5HOLA

The crystal structure of the mers-cov macro domain with adp-ribose
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
167
structure length
167
Chain Sequence
MDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTIV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
pubmed doi rcsb
molecule tags Viral protein
source organism Middle east respiratory syndrome coronavirus
molecule keywords ORF1a
total genus 54
structure length 167
sequence length 167
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 2016-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 5holA00
3Q6ZA 2FG1A 4JLLA 3IIFA 4ETKA 4J5RA 5FSVA 5CB5A 3VFQA 4J5SA 1VHUA 2LGRA 4JVVA 3H8GA 1HJZA 4GVWA 4ZY0A 2DX6A 4KYBA 4K3NA 5CB3A 4K0CA 4ZX9A 3EWOA 3GPQA 3EW5A 3H8FA 4KSIA 3GPOA 1TY8A 2BFRA 5FSYA 1TXZA 4ABLA 2XD7A 3EWQA 4R7MA 2FXKA 2ACFA 2J9AA 1BLLE 3IJ3A 3JZTA 3SIIA 2L8RA 2EWBA 3GQOA 5HOLA 2X47A 1LANA 2FAVA 2AFCA 4J4ZA 4UMLA 4ZY1A 4TU0A 3KR4A 1SPVA 3V2BA 1LCPA 3SIGA 4R76A 3GPGA 2EEEA 5HIHA 1YD9A 3KQXA 1ZR5A 3GQEA 3IIDA 1NJRA 4GUAA 3EWPA 4IQYA 4JCAA 1GYTA 4X2TA 5FSXA 4ABKA 3EKEA 4ZX8A 3T8WA 5CMSA 3ETIA 4D86A 5FSZA 1BPMA 3SIJA 3PEIA 4ETJA 3EJFA 5AILA 4JGKA 3H8EA 2VRIA 5FSUA 4ZY2A 3SIHA 4ESSA 4R6TA 1LAMA 3KQZA 3JRUA 5DUSA 3EJGA 5CBMA 5E3BA 1LAPA 1BPNA 4ZYQA 3KZWA 5D8NA 3V45A 2BFQA 4ZI6A 4GVVA 4J5QA 3KR5A 3EWRA 1ZR3A 3Q71A
chains in the Genus database with same CATH superfamily
3Q6ZA 2FG1A 4JLLA 3IIFA 4ETKA 4J5RA 5FSVA 5CB5A 3VFQA 4J5SA 1VHUA 2LGRA 3H8GA 4GVWA 1HJZA 4JVVA 4ZY0A 2DX6A 4KYBA 4K3NA 5CB3A 2JZFA 2JZEA 4K0CA 4ZX9A 3EWOA 3GPQA 3EW5A 3H8FA 4KSIA 3GPOA 1TY8A 2BFRA 5FSYA 1TXZA 2JZDA 4ABLA 2XD7A 3EWQA 4R7MA 2FXKA 2WCTA 2ACFA 2J9AA 1BLLE 3IJ3A 3JZTA 3SIIA 2L8RA 2EWBA 3GQOA 5HOLA 2X47A 1LANA 2FAVA 2AFCA 4J4ZA 4UMLA 4ZY1A 4TU0A 3KR4A 1SPVA 3V2BA 1LCPA 2W2GA 3SIGA 4R76A 3GPGA 2EEEA 5HIHA 1YD9A 3KQXA 1ZR5A 3GQEA 3IIDA 1NJRA 2RNKA 4GUAA 3EWPA 4IQYA 4JCAA 1GYTA 4X2TA 5FSXA 4ABKA 3EKEA 4ZX8A 3T8WA 5CMSA 2KQVA 3ETIA 4D86A 5FSZA 1BPMA 3SIJA 3PEIA 4ETJA 3EJFA 5AILA 4JGKA 3H8EA 2VRIA 5FSUA 4ZY2A 3SIHA 4ESSA 4R6TA 1LAMA 3KQZA 3JRUA 5DUSA 3EJGA 5CBMA 5E3BA 1LAPA 1BPNA 4ZYQA 3KZWA 5D8NA 3V45A 2BFQA 4ZI6A 4GVVA 4J5QA 3KR5A 3EWRA 1ZR3A 3Q71A
chains in the Genus database with same CATH topology
