5HYPA

Structure of human c4b-binding protein alpha cain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m28 protein
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords C4b-binding protein alpha chain
total genus 16
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2016-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hypA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hypA01
2CKUA 1HFHA 1OK2A 1E88A 4B2RA 2QY0A 1LY2A 2YBYA 1H2QP 2A55A 3SW0X 4PZ5A 3OXUD 3ZRZA 2RL0A 2MCYA 1QUBA 1TPMA 3KZJA 1GPZA 4KKDA 3R62A 4WJG2 2LOJA 3GXEA 4YNXA 2KMSA 1CKLA 1G4FA 5HYTB 1GHQB 2W80A 3RJ3D 2IZ4A 1NWVA 2YRAA 1PPQA 5HYUB 2XQWC 4DJZA 1Z92B 3KXVA 2JGWA 1C1ZA 2JGXA 1H03P 3NFPI 4J38B 4MUCA 3ZD2A 4C16A 1SS2A 3OEDC 1E5GA 2WIIC 1O9AA 2ERJA 2CG7A 2RLPA 4K12A 2CG6A 4FXGG 3OP8A 3ZD1A 4B2SA 3EJHA 4CSYA 1OK1A 3INBC 2BZMA 1QO6A 5HZPB 1G4GA 1OK3A 2RKYA 3L89M 2EC3A 2EHFA 5I0QB 4ZH1D 2RLQA 1GKNA 3O8EB 2XRDA 2IZ3A 2MCZA 1OJWA 1VVCA 1OK9A 1U5MA 4AYDA 1ZJKA 2XWJI 2B5ID 3ERBA 1TPNA 5JPMG 1HCCA 1Q3XA 4A5WB 1ELVA 3CALA 3M7PA 4ONTD 1E8BA 2V8EA 4LOTA 2O39C 1OJYA 1H2PP 1SRZA 1MD8A 2W81A 4JHSA 1MD7A 3T5OA 4AYMA 2UWNA 4LOSA 1H04P 1VVDA 5FO8C 4AYEA 2RKZA 4F4OC 1TPGA 3TVJA 1FBRA 3GOVA 4IGDA 4AYIA 3MQLA 2G7IA 1OJVA 2JRAA 1HFIA 1GKGA 2XRBA 5HYPA 1UOTP 3IU3I 2XWBF 2KRIA 1QGBA 3IX0A
chains in the Genus database with same CATH superfamily
2CKUA 1HFHA 1OK2A 1E88A 4B2RA 2QY0A 1LY2A 2YBYA 1H2QP 2A55A 3SW0X 4PZ5A 5DN4A 3OXUD 3ZRZA 2RL0A 2MCYA 1QUBA 1TPMA 3KZJA 2I2LA 4PO7A 1GPZA 4KKDA 3R62A 4WJG2 2LOJA 3GXEA 4YNXA 2KMSA 1CKLA 1G4FA 5HYTB 1GHQB 2Y8RA 2W80A 3RJ3D 2IZ4A 1NWVA 2YRAA 1PPQA 5HYUB 2XQWC 4DJZA 4APLA 1Z92B 3KXVA 2JGWA 1C1ZA 3K3TA 2JGXA 1H03P 3NFPI 4J38B 4MUCA 3ZD2A 4C16A 1SS2A 3OEDC 1E5GA 2X2ZA 2WIIC 1O9AA 2ERJA 2CG7A 2RLPA 4K12A 2CG6A 3CI0J 4MSLA 3FGTA 4FXGG 3OP8A 3ZD1A 2ZYCA 4B2SA 3EJHA 3WSYA 4CSYA 1OK1A 4BWCA 3INBC 2BZMA 1QO6A 5HZPB 1G4GA 1OK3A 2RKYA 3L89M 2EC3A 2EHFA 5I0QB 5DN5A 2RLQA 4ZH1D 1GKNA 3O8EB 2XRDA 2IZ3A 