5HI3A

Binding site elucidation and structure guided design of macrocyclic il-17a antagonists
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
110
structure length
100
Chain Sequence
VMVNLNIHNNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRRENSFRLEKILVSVGCTCVTPIVHHV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system/inhibitor
molecule keywords Interleukin-17A
publication title Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
pubmed doi rcsb
source organism Homo sapiens
total genus 13
structure length 100
sequence length 110
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF06083 IL17 Interleukin-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 5hi3A01
4KZNA 5HK5E 2GOOA 2GH0C 4WPBA 5HI4A 1BMPA 1SG1A 4N1DA 4UI2B 3P9WA 1TZIV 3QB4A 5BQEB 4HSAA 3MJGA 2B0UA 4UHYA 5BQEA 5HHXA 2R53A 4UI0A 4HR9A 5F3BC 1MKKA 1ES7A 2ASKA 4MIDA 1CZ8V 5HHDA 5BQ8B 1BETA 2FJGV 2IFGE 1XWDB 2QJBA 2H64A 2P6AA 1SGFB 3MJKA 1FZVA 1VPFA 1BNDB 2TGIA 3S1BV 1JPYA 1BNDA 4EAXA 5F3HI 3EVSB 1REWA 2PJYA 1FL7B 4YCIC 5HHVA 1FL7A 1AOCA 3V2AA 2R52A 4QHUC 4MQWB 3S1KV 1KTZA 4MQWA 4AY9B 2KD3A 1DZ7A 1NYSB 2QCWA 5BQ8D 4HQUA 1ZKZA 5FV2V 1WWWV 3IJ2A 4EFVA 3JVFA 4X1JA 5BQ8A 1XWDA 4EC7A 1TZHV 1TGJA 1QFWB 2GYZA 1B98A 1RV6V 1QFWA 2ARPA 3FUBB 1HD4A 1WQ8A 4ZFFC 4UHZA 3KFDA 4GLSE 2XACA 3SEKB 5HK5A 1LXIA 1E9JA 4EDXV 1M4UA 3BUKA 1REUA 4YCGC 4FAOA 1MJVA 4MPLA 2X1WA 2QJ9A 3QTKA 5JZ7A 4ZBNA 3HH2A 2X1XE 1HCFA 4LXRJ 2BHKA 4AY9A 4BV4L 1HRPB 1HRPA 1KLCA 2ARVA 1PDGA 1VPPV 4GLNE 1B8MB 4KV5A 3E07A 3EO1C 5HI5A 4HQXA 1QTYR 2FJHV 1MKGA 1M4UL 2C7WA 4QAFC 5BPUA 3B4VA 4UI1A 5FV1V 1NT3A 2QR0C 5BQBA 3V6BA 1HCNB 1FLTV 2VXSA 1HCNA 1BJ1V 1AGQA 4KXZA 5HI3A 5E4GA 4QCIC 1S4YB 4EDWV 1BTGA 1TFGA 2V5EB 1B8KA 3BK3A 2VWEA 5HHCA 5AEJA 2GNNA 2H62A 1TGKA 1KATW 1NYUB 2QCQA 5BQCA 1LX5A 2VPFA 4XPJA 1WAQA 3BMPA 3RJRA 2GYRA 1B8MA 3BDYV 1WQ9B 4LXSJ 2QJAA 2XV7A 1WQ9A 1KLAA
chains in the Genus database with same CATH superfamily
