5GREA

Crystal structure of the alpha gamma heterodimer of human idh3 in complex with mg(2+), citrate and adp
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
335
structure length
325
Chain Sequence
VQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQWMIPSEAKESMDKNKMGLKGPLKTPPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
publication title Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
pubmed doi rcsb
source organism Homo sapiens
total genus 106
structure length 325
sequence length 335
ec nomenclature ec 1.1.1.41: Isocitrate dehydrogenase (NAD(+)).
pdb deposition date 2016-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 5greA00
5L58A 1GRPA 3VL3A 1PS6A 5GREA 3WZYA 1GC8A 3VL7A 3VL2A 1XGVA 1GC9A 1CW1A 1PS7A 1W0DA 3TNGA 3US8A 8ICDA 2Y42A 4AJRA 1WPWA 1OSJA 4HCXA 3U9EA 1SJSA 4I3KA 2HI1A 4Y1PA 4AJCA 1OSIA 3LCBC 5K10A 1R8KA 2QFWA 4JA8A 3UDUA 3VMKA 3VMJA 3MASB 3WZXA 4I3LA 3VL6A 4XXVA 1PB3A 3BLVA 1IDDA 3WZWA 4AJAA 5GRFA 1HQSA 5K11A 1XADA 1TYOA 4L04A 1IDMA 3VMLA 5GRLB 5LGEA 1DR8A 1XABA 2DHTA 3TY4A 5I95A 4YB4A 5ICDA 1X0LA 5HN4A 4JQPA 5GRHB 1A05A 2Y40A 1VI1A 5GRIA 1V53A 2QFYA 4UMXA 1HJ6A 1IDCA 4AOUA 5L57A 1T0LA 4ATYA 4L06A 1DR0A 4BNPA 4XS3A 2QFVA 4XRXA 2IV0A 7ICDA 1XACA 4P69C 3AH3A 3FLKA 3VKZA 1PTMA 1V94A 1XKDA 2E0CA 5HN3A 1IKAA 3R8WA 3TY3A 3VL4A 2E5MA 3MAPA 5GRFB 4L03A 9ICDA 4AOVA 1DPZA 3INMA 3FMXX 1AI2A 1IDFA 1LWDA 3WZVA 4AJBA 1V5BA 3MASA 2ZTWA 2Y41A 1GROA 3DMSA 5GREB 2D1CA 2D4VA 3U1HA 1CM7A 1CW7A 5GRLA 2UXRA 5HN6A 5J33A 3MARA 1XAAA 1ZORA 4F7IA 3BLXA 3UDOA 1VLCA 1ISOA 2AYQA 2QFXA 3LXYA 1T09A 2UXQA 4IWHA 1WALA 1YXOA 3BLVB 3ICDA 5I96A 1U7NA 4ICDA 1AI3A 1CW4A 4AJSA 1CNZA 5J34A 1IPDA 1HEXA 2Y3ZA 1P8FA 5HN5A 4WUOA 4UMYA 6ICDA 2G4OA 5GRIB 5DE1A 5J32A 1YCOA 4AJ3A 1BL5A 4KZOA 3UF6A 1G2UA 1IDEA 4AOYA 5GRHA 3ASJA 3BLXB 1PB1A 3TSNA
chains in the Genus database with same CATH superfamily
5L58A 1GRPA 3VL3A 1PS6A 5GREA 3WZYA 1GC8A 3VL7A 3VL2A 1XGVA 1GC9A 1CW1A 1PS7A 1W0DA 3TNGA 3US8A 8ICDA 2Y42A 4AJRA 1WPWA 1OSJA 4HCXA 3U9EA 1SJSA 4I3KA 2HI1A 4Y1PA 4AJCA 1OSIA 3LCBC 5K10A 1R8KA 2QFWA 4JA8A 3UDUA 3VMKA 3VMJA 3MASB 3WZXA 4I3LA 3VL6A 4XXVA 1PB3A 3BLVA 1IDDA 3WZWA 4AJAA 5GRFA 1HQSA 5K11A 1XADA 1TYOA 4L04A 1IDMA 3VMLA 5GRLB 5LGEA 1DR8A 1XABA 2DHTA 3TY4A 5I95A 4YB4A 5ICDA 1X0LA 5HN4A 4JQPA 5GRHB 1A05A 2Y40A 1VI1A 5GRIA 1V53A 2QFYA 4UMXA 1HJ6A 1IDCA 4AOUA 5L57A 1T0LA 4ATYA 4L06A 1DR0A 4BNPA 