5HL7S

The crystal structure of the large ribosomal subunit of staphylococcus aureus in complex with lefamulin
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
167
structure length
167
Chain Sequence
SLKSIIRQGKQTRSDLKQLRKSGKVPAVVYGYGTKNVSVKVDEVEFIKVIREVGRNGVIELGVGSKTIKVMVADYQFDPLKNQITHIDFLAINMSEERTVEVPVQLVGEAVGAKEGGVVEQPLFNLEVTATPDNIPEAIEVDITELNINDSLTVADVKVTGDFKIEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 50S ribosomal protein L2
total genus 22
structure length 167
sequence length 167
ec nomenclature
pdb deposition date 2016-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 5hl7S01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 5hl7S02
4U67S 5GAGW 1QRUA 4WCES 1O0BA 5HL7S 1O0CA 5DM7S 4WFNS 1FEUA 2RD2A 4IO9S 4WFAS 3CF5S 5BNZA 1EUQA 4JXXA 4WFBS 4JYZA 1DFUP 4JXZA 5GADW 3PIOS 5GAEW 5DM6S 1QRSA 1GTRA 5IZNA 4UY88 2RE8A 1QRTA 1GTSA 4WF9S 1D6KA 2ZJRS 4H3SA 1EUYA 4P2BA 3AIIA 2HZ7A 4IOCS 2ZJQS 1NYLA 3J7ZV 5JVGS 1QTQA 4IOAS 5GAHW 3DLLS 5JVHS 2ZJPS 3PIPS 1EXDA 1B75A 1ZJWA
chains in the Genus database with same CATH superfamily
2Y0SD 4U67S 2PJJA 2PMZD 1SFOC 2E2IC 3S1QC 3WODA 4WCES 1K83C 2NVQC 4XSXA 3HOYC 2B63C 1FEUA 1TWFC 2CX8A 3GTPC 2KXYA 2Z0YA 2R92C 2EGWA 4A3EC 2GAEA 4WFBS 4XSZA 2BE5A 2G5DA 4KN7A 2PPBA 5C3EC 2PA8D 3CQZC 4MQ9A 1GTRA 1IW7A 4X6AC 1D6KA 1V6ZA 3CZBA 4BBRC 3M3YC 1UDXA 1NXZA 1YNNA 5IP9C 4YG2A 2JA5C 2E2JC 4KN4A 3J7ZV 5JVGS 1QTQA 3S1RC 5GAHW 3S14C 4OINA 1TWHC 4LK1A 3S2HC 3PIPS 3HOUC 1B75A 4A3CC 4A3JC 1ZJWA 3KW2A 1Y1WC 3H0GC 4BBSC 1QRUA 4BY7C 3GTLC 1I6HC 1ZYRA 5HL7S 4C3JC 2RD2A 1I50C 1SMYA 2A6HA 2NWAA 1HQMA 2NVYC 3W2VB 2AE0X 1Y1VC 4MEXA 2PNWA 1EUQA 4JXXA 3I4NC 4C3IC 1R9TC 4JYZA 5IYDC 4G7ZA 2JA7C 2E2HC 2O5IA 1VHYA 1Z85A 5DM6S 3X1LB 2L3UA 2JA8C 3HOVC 3S1MC 1I3QC 3RZDC 4JK1A 3PO3C 1EUYA 2L5NA 4XLNA 2HZ7A 4YFKA 4A3MC 4A3BC 1VHKA 1TWCC 4XLPA 5IYCC 2NVXC 3GTGC 2A68A 4QIWD 4BY1C 2JA6C 3DLLS 4LJZA 4Y52C 3K7AC 5HQHA 3EQLA 4A3GC 2KQ1A 3RZOC 4V194 5GAGW 3I4MC 2R7ZC 4ZH4A 1YNJA 4YFNA 4OIRA 5DM7S 4WFNS 4AYBD 4IO9S 2G6GA 3GTQC 4WFAS 4OIQA 3CF5S 4MEYA 5BNZA 4NOIA 3PO2C 4A3LC 5FLMC 2A69A 3HOZC 4A3FC 1DFUP 4JXZA 5GADW 2KPUA 2WB1D 3FKIC 4UY88 3S2DC 5C4XC 4E8BA 4WF9S 4A3DC 3LYWA 3AIIA 4IOCS 4A3IC 2ZJQS 3HKZD 4Y7NC 4IOAS 1BDFA 5C4JC 1WCMC 5JVHS 4KMUA 1TWGC 2VUMC 3GTMC 2NVTC 