4KZNA 5HK5E 2GOOA 2GH0C 4WPBA 5HI4A 1BMPA 1SG1A 4N1DA 4UI2B 3P9WA 1TZIV 3QB4A 5BQEB 4HSAA 3MJGA 2B0UA 4UHYA 5BQEA 5HHXA 2R53A 4UI0A 4HR9A 5F3BC 1MKKA 1ES7A 2ASKA 4MIDA 1CZ8V 5HHDA 5BQ8B 1BETA 2FJGV 2IFGE 1XWDB 2QJBA 2H64A 2P6AA 1SGFB 3MJKA 1FZVA 1VPFA 1BNDB 2TGIA 3S1BV 1JPYA 1BNDA 4EAXA 5F3HI 3EVSB 1REWA 2PJYA 1FL7B 4YCIC 5HHVA 1FL7A 1AOCA 3V2AA 2R52A 4QHUC 4MQWB 3S1KV 1KTZA 4MQWA 4AY9B 2KD3A 1DZ7A 1NYSB 2QCWA 5BQ8D 4HQUA 1ZKZA 5FV2V 1WWWV 3IJ2A 4EFVA 3JVFA 4X1JA 5BQ8A 1XWDA 4EC7A 1TZHV 1TGJA 1QFWB 2GYZA 1B98A 1RV6V 1QFWA 2ARPA 3FUBB 1HD4A 1WQ8A 4ZFFC 4UHZA 3KFDA 4GLSE 2XACA 3SEKB 5HK5A 1LXIA 1E9JA 4EDXV 1M4UA 3BUKA 1REUA 4YCGC 4FAOA 1MJVA 4MPLA 2X1WA 2QJ9A 3QTKA 5JZ7A 4ZBNA 3HH2A 2X1XE 1HCFA 4LXRJ 2BHKA 4AY9A 4BV4L 1HRPB 1HRPA 1KLCA 2ARVA 1PDGA 1VPPV 4GLNE 1B8MB 4KV5A 3E07A 3EO1C 5HI5A 4HQXA 1QTYR 2FJHV 1MKGA 1M4UL 2C7WA 4QAFC 5BPUA 3B4VA 4UI1A 5FV1V 1NT3A 2QR0C 5BQBA 3V6BA 1HCNB 1FLTV 2VXSA 1HCNA 1BJ1V 1AGQA 4KXZA 5HI3A 5E4GA 4QCIC 1S4YB 4EDWV 1BTGA 1TFGA 2V5EB 1B8KA 3BK3A 2VWEA 5HHCA 5AEJA 2GNNA 2H62A 1TGKA 1KATW 1NYUB 2QCQA 5BQCA 1LX5A 2VPFA 4XPJA 1WAQA 3BMPA 3RJRA 2GYRA 1B8MA 3BDYV 1WQ9B 4LXSJ 2QJAA 2XV7A 1WQ9A 1KLAA
chains in the Genus database with same CATH topology
4KZNA 5HK5E 2GOOA 2GH0C 4WPBA 5HI4A 1BMPA 1SG1A 4N1DA 4UI2B 3P9WA 1TZIV 3QB4A 5BQEB 4HSAA 3MJGA 2B0UA 4UHYA 5BQEA 5HHXA 2R53A 4UI0A 4HR9A 5F3BC 1MKKA 1ES7A 2ASKA 4MIDA 1CZ8V 5HHDA 5BQ8B 1BETA 2FJGV 2IFGE 1XWDB 2QJBA 2H64A 2P6AA 1SGFB 3MJKA 1FZVA 1VPFA 1BNDB 2TGIA 3S1BV 1JPYA 1BNDA 4EAXA 5F3HI 3EVSB 1REWA 2PJYA 1FL7B 4YCIC 5HHVA 1FL7A 1AOCA 3V2AA 2R52A 4QHUC 4MQWB 3S1KV 1KTZA 4MQWA 4AY9B 2KD3A 1DZ7A 1NYSB 2QCWA 5BQ8D 4HQUA 1ZKZA 5FV2V 1WWWV 3IJ2A 4EFVA 3JVFA 4X1JA 5BQ8A 1XWDA 4EC7A 1TZHV 1TGJA 1QFWB 2GYZA 1B98A 1RV6V 1QFWA 2ARPA 3FUBB 1HD4A 1WQ8A 4ZFFC 4UHZA 3KFDA 4GLSE 2XACA 3SEKB 5HK5A 1LXIA 1E9JA 4EDXV 1M4UA 3BUKA 1REUA 4YCGC 4FAOA 1MJVA 4MPLA 2X1WA 2QJ9A 3QTKA 5JZ7A 4ZBNA 3HH2A 2X1XE 1HCFA 4LXRJ 2BHKA 4AY9A 4BV4L 1HRPB 1HRPA 1KLCA 2ARVA 1PDGA 1VPPV 