2MCZA 1OJWA 1VVCA 1OK9A 1U5MA 1RLHA 3NJAA 4AYDA 1ZJKA 2XWJI 2B5ID 3ERBA 1TPNA 5JPMG 1HCCA 1Q3XA 4A5WB 1ELVA 3CALA 3M7PA 4ONTD 1E8BA 2V8EA 3ZLDA 4LOTA 2O39C 1OJYA 1H2PP 4N7EA 1SRZA 1MD8A 2W81A 4JHSA 1MD7A 3T5OA 4AYMA 2UWNA 3F6KA 4LOSA 1H04P 1VVDA 3ZLEA 5FO8C 4AYEA 2RKZA 4F4OC 1TPGA 3TVJA 1FBRA 3GOVA 4IGDA 4AYIA 4YIZA 3MQLA 3FGRA 2G7IA 1OJVA 2Y8TA 2JRAA 1HFIA 3WSXA 1GKGA 2XRBA 2Y8SA 3VWOA 5HYPA 1UOTP 3IU3I 2XWBF 2KRIA 1QGBA 3IX0A
chains in the Genus database with same CATH topology
2CKUA 1HFHA 1OK2A 1E88A 4B2RA 2QY0A 1LY2A 2YBYA 1H2QP 2A55A 3SW0X 4PZ5A 3OXUD 3ZRZA 2RL0A 2MCYA 1QUBA 1TPMA 3KZJA 1GPZA 4KKDA 3R62A 4WJG2 2LOJA 3GXEA 4YNXA 2KMSA 1CKLA 1G4FA 5HYTB 1GHQB 2W80A 3RJ3D 2IZ4A 1NWVA 2YRAA 1PPQA 5HYUB 2XQWC 4DJZA 1Z92B 3KXVA 2JGWA 1C1ZA 2JGXA 1H03P 3NFPI 4J38B 4MUCA 3ZD2A 4C16A 1SS2A 3OEDC 1E5GA 2WIIC 1O9AA 2ERJA 2CG7A 2RLPA 4K12A 2CG6A 4FXGG 3OP8A 3ZD1A 4B2SA 3EJHA 4CSYA 1OK1A 3INBC 2BZMA 1QO6A 5HZPB 1G4GA 1OK3A 2RKYA 3L89M 2EC3A 2EHFA 5I0QB 4ZH1D 2RLQA 1GKNA 3O8EB 2XRDA 2IZ3A 2MCZA 1OJWA 1VVCA 1OK9A 1U5MA 4AYDA 1ZJKA 2XWJI 2B5ID 3ERBA 1TPNA 5JPMG 1HCCA 1Q3XA 4A5WB 1ELVA 3CALA 3M7PA 4ONTD 1E8BA 2V8EA 4LOTA 2O39C 1OJYA 1H2PP 1SRZA 1MD8A 2W81A 4JHSA 1MD7A 3T5OA 4AYMA 2UWNA 4LOSA 1H04P 1VVDA 5FO8C 4AYEA 2RKZA 4F4OC 1TPGA 3TVJA 1FBRA 3GOVA 4IGDA 4AYIA 3MQLA 2G7IA 1OJVA 2JRAA 1HFIA 1GKGA 2XRBA 5HYPA 1UOTP 3IU3I 2XWBF 2KRIA 1QGBA 3IX0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CKU A;  1HFH A;  1OK2 A;  1E88 A;  4B2R A;  2QY0 A;  1LY2 A;  2YBY A;  1H2Q P;  2A55 A;  3SW0 X;  4PZ5 A;  3OXU D;  3ZRZ A;  2RL0 A;  2MCY A;  1QUB A;  1TPM A;  3KZJ A;  1GPZ A;  4KKD A;  3R62 A;  4WJG 2;  2LOJ A;  3GXE A;  4YNX A;  2KMS A;  1CKL A;  1G4F A;  5HYT B;  1GHQ B;  2W80 A;  3RJ3 D;  2IZ4 A;  1NWV A;  2YRA A;  1PPQ A;  5HYU B;  2XQW C;  4DJZ A;  1Z92 B;  3KXV A;  2JGW A;  1C1Z A;  2JGX A;  1H03 P;  3NFP I;  4J38 B;  4MUC A;  3ZD2 A;  4C16 A;  1SS2 A;  3OED C;  1E5G A;  2WII C;  1O9A A;  2ERJ A;  2CG7 