5GRIB

Crystal structure of the alpha gamma heterodimer of human idh3 in complex with mg(2+) and citrate
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
335
structure length
335
Chain Sequence
RHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIRVING
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
publication title Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
pubmed doi rcsb
source organism Homo sapiens
total genus 117
structure length 335
sequence length 335
ec nomenclature
pdb deposition date 2016-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 5griB00
5ICDA 1DR0A 1OSJA 2E0CA 3FLKA 3WZYA 4UMXA 5GRFB 3LXYA 3WZVA 3MAPA 1HJ6A 5GRLB 1PB1A 4Y1PA 1W0DA 1IDMA 3VMKA 3VL7A 3UF6A 1HQSA 4I3KA 1XABA 3VKZA 2HI1A 4JQPA 4AJSA 5HN3A 4L06A 5L58A 2QFWA 4WUOA 3TSNA 4AJAA 1T0LA 4XXVA 2AYQA 4P69C 5GRHB 3AH3A 1LWDA 3VL2A 1V94A 1DR8A 2G4OA 7ICDA 4YB4A 3U9EA 4XRXA 4AJRA 5GRIA 1PTMA 4AJBA 3VL4A 3MASA 2D1CA 4AJ3A 4ICDA 1CM7A 1OSIA 1WPWA 2UXRA 5HN6A 3VL3A 4IWHA 1G2UA 3VL6A 1DPZA 1GC9A 1YXOA 4AOUA 1ISOA 5DE1A 3VMJA 2D4VA 3TY3A 3WZXA 4ATYA 4KZOA 3BLVA 5J33A 1WALA 2UXQA 3MASB 4L03A 2Y3ZA 3INMA 3U1HA 3FMXX 2Y40A 4I3LA 1GROA 1IKAA 3TY4A 2E5MA 1A05A 4JA8A 1PB3A 1PS7A 3ICDA 4BNPA 1CW1A 3MARA 5J32A 1U7NA 5K10A 5LGEA 1TYOA 1R8KA 3BLVB 4AOVA 1CW7A 1CNZA 1T09A 2Y42A 4AOYA 1VLCA 5L57A 9ICDA 1X0LA 1IDCA 1IDDA 1VI1A 1XAAA 5GRIB 1V5BA 3LCBC 5J34A 1IDEA 1XACA 1YCOA 1CW4A 1GRPA 5I96A 1PS6A 8ICDA 3US8A 1IDFA 4UMYA 1ZORA 1XKDA 4AJCA 5I95A 4F7IA 5HN5A 5GRHA 1V53A 2QFYA 1HEXA 1BL5A 3UDUA 5GREA 3BLXA 4L04A 3VMLA 3R8WA 1P8FA 3UDOA 3TNGA 2IV0A 1SJSA 3WZWA 2QFVA 3ASJA 5K11A 5GRFA 5HN4A 2QFXA 2DHTA 5GRLA 1AI3A 1XGVA 3DMSA 2Y41A 2ZTWA 4HCXA 5GREB 3BLXB 1GC8A 6ICDA 1XADA 4XS3A 1AI2A 1IPDA
chains in the Genus database with same CATH superfamily
5ICDA 1DR0A 1OSJA 2E0CA 3FLKA 3WZYA 4UMXA 5GRFB 3LXYA 3WZVA 3MAPA 1HJ6A 5GRLB 1PB1A 4Y1PA 1W0DA 1IDMA 3VMKA 3VL7A 3UF6A 1HQSA 4I3KA 1XABA 3VKZA 2HI1A 4JQPA 4AJSA 5HN3A 4L06A 5L58A 2QFWA 4WUOA 3TSNA 4AJAA 1T0LA 4XXVA 2AYQA 4P69C 5GRHB 3AH3A 1LWDA 3VL2A 1V94A 1DR8A 2G4OA 7ICDA 4YB4A 3U9EA 4XRXA 4AJRA 5GRIA 1PTMA 4AJBA 3VL4A 3MASA 2D1CA 4AJ3A 4ICDA 1CM7A 1OSIA 1WPWA 2UXRA 5HN6A 3VL3A 4IWHA 1G2UA 3VL6A 1DPZA 1GC9A 1YXOA 4AOUA 1ISOA 5DE1A 3VMJA 2D4VA 3TY3A 3WZXA 4ATYA 4KZOA 3BLVA 5J33A 1WALA 2UXQA 3MASB 4L03A 2Y3ZA 3INMA 3U1HA 3FMXX 2Y40A 4I3LA 1GROA 1IKAA 