4GLNE 1B8MB 4KV5A 3E07A 3EO1C 5HI5A 4HQXA 1QTYR 2FJHV 1MKGA 1M4UL 2C7WA 4QAFC 5BPUA 3B4VA 4UI1A 5FV1V 1NT3A 2QR0C 5BQBA 3V6BA 1HCNB 1FLTV 2VXSA 1HCNA 1BJ1V 1AGQA 4KXZA 5HI3A 5E4GA 4QCIC 1S4YB 4EDWV 1BTGA 1TFGA 2V5EB 1B8KA 3BK3A 2VWEA 5HHCA 5AEJA 2GNNA 2H62A 1TGKA 1KATW 1NYUB 2QCQA 5BQCA 1LX5A 2VPFA 4XPJA 1WAQA 3BMPA 3RJRA 2GYRA 1B8MA 3BDYV 1WQ9B 4LXSJ 2QJAA 2XV7A 1WQ9A 1KLAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KZN A;  5HK5 E;  2GOO A;  2GH0 C;  4WPB A;  5HI4 A;  1BMP A;  1SG1 A;  4N1D A;  4UI2 B;  3P9W A;  1TZI V;  3QB4 A;  5BQE B;  4HSA A;  3MJG A;  2B0U A;  4UHY A;  5BQE A;  5HHX A;  2R53 A;  4UI0 A;  4HR9 A;  5F3B C;  1MKK A;  1ES7 A;  2ASK A;  4MID A;  1CZ8 V;  5HHD A;  5BQ8 B;  1BET A;  2FJG V;  2IFG E;  1XWD B;  2QJB A;  2H64 A;  2P6A A;  1SGF B;  3MJK A;  1FZV A;  1VPF A;  1BND B;  2TGI A;  3S1B V;  1JPY A;  1BND A;  4EAX A;  5F3H I;  3EVS B;  1REW A;  2PJY A;  1FL7 B;  4YCI C;  5HHV A;  1FL7 A;  1AOC A;  3V2A A;  2R52 A;  4QHU C;  4MQW B;  3S1K V;  1KTZ A;  4MQW A;  4AY9 B;  2KD3 A;  1DZ7 A;  1NYS B;  2QCW A;  5BQ8 D;  4HQU A;  1ZKZ A;  5FV2 V;  1WWW V;  3IJ2 A;  4EFV A;  3JVF A;  4X1J A;  5BQ8 A;  1XWD A;  4EC7 A;  1TZH V;  1TGJ A;  1QFW B;  2GYZ A;  1B98 A;  1RV6 V;  1QFW A;  2ARP A;  3FUB B;  1HD4 A;  1WQ8 A;  4ZFF C;  4UHZ A;  3KFD A;  4GLS E;  2XAC A;  3SEK B;  5HK5 A;  1LXI A;  1E9J A;  4EDX V;  1M4U A;  3BUK A;  1REU A;  4YCG C;  4FAO A;  1MJV A;  4MPL A;  2X1W A;  2QJ9 A;  3QTK A;  5JZ7 A;  4ZBN A;  3HH2 A;  2X1X E;  1HCF A;  4LXR J;  2BHK A;  4AY9 A;  4BV4 L;  1HRP B;  1HRP A;  1KLC A;  2ARV A;  1PDG A;  1VPP V;  4GLN E;  1B8M B;  4KV5 A;  3E07 A;  3EO1 C;  5HI5 A;  4HQX A;  1QTY R;  2FJH V;  1MKG A;  1M4U L;  2C7W A;  4QAF C;  5BPU A;  3B4V A;  4UI1 A;  5FV1 V;  1NT3 A;  2QR0 C;  5BQB A;  3V6B A;  1HCN B;  1FLT V;  2VXS A;  1HCN A;  1BJ1 V;  1AGQ A;  4KXZ A;  5HI3 A;  5E4G A;  4QCI C;  1S4Y B;  4EDW V;  1BTG A;  1TFG A;  2V5E B;  1B8K A;  3BK3 A;  2VWE A;  5HHC A;  5AEJ A;  2GNN A;  2H62 A;  1TGK A;  1KAT W;  1NYU B;  2QCQ A;  5BQC A;  1LX5 A;  2VPF A;  4XPJ A;  1WAQ A;  3BMP A;  3RJR A;  2GYR A;  1B8M A;  3BDY V;  1WQ9 B;  4LXS J;  2QJA A;  2XV7 A;  1WQ9 A;  1KLA A; 