3Q6ZA 2FG1A 4JLLA 3IIFA 4ETKA 4J5RA 5FSVA 5CB5A 3VFQA 4J5SA 1VHUA 2LGRA 4JVVA 3H8GA 1HJZA 4GVWA 4ZY0A 2DX6A 4KYBA 4K3NA 5CB3A 4K0CA 4ZX9A 3EWOA 3GPQA 3EW5A 3H8FA 4KSIA 3GPOA 1TY8A 2BFRA 5FSYA 1TXZA 4ABLA 2XD7A 3EWQA 4R7MA 2FXKA 2ACFA 2J9AA 1BLLE 3IJ3A 3JZTA 3SIIA 2L8RA 2EWBA 3GQOA 5HOLA 2X47A 1LANA 2FAVA 2AFCA 4J4ZA 4UMLA 4ZY1A 4TU0A 3KR4A 1SPVA 3V2BA 1LCPA 3SIGA 4R76A 3GPGA 2EEEA 5HIHA 1YD9A 3KQXA 1ZR5A 3GQEA 3IIDA 1NJRA 4GUAA 3EWPA 4IQYA 4JCAA 1GYTA 4X2TA 5FSXA 4ABKA 3EKEA 4ZX8A 3T8WA 5CMSA 3ETIA 4D86A 5FSZA 1BPMA 3SIJA 3PEIA 4ETJA 3EJFA 5AILA 4JGKA 3H8EA 2VRIA 5FSUA 4ZY2A 3SIHA 4ESSA 4R6TA 1LAMA 3KQZA 3JRUA 5DUSA 3EJGA 5CBMA 5E3BA 1LAPA 1BPNA 4ZYQA 3KZWA 5D8NA 3V45A 2BFQA 4ZI6A 4GVVA 4J5QA 3KR5A 3EWRA 1ZR3A 3Q71A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q6Z A;  2FG1 A;  4JLL A;  3IIF A;  4ETK A;  4J5R A;  5FSV A;  5CB5 A;  3VFQ A;  4J5S A;  1VHU A;  2LGR A;  4JVV A;  3H8G A;  1HJZ A;  4GVW A;  4ZY0 A;  2DX6 A;  4KYB A;  4K3N A;  5CB3 A;  4K0C A;  4ZX9 A;  3EWO A;  3GPQ A;  3EW5 A;  3H8F A;  4KSI A;  3GPO A;  1TY8 A;  2BFR A;  5FSY A;  1TXZ A;  4ABL A;  2XD7 A;  3EWQ A;  4R7M A;  2FXK A;  2ACF A;  2J9A A;  1BLL E;  3IJ3 A;  3JZT A;  3SII A;  2L8R A;  2EWB A;  3GQO A;  5HOL A;  2X47 A;  1LAN A;  2FAV A;  2AFC A;  4J4Z A;  4UML A;  4ZY1 A;  4TU0 A;  3KR4 A;  1SPV A;  3V2B A;  1LCP A;  3SIG A;  4R76 A;  3GPG A;  2EEE A;  5HIH A;  1YD9 A;  3KQX A;  1ZR5 A;  3GQE A;  3IID A;  1NJR A;  4GUA A;  3EWP A;  4IQY A;  4JCA A;  1GYT A;  4X2T A;  5FSX A;  4ABK A;  3EKE A;  4ZX8 A;  3T8W A;  5CMS A;  3ETI A;  4D86 A;  5FSZ A;  1BPM A;  3SIJ A;  3PEI A;  4ETJ A;  3EJF A;  5AIL A;  4JGK A;  3H8E A;  2VRI A;  5FSU A;  4ZY2 A;  3SIH A;  4ESS A;  4R6T A;  1LAM A;  3KQZ A;  3JRU A;  5DUS A;  3EJG A;  5CBM A;  5E3B A;  1LAP A;  1BPN A;  4ZYQ A;  3KZW A;  5D8N A;  3V45 A;  2BFQ A;  4ZI6 A;  4GVV A;  4J5Q A;  3KR5 A;  3EWR A;  1ZR3 A;  3Q71 A; 
#chains in the Genus database with same CATH topology
