V2BA 4R76A 1VHUA 4GUAA 4ETJA 2VRIA 5CB3A 4ZI6A 2LGRA 5HIHA 2XD7A 3KZWA 5DUSA 3IIDA 1LAPA 1BLLE 5E3BA 3SIIA 4JCAA 3GQOA 5FSVA 1GYTA 2EEEA 5HOLA 3VFQA 3GPQA 3SIGA 3KQXA 2X47A 1LANA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q71 A;  5FSU A;  1YD9 A;  1TY8 A;  2ACF A;  3SIH A;  2BFQ A;  5CB5 A;  3EW5 A;  1ZR5 A;  4IQY A;  5FSZ A;  2AFC A;  4ETK A;  4TU0 A;  1SPV A;  4ZY1 A;  2FXK A;  4J4Z A;  4ZX8 A;  2J9A A;  4ZY0 A;  2FAV A;  4ZX9 A;  3EWO A;  3EWP A;  3EJG A;  4J5Q A;  5AIL A;  4K3N A;  5FSX A;  4JGK A;  4X2T A;  5FSY A;  3EWR A;  3H8G A;  1ZR3 A;  4GVV A;  3KR4 A;  4R7M A;  3EKE A;  3JZT A;  3PEI A;  3IIF A;  4GVW A;  2EWB A;  1BPM A;  5CMS A;  3EJF A;  4J5R A;  3H8F A;  2BFR A;  3KR5 A;  3SIJ A;  1LAM A;  4KYB A;  3H8E A;  3JRU A;  4ZY2 A;  4ABK A;  3GPO A;  4K0C A;  1HJZ A;  3EWQ A;  3GQE A;  1BPN A;  4JVV A;  3Q6Z A;  1LCP A;  3GPG A;  2L8R A;  3V45 A;  4ABL A;  4KSI A;  3KQZ A;  4J5S A;  5D8N A;  3T8W A;  4ESS A;  4JLL A;  3IJ3 A;  2FG1 A;  2DX6 A;  4R6T A;  4UML A;  1NJR A;  5CBM A;  1TXZ A;  4D86 A;  3ETI A;  4ZYQ A;  3V2B A;  4R76 A;  1VHU A;  4GUA A;  4ETJ A;  2VRI A;  5CB3 A;  4ZI6 A;  2LGR A;  5HIH A;  2XD7 A;  3KZW A;  5DUS A;  3IID A;  1LAP A;  1BLL E;  5E3B A;  3SII A;  4JCA A;  3GQO A;  5FSV A;  1GYT A;  2EEE A;  5HOL A;  3VFQ A;  3GPQ A;  3SIG A;  3KQX A;  2X47 A;  1LAN A; 
#chains in the Genus database with same CATH topology
 3Q71 A;  5FSU A;  2WCT A;  1YD9 A;  1TY8 A;  2ACF A;  3SIH A;  2BFQ A;  5CB5 A;  3EW5 A;  1ZR5 A;  4IQY A;  5FSZ A;  2AFC A;  4ETK A;  4TU0 A;  1SPV A;  4ZY1 A;  2FXK A;  4J4Z A;  4ZX8 A;  2J9A A;  4ZY0 A;  2FAV A;  4ZX9 A;  2JZF A;  3EWO A;  3EWP A;  3EJG A;  4J5Q A;  5AIL A;  4K3N A;  5FSX A;  4JGK A;  4X2T A;  5FSY A;  3EWR A;  3H8G A;  1ZR3 A;  4GVV A;  3KR4 A;  4R7M A;  3EKE A;  3JZT A;  3PEI A;  3IIF A;  2JZE A;  4GVW A;  2EWB A;  1BPM A;  5CMS A;  3EJF A;  2W2G A;  4J5R A;  3H8F A;  2JZD A;  2BFR A;  3KR5 A;  3SIJ A;  1LAM A;  4KYB A;  3H8E A;  3JRU A;  4ZY2 A;  4ABK A;  3GPO A;  4K0C A;  1HJZ A;  3EWQ A;  3GQE A;  1BPN A;  4JVV A;  3Q6Z A;  1LCP A;  3GPG A;  2L8R A;  3V45 A;  4ABL A;  4KSI A;  3KQZ A;  4J5S A;  5D8N A;  3T8W A;  4ESS A;  4JLL A;  3IJ3 A;  2FG1 A;  2DX6 A;  4R6T A;  4UML A;  1NJR A;  5CBM A;  1TXZ A;  4D86 A;  3ETI A;  4ZYQ A;  3V2B A;  4R76 A;  1VHU A;  4GUA A;  4ETJ A;  2VRI A;  5CB3 A;  2KQV A;  4ZI6 A;  2LGR A;  5HIH A;  2XD7 A;  3KZW A;  5DUS A;  3IID A;  1LAP A;  1BLL E;  2RNK A;  5E3B A;  3SII A;  4JCA A;  3GQO A;  5FSV A;  1GYT A;  2EEE A;  5HOL A;  3VFQ A;  3GPQ A;  3SIG A;  3KQX A;  2X47 A;  1LAN A; 
#chains in the Genus database with same CATH homology
 3Q71 A;  5FSU A;  1YD9 A;  1TY8 A;  2ACF A;  3SIH A;  2BFQ A;  5CB5 A;  3EW5 A;  1ZR5 A;  4IQY A;  5FSZ A;  2AFC A;  4ETK A;  4TU0 A;  1SPV A;  4ZY1 A;  2FXK A;  4J4Z A;  4ZX8 A;  2J9A A;  4ZY0 A;  2FAV A;  4ZX9 A;  3EWO A;  3EWP A;  3EJG A;  4J5Q A;  5AIL A;  4K3N A;  5FSX A;  4JGK A;  4X2T A;  5FSY A;  3EWR A;  3H8G A;  1ZR3 A;  4GVV A;  3KR4 A;  4R7M A;  3EKE A;  3JZT A;  3PEI A;  3IIF A;  4GVW A;  2EWB A;  1BPM A;  5CMS A;  3EJF A;  4J5R A;  3H8F A;  2BFR A;  3KR5 A;  3SIJ A;  1LAM A;  4KYB A;  3H8E A;  3JRU A;  4ZY2 A;  4ABK A;  3GPO A;  4K0C A;  1HJZ A;  3EWQ A;  3GQE A;  1BPN A;  4JVV A;  3Q6Z A;  1LCP A;  3GPG A;  2L8R A;  3V45 A;  4ABL A;  4KSI A;  3KQZ A;  4J5S A;  5D8N A;  3T8W A;  4ESS A;  4JLL A;  3IJ3 A;  2FG1 A;  2DX6 A;  4R6T A;  4UML A;  1NJR A;  5CBM A;  1TXZ A;  4D86 A;  3ETI A;  4ZYQ A;  3V2B A;  4R76 A;  1VHU A;  4GUA A;  4ETJ A;  2VRI A;  5CB3 A;  4ZI6 A;  2LGR A;  5HIH A;  2XD7 A;  3KZW A;  5DUS A;  3IID A;  1LAP A;  1BLL E;  5E3B A;  3SII A;  4JCA A;  3GQO A;  5FSV A;  1GYT A;  2EEE A;  5HOL A;  3VFQ A;  3GPQ A;  3SIG A;  3KQX A;  2X47 A;  1LAN A; 
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similar chains in the Genus database (?% sequence similarity)
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