3M4OC 2O5JA 2YU9C 2WAQD 3S15C 4A3KC 4YFXA 4G7OA 5D4DA 4Q4ZA 4GZYA 1O0BA 2CW0A 1O0CA 4LLGA 3HOWC 3S16C 4C2MC 1I6VA 5IP7C 3DXJA 4H4KA 5C44C 2A6EA 3GTOC 4LK0A 3PIOS 5GAEW 4L69A 1QRSA 5TMCA 5IZNA 1TWAC 3GTJC 5TMFA 2RE8A 2PICA 1QRTA 1GTSA 3HOXC 4QJVA 2ZJRS 4H3SA 4OIPA 2EGVA 4J3CA 4P2BA 3H3VD 3S17C 4A93C 4BXXC 4G7HA 2PI8A 1NYLA 4C3HC 3S1NC 3W2WB 5IYBC 2ZJPS 4OIOA 3GTKC 2R93C 1EXDA 4Q5SA
chains in the Genus database with same CATH topology
4V194 4U67S 5GAGW 1QRUA 4WCES 1O0BA 5HL7S 1O0CA 5DM7S 4WFNS 1FEUA 2RD2A 4IO9S 4WFAS 3W2VB 3CF5S 5BNZA 1EUQA 4H4KA 4WFBS 4JXXA 4JYZA 1DFUP 4JXZA 5GADW 3PIOS 5GAEW 5DM6S 1QRSA 1GTRA 5IZNA 4UY88 3X1LB 2RE8A 1QRTA 1GTSA 4WF9S 1D6KA 2ZJRS 4H3SA 1EUYA 1UDXA 4P2BA 3AIIA 2HZ7A 4IOCS 2ZJQS 1NYLA 3J7ZV 5JVGS 1QTQA 4IOAS 5GAHW 3W2WB 3DLLS 5JVHS 2ZJPS 3PIPS 1EXDA 1B75A 1ZJWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U67 S;  5GAG W;  1QRU A;  4WCE S;  1O0B A;  5HL7 S;  1O0C A;  5DM7 S;  4WFN S;  1FEU A;  2RD2 A;  4IO9 S;  4WFA S;  3CF5 S;  5BNZ A;  1EUQ A;  4JXX A;  4WFB S;  4JYZ A;  1DFU P;  4JXZ A;  5GAD W;  3PIO S;  5GAE W;  5DM6 S;  1QRS A;  1GTR A;  5IZN A;  4UY8 8;  2RE8 A;  1QRT A;  1GTS A;  4WF9 S;  1D6K A;  2ZJR S;  4H3S A;  1EUY A;  4P2B A;  3AII A;  2HZ7 A;  4IOC S;  2ZJQ S;  1NYL A;  3J7Z V;  5JVG S;  1QTQ A;  4IOA S;  5GAH W;  3DLL S;  5JVH S;  2ZJP S;  3PIP S;  1EXD A;  1B75 A;  1ZJW A; 
#chains in the Genus database with same CATH topology
 2Y0S D;  4U67 S;  2PJJ A;  2PMZ D;  1SFO C;  2E2I C;  3S1Q C;  3WOD A;  4WCE S;  1K83 C;  2NVQ C;  4XSX A;  3HOY C;  2B63 C;  1FEU A;  1TWF C;  2CX8 A;  3GTP C;  2KXY A;  2Z0Y A;  2R92 C;  2EGW A;  4A3E C;  2GAE A;  4WFB S;  4XSZ A;  2BE5 A;  2G5D A;  4KN7 A;  2PPB A;  5C3E C;  2PA8 D;  3CQZ C;  4MQ9 A;  1GTR A;  1IW7 A;  4X6A C;  1D6K A;  1V6Z A;  3CZB A;  4BBR C;  3M3Y C;  1UDX A;  1NXZ A;  1YNN A;  5IP9 C;  4YG2 A;  2JA5 C;  2E2J C;  4KN4 A;  3J7Z V;  5JVG S;  1QTQ A;  3S1R C;  5GAH W;  3S14 C;  4OIN A;  1TWH C;  4LK1 A;  3S2H C;  3PIP S;  3HOU C;  1B75 A;  4A3C C;  4A3J C;  1ZJW A;  3KW2 A;  1Y1W C;  3H0G C;  4BBS C;  1QRU A;  4BY7 C;  3GTL C;  1I6H C;  1ZYR A;  5HL7 S;  4C3J C;  2RD2 A;  1I50 C;  1SMY A;  2A6H A;  2NWA A;  1HQM A;  2NVY C;  3W2V B;  2AE0 X;  1Y1V C;  4MEX A;  2PNW A;  1EUQ A;  4JXX A;  3I4N C;  4C3I C;  1R9T C;  4JYZ A;  5IYD C;  4G7Z A;  2JA7 C;  2E2H C;  2O5I A;  1VHY A;  1Z85 A;  5DM6 S;  3X1L B;  2L3U A;  2JA8 C;  3HOV C;  3S1M C;  1I3Q C;  3RZD C;  4JK1 A;  3PO3 C;  1EUY A;  2L5N A;  4XLN A;  2HZ7 A;  4YFK A;  4A3M C;  4A3B C;  1VHK A;  1TWC C;  4XLP A;  5IYC C;  2NVX C;  3GTG C;  2A68 A;  4QIW D;  4BY1 C;  2JA6 C;  3DLL S;  4LJZ A;  4Y52 C;  3K7A C;  5HQH A;  3EQL A;  4A3G C;  2KQ1 A;  3RZO C;  4V19 4;  5GAG W;  3I4M C;  2R7Z C;  4ZH4 A;  1YNJ A;  4YFN A;  4OIR A;  5DM7 S;  4WFN S;  4AYB D;  4IO9 S;  2G6G A;  3GTQ C;  4WFA S;  4OIQ A;  3CF5 S;  4MEY A;  5BNZ A;  4NOI A;  3PO2 C;  4A3L C;  5FLM C;  2A69 A;  3HOZ C;  4A3F C;  1DFU P;  4JXZ A;  5GAD W;  2KPU A;  2WB1 D;  3FKI C;  4UY8 8;  3S2D C;  5C4X C;  4E8B A;  4WF9 S;  4A3D C;  3LYW A;  3AII A;  4IOC S;  4A3I C;  2ZJQ S;  3HKZ D;  4Y7N C;  4IOA S;  1BDF A;  5C4J C;  1WCM C;  5JVH S;  4KMU A;  1TWG C;  2VUM C;  3GTM C;  2NVT C;  3M4O C;  2O5J A;  2YU9 C;  2WAQ D;  3S15 C;  4A3K C;  4YFX A;  4G7O A;  5D4D A;  4Q4Z A;  4GZY A;  1O0B A;  2CW0 A;  1O0C A;  4LLG A;  3HOW C;  3S16 C;  4C2M C;  1I6V A;  5IP7 C;  3DXJ A;  4H4K A;  5C44 C;  2A6E A;  3GTO C;  4LK0 A;  3PIO S;  5GAE W;  4L69 A;  1QRS A;  5TMC A;  5IZN A;  1TWA C;  3GTJ C;  5TMF A;  2RE8 A;  2PIC A;  1QRT A;  1GTS A;  3HOX C;  4QJV A;  2ZJR S;  4H3S A;  4OIP A;  2EGV A;  4J3C A;  4P2B A;  3H3V D;  3S17 C;  4A93 C;  4BXX C;  4G7H A;  2PI8 A;  1NYL A;  4C3H C;  3S1N C;  3W2W B;  5IYB C;  2ZJP S;  4OIO A;  3GTK C;  2R93 C;  1EXD A;  4Q5S A; 
#chains in the Genus database with same CATH homology
 4V19 4;  4U67 S;  5GAG W;  1QRU A;  4WCE S;  1O0B A;  5HL7 S;  1O0C A;  5DM7 S;  4WFN S;  1FEU A;  2RD2 A;  4IO9 S;  4WFA S;  3W2V B;  3CF5 S;  5BNZ A;  1EUQ A;  4H4K A;  4WFB S;  4JXX A;  4JYZ A;  1DFU P;  4JXZ A;  5GAD W;  3PIO S;  5GAE W;  5DM6 S;  1QRS A;  1GTR A;  5IZN A;  4UY8 8;  3X1L B;  2RE8 A;  1QRT A;  1GTS A;  4WF9 S;  1D6K A;  2ZJR S;  4H3S A;  1EUY A;  1UDX A;  4P2B A;  3AII A;  2HZ7 A;  4IOC S;  2ZJQ S;  1NYL A;  3J7Z V;  5JVG S;  1QTQ A;  4IOA S;  5GAH W;  3W2W B;  3DLL S;  5JVH S;  2ZJP S;  3PIP S;  1EXD A;  1B75 A;  1ZJW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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