#chains in the Genus database with same CATH topology
 4KZN A;  5HK5 E;  2GOO A;  2GH0 C;  4WPB A;  5HI4 A;  1BMP A;  1SG1 A;  4N1D A;  4UI2 B;  3P9W A;  1TZI V;  3QB4 A;  5BQE B;  4HSA A;  3MJG A;  2B0U A;  4UHY A;  5BQE A;  5HHX A;  2R53 A;  4UI0 A;  4HR9 A;  5F3B C;  1MKK A;  1ES7 A;  2ASK A;  4MID A;  1CZ8 V;  5HHD A;  5BQ8 B;  1BET A;  2FJG V;  2IFG E;  1XWD B;  2QJB A;  2H64 A;  2P6A A;  1SGF B;  3MJK A;  1FZV A;  1VPF A;  1BND B;  2TGI A;  3S1B V;  1JPY A;  1BND A;  4EAX A;  5F3H I;  3EVS B;  1REW A;  2PJY A;  1FL7 B;  4YCI C;  5HHV A;  1FL7 A;  1AOC A;  3V2A A;  2R52 A;  4QHU C;  4MQW B;  3S1K V;  1KTZ A;  4MQW A;  4AY9 B;  2KD3 A;  1DZ7 A;  1NYS B;  2QCW A;  5BQ8 D;  4HQU A;  1ZKZ A;  5FV2 V;  1WWW V;  3IJ2 A;  4EFV A;  3JVF A;  4X1J A;  5BQ8 A;  1XWD A;  4EC7 A;  1TZH V;  1TGJ A;  1QFW B;  2GYZ A;  1B98 A;  1RV6 V;  1QFW A;  2ARP A;  3FUB B;  1HD4 A;  1WQ8 A;  4ZFF C;  4UHZ A;  3KFD A;  4GLS E;  2XAC A;  3SEK B;  5HK5 A;  1LXI A;  1E9J A;  4EDX V;  1M4U A;  3BUK A;  1REU A;  4YCG C;  4FAO A;  1MJV A;  4MPL A;  2X1W A;  2QJ9 A;  3QTK A;  5JZ7 A;  4ZBN A;  3HH2 A;  2X1X E;  1HCF A;  4LXR J;  2BHK A;  4AY9 A;  4BV4 L;  1HRP B;  1HRP A;  1KLC A;  2ARV A;  1PDG A;  1VPP V;  4GLN E;  1B8M B;  4KV5 A;  3E07 A;  3EO1 C;  5HI5 A;  4HQX A;  1QTY R;  2FJH V;  1MKG A;  1M4U L;  2C7W A;  4QAF C;  5BPU A;  3B4V A;  4UI1 A;  5FV1 V;  1NT3 A;  2QR0 C;  5BQB A;  3V6B A;  1HCN B;  1FLT V;  2VXS A;  1HCN A;  1BJ1 V;  1AGQ A;  4KXZ A;  5HI3 A;  5E4G A;  4QCI C;  1S4Y B;  4EDW V;  1BTG A;  1TFG A;  2V5E B;  1B8K A;  3BK3 A;  2VWE A;  5HHC A;  5AEJ A;  2GNN A;  2H62 A;  1TGK A;  1KAT W;  1NYU B;  2QCQ A;  5BQC A;  1LX5 A;  2VPF A;  4XPJ A;  1WAQ A;  3BMP A;  3RJR A;  2GYR A;  1B8M A;  3BDY V;  1WQ9 B;  4LXS J;  2QJA A;  2XV7 A;  1WQ9 A;  1KLA A; 