3TY4A 2E5MA 1A05A 4JA8A 1PB3A 1PS7A 3ICDA 4BNPA 1CW1A 3MARA 5J32A 1U7NA 5K10A 5LGEA 1TYOA 1R8KA 3BLVB 4AOVA 1CW7A 1CNZA 1T09A 2Y42A 4AOYA 1VLCA 5L57A 9ICDA 1X0LA 1IDCA 1IDDA 1VI1A 1XAAA 5GRIB 1V5BA 3LCBC 5J34A 1IDEA 1XACA 1YCOA 1CW4A 1GRPA 5I96A 1PS6A 8ICDA 3US8A 1IDFA 4UMYA 1ZORA 1XKDA 4AJCA 5I95A 4F7IA 5HN5A 5GRHA 1V53A 2QFYA 1HEXA 1BL5A 3UDUA 5GREA 3BLXA 4L04A 3VMLA 3R8WA 1P8FA 3UDOA 3TNGA 2IV0A 1SJSA 3WZWA 2QFVA 3ASJA 5K11A 5GRFA 5HN4A 2QFXA 2DHTA 5GRLA 1AI3A 1XGVA 3DMSA 2Y41A 2ZTWA 4HCXA 5GREB 3BLXB 1GC8A 6ICDA 1XADA 4XS3A 1AI2A 1IPDA
chains in the Genus database with same CATH topology
5ICDA 1DR0A 1OSJA 2E0CA 3FLKA 3WZYA 4UMXA 5GRFB 3LXYA 3WZVA 3MAPA 1HJ6A 5GRLB 1PB1A 4Y1PA 1W0DA 1IDMA 3VMKA 3VL7A 3UF6A 1HQSA 4I3KA 1XABA 3VKZA 2HI1A 4JQPA 4AJSA 5HN3A 4L06A 5L58A 2QFWA 4WUOA 3TSNA 4AJAA 1T0LA 4XXVA 2AYQA 4P69C 5GRHB 3AH3A 1LWDA 3VL2A 1V94A 1DR8A 2G4OA 7ICDA 4YB4A 3U9EA 4XRXA 4AJRA 5GRIA 1PTMA 4AJBA 3VL4A 3MASA 2D1CA 4AJ3A 4ICDA 1CM7A 1OSIA 1WPWA 2UXRA 5HN6A 3VL3A 4IWHA 1G2UA 3VL6A 1DPZA 1GC9A 1YXOA 4AOUA 1ISOA 5DE1A 3VMJA 2D4VA 3TY3A 3WZXA 4ATYA 4KZOA 3BLVA 5J33A 1WALA 2UXQA 3MASB 4L03A 2Y3ZA 3INMA 3U1HA 3FMXX 2Y40A 4I3LA 1GROA 1IKAA 3TY4A 2E5MA 1A05A 4JA8A 1PB3A 1PS7A 3ICDA 4BNPA 1CW1A 3MARA 5J32A 1U7NA 5K10A 5LGEA 1TYOA 1R8KA 3BLVB 4AOVA 1CW7A 1CNZA 1T09A 2Y42A 4AOYA 1VLCA 5L57A 9ICDA 1X0LA 1IDCA 1IDDA 1VI1A 1XAAA 5GRIB 1V5BA 3LCBC 5J34A 1IDEA 1XACA 1YCOA 1CW4A 1GRPA 5I96A 1PS6A 8ICDA 3US8A 1IDFA 4UMYA 1ZORA 1XKDA 4AJCA 5I95A 4F7IA 5HN5A 5GRHA 1V53A 2QFYA 1HEXA 1BL5A 3UDUA 5GREA 3BLXA 4L04A 3VMLA 3R8WA 1P8FA 3UDOA 3TNGA 2IV0A 1SJSA 3WZWA 2QFVA 3ASJA 5K11A 5GRFA 5HN4A 2QFXA 2DHTA 5GRLA 1AI3A 1XGVA 3DMSA 2Y41A 2ZTWA 4HCXA 5GREB 3BLXB 1GC8A 6ICDA 1XADA 4XS3A 1AI2A 1IPDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ICD A;  1DR0 A;  1OSJ A;  2E0C A;  3FLK A;  3WZY A;  4UMX A;  5GRF B;  3LXY A;  3WZV A;  3MAP A;  1HJ6 A;  5GRL B;  1PB1 A;  4Y1P A;  1W0D A;  1IDM A;  3VMK A;  3VL7 A;  3UF6 A;  1HQS A;  4I3K A;  1XAB A;  3VKZ A;  2HI1 A;  4JQP A;  4AJS A;  5HN3 A;  4L06 A;  5L58 A;  2QFW A;  4WUO A;  3TSN A;  4AJA A;  1T0L A;  4XXV A;  2AYQ A;  4P69 C;  5GRH B;  3AH3 A;  1LWD A;  3VL2 A;  1V94 A;  1DR8 A;  2G4O A;  7ICD A;  4YB4 A;  3U9E A;  4XRX A;  4AJR A;  5GRI A;  1PTM A;  4AJB A;  3VL4 A;  3MAS A;  2D1C A;  4AJ3 A;  4ICD A;  1CM7 A;  1OSI A;  1WPW A;  2UXR A;  5HN6 A;  3VL3 A;  4IWH A;  1G2U A;  3VL6 A;  1DPZ A;  1GC9 A;  1YXO A;  4AOU A;  1ISO A;  5DE1 A;  3VMJ A;  2D4V A;  3TY3 A;  3WZX A;  4ATY A;  4KZO A;  3BLV A;  5J33 A;  1WAL A;  2UXQ A;  3MAS B;  4L03 A;  2Y3Z A;  3INM A;  3U1H A;  3FMX X;  2Y40 A;  4I3L A;  1GRO A;  1IKA A;  3TY4 A;  2E5M A;  1A05 A;  4JA8 A;  1PB3 A;  1PS7 A;  3ICD A;  4BNP A;  1CW1 A;  3MAR A;  5J32 A;  1U7N A;  5K10 A;  5LGE A;  1TYO A;  1R8K A;  3BLV B;  4AOV A;  1CW7 A;  1CNZ A;  1T09 A;  2Y42 A;  4AOY A;  1VLC A;  5L57 A;  9ICD A;  1X0L A;  1IDC A;  1IDD A;  1VI1 A;  1XAA A;  5GRI B;  1V5B A;  3LCB C;  5J34 A;  1IDE A;  1XAC A;  1YCO A;  1CW4 A;  1GRP A;  5I96 A;  1PS6 A;  8ICD A;  3US8 A;  1IDF A;  4UMY A;  1ZOR A;  1XKD A;  4AJC A;  5I95 A;  4F7I A;  5HN5 A;  5GRH A;  1V53 A;  2QFY A;  1HEX A;  1BL5 A;  3UDU A;  5GRE A;  3BLX A;  4L04 A;  3VML A;  3R8W A;  1P8F A;  3UDO A;  3TNG A;  2IV0 A;  1SJS A;  3WZW A;  2QFV A;  3ASJ A;  5K11 A;  5GRF A;  5HN4 A;  2QFX A;  2DHT A;  5GRL A;  1AI3 A;  1XGV A;  3DMS A;  2Y41 A;  2ZTW A;  4HCX A;  5GRE B;  3BLX B;  1GC8 A;  6ICD A;  1XAD A;  4XS3 A;  1AI2 A;  1IPD A; 
#chains in the Genus database with same CATH topology
 5ICD A;  1DR0 A;  1OSJ A;  2E0C A;  3FLK A;  3WZY A;  4UMX A;  5GRF B;  3LXY A;  3WZV A;  3MAP A;  1HJ6 A;  5GRL B;  1PB1 A;  4Y1P A;  1W0D A;  1IDM A;  3VMK A;  3VL7 A;  3UF6 A;  1HQS A;  4I3K A;  1XAB A;  3VKZ A;  2HI1 A;  4JQP A;  4AJS A;  5HN3 A;  4L06 A;  5L58 A;  2QFW A;  4WUO A;  3TSN A;  4AJA A;  1T0L A;  4XXV A;  2AYQ A;  4P69 C;  5GRH B;  3AH3 A;  1LWD A;  3VL2 A;  1V94 A;  1DR8 A;  2G4O A;  7ICD A;  4YB4 A;  3U9E A;  4XRX A;  4AJR A;  5GRI A;  1PTM A;  4AJB A;  3VL4 A;  3MAS A;  2D1C A;  4AJ3 A;  4ICD A;  1CM7 A;  1OSI A;  1WPW A;  2UXR A;  5HN6 A;  3VL3 A;  4IWH A;  1G2U A;  3VL6 A;  1DPZ A;  1GC9 A;  1YXO A;  4AOU A;  1ISO A;  5DE1 A;  3VMJ A;  2D4V A;  3TY3 A;  3WZX A;  4ATY A;  4KZO A;  3BLV A;  5J33 A;  1WAL A;  2UXQ A;  3MAS B;  4L03 A;  2Y3Z A;  3INM A;  3U1H A;  3FMX X;  2Y40 A;  4I3L A;  1GRO A;  1IKA A;  3TY4 A;  2E5M A;  1A05 A;  4JA8 A;  1PB3 A;  1PS7 A;  3ICD A;  4BNP A;  1CW1 A;  3MAR A;  5J32 A;  1U7N A;  5K10 A;  5LGE A;  1TYO A;  1R8K A;  3BLV B;  4AOV A;  1CW7 A;  1CNZ A;  1T09 A;  2Y42 A;  4AOY A;  1VLC A;  5L57 A;  9ICD A;  1X0L A;  1IDC A;  1IDD A;  1VI1 A;  1XAA A;  5GRI B;  1V5B A;  3LCB C;  5J34 A;  1IDE