4XS3A 2QFVA 4XRXA 2IV0A 7ICDA 1XACA 4P69C 3AH3A 3FLKA 3VKZA 1PTMA 1V94A 1XKDA 2E0CA 5HN3A 1IKAA 3R8WA 3TY3A 3VL4A 2E5MA 3MAPA 5GRFB 4L03A 9ICDA 4AOVA 1DPZA 3INMA 3FMXX 1AI2A 1IDFA 1LWDA 3WZVA 4AJBA 1V5BA 3MASA 2ZTWA 2Y41A 1GROA 3DMSA 5GREB 2D1CA 2D4VA 3U1HA 1CM7A 1CW7A 5GRLA 2UXRA 5HN6A 5J33A 3MARA 1XAAA 1ZORA 4F7IA 3BLXA 3UDOA 1VLCA 1ISOA 2AYQA 2QFXA 3LXYA 1T09A 2UXQA 4IWHA 1WALA 1YXOA 3BLVB 3ICDA 5I96A 1U7NA 4ICDA 1AI3A 1CW4A 4AJSA 1CNZA 5J34A 1IPDA 1HEXA 2Y3ZA 1P8FA 5HN5A 4WUOA 4UMYA 6ICDA 2G4OA 5GRIB 5DE1A 5J32A 1YCOA 4AJ3A 1BL5A 4KZOA 3UF6A 1G2UA 1IDEA 4AOYA 5GRHA 3ASJA 3BLXB 1PB1A 3TSNA
chains in the Genus database with same CATH topology
5L58A 1GRPA 3VL3A 1PS6A 5GREA 3WZYA 1GC8A 3VL7A 3VL2A 1XGVA 1GC9A 1CW1A 1PS7A 1W0DA 3TNGA 3US8A 8ICDA 2Y42A 4AJRA 1WPWA 1OSJA 4HCXA 3U9EA 1SJSA 4I3KA 2HI1A 4Y1PA 4AJCA 1OSIA 3LCBC 5K10A 1R8KA 2QFWA 4JA8A 3UDUA 3VMKA 3VMJA 3MASB 3WZXA 4I3LA 3VL6A 4XXVA 1PB3A 3BLVA 1IDDA 3WZWA 4AJAA 5GRFA 1HQSA 5K11A 1XADA 1TYOA 4L04A 1IDMA 3VMLA 5GRLB 5LGEA 1DR8A 1XABA 2DHTA 3TY4A 5I95A 4YB4A 5ICDA 1X0LA 5HN4A 4JQPA 5GRHB 1A05A 2Y40A 1VI1A 5GRIA 1V53A 2QFYA 4UMXA 1HJ6A 1IDCA 4AOUA 5L57A 1T0LA 4ATYA 4L06A 1DR0A 4BNPA 4XS3A 2QFVA 4XRXA 2IV0A 7ICDA 1XACA 4P69C 3AH3A 3FLKA 3VKZA 1PTMA 1V94A 1XKDA 2E0CA 5HN3A 1IKAA 3R8WA 3TY3A 3VL4A 2E5MA 3MAPA 5GRFB 4L03A 9ICDA 4AOVA 1DPZA 3INMA 3FMXX 1AI2A 1IDFA 1LWDA 3WZVA 4AJBA 1V5BA 3MASA 2ZTWA 2Y41A 1GROA 3DMSA 5GREB 2D1CA 2D4VA 3U1HA 1CM7A 1CW7A 5GRLA 2UXRA 5HN6A 5J33A 3MARA 1XAAA 1ZORA 4F7IA 3BLXA 3UDOA 1VLCA 1ISOA 2AYQA 2QFXA 3LXYA 1T09A 2UXQA 4IWHA 1WALA 1YXOA 3BLVB 3ICDA 5I96A 1U7NA 4ICDA 1AI3A 1CW4A 4AJSA 1CNZA 5J34A 1IPDA 1HEXA 2Y3ZA 1P8FA 5HN5A 4WUOA 4UMYA 6ICDA 2G4OA 5GRIB 5DE1A 5J32A 1YCOA 4AJ3A 1BL5A 4KZOA 3UF6A 1G2UA 1IDEA 4AOYA 5GRHA 3ASJA 3BLXB 1PB1A 3TSNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L58 A;  1GRP A;  3VL3 A;  1PS6 A;  5GRE A;  3WZY A;  1GC8 A;  3VL7 A;  3VL2 A;  1XGV A;  1GC9 A;  1CW1 A;  1PS7 A;  1W0D A;  3TNG A;  3US8 A;  8ICD A;  2Y42 A;  4AJR A;  1WPW A;  1OSJ A;  4HCX A;  3U9E A;  1SJS A;  4I3K A;  2HI1 A;  4Y1P A;  4AJC A;  1OSI A;  3LCB C;  5K10 A;  1R8K A;  2QFW A;  4JA8 A;  3UDU A;  3VMK A;  3VMJ A;  3MAS B;  3WZX A;  4I3L A;  3VL6 A;  4XXV A;  1PB3 A;  3BLV A;  1IDD A;  3WZW A;  4AJA A;  5GRF A;  1HQS A;  5K11 A;  1XAD A;  1TYO A;  4L04 A;  1IDM A;  3VML A;  5GRL B;  5LGE A;  1DR8 A;  