A;  2RLP A;  4K12 A;  2CG6 A;  4FXG G;  3OP8 A;  3ZD1 A;  4B2S A;  3EJH A;  4CSY A;  1OK1 A;  3INB C;  2BZM A;  1QO6 A;  5HZP B;  1G4G A;  1OK3 A;  2RKY A;  3L89 M;  2EC3 A;  2EHF A;  5I0Q B;  4ZH1 D;  2RLQ A;  1GKN A;  3O8E B;  2XRD A;  2IZ3 A;  2MCZ A;  1OJW A;  1VVC A;  1OK9 A;  1U5M A;  4AYD A;  1ZJK A;  2XWJ I;  2B5I D;  3ERB A;  1TPN A;  5JPM G;  1HCC A;  1Q3X A;  4A5W B;  1ELV A;  3CAL A;  3M7P A;  4ONT D;  1E8B A;  2V8E A;  4LOT A;  2O39 C;  1OJY A;  1H2P P;  1SRZ A;  1MD8 A;  2W81 A;  4JHS A;  1MD7 A;  3T5O A;  4AYM A;  2UWN A;  4LOS A;  1H04 P;  1VVD A;  5FO8 C;  4AYE A;  2RKZ A;  4F4O C;  1TPG A;  3TVJ A;  1FBR A;  3GOV A;  4IGD A;  4AYI A;  3MQL A;  2G7I A;  1OJV A;  2JRA A;  1HFI A;  1GKG A;  2XRB A;  5HYP A;  1UOT P;  3IU3 I;  2XWB F;  2KRI A;  1QGB A;  3IX0 A; 
#chains in the Genus database with same CATH topology
 2CKU A;  1HFH A;  1OK2 A;  1E88 A;  4B2R A;  2QY0 A;  1LY2 A;  2YBY A;  1H2Q P;  2A55 A;  3SW0 X;  4PZ5 A;  5DN4 A;  3OXU D;  3ZRZ A;  2RL0 A;  2MCY A;  1QUB A;  1TPM A;  3KZJ A;  2I2L A;  4PO7 A;  1GPZ A;  4KKD A;  3R62 A;  4WJG 2;  2LOJ A;  3GXE A;  4YNX A;  2KMS A;  1CKL A;  1G4F A;  5HYT B;  1GHQ B;  2Y8R A;  2W80 A;  3RJ3 D;  2IZ4 A;  1NWV A;  2YRA A;  1PPQ A;  5HYU B;  2XQW C;  4DJZ A;  4APL A;  1Z92 B;  3KXV A;  2JGW A;  1C1Z A;  3K3T A;  2JGX A;  1H03 P;  3NFP I;  4J38 B;  4MUC A;  3ZD2 A;  4C16 A;  1SS2 A;  3OED C;  1E5G A;  2X2Z A;  2WII C;  1O9A A;  2ERJ A;  2CG7 A;  2RLP A;  4K12 A;  2CG6 A;  3CI0 J;  4MSL A;  3FGT A;  4FXG G;  3OP8 A;  3ZD1 A;  2ZYC A;  4B2S A;  3EJH A;  3WSY A;  4CSY A;  1OK1 A;  4BWC A;  3INB C;  2BZM A;  1QO6 A;  5HZP B;  1G4G A;  1OK3 A;  2RKY A;  3L89 M;  2EC3 A;  2EHF A;  5I0Q B;  5DN5 A;  2RLQ A;  4ZH1 D;  1GKN A;  3O8E B;  2XRD A;  2IZ3 A;  2MCZ A;  1OJW A;  1VVC A;  1OK9 A;  1U5M A;  1RLH A;  3NJA A;  4AYD A;  1ZJK A;  2XWJ I;  2B5I D;  3ERB A;  1TPN A;  5JPM G;  1HCC A;  1Q3X A;  4A5W B;  1ELV A;  3CAL A;  3M7P A;  4ONT D;  