5HYTB

Structure of human c4b-binidng protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m22 protein
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
124
structure length
124
Chain Sequence
NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule tags Immune system
source organism Streptococcus pyogenes
molecule keywords Precursor to Protein Sir22
total genus 22
structure length 124
sequence length 124
chains with identical sequence D, F, H
ec nomenclature
pdb deposition date 2016-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hytB02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hytB01
1ELVA 2XQWC 1GKNA 3IX0A 5FO8C 2MCZA 2YRAA 3TVJA 4AYEA 3O8EB 3R62A 3INBC 2XWBF 1VVCA 1SRZA 2RKYA 2G7IA 2IZ4A 1OK2A 3ZRZA 2B5ID 1QO6A 3ERBA 1OK1A 1OJYA 2MCYA 4K12A 1E8BA 4AYMA 2A55A 1OK3A 3ZD1A 3KZJA 1SS2A 3M7PA 1Z92B 4AYIA 1C1ZA 1H03P 5HYUB 2LOJA 2XWJI 2WIIC 3EJHA 3NFPI 5I0QB 4A5WB 4C16A 4LOTA 5HYPA 4CSYA 2ERJA 1OJWA 5HYTB 3OXUD 4B2SA 1UOTP 1LY2A 1HFIA 2JRAA 2W80A 4IGDA 2KRIA 2EC3A 2JGXA 1CKLA 4YNXA 1MD8A 2CG7A 1Q3XA 1OK9A 3T5OA 1E5GA 3OEDC 3SW0X 4J38B 2QY0A 4JHSA 1G4FA 1E88A 2RKZA 4KKDA 2RLQA 2IZ3A 1MD7A 3L89M 1HFHA 1QGBA 1U5MA 2O39C 1H2QP 4B2RA 1NWVA 3GXEA 4ZH1D 1H2PP 3CALA 1HCCA 4PZ5A 4F4OC 2KMSA 2YBYA 1GKGA 5JPMG 1ZJKA 4AYDA 1PPQA 1VVDA 5HZPB 2JGWA 4DJZA 1GHQB 4LOSA 3RJ3D 1O9AA 1GPZA 2UWNA 1QUBA 4ONTD 3ZD2A 3OP8A 2CG6A 2XRDA 2BZMA 2V8EA 1TPMA 1FBRA 1TPNA 4WJG2 4MUCA 3GOVA 3IU3I 3KXVA 2RL0A 4FXGG 1OJVA 3MQLA 2RLPA 1TPGA 1G4GA 1H04P 2CKUA 2EHFA 2XRBA 2W81A
chains in the Genus database with same CATH superfamily
2Y8RA 1ELVA 2XQWC 1GKNA 3IX0A 5FO8C 2MCZA 2YRAA 3TVJA 4AYEA 3O8EB 3R62A 3INBC 3FGRA 2XWBF 1VVCA 1SRZA 2RKYA 4APLA 2G7IA 2IZ4A 1OK2A 3ZLDA 2B5ID 1QO6A 3ERBA 3ZRZA 1OK1A 1OJYA 2MCYA 4K12A 1E8BA 4AYMA 4PO7A 2A55A 1OK3A 5DN5A 3KZJA 3ZD1A 1SS2A 3M7PA 2I2LA 1Z92B 4AYIA 1C1ZA 1H03P 4BWCA 5HYUB 2LOJA 2XWJI 2WIIC 3EJHA 3NFPI 5I0QB 4A5WB 3VWOA 4LOTA 4C16A 5HYPA 2X2ZA 2Y8SA 2ERJA 1OJWA 4MSLA 4CSYA 3OXUD 4B2SA 5HYTB 1UOTP 1LY2A 1HFIA 3NJAA 