5HPEA

Phosphatase domain of pp5 bound to a phosphomimetic cdc37 substrate peptide
Total Genus 119
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
346
structure length
326
Chain Sequence
EYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYAWDHIEVEDDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural and functional basis of protein phosphatase 5 substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 5,Hsp90 co-chaperone Cd
total genus 119
structure length 326
sequence length 346
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2016-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5hpeA00
2WDEA 2USHA 3JYFA 4XPNA 4KBPA 1FJMA 1Z2WA 3P71C 1WAO1 2QFPA 4O5GA 4YKEA 3FGAC 4IYPC 4UT3A 3E7AA 2O8AA 4WWLA 3RQZA 2NPPC 5JPEA 4V0XA 3K7VC 1T70A 1T71A 3PSOA 4FBKA 4Q7FA 4B2OA 1S3MA 1SU1A 1WARA 2KKNA 1S3LA 4FCXA 4O4KA 4UWQA 3H62B 3CK2A 5C1VA 4DSYA 1IT6A 1XZWA 4JA7A 2NXFA 4OR9A 3C5WC 5INBA 2AHDA 2P6BA 3EGHA 4DT2A 3N5UA 3V4YA 1S95A 3H66A 5GTUA 2A22A 3AV0A 1MF8A 2IE3C 4M0VA 4ORAA 4I5NC 5JJTA 4JA9A 3H60A 1QFCA 3QFNA 2WDCA 4TUIA 1G5BA 4G9JA 5EQVA 3K7WC 4MOVA 4H2GA 4KKZA 1OIDA 2QFRA 3QFOA 3RL4A 4IL1A 5B8IA 3QFMA 1M63A 4O43A 1XM7A 2ZBMA 4I5LC 3DW8C 4UT3B 4DHLA 4F0ZA 4ZX2A 5JPFA 3RL5A 3THOB 3PSNA 4NZVA 1Z2XA 3LL8A 3RL3A 1OIEA 1HP1A 1QHWA 3T1IA 2HYOA 3THNA 4H2IA 2GJUA 2NYMC 3H63A 1UTEA 2IAEC 2NYLC 1U32A 2Z72A 3DSCA 4H1YP 3KBPA 5HPEA 4FBWA 2CV9A 1JK7A 4J6OA 1NNWA 1UF3A 4MP0A 4TUGA 2BQ8X 1USHA 1W24A 2Z06A 1KBPA 2QJCA 3EGGA 3H68A 3AUZA 2XMOA 5F3WA 1S3NA 2Q8UA 2YVTA 4ORBA 4ZVZA 2BDXA 3H61A 3ICFA 3IB8A 4O24A 1HPUA 2HY1A 2O8GA 3C9FA 3IB7A 2BCDA 1HO5A 4V0WA 3HVQA 3IVDA 2WDFA 4V0VA 3ZTVA 2WDDA 5J28A 2JOGA 1OI8A 2HYPA 2R17A 3QG5C 4HD0A 4H2FA 4LTYA 4ORCA 3TGHA 3E7BA 3H64A 4H2BA 3ZU0A 5IOHA 1S70A 2Z1AA 4LACC 1II7A 3DSDA 1TCOA 2DFJA 3GVEA 3IVEA 5DNYA 1V73A 4FBQA 3QFKA 1S8EA 2IE4C 3H69A 4H1SA 4LU9A 4MOYA 1AUIA 3H67A 4UT2A
chains in the Genus database with same CATH superfamily