 3Q6Z A;  2FG1 A;  4JLL A;  3IIF A;  4ETK A;  4J5R A;  5FSV A;  5CB5 A;  3VFQ A;  4J5S A;  1VHU A;  2LGR A;  3H8G A;  4GVW A;  1HJZ A;  4JVV A;  4ZY0 A;  2DX6 A;  4KYB A;  4K3N A;  5CB3 A;  2JZF A;  2JZE A;  4K0C A;  4ZX9 A;  3EWO A;  3GPQ A;  3EW5 A;  3H8F A;  4KSI A;  3GPO A;  1TY8 A;  2BFR A;  5FSY A;  1TXZ A;  2JZD A;  4ABL A;  2XD7 A;  3EWQ A;  4R7M A;  2FXK A;  2WCT A;  2ACF A;  2J9A A;  1BLL E;  3IJ3 A;  3JZT A;  3SII A;  2L8R A;  2EWB A;  3GQO A;  5HOL A;  2X47 A;  1LAN A;  2FAV A;  2AFC A;  4J4Z A;  4UML A;  4ZY1 A;  4TU0 A;  3KR4 A;  1SPV A;  3V2B A;  1LCP A;  2W2G A;  3SIG A;  4R76 A;  3GPG A;  2EEE A;  5HIH A;  1YD9 A;  3KQX A;  1ZR5 A;  3GQE A;  3IID A;  1NJR A;  2RNK A;  4GUA A;  3EWP A;  4IQY A;  4JCA A;  1GYT A;  4X2T A;  5FSX A;  4ABK A;  3EKE A;  4ZX8 A;  3T8W A;  5CMS A;  2KQV A;  3ETI A;  4D86 A;  5FSZ A;  1BPM A;  3SIJ A;  3PEI A;  4ETJ A;  3EJF A;  5AIL A;  4JGK A;  3H8E A;  2VRI A;  5FSU A;  4ZY2 A;  3SIH A;  4ESS A;  4R6T A;  1LAM A;  3KQZ A;  3JRU A;  5DUS A;  3EJG A;  5CBM A;  5E3B A;  1LAP A;  1BPN A;  4ZYQ A;  3KZW A;  5D8N A;  3V45 A;  2BFQ A;  4ZI6 A;  4GVV A;  4J5Q A;  3KR5 A;  3EWR A;  1ZR3 A;  3Q71 A; 
#chains in the Genus database with same CATH homology
 3Q6Z A;  2FG1 A;  4JLL A;  3IIF A;  4ETK A;  4J5R A;  5FSV A;  5CB5 A;  3VFQ A;  4J5S A;  1VHU A;  2LGR A;  4JVV A;  3H8G A;  1HJZ A;  4GVW A;  4ZY0 A;  2DX6 A;  4KYB A;  4K3N A;  5CB3 A;  4K0C A;  4ZX9 A;  3EWO A;  3GPQ A;  3EW5 A;  3H8F A;  4KSI A;  3GPO A;  1TY8 A;  2BFR A;  5FSY A;  1TXZ A;  4ABL A;  2XD7 A;  3EWQ A;  4R7M A;  2FXK A;  2ACF A;  2J9A A;  1BLL E;  3IJ3 A;  3JZT A;  3SII A;  2L8R A;  2EWB A;  3GQO A;  5HOL A;  2X47 A;  1LAN A;  2FAV A;  2AFC A;  4J4Z A;  4UML A;  4ZY1 A;  4TU0 A;  3KR4 A;  1SPV A;  3V2B A;  1LCP A;  3SIG A;  4R76 A;  3GPG A;  2EEE A;  5HIH A;  1YD9 A;  3KQX A;  1ZR5 A;  3GQE A;  3IID A;  1NJR A;  4GUA A;  3EWP A;  4IQY A;  4JCA A;  1GYT A;  4X2T A;  5FSX A;  4ABK A;  3EKE A;  4ZX8 A;  3T8W A;  5CMS A;  3ETI A;  4D86 A;  5FSZ A;  1BPM A;  3SIJ A;  3PEI A;  4ETJ A;  3EJF A;  5AIL A;  4JGK A;  3H8E A;  2VRI A;  5FSU A;  4ZY2 A;  3SIH A;  4ESS A;  4R6T A;  1LAM A;  3KQZ A;  3JRU A;  5DUS A;  3EJG A;  5CBM A;  5E3B A;  1LAP A;  1BPN A;  4ZYQ A;  3KZW A;  5D8N A;  3V45 A;  2BFQ A;  4ZI6 A;  4GVV A;  4J5Q A;  3KR5 A;  3EWR A;  1ZR3 A;  3Q71 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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