1XAB A;  2DHT A;  3TY4 A;  5I95 A;  4YB4 A;  5ICD A;  1X0L A;  5HN4 A;  4JQP A;  5GRH B;  1A05 A;  2Y40 A;  1VI1 A;  5GRI A;  1V53 A;  2QFY A;  4UMX A;  1HJ6 A;  1IDC A;  4AOU A;  5L57 A;  1T0L A;  4ATY A;  4L06 A;  1DR0 A;  4BNP A;  4XS3 A;  2QFV A;  4XRX A;  2IV0 A;  7ICD A;  1XAC A;  4P69 C;  3AH3 A;  3FLK A;  3VKZ A;  1PTM A;  1V94 A;  1XKD A;  2E0C A;  5HN3 A;  1IKA A;  3R8W A;  3TY3 A;  3VL4 A;  2E5M A;  3MAP A;  5GRF B;  4L03 A;  9ICD A;  4AOV A;  1DPZ A;  3INM A;  3FMX X;  1AI2 A;  1IDF A;  1LWD A;  3WZV A;  4AJB A;  1V5B A;  3MAS A;  2ZTW A;  2Y41 A;  1GRO A;  3DMS A;  5GRE B;  2D1C A;  2D4V A;  3U1H A;  1CM7 A;  1CW7 A;  5GRL A;  2UXR A;  5HN6 A;  5J33 A;  3MAR A;  1XAA A;  1ZOR A;  4F7I A;  3BLX A;  3UDO A;  1VLC A;  1ISO A;  2AYQ A;  2QFX A;  3LXY A;  1T09 A;  2UXQ A;  4IWH A;  1WAL A;  1YXO A;  3BLV B;  3ICD A;  5I96 A;  1U7N A;  4ICD A;  1AI3 A;  1CW4 A;  4AJS A;  1CNZ A;  5J34 A;  1IPD A;  1HEX A;  2Y3Z A;  1P8F A;  5HN5 A;  4WUO A;  4UMY A;  6ICD A;  2G4O A;  5GRI B;  5DE1 A;  5J32 A;  1YCO A;  4AJ3 A;  1BL5 A;  4KZO A;  3UF6 A;  1G2U A;  1IDE A;  4AOY A;  5GRH A;  3ASJ A;  3BLX B;  1PB1 A;  3TSN A; 
#chains in the Genus database with same CATH topology
 5L58 A;  1GRP A;  3VL3 A;  1PS6 A;  5GRE A;  3WZY A;  1GC8 A;  3VL7 A;  3VL2 A;  1XGV A;  1GC9 A;  1CW1 A;  1PS7 A;  1W0D A;  3TNG A;  3US8 A;  8ICD A;  2Y42 A;  4AJR A;  1WPW A;  1OSJ A;  4HCX A;  3U9E A;  1SJS A;  4I3K A;  2HI1 A;  4Y1P A;  4AJC A;  1OSI A;  3LCB C;  5K10 A;  1R8K A;  2QFW A;  4JA8 A;  3UDU A;  3VMK A;  3VMJ A;  3MAS B;  3WZX A;  4I3L A;  3VL6 A;  4XXV A;  1PB3 A;  3BLV A;  1IDD A;  3WZW A;  4AJA A;  5GRF A;  1HQS A;  5K11 A;  1XAD A;  1TYO A;  4L04 A;  1IDM A;  3VML A;  5GRL B;  5LGE A;  1DR8 A;  1XAB A;  2DHT A;  3TY4 A;  5I95 A;  4YB4 A;  5ICD A;  1X0L A;  5HN4 A;  4JQP A;  5GRH B;  1A05 A;  2Y40 A;  1VI1 A;  5GRI A;  1V53 A;  2QFY A;  4UMX A;  1HJ6 A;  1IDC A;  4AOU A;  5L57 A;  1T0L A;  4ATY A;  4L06 A;  1DR0 A;  4BNP A;  4XS3 A;  2QFV A;  4XRX A;  2IV0 A;  7ICD A;  1XAC A;  4P69 C;  3AH3 A;  3FLK A;  3VKZ A;  1PTM A;  1V94 A;  1XKD A;  2E0C A;  5HN3 A;  1IKA A;  3R8W A;  3TY3 A;  3VL4 A;  2E5M A;  3MAP A;  5GRF B;  4L03 A;  9ICD A;  4AOV A;  1DPZ A;  3INM A;  3FMX X;  1AI2 A;  1IDF A;  1LWD A;  3WZV A;  4AJB A;  1V5B A;  3MAS A;  2ZTW A;  2Y41 A;  1GRO A;  3DMS A;  5GRE B;  2D1C A;  2D4V A;  3U1H