#chains in the Genus database with same CATH homology
 4KZN A;  5HK5 E;  2GOO A;  2GH0 C;  4WPB A;  5HI4 A;  1BMP A;  1SG1 A;  4N1D A;  4UI2 B;  3P9W A;  1TZI V;  3QB4 A;  5BQE B;  4HSA A;  3MJG A;  2B0U A;  4UHY A;  5BQE A;  5HHX A;  2R53 A;  4UI0 A;  4HR9 A;  5F3B C;  1MKK A;  1ES7 A;  2ASK A;  4MID A;  1CZ8 V;  5HHD A;  5BQ8 B;  1BET A;  2FJG V;  2IFG E;  1XWD B;  2QJB A;  2H64 A;  2P6A A;  1SGF B;  3MJK A;  1FZV A;  1VPF A;  1BND B;  2TGI A;  3S1B V;  1JPY A;  1BND A;  4EAX A;  5F3H I;  3EVS B;  1REW A;  2PJY A;  1FL7 B;  4YCI C;  5HHV A;  1FL7 A;  1AOC A;  3V2A A;  2R52 A;  4QHU C;  4MQW B;  3S1K V;  1KTZ A;  4MQW A;  4AY9 B;  2KD3 A;  1DZ7 A;  1NYS B;  2QCW A;  5BQ8 D;  4HQU A;  1ZKZ A;  5FV2 V;  1WWW V;  3IJ2 A;  4EFV A;  3JVF A;  4X1J A;  5BQ8 A;  1XWD A;  4EC7 A;  1TZH V;  1TGJ A;  1QFW B;  2GYZ A;  1B98 A;  1RV6 V;  1QFW A;  2ARP A;  3FUB B;  1HD4 A;  1WQ8 A;  4ZFF C;  4UHZ A;  3KFD A;  4GLS E;  2XAC A;  3SEK B;  5HK5 A;  1LXI A;  1E9J A;  4EDX V;  1M4U A;  3BUK A;  1REU A;  4YCG C;  4FAO A;  1MJV A;  4MPL A;  2X1W A;  2QJ9 A;  3QTK A;  5JZ7 A;  4ZBN A;  3HH2 A;  2X1X E;  1HCF A;  4LXR J;  2BHK A;  4AY9 A;  4BV4 L;  1HRP B;  1HRP A;  1KLC A;  2ARV A;  1PDG A;  1VPP V;  4GLN E;  1B8M B;  4KV5 A;  3E07 A;  3EO1 C;  5HI5 A;  4HQX A;  1QTY R;  2FJH V;  1MKG A;  1M4U L;  2C7W A;  4QAF C;  5BPU A;  3B4V A;  4UI1 A;  5FV1 V;  1NT3 A;  2QR0 C;  5BQB A;  3V6B A;  1HCN B;  1FLT V;  2VXS A;  1HCN A;  1BJ1 V;  1AGQ A;  4KXZ A;  5HI3 A;  5E4G A;  4QCI C;  1S4Y B;  4EDW V;  1BTG A;  1TFG A;  2V5E B;  1B8K A;  3BK3 A;  2VWE A;  5HHC A;  5AEJ A;  2GNN A;  2H62 A;  1TGK A;  1KAT W;  1NYU B;  2QCQ A;  5BQC A;  1LX5 A;  2VPF A;  4XPJ A;  1WAQ A;  3BMP A;  3RJR A;  2GYR A;  1B8M A;  3BDY V;  1WQ9 B;  4LXS J;  2QJA A;  2XV7 A;  1WQ9 A;  1KLA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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