1E8B A;  2V8E A;  3ZLD A;  4LOT A;  2O39 C;  1OJY A;  1H2P P;  4N7E A;  1SRZ A;  1MD8 A;  2W81 A;  4JHS A;  1MD7 A;  3T5O A;  4AYM A;  2UWN A;  3F6K A;  4LOS A;  1H04 P;  1VVD A;  3ZLE A;  5FO8 C;  4AYE A;  2RKZ A;  4F4O C;  1TPG A;  3TVJ A;  1FBR A;  3GOV A;  4IGD A;  4AYI A;  4YIZ A;  3MQL A;  3FGR A;  2G7I A;  1OJV A;  2Y8T A;  2JRA A;  1HFI A;  3WSX A;  1GKG A;  2XRB A;  2Y8S A;  3VWO A;  5HYP A;  1UOT P;  3IU3 I;  2XWB F;  2KRI A;  1QGB A;  3IX0 A; 
#chains in the Genus database with same CATH homology
 2CKU A;  1HFH A;  1OK2 A;  1E88 A;  4B2R A;  2QY0 A;  1LY2 A;  2YBY A;  1H2Q P;  2A55 A;  3SW0 X;  4PZ5 A;  3OXU D;  3ZRZ A;  2RL0 A;  2MCY A;  1QUB A;  1TPM A;  3KZJ A;  1GPZ A;  4KKD A;  3R62 A;  4WJG 2;  2LOJ A;  3GXE A;  4YNX A;  2KMS A;  1CKL A;  1G4F A;  5HYT B;  1GHQ B;  2W80 A;  3RJ3 D;  2IZ4 A;  1NWV A;  2YRA A;  1PPQ A;  5HYU B;  2XQW C;  4DJZ A;  1Z92 B;  3KXV A;  2JGW A;  1C1Z A;  2JGX A;  1H03 P;  3NFP I;  4J38 B;  4MUC A;  3ZD2 A;  4C16 A;  1SS2 A;  3OED C;  1E5G A;  2WII C;  1O9A A;  2ERJ A;  2CG7 A;  2RLP A;  4K12 A;  2CG6 A;  4FXG G;  3OP8 A;  3ZD1 A;  4B2S A;  3EJH A;  4CSY A;  1OK1 A;  3INB C;  2BZM A;  1QO6 A;  5HZP B;  1G4G A;  1OK3 A;  2RKY A;  3L89 M;  2EC3 A;  2EHF A;  5I0Q B;  4ZH1 D;  2RLQ A;  1GKN A;  3O8E B;  2XRD A;  2IZ3 A;  2MCZ A;  1OJW A;  1VVC A;  1OK9 A;  1U5M A;  4AYD A;  1ZJK A;  2XWJ I;  2B5I D;  3ERB A;  1TPN A;  5JPM G;  1HCC A;  1Q3X A;  4A5W B;  1ELV A;  3CAL A;  3M7P A;  4ONT D;  1E8B A;  2V8E A;  4LOT A;  2O39 C;  1OJY A;  1H2P P;  1SRZ A;  1MD8 A;  2W81 A;  4JHS A;  1MD7 A;  3T5O A;  4AYM A;  2UWN A;  4LOS A;  1H04 P;  1VVD A;  5FO8 C;  4AYE A;  2RKZ A;  4F4O C;  1TPG A;  3TVJ A;  1FBR A;  3GOV A;  4IGD A;  4AYI A;  3MQL A;  2G7I A;  1OJV A;  2JRA A;  1HFI A;  1GKG A;  2XRB A;  5HYP A;  1UOT P;  3IU3 I;  2XWB F;  2KRI A;  1QGB A;  3IX0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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