A;  1CM7 A;  1CW7 A;  5GRL A;  2UXR A;  5HN6 A;  5J33 A;  3MAR A;  1XAA A;  1ZOR A;  4F7I A;  3BLX A;  3UDO A;  1VLC A;  1ISO A;  2AYQ A;  2QFX A;  3LXY A;  1T09 A;  2UXQ A;  4IWH A;  1WAL A;  1YXO A;  3BLV B;  3ICD A;  5I96 A;  1U7N A;  4ICD A;  1AI3 A;  1CW4 A;  4AJS A;  1CNZ A;  5J34 A;  1IPD A;  1HEX A;  2Y3Z A;  1P8F A;  5HN5 A;  4WUO A;  4UMY A;  6ICD A;  2G4O A;  5GRI B;  5DE1 A;  5J32 A;  1YCO A;  4AJ3 A;  1BL5 A;  4KZO A;  3UF6 A;  1G2U A;  1IDE A;  4AOY A;  5GRH A;  3ASJ A;  3BLX B;  1PB1 A;  3TSN A; 
#chains in the Genus database with same CATH homology
 5L58 A;  1GRP A;  3VL3 A;  1PS6 A;  5GRE A;  3WZY A;  1GC8 A;  3VL7 A;  3VL2 A;  1XGV A;  1GC9 A;  1CW1 A;  1PS7 A;  1W0D A;  3TNG A;  3US8 A;  8ICD A;  2Y42 A;  4AJR A;  1WPW A;  1OSJ A;  4HCX A;  3U9E A;  1SJS A;  4I3K A;  2HI1 A;  4Y1P A;  4AJC A;  1OSI A;  3LCB C;  5K10 A;  1R8K A;  2QFW A;  4JA8 A;  3UDU A;  3VMK A;  3VMJ A;  3MAS B;  3WZX A;  4I3L A;  3VL6 A;  4XXV A;  1PB3 A;  3BLV A;  1IDD A;  3WZW A;  4AJA A;  5GRF A;  1HQS A;  5K11 A;  1XAD A;  1TYO A;  4L04 A;  1IDM A;  3VML A;  5GRL B;  5LGE A;  1DR8 A;  1XAB A;  2DHT A;  3TY4 A;  5I95 A;  4YB4 A;  5ICD A;  1X0L A;  5HN4 A;  4JQP A;  5GRH B;  1A05 A;  2Y40 A;  1VI1 A;  5GRI A;  1V53 A;  2QFY A;  4UMX A;  1HJ6 A;  1IDC A;  4AOU A;  5L57 A;  1T0L A;  4ATY A;  4L06 A;  1DR0 A;  4BNP A;  4XS3 A;  2QFV A;  4XRX A;  2IV0 A;  7ICD A;  1XAC A;  4P69 C;  3AH3 A;  3FLK A;  3VKZ A;  1PTM A;  1V94 A;  1XKD A;  2E0C A;  5HN3 A;  1IKA A;  3R8W A;  3TY3 A;  3VL4 A;  2E5M A;  3MAP A;  5GRF B;  4L03 A;  9ICD A;  4AOV A;  1DPZ A;  3INM A;  3FMX X;  1AI2 A;  1IDF A;  1LWD A;  3WZV A;  4AJB A;  1V5B A;  3MAS A;  2ZTW A;  2Y41 A;  1GRO A;  3DMS A;  5GRE B;  2D1C A;  2D4V A;  3U1H A;  1CM7 A;  1CW7 A;  5GRL A;  2UXR A;  5HN6 A;  5J33 A;  3MAR A;  1XAA A;  1ZOR A;  4F7I A;  3BLX A;  3UDO A;  1VLC A;  1ISO A;  2AYQ A;  2QFX A;  3LXY A;  1T09 A;  2UXQ A;  4IWH A;  1WAL A;  1YXO A;  3BLV B;  3ICD A;  5I96 A;  1U7N A;  4ICD A;  1AI3 A;  1CW4 A;  4AJS A;  1CNZ A;  5J34 A;  1IPD A;  1HEX A;  2Y3Z A;  1P8F A;  5HN5 A;  4WUO A;  4UMY A;  6ICD A;  2G4O A;  5GRI B;  5DE1 A;  5J32 A;  1YCO A;  4AJ3 A;  1BL5 A;  4KZO A;  3UF6 A;  1G2U A;  1IDE A;  4AOY A;  5GRH A;  3ASJ A;  3BLX B;  1PB1 A;  3TSN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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