2JRAA 2W80A 4IGDA 2KRIA 2EC3A 2JGXA 1CKLA 4YNXA 1MD8A 3K3TA 2CG7A 1Q3XA 1OK9A 3T5OA 1E5GA 3OEDC 3SW0X 4J38B 2QY0A 4JHSA 3WSYA 1G4FA 1E88A 2RKZA 4KKDA 2RLQA 2IZ3A 1MD7A 3L89M 1HFHA 1QGBA 1U5MA 2O39C 1H2QP 2ZYCA 4B2RA 1NWVA 3GXEA 4ZH1D 1H2PP 3CALA 1HCCA 4PZ5A 4F4OC 2KMSA 4YIZA 2YBYA 1GKGA 5JPMG 1ZJKA 4AYDA 1PPQA 1VVDA 5HZPB 2JGWA 4DJZA 1GHQB 2Y8TA 4LOSA 3RJ3D 1O9AA 1GPZA 2UWNA 5DN4A 3ZLEA 1QUBA 4N7EA 4ONTD 3CI0J 3ZD2A 3OP8A 2CG6A 2XRDA 2BZMA 2V8EA 1TPMA 1FBRA 1TPNA 1RLHA 4WJG2 4MUCA 3GOVA 3WSXA 3IU3I 3KXVA 2RL0A 3F6KA 4FXGG 1OJVA 3MQLA 2RLPA 1TPGA 1G4GA 3FGTA 1H04P 2CKUA 2EHFA 2XRBA 2W81A
chains in the Genus database with same CATH topology
1ELVA 2XQWC 1GKNA 3IX0A 5FO8C 2MCZA 2YRAA 3TVJA 4AYEA 3O8EB 3R62A 3INBC 2XWBF 1VVCA 1SRZA 2RKYA 2G7IA 2IZ4A 1OK2A 3ZRZA 2B5ID 1QO6A 3ERBA 1OK1A 1OJYA 2MCYA 4K12A 1E8BA 4AYMA 2A55A 1OK3A 3ZD1A 3KZJA 1SS2A 3M7PA 1Z92B 4AYIA 1C1ZA 1H03P 5HYUB 2LOJA 2XWJI 2WIIC 3EJHA 3NFPI 5I0QB 4A5WB 4C16A 4LOTA 5HYPA 4CSYA 2ERJA 1OJWA 5HYTB 3OXUD 4B2SA 1UOTP 1LY2A 1HFIA 2JRAA 2W80A 4IGDA 2KRIA 2EC3A 2JGXA 1CKLA 4YNXA 1MD8A 2CG7A 1Q3XA 1OK9A 3T5OA 1E5GA 3OEDC 3SW0X 4J38B 2QY0A 4JHSA 1G4FA 1E88A 2RKZA 4KKDA 2RLQA 2IZ3A 1MD7A 3L89M 1HFHA 1QGBA 1U5MA 2O39C 1H2QP 4B2RA 1NWVA 3GXEA 4ZH1D 1H2PP 3CALA 1HCCA 4PZ5A 4F4OC 2KMSA 2YBYA 1GKGA 5JPMG 1ZJKA 4AYDA 1PPQA 1VVDA 5HZPB 2JGWA 4DJZA 1GHQB 4LOSA 3RJ3D 1O9AA 1GPZA 2UWNA 1QUBA 4ONTD 3ZD2A 3OP8A 2CG6A 2XRDA 2BZMA 2V8EA 1TPMA 1FBRA 1TPNA 4WJG2 4MUCA 3GOVA 3IU3I 3KXVA 2RL0A 4FXGG 1OJVA 3MQLA 2RLPA 1TPGA 1G4GA 1H04P 2CKUA 2EHFA 2XRBA 2W81A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ELV A;  2XQW C;  1GKN A;  3IX0 A;  5FO8 C;  2MCZ A;  2YRA A;  3TVJ A;  4AYE A;  3O8E B;  3R62 A;  3INB C;  2XWB F;  1VVC A;  1SRZ A;  2RKY A;  2G7I A;  2IZ4 A;  1OK2 A;  3ZRZ A;  2B5I D;  1QO6 A;  3ERB A;  1OK1 A;  1OJY A;  2MCY A;  4K12 A;  1E8B A;  4AYM A;  2A55 A;  1OK3 A;  3ZD1 A;  3KZJ A;  1SS2 A;  3M7P A;  1Z92 B;  4AYI A;  1C1Z A;  1H03 P;  5HYU B;  2LOJ A;  2XWJ I;  2WII C;  3EJH A;  3NFP I;  5I0Q