2WDEA 2USHA 3JYFA 4XPNA 4KBPA 3D03A 1FJMA 1Z2WA 2ZO9B 3P71C 1WAO1 2QFPA 4O5GA 4YKEA 3FGAC 4IYPC 4UT3A 3E7AA 2O8AA 4WWLA 3RQZA 2NPPC 5JPEA 4V0XA 3K7VC 1T70A 2YEQA 1T71A 3PSOA 4FBKA 4Q7FA 4B2OA 1S3MA 1SU1A 1WARA 2KKNA 1S3LA 4FCXA 4O4KA 4UWQA 3H62B 3CK2A 5C1VA 4DSYA 1IT6A 1XZWA 4JA7A 2NXFA 4OR9A 3C5WC 5INBA 2AHDA 2P6BA 3EGHA 4DT2A 3N5UA 3V4YA 1S95A 3H66A 5GTUA 2A22A 3AV0A 1MF8A 2IE3C 4M0VA 4ORAA 4I5NC 5JJTA 4JA9A 3H60A 1QFCA 3QFNA 2WDCA 4TUIA 1G5BA 4G9JA 5EQVA 3E0JA 3K7WC 4MOVA 4H2GA 4KKZA 1OIDA 2QFRA 3QFOA 3RL4A 2DXNA 4IL1A 5B8IA 3QFMA 1M63A 4O43A 1XM7A 2ZBMA 4I5LC 3DW8C 4UT3B 4DHLA 4F0ZA 4ZX2A 5JPFA 3RL5A 3THOB 3PSNA 4NZVA 1Z2XA 3LL8A 3RL3A 1OIEA 1HP1A 1QHWA 3T1IA 2HYOA 3THNA 4H2IA 2GJUA 2NYMC 3H63A 1UTEA 2IAEC 2NYLC 1U32A 2Z72A 3DSCA 4H1YP 3FLOA 3KBPA 5HPEA 4FBWA 2CV9A 1JK7A 4J6OA 1NNWA 1UF3A 4MP0A 4TUGA 2BQ8X 1USHA 1W24A 2Z06A 1KBPA 2QJCA 3EGGA 3H68A 3AUZA 2XMOA 5F3WA 1S3NA 2Q8UA 2YVTA 4ORBA 4ZVZA 2DXLA 2BDXA 3H61A 3ICFA 3IB8A 4O24A 1HPUA 2HY1A 2O8GA 3C9FA 3IB7A 2BCDA 1HO5A 4V0WA 3HVQA 3IVDA 2WDFA 4V0VA 3ZTVA 2WDDA 5J28A 2JOGA 1OI8A 2HYPA 2R17A 3QG5C 4HD0A 4H2FA 4LTYA 4ORCA 3TGHA 3E7BA 3H64A 4H2BA 3ZU0A 5IOHA 1S70A 2Z1AA 4LACC 1II7A 3DSDA 1TCOA 2DFJA 3GVEA 3IVEA 5DNYA 1V73A 4FBQA 3QFKA 1S8EA 2IE4C 3H69A 4H1SA 4LU9A 2ZOAA 1AUIA 4MOYA 3H67A 4UT2A
chains in the Genus database with same CATH topology
2WDEA 2USHA 3JYFA 4XPNA 4KBPA 3D03A 1FJMA 1Z2WA 2ZO9B 3P71C 1WAO1 2QFPA 4O5GA 4YKEA 3FGAC 4IYPC 4UT3A 3E7AA 2O8AA 4WWLA 3RQZA 2NPPC 5JPEA 4V0XA 3K7VC 1T70A 2YEQA 1T71A 3PSOA 4FBKA 4Q7FA 4B2OA 1S3MA 1SU1A 1WARA 2KKNA 1S3LA 4FCXA 4O4KA 4UWQA 3H62B 3CK2A 5C1VA 4DSYA 1IT6A 1XZWA 4JA7A 2NXFA 4OR9A 3C5WC 5INBA 2AHDA 2P6BA 3EGHA 4DT2A 3N5UA 3V4YA 1S95A 3H66A 5GTUA 2A22A 3AV0A 1MF8A 2IE3C 4M0VA 4ORAA 4I5NC 5JJTA 4JA9A 3H60A 1QFCA 3QFNA 2WDCA 4TUIA 1G5BA 4G9JA 5EQVA 3E0JA 3K7WC 4MOVA 4H2GA 4KKZA 1OIDA 2QFRA 3QFOA 3RL4A 2DXNA 4IL1A 5B8IA 3QFMA 1M63A 4O43A 1XM7A 2ZBMA 4I5LC 3DW8C 4UT3B 4DHLA 4F0ZA 4ZX2A 5JPFA 3RL5A 3THOB 3PSNA 4NZVA 1Z2XA 3LL8A 3RL3A 1OIEA 1HP1A 1QHWA 3T1IA 2HYOA 3THNA 4H2IA 2GJUA 2NYMC 3H63A 1UTEA 2IAEC 2NYLC 1U32A 2Z72A 3DSCA 4H1YP 3FLOA 3KBPA 5HPEA 4FBWA 2CV9A 1JK7A 4J6OA 1NNWA 1UF3A 4MP0A 4TUGA 2BQ8X 1USHA 1W24A 2Z06A 1KBPA 2QJCA 3EGGA 3H68A 3AUZA 2XMOA 5F3WA 1S3NA 2Q8UA 2YVTA 4ORBA 4ZVZA 