5HVKB

Crystal structure of limk1 mutant d460n in complex with full-length cofilin-1
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
165
structure length
164
Chain Sequence
AGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYTTFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords LIM domain kinase 1
total genus 34
structure length 164
sequence length 165
ec nomenclature
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 5hvkB00
5HVKB 3EGDA 2NUTB 2VIKA 3EGXA 3CIPG 1T3YA 3A5NS 2FGHA 2MV2A 4KEFA 3Q2BA 2FH4A 3A5MS 4KEDA 2NUTA 4BEX1 1WM4A 1CNUA 1WFSA 3A5LS 3DAWB 4LIZA 1Q8XA 5KYYB 2LXXA 1UDMA 5FAFA 3EH2A 4JD2H 1SVRA 2XF1A 1TMWA 1COFA 5KYYA 4CBUG 1NLVG 1JHWA 3A5OS 3TU5B 1P8ZG 1V6FA 5DD2A 5KYXB 3CJCG 3EG9B 2D8BA 1M2OA 1KCQA 1NPHA 1VKKA 1C0FS 2LLFA 5KYXA 5KYNA 3EG9A 1D0NA 1PD1A 2FF3A 3FFKA 1CFYA 4Z94G 1RGIG 1M4JA 1TVJA 2XFAA 1F7SA 1AHQA 3EFOB 5KYWB 1PCXA 1X67A 2KVKA 2QTVA 1AK7A 2L72A 1EQYS 4KEEA 4S10C 1SVYA 4CBWG 3EFOA 4PKHB 3L50A 1NM1G 2NUPB 5IVUA 1QPVA 1T44G 5FAEA 1DEJS 3EH1A 3FG7A 1D4XG 2MP4A 2VACA 2NUPA 2W0IA 5A1MA 1H1VG 4PKGG 1T3XA 1Q8GA 1M2VB 3CI5G 1C0GS 3CJBG 2MOTA 2FF6G 3FFNA 1AK6A 1ESVS 1PD0A 1YAGG 1SVQA 2I2QA 1M2VA 4CBXG 2LJ8A 1HQZ1 2FH2A 1P8XA 2HD7A 1J72A 1VFQA 5KYWA 1NMDG 2FH3A 5KYUB 2VILA 1WNJA 5HVKD 3EGDB 5L6WC 1YVNG 1T2LA 3EGXB 3FG6A 5KYUA 2FH1A 4PKIG 1MDUA
chains in the Genus database with same CATH superfamily
5HVKB 3EGDA 2NUTB 2VIKA 3EGXA 3CIPG 1T3YA 3A5NS 2FGHA 2MV2A 4KEFA 3Q2BA 2FH4A 3A5MS 4KEDA 2NUTA 4BEX1 1WM4A 1CNUA 1WFSA 3A5LS 3DAWB 4LIZA 1Q8XA 5KYYB 2LXXA 1UDMA 5FAFA 3EH2A 4JD2H 1SVRA 2XF1A 1TMWA 1COFA 5KYYA 4CBUG 1NLVG 1JHWA 3A5OS 3TU5B 1P8ZG 1V6FA 5DD2A 5KYXB 3CJCG 3EG9B 2D8BA 1M2OA 1KCQA 1NPHA 1VKKA 1C0FS 2LLFA 5KYXA 5KYNA 3EG9A 1D0NA 1PD1A 2FF3A 3FFKA 1CFYA 4Z94G 1RGIG 1M4JA 1TVJA 2XFAA 1F7SA 1AHQA 3EFOB 5KYWB 1PCXA 1X67A 2KVKA 2QTVA 1AK7A 2L72A 1EQYS 4KEEA 4S10C 1SVYA 4CBWG 3EFOA 4PKHB 3L50A 1NM1G 2NUPB 5IVUA 1QPVA 1T44G 5FAEA 1DEJS 3EH1A 3FG7A 1D4XG 2MP4A 2VACA 2NUPA 2W0IA 5A1MA 1H1VG 3DA7A 4PKGG 1T3XA 1Q8GA 1M2VB 3CI5G 1C0GS 3CJBG 2MOTA 2FF6G 3FFNA 1AK6A 1ESVS 1PD0A 1YAGG 1SVQA 2I2QA 1M2VA 4CBXG 2LJ8A 1HQZ1 2FH2A 1P8XA 2HD7A 1J72A 1VFQA 5KYWA 1NMDG 2FH3A 5KYUB 2VILA 1WNJA 5HVKD 3EGDB 5L6WC 1YVNG 1T2LA 3EGXB 3FG6A 5KYUA 2FH1A 4PKIG 1MDUA
chains in the Genus database with same CATH topology