B;  4A5W B;  4C16 A;  4LOT A;  5HYP A;  4CSY A;  2ERJ A;  1OJW A;  5HYT B;  3OXU D;  4B2S A;  1UOT P;  1LY2 A;  1HFI A;  2JRA A;  2W80 A;  4IGD A;  2KRI A;  2EC3 A;  2JGX A;  1CKL A;  4YNX A;  1MD8 A;  2CG7 A;  1Q3X A;  1OK9 A;  3T5O A;  1E5G A;  3OED C;  3SW0 X;  4J38 B;  2QY0 A;  4JHS A;  1G4F A;  1E88 A;  2RKZ A;  4KKD A;  2RLQ A;  2IZ3 A;  1MD7 A;  3L89 M;  1HFH A;  1QGB A;  1U5M A;  2O39 C;  1H2Q P;  4B2R A;  1NWV A;  3GXE A;  4ZH1 D;  1H2P P;  3CAL A;  1HCC A;  4PZ5 A;  4F4O C;  2KMS A;  2YBY A;  1GKG A;  5JPM G;  1ZJK A;  4AYD A;  1PPQ A;  1VVD A;  5HZP B;  2JGW A;  4DJZ A;  1GHQ B;  4LOS A;  3RJ3 D;  1O9A A;  1GPZ A;  2UWN A;  1QUB A;  4ONT D;  3ZD2 A;  3OP8 A;  2CG6 A;  2XRD A;  2BZM A;  2V8E A;  1TPM A;  1FBR A;  1TPN A;  4WJG 2;  4MUC A;  3GOV A;  3IU3 I;  3KXV A;  2RL0 A;  4FXG G;  1OJV A;  3MQL A;  2RLP A;  1TPG A;  1G4G A;  1H04 P;  2CKU A;  2EHF A;  2XRB A;  2W81 A; 
#chains in the Genus database with same CATH topology
 2Y8R A;  1ELV A;  2XQW C;  1GKN A;  3IX0 A;  5FO8 C;  2MCZ A;  2YRA A;  3TVJ A;  4AYE A;  3O8E B;  3R62 A;  3INB C;  3FGR A;  2XWB F;  1VVC A;  1SRZ A;  2RKY A;  4APL A;  2G7I A;  2IZ4 A;  1OK2 A;  3ZLD A;  2B5I D;  1QO6 A;  3ERB A;  3ZRZ A;  1OK1 A;  1OJY A;  2MCY A;  4K12 A;  1E8B A;  4AYM A;  4PO7 A;  2A55 A;  1OK3 A;  5DN5 A;  3KZJ A;  3ZD1 A;  1SS2 A;  3M7P A;  2I2L A;  1Z92 B;  4AYI A;  1C1Z A;  1H03 P;  4BWC A;  5HYU B;  2LOJ A;  2XWJ I;  2WII C;  3EJH A;  3NFP I;  5I0Q B;  4A5W B;  3VWO A;  4LOT A;  4C16 A;  5HYP A;  2X2Z A;  2Y8S A;  2ERJ A;  1OJW A;  4MSL A;  4CSY A;  3OXU D;  4B2S A;  5HYT B;  1UOT P;  1LY2 A;  1HFI A;  3NJA A;  2JRA A;  2W80 A;  4IGD A;  2KRI A;  2EC3 A;  2JGX A;  1CKL A;  4YNX A;  1MD8 A;  3K3T A;  2CG7 A;  1Q3X A;  1OK9 A;  3T5O A;  1E5G A;  3OED C;  3SW0 X;  4J38 B;  2QY0 A;  4JHS A;  3WSY A;  1G4F A;  1E88 A;  2RKZ A;  4KKD A;  2RLQ A;  2IZ3 A;  1MD7 A;  3L89 M;  1HFH A;  1QGB A;  1U5M A;  2O39 C;  1H2Q P;  2ZYC A;  4B2R A;  1NWV A;  3GXE A;  4ZH1 D;  1H2P P;  3CAL A;  1HCC A;  