2DXLA 2BDXA 3H61A 3ICFA 3IB8A 4O24A 1HPUA 2HY1A 2O8GA 3C9FA 3IB7A 2BCDA 1HO5A 4V0WA 3HVQA 3IVDA 2WDFA 4V0VA 3ZTVA 2WDDA 5J28A 2JOGA 1OI8A 2HYPA 2R17A 3QG5C 4HD0A 4H2FA 4LTYA 4ORCA 3TGHA 3E7BA 3H64A 4H2BA 3ZU0A 5IOHA 1S70A 2Z1AA 4LACC 1II7A 3DSDA 1TCOA 2DFJA 3GVEA 3IVEA 5DNYA 1V73A 4FBQA 3QFKA 1S8EA 2IE4C 3H69A 4H1SA 4LU9A 2ZOAA 1AUIA 4MOYA 3H67A 4UT2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WDE A;  2USH A;  3JYF A;  4XPN A;  4KBP A;  1FJM A;  1Z2W A;  3P71 C;  1WAO 1;  2QFP A;  4O5G A;  4YKE A;  3FGA C;  4IYP C;  4UT3 A;  3E7A A;  2O8A A;  4WWL A;  3RQZ A;  2NPP C;  5JPE A;  4V0X A;  3K7V C;  1T70 A;  1T71 A;  3PSO A;  4FBK A;  4Q7F A;  4B2O A;  1S3M A;  1SU1 A;  1WAR A;  2KKN A;  1S3L A;  4FCX A;  4O4K A;  4UWQ A;  3H62 B;  3CK2 A;  5C1V A;  4DSY A;  1IT6 A;  1XZW A;  4JA7 A;  2NXF A;  4OR9 A;  3C5W C;  5INB A;  2AHD A;  2P6B A;  3EGH A;  4DT2 A;  3N5U A;  3V4Y A;  1S95 A;  3H66 A;  5GTU A;  2A22 A;  3AV0 A;  1MF8 A;  2IE3 C;  4M0V A;  4ORA A;  4I5N C;  5JJT A;  4JA9 A;  3H60 A;  1QFC A;  3QFN A;  2WDC A;  4TUI A;  1G5B A;  4G9J A;  5EQV A;  3K7W C;  4MOV A;  4H2G A;  4KKZ A;  1OID A;  2QFR A;  3QFO A;  3RL4 A;  4IL1 A;  5B8I A;  3QFM A;  1M63 A;  4O43 A;  1XM7 A;  2ZBM A;  4I5L C;  3DW8 C;  4UT3 B;  4DHL A;  4F0Z A;  4ZX2 A;  5JPF A;  3RL5 A;  3THO B;  3PSN A;  4NZV A;  1Z2X A;  3LL8 A;  3RL3 A;  1OIE A;  1HP1 A;  1QHW A;  3T1I A;  2HYO A;  3THN A;  4H2I A;  2GJU A;  2NYM C;  3H63 A;  1UTE A;  2IAE C;  2NYL C;  1U32 A;  2Z72 A;  3DSC A;  4H1Y P;  3KBP A;  5HPE A;  4FBW A;  2CV9 A;  1JK7 A;  4J6O A;  1NNW A;  1UF3 A;  4MP0 A;  4TUG A;  2BQ8 X;  1USH A;  1W24 A;  2Z06 A;  1KBP A;  2QJC A;  3EGG A;  3H68 A;  3AUZ A;  2XMO A;  5F3W A;  1S3N A;  2Q8U A;  2YVT A;  4ORB A;  4ZVZ A;  2BDX A;  3H61 A;  3ICF A;  3IB8 A;  4O24 A;  1HPU A;  2HY1 A;  2O8G A;  3C9F A;  3IB7 A;  2BCD A;  1HO5 A;  4V0W A;  3HVQ A;  3IVD A;  2WDF A;  4V0V A;  3ZTV A;  2WDD A;  5J28 A;  2JOG A;  1OI8 A;  2HYP A;  2R17 A;  3QG5 C;  4HD0 A;  4H2F A;  4LTY A;  4ORC A;  3TGH A;  3E7B A;  3H64 A;  4H2B A;  3ZU0 A;  5IOH A;  1S70 A;  2Z1A A;  4LAC C;  1II7 A;  3DSD A;  1TCO A;  2DFJ A;  3GVE A;  3IVE A;  5DNY A;  1V73 A;  4FBQ A;  3QFK A;  1S8E A;  2IE4 C;  3H69 A;  4H1S A;  4LU9 A;  4MOY A;  1AUI A;  3H67 A;  4UT2 A; 