A;  1XAC A;  1YCO A;  1CW4 A;  1GRP A;  5I96 A;  1PS6 A;  8ICD A;  3US8 A;  1IDF A;  4UMY A;  1ZOR A;  1XKD A;  4AJC A;  5I95 A;  4F7I A;  5HN5 A;  5GRH A;  1V53 A;  2QFY A;  1HEX A;  1BL5 A;  3UDU A;  5GRE A;  3BLX A;  4L04 A;  3VML A;  3R8W A;  1P8F A;  3UDO A;  3TNG A;  2IV0 A;  1SJS A;  3WZW A;  2QFV A;  3ASJ A;  5K11 A;  5GRF A;  5HN4 A;  2QFX A;  2DHT A;  5GRL A;  1AI3 A;  1XGV A;  3DMS A;  2Y41 A;  2ZTW A;  4HCX A;  5GRE B;  3BLX B;  1GC8 A;  6ICD A;  1XAD A;  4XS3 A;  1AI2 A;  1IPD A; 
#chains in the Genus database with same CATH homology
 5ICD A;  1DR0 A;  1OSJ A;  2E0C A;  3FLK A;  3WZY A;  4UMX A;  5GRF B;  3LXY A;  3WZV A;  3MAP A;  1HJ6 A;  5GRL B;  1PB1 A;  4Y1P A;  1W0D A;  1IDM A;  3VMK A;  3VL7 A;  3UF6 A;  1HQS A;  4I3K A;  1XAB A;  3VKZ A;  2HI1 A;  4JQP A;  4AJS A;  5HN3 A;  4L06 A;  5L58 A;  2QFW A;  4WUO A;  3TSN A;  4AJA A;  1T0L A;  4XXV A;  2AYQ A;  4P69 C;  5GRH B;  3AH3 A;  1LWD A;  3VL2 A;  1V94 A;  1DR8 A;  2G4O A;  7ICD A;  4YB4 A;  3U9E A;  4XRX A;  4AJR A;  5GRI A;  1PTM A;  4AJB A;  3VL4 A;  3MAS A;  2D1C A;  4AJ3 A;  4ICD A;  1CM7 A;  1OSI A;  1WPW A;  2UXR A;  5HN6 A;  3VL3 A;  4IWH A;  1G2U A;  3VL6 A;  1DPZ A;  1GC9 A;  1YXO A;  4AOU A;  1ISO A;  5DE1 A;  3VMJ A;  2D4V A;  3TY3 A;  3WZX A;  4ATY A;  4KZO A;  3BLV A;  5J33 A;  1WAL A;  2UXQ A;  3MAS B;  4L03 A;  2Y3Z A;  3INM A;  3U1H A;  3FMX X;  2Y40 A;  4I3L A;  1GRO A;  1IKA A;  3TY4 A;  2E5M A;  1A05 A;  4JA8 A;  1PB3 A;  1PS7 A;  3ICD A;  4BNP A;  1CW1 A;  3MAR A;  5J32 A;  1U7N A;  5K10 A;  5LGE A;  1TYO A;  1R8K A;  3BLV B;  4AOV A;  1CW7 A;  1CNZ A;  1T09 A;  2Y42 A;  4AOY A;  1VLC A;  5L57 A;  9ICD A;  1X0L A;  1IDC A;  1IDD A;  1VI1 A;  1XAA A;  5GRI B;  1V5B A;  3LCB C;  5J34 A;  1IDE A;  1XAC A;  1YCO A;  1CW4 A;  1GRP A;  5I96 A;  1PS6 A;  8ICD A;  3US8 A;  1IDF A;  4UMY A;  1ZOR A;  1XKD A;  4AJC A;  5I95 A;  4F7I A;  5HN5 A;  5GRH A;  1V53 A;  2QFY A;  1HEX A;  1BL5 A;  3UDU A;  5GRE A;  3BLX A;  4L04 A;  3VML A;  3R8W A;  1P8F A;  3UDO A;  3TNG A;  2IV0 A;  1SJS A;  3WZW A;  2QFV A;  3ASJ A;  5K11 A;  5GRF A;  5HN4 A;  2QFX A;  2DHT A;  5GRL A;  1AI3 A;  1XGV A;  3DMS A;  2Y41 A;  2ZTW A;  4HCX A;  5GRE B;  3BLX B;  1GC8 A;  6ICD A;  1XAD A;  4XS3 A;  1AI2 A;  1IPD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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