4PZ5 A;  4F4O C;  2KMS A;  4YIZ A;  2YBY A;  1GKG A;  5JPM G;  1ZJK A;  4AYD A;  1PPQ A;  1VVD A;  5HZP B;  2JGW A;  4DJZ A;  1GHQ B;  2Y8T A;  4LOS A;  3RJ3 D;  1O9A A;  1GPZ A;  2UWN A;  5DN4 A;  3ZLE A;  1QUB A;  4N7E A;  4ONT D;  3CI0 J;  3ZD2 A;  3OP8 A;  2CG6 A;  2XRD A;  2BZM A;  2V8E A;  1TPM A;  1FBR A;  1TPN A;  1RLH A;  4WJG 2;  4MUC A;  3GOV A;  3WSX A;  3IU3 I;  3KXV A;  2RL0 A;  3F6K A;  4FXG G;  1OJV A;  3MQL A;  2RLP A;  1TPG A;  1G4G A;  3FGT A;  1H04 P;  2CKU A;  2EHF A;  2XRB A;  2W81 A; 
#chains in the Genus database with same CATH homology
 1ELV A;  2XQW C;  1GKN A;  3IX0 A;  5FO8 C;  2MCZ A;  2YRA A;  3TVJ A;  4AYE A;  3O8E B;  3R62 A;  3INB C;  2XWB F;  1VVC A;  1SRZ A;  2RKY A;  2G7I A;  2IZ4 A;  1OK2 A;  3ZRZ A;  2B5I D;  1QO6 A;  3ERB A;  1OK1 A;  1OJY A;  2MCY A;  4K12 A;  1E8B A;  4AYM A;  2A55 A;  1OK3 A;  3ZD1 A;  3KZJ A;  1SS2 A;  3M7P A;  1Z92 B;  4AYI A;  1C1Z A;  1H03 P;  5HYU B;  2LOJ A;  2XWJ I;  2WII C;  3EJH A;  3NFP I;  5I0Q B;  4A5W B;  4C16 A;  4LOT A;  5HYP A;  4CSY A;  2ERJ A;  1OJW A;  5HYT B;  3OXU D;  4B2S A;  1UOT P;  1LY2 A;  1HFI A;  2JRA A;  2W80 A;  4IGD A;  2KRI A;  2EC3 A;  2JGX A;  1CKL A;  4YNX A;  1MD8 A;  2CG7 A;  1Q3X A;  1OK9 A;  3T5O A;  1E5G A;  3OED C;  3SW0 X;  4J38 B;  2QY0 A;  4JHS A;  1G4F A;  1E88 A;  2RKZ A;  4KKD A;  2RLQ A;  2IZ3 A;  1MD7 A;  3L89 M;  1HFH A;  1QGB A;  1U5M A;  2O39 C;  1H2Q P;  4B2R A;  1NWV A;  3GXE A;  4ZH1 D;  1H2P P;  3CAL A;  1HCC A;  4PZ5 A;  4F4O C;  2KMS A;  2YBY A;  1GKG A;  5JPM G;  1ZJK A;  4AYD A;  1PPQ A;  1VVD A;  5HZP B;  2JGW A;  4DJZ A;  1GHQ B;  4LOS A;  3RJ3 D;  1O9A A;  1GPZ A;  2UWN A;  1QUB A;  4ONT D;  3ZD2 A;  3OP8 A;  2CG6 A;  2XRD A;  2BZM A;  2V8E A;  1TPM A;  1FBR A;  1TPN A;  4WJG 2;  4MUC A;  3GOV A;  3IU3 I;  3KXV A;  2RL0 A;  4FXG G;  1OJV A;  3MQL A;  2RLP A;  1TPG A;  1G4G A;  1H04 P;  2CKU A;  2EHF A;  2XRB A;  2W81 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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