#chains in the Genus database with same CATH topology
 2WDE A;  2USH A;  3JYF A;  4XPN A;  4KBP A;  3D03 A;  1FJM A;  1Z2W A;  2ZO9 B;  3P71 C;  1WAO 1;  2QFP A;  4O5G A;  4YKE A;  3FGA C;  4IYP C;  4UT3 A;  3E7A A;  2O8A A;  4WWL A;  3RQZ A;  2NPP C;  5JPE A;  4V0X A;  3K7V C;  1T70 A;  2YEQ A;  1T71 A;  3PSO A;  4FBK A;  4Q7F A;  4B2O A;  1S3M A;  1SU1 A;  1WAR A;  2KKN A;  1S3L A;  4FCX A;  4O4K A;  4UWQ A;  3H62 B;  3CK2 A;  5C1V A;  4DSY A;  1IT6 A;  1XZW A;  4JA7 A;  2NXF A;  4OR9 A;  3C5W C;  5INB A;  2AHD A;  2P6B A;  3EGH A;  4DT2 A;  3N5U A;  3V4Y A;  1S95 A;  3H66 A;  5GTU A;  2A22 A;  3AV0 A;  1MF8 A;  2IE3 C;  4M0V A;  4ORA A;  4I5N C;  5JJT A;  4JA9 A;  3H60 A;  1QFC A;  3QFN A;  2WDC A;  4TUI A;  1G5B A;  4G9J A;  5EQV A;  3E0J A;  3K7W C;  4MOV A;  4H2G A;  4KKZ A;  1OID A;  2QFR A;  3QFO A;  3RL4 A;  2DXN A;  4IL1 A;  5B8I A;  3QFM A;  1M63 A;  4O43 A;  1XM7 A;  2ZBM A;  4I5L C;  3DW8 C;  4UT3 B;  4DHL A;  4F0Z A;  4ZX2 A;  5JPF A;  3RL5 A;  3THO B;  3PSN A;  4NZV A;  1Z2X A;  3LL8 A;  3RL3 A;  1OIE A;  1HP1 A;  1QHW A;  3T1I A;  2HYO A;  3THN A;  4H2I A;  2GJU A;  2NYM C;  3H63 A;  1UTE A;  2IAE C;  2NYL C;  1U32 A;  2Z72 A;  3DSC A;  4H1Y P;  3FLO A;  3KBP A;  5HPE A;  4FBW A;  2CV9 A;  1JK7 A;  4J6O A;  1NNW A;  1UF3 A;  4MP0 A;  4TUG A;  2BQ8 X;  1USH A;  1W24 A;  2Z06 A;  1KBP A;  2QJC A;  3EGG A;  3H68 A;  3AUZ A;  2XMO A;  5F3W A;  1S3N A;  2Q8U A;  2YVT A;  4ORB A;  4ZVZ A;  2DXL A;  2BDX A;  3H61 A;  3ICF A;  3IB8 A;  4O24 A;  1HPU A;  2HY1 A;  2O8G A;  3C9F A;  3IB7 A;  2BCD A;  1HO5 A;  4V0W A;  3HVQ A;  3IVD A;  2WDF A;  4V0V A;  3ZTV A;  2WDD A;  5J28 A;  2JOG A;  1OI8 A;  2HYP A;  2R17 A;  3QG5 C;  4HD0 A;  4H2F A;  4LTY A;  4ORC A;  3TGH A;  3E7B A;  3H64 A;  4H2B A;  3ZU0 A;  5IOH A;  1S70 A;  2Z1A A;  4LAC C;  1II7 A;  3DSD A;  1TCO A;  2DFJ A;  3GVE A;  3IVE A;  5DNY A;  1V73 A;  4FBQ A;  3QFK A;  1S8E A;  2IE4 C;  3H69 A;  4H1S A;  4LU9 A;  2ZOA A;  1AUI A;  4MOY A;  3H67 A;  4UT2 A; 