5HVKB 3EGDA 2NUTB 2VIKA 3EGXA 3CIPG 1T3YA 3A5NS 2FGHA 2MV2A 4KEFA 3Q2BA 2FH4A 3A5MS 4KEDA 2NUTA 4BEX1 1WM4A 1CNUA 1WFSA 3A5LS 3DAWB 4LIZA 1Q8XA 5KYYB 2LXXA 1UDMA 5FAFA 3EH2A 4JD2H 1SVRA 2XF1A 1TMWA 1COFA 5KYYA 4CBUG 1NLVG 1JHWA 3A5OS 3TU5B 1P8ZG 1V6FA 5DD2A 5KYXB 3CJCG 3EG9B 2D8BA 1M2OA 1KCQA 1NPHA 1VKKA 1C0FS 2LLFA 5KYXA 5KYNA 3EG9A 1D0NA 1PD1A 2FF3A 3FFKA 1CFYA 4Z94G 1RGIG 1M4JA 1TVJA 2XFAA 1F7SA 1AHQA 3EFOB 5KYWB 1PCXA 1X67A 2KVKA 2QTVA 1AK7A 2L72A 1EQYS 4KEEA 4S10C 1SVYA 4CBWG 3EFOA 4PKHB 3L50A 1NM1G 2NUPB 5IVUA 1QPVA 1T44G 5FAEA 1DEJS 3EH1A 3FG7A 1D4XG 2MP4A 2VACA 2NUPA 2W0IA 5A1MA 1H1VG 3DA7A 4PKGG 1T3XA 1Q8GA 1M2VB 3CI5G 1C0GS 3CJBG 2MOTA 2FF6G 3FFNA 1AK6A 1ESVS 1PD0A 1YAGG 1SVQA 2I2QA 1M2VA 4CBXG 2LJ8A 1HQZ1 2FH2A 1P8XA 2HD7A 1J72A 1VFQA 5KYWA 1NMDG 2FH3A 5KYUB 2VILA 1WNJA 5HVKD 3EGDB 5L6WC 1YVNG 1T2LA 3EGXB 3FG6A 5KYUA 2FH1A 4PKIG 1MDUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HVK B;  3EGD A;  2NUT B;  2VIK A;  3EGX A;  3CIP G;  1T3Y A;  3A5N S;  2FGH A;  2MV2 A;  4KEF A;  3Q2B A;  2FH4 A;  3A5M S;  4KED A;  2NUT A;  4BEX 1;  1WM4 A;  1CNU A;  1WFS A;  3A5L S;  3DAW B;  4LIZ A;  1Q8X A;  5KYY B;  2LXX A;  1UDM A;  5FAF A;  3EH2 A;  4JD2 H;  1SVR A;  2XF1 A;  1TMW A;  1COF A;  5KYY A;  4CBU G;  1NLV G;  1JHW A;  3A5O S;  3TU5 B;  1P8Z G;  1V6F A;  5DD2 A;  5KYX B;  3CJC G;  3EG9 B;  2D8B A;  1M2O A;  1KCQ A;  1NPH A;  1VKK A;  1C0F S;  2LLF A;  5KYX A;  5KYN A;  3EG9 A;  1D0N A;  1PD1 A;  2FF3 A;  3FFK A;  1CFY A;  4Z94 G;  1RGI G;  1M4J A;  1TVJ A;  2XFA A;  1F7S A;  1AHQ A;  3EFO B;  5KYW B;  1PCX A;  1X67 A;  2KVK A;  2QTV A;  1AK7 A;  2L72 A;  1EQY S;  4KEE A;  4S10 C;  1SVY A;  4CBW G;  3EFO A;  4PKH B;  3L50 A;  1NM1 G;  2NUP B;  5IVU A;  1QPV A;  1T44 G;  5FAE A;  1DEJ S;  3EH1 A;  3FG7 A;  1D4X G;  2MP4 A;  2VAC A;  2NUP A;  2W0I A;  5A1M A;  1H1V G;  4PKG G;  1T3X A;  1Q8G A;  1M2V B;  3CI5 G;  1C0G S;  3CJB G;  2MOT A;  2FF6 G;  3FFN A;  1AK6 A;  1ESV S;  1PD0 A;  1YAG G;  1SVQ A;  2I2Q A;  1M2V A;  4CBX G;  2LJ8 A;  1HQZ 1;  2FH2 A;  1P8X A;  2HD7 A;  1J72 A;  1VFQ A;  5KYW A;  1NMD G;  2FH3 A;  5KYU B;  2VIL A;  1WNJ A;  5HVK D;  3EGD B;  5L6W C;  1YVN G;  1T2L A;  3EGX B;  3FG6 A;  5KYU A;  2FH1 A;  4PKI G;  1MDU A; 
#chains in the Genus database with same CATH topology
 5HVK B;  3EGD A;  2NUT B;  2VIK A;  3EGX A;  3CIP G;  1T3Y A;  3A5N S;  2FGH A;  2MV2 A;  4KEF A;  3Q2B A;  2FH4 A;  3A5M S;  4KED A;  2NUT A;  4BEX 1;  1WM4 A;  1CNU A;  1WFS A;  3A5L S;  3DAW B;  4LIZ A;  1Q8X A;  5KYY B;  2LXX A;  1UDM A;  5FAF A;  3EH2 A;  4JD2 H;  1SVR A;  2XF1 A;  1TMW A;  1COF A;  5KYY A;  4CBU G;  1NLV G;  1JHW A;  3A5O S;  3TU5 B;  1P8Z G;  1V6F A;  5DD2 A;  5KYX B;  3CJC G;  3EG9 B;  2D8B A;  1M2O A;  1KCQ A;  1NPH A;  1VKK A;  1C0F S;  2LLF A;  5KYX A;  5KYN A;  3EG9 A;  1D0N A;  1PD1 A;  2FF3 A;  3FFK A;  1CFY A;  4Z94 G;  1RGI G;  1M4J A;  1TVJ A;  2XFA A;  1F7S A;  1AHQ A;  3EFO B;  5KYW B;  1PCX A;  1X67 A;  2KVK A;  2QTV A;  1AK7 A;  2L72 A;  1EQY S;  4KEE A;  4S10 C;  1SVY A;  4CBW G;  3EFO A;  4PKH B;  3L50 A;  1NM1 G;  2NUP B;  5IVU A;  1QPV A;  1T44 G;  5FAE A;  1DEJ S;  3EH1 A;  3FG7 A;  1D4X G;  2MP4 A;  2VAC A;  2NUP A;  2W0I A;  5A1M A;  1H1V G;  3DA7 A;  4PKG G;  1T3X A;  1Q8G A;  1M2V B;  3CI5 G;  1C0G S;  3CJB G;  2MOT A;  2FF6 G;  3FFN A;  1AK6 A;  1ESV S;  1PD0 A;  1YAG G;  1SVQ A;  2I2Q A;  1M2V A;  4CBX G;  2LJ8 A;  1HQZ 1;  2FH2 A;  1P8X A;  2HD7 A;  1J72 A;  1VFQ A;  5KYW A;  1NMD G;  2FH3 A;  5KYU B;  2VIL A;  1WNJ A;  5HVK D;  3EGD B;  5L6W C;  1YVN G;  1T2L A;  3EGX B;  3FG6 A;  5KYU A;  2FH1 A;  4PKI G;  1MDU A; 
#chains in the Genus database with same CATH homology
 5HVK B;  3EGD A;  2NUT B;  2VIK A;  3EGX A;  3CIP G;  1T3Y A;  3A5N S;  2FGH A;  2MV2 A;  4KEF A;  3Q2B A;  2FH4 A;  3A5M S;  4KED A;  2NUT A;  4BEX 1;  1WM4 A;  1CNU A;  1WFS A;  3A5L S;  3DAW B;  4LIZ A;  1Q8X A;  5KYY B;  2LXX A;  1UDM A;  5FAF A;  3EH2 A;  4JD2 H;  1SVR A;  2XF1 A;  1TMW A;  1COF A;  5KYY A;  4CBU G;  1NLV G;  1JHW A;  3A5O S;  3TU5 B;  1P8Z G;  1V6F A;  5DD2 A;  5KYX B;  3CJC G;  3EG9 B;  2D8B A;  1M2O A;  1KCQ A;  1NPH A;  1VKK A;  1C0F S;  2LLF A;  5KYX A;  5KYN A;  3EG9 A;  1D0N A;  1PD1 A;  2FF3 A;  3FFK A;  1CFY A;  4Z94 G;  1RGI G;  1M4J A;  1TVJ A;  2XFA A;  1F7S A;  1AHQ A;  3EFO B;  5KYW B;  1PCX A;  1X67 A;  2KVK A;  2QTV A;  1AK7 A;  2L72 A;  1EQY S;  4KEE A;  4S10 C;  1SVY A;  4CBW G;  3EFO A;  4PKH B;  3L50 A;  1NM1 G;  2NUP B;  5IVU A;  1QPV A;  1T44 G;  5FAE A;  1DEJ S;  3EH1 A;  3FG7 A;  1D4X G;  2MP4 A;  2VAC A;  2NUP A;  2W0I A;  5A1M A;  1H1V G;  3DA7 A;  4PKG G;  1T3X A;  1Q8G A;  1M2V B;  3CI5 G;  1C0G S;  3CJB G;  2MOT A;  2FF6 G;  3FFN A;  1AK6 A;  1ESV S;  1PD0 A;  1YAG G;  1SVQ A;  2I2Q A;  1M2V A;  4CBX G;  2LJ8 A;  1HQZ 1;  2FH2 A;  1P8X A;  2HD7 A;  1J72 A;  1VFQ A;  5KYW A;  1NMD G;  2FH3 A;  5KYU B;  2VIL A;  1WNJ A;  5HVK D;  3EGD B;  5L6W C;  1YVN G;  1T2L A;  3EGX B;  3FG6 A;  5KYU A;  2FH1 A;  4PKI G;  1MDU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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