#chains in the Genus database with same CATH homology
 2WDE A;  2USH A;  3JYF A;  4XPN A;  4KBP A;  3D03 A;  1FJM A;  1Z2W A;  2ZO9 B;  3P71 C;  1WAO 1;  2QFP A;  4O5G A;  4YKE A;  3FGA C;  4IYP C;  4UT3 A;  3E7A A;  2O8A A;  4WWL A;  3RQZ A;  2NPP C;  5JPE A;  4V0X A;  3K7V C;  1T70 A;  2YEQ A;  1T71 A;  3PSO A;  4FBK A;  4Q7F A;  4B2O A;  1S3M A;  1SU1 A;  1WAR A;  2KKN A;  1S3L A;  4FCX A;  4O4K A;  4UWQ A;  3H62 B;  3CK2 A;  5C1V A;  4DSY A;  1IT6 A;  1XZW A;  4JA7 A;  2NXF A;  4OR9 A;  3C5W C;  5INB A;  2AHD A;  2P6B A;  3EGH A;  4DT2 A;  3N5U A;  3V4Y A;  1S95 A;  3H66 A;  5GTU A;  2A22 A;  3AV0 A;  1MF8 A;  2IE3 C;  4M0V A;  4ORA A;  4I5N C;  5JJT A;  4JA9 A;  3H60 A;  1QFC A;  3QFN A;  2WDC A;  4TUI A;  1G5B A;  4G9J A;  5EQV A;  3E0J A;  3K7W C;  4MOV A;  4H2G A;  4KKZ A;  1OID A;  2QFR A;  3QFO A;  3RL4 A;  2DXN A;  4IL1 A;  5B8I A;  3QFM A;  1M63 A;  4O43 A;  1XM7 A;  2ZBM A;  4I5L C;  3DW8 C;  4UT3 B;  4DHL A;  4F0Z A;  4ZX2 A;  5JPF A;  3RL5 A;  3THO B;  3PSN A;  4NZV A;  1Z2X A;  3LL8 A;  3RL3 A;  1OIE A;  1HP1 A;  1QHW A;  3T1I A;  2HYO A;  3THN A;  4H2I A;  2GJU A;  2NYM C;  3H63 A;  1UTE A;  2IAE C;  2NYL C;  1U32 A;  2Z72 A;  3DSC A;  4H1Y P;  3FLO A;  3KBP A;  5HPE A;  4FBW A;  2CV9 A;  1JK7 A;  4J6O A;  1NNW A;  1UF3 A;  4MP0 A;  4TUG A;  2BQ8 X;  1USH A;  1W24 A;  2Z06 A;  1KBP A;  2QJC A;  3EGG A;  3H68 A;  3AUZ A;  2XMO A;  5F3W A;  1S3N A;  2Q8U A;  2YVT A;  4ORB A;  4ZVZ A;  2DXL A;  2BDX A;  3H61 A;  3ICF A;  3IB8 A;  4O24 A;  1HPU A;  2HY1 A;  2O8G A;  3C9F A;  3IB7 A;  2BCD A;  1HO5 A;  4V0W A;  3HVQ A;  3IVD A;  2WDF A;  4V0V A;  3ZTV A;  2WDD A;  5J28 A;  2JOG A;  1OI8 A;  2HYP A;  2R17 A;  3QG5 C;  4HD0 A;  4H2F A;  4LTY A;  4ORC A;  3TGH A;  3E7B A;  3H64 A;  4H2B A;  3ZU0 A;  5IOH A;  1S70 A;  2Z1A A;  4LAC C;  1II7 A;  3DSD A;  1TCO A;  2DFJ A;  3GVE A;  3IVE A;  5DNY A;  1V73 A;  4FBQ A;  3QFK A;  1S8E A;  2IE4 C;  3H69 A;  4H1S A;  4LU9 A;  2ZOA A;  1AUI A;  4MOY A;  3H67 A;  4UT2 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...