5HZPB

Structure of human c4b-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus m49 protein.
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
125
structure length
125
Chain Sequence
SNCGPPPTLSFAAPMDITLTETRFKTGTTMKYTCLPGYVRSHSTQTMTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
pubmed doi rcsb
molecule keywords M protein, serotype 49
molecule tags Immune system
source organism Streptococcus pyogenes serotype m49
total genus 18
structure length 125
sequence length 125
chains with identical sequence D
ec nomenclature
pdb deposition date 2016-02-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hzpB02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 5hzpB01
2XWBF 1E5GA 3GOVA 3INBC 4ZH1D 1QO6A 2V8EA 1OJYA 1Q3XA 1H2QP 2CKUA 1SRZA 3ZD1A 2O39C 1ZJKA 3L89M 1HCCA 1OK9A 5I0QB 1MD7A 4B2SA 2YBYA 3EJHA 3ZD2A 4AYMA 4AYIA 3MQLA 1PPQA 2IZ4A 3OXUD 2RL0A 4KKDA 4FXGG 4WJG2 2KRIA 1LY2A 1U5MA 3R62A 2A55A 2LOJA 4CSYA 4DJZA 3ZRZA 5HYPA 2G7IA 2YRAA 1UOTP 4A5WB 1OK3A 3KXVA 1TPMA 2JGWA 1Z92B 2XWJI 2IZ3A 2CG7A 1QUBA 4LOTA 2XRBA 2W81A 1SS2A 4LOSA 4MUCA 2RLQA 4YNXA 4B2RA 2EC3A 5JPMG 2XRDA 3IU3I 4IGDA 4ONTD 3SW0X 3KZJA 1GKNA 5HZPB 1ELVA 2WIIC 1OJWA 1G4GA 1MD8A 1CKLA 2RKZA 4K12A 2KMSA 3OP8A 1G4FA 1FBRA 1HFHA 2EHFA 1H03P 4F4OC 4AYEA 4PZ5A 1GKGA 4C16A 3T5OA 2BZMA 1HFIA 2MCZA 4AYDA 1TPNA 2UWNA 2XQWC 1H04P 2RKYA 3IX0A 1O9AA 1OJVA 3TVJA 2B5ID 1E88A 1H2PP 4J38B 2QY0A 1OK2A 1QGBA 3RJ3D 2RLPA 1OK1A 5HYTB 1VVDA 3OEDC 3M7PA 1TPGA 3NFPI 2JRAA 1GPZA 3CALA 2MCYA 1NWVA 3O8EB 2W80A 2JGXA 3ERBA 5HYUB 1C1ZA 3GXEA 2CG6A 4JHSA 5FO8C 1E8BA 1GHQB 1VVCA 2ERJA
chains in the Genus database with same CATH superfamily
2XWBF 2I2LA 1E5GA 3GOVA 3INBC 3ZLDA 3VWOA 4ZH1D 1QO6A 2V8EA 1OJYA 1Q3XA 1H2QP 2CKUA 1SRZA 3ZD1A 2O39C 1ZJKA 3L89M 1HCCA 3CI0J 1OK9A 5I0QB 1MD7A 4B2SA 2YBYA 5DN5A 4N7EA 3EJHA 3ZD2A 4AYMA 4AYIA 3MQLA 1PPQA 2IZ4A 3OXUD 2RL0A 2Y8TA 4KKDA 4FXGG 4WJG2 3WSXA 2KRIA 1LY2A 1U5MA 3R62A 2A55A 2LOJA 4CSYA 4DJZA 3ZRZA 5HYPA 2G7IA 1RLHA 2YRAA 1UOTP 4A5WB 1OK3A 3KXVA 1TPMA 2JGWA 1Z92B 2XWJI 2IZ3A 2CG7A 1QUBA 4LOTA 2XRBA 2W81A 1SS2A 4LOSA 4MSLA 4MUCA 2RLQA 4YNXA 4B2RA 2EC3A 5JPMG 2XRDA 3IU3I 4IGDA 4ONTD 3SW0X 3KZJA 3FGRA 1GKNA 5HZPB 1ELVA 3F6KA 2WIIC 1OJWA 1G4GA 1MD8A 1CKLA 2RKZA 2Y8RA 4K12A 2KMSA 3OP8A 1G4FA 1FBRA 1HFHA 3K3TA 3ZLEA 4YIZA 2EHFA 1H03P 4F4OC 4AYEA 4PZ5A 1GKGA 4C16A 3T5OA 2BZMA 1HFIA 2X2ZA 2MCZA 4AYDA 1TPNA 2UWNA 2XQWC 4APLA 1H04P 2RKYA 3IX0A 1O9AA 1OJVA 3FGTA 3TVJA 2B5ID 1E88A 1H2PP 4J38B 3NJAA 2QY0A 1OK2A 1QGBA 5DN4A 2RLPA 3RJ3D 1OK1A 2Y8SA 5HYTB 1VVDA 3OEDC 4PO7A 3M7PA 1TPGA 2ZYCA 3NFPI 2JRAA 1GPZA 3CALA 2MCYA 1NWVA 3O8EB 2W80A 2JGXA 3ERBA 5HYUB 4BWCA 1C1ZA 3GXEA 2CG6A 4JHSA 5FO8C 1E8BA 1GHQB 1VVCA 3WSYA 2ERJA
chains in the Genus database with same CATH topology
2XWBF 1E5GA 3GOVA 3INBC 4ZH1D 1QO6A 2V8EA 1OJYA 1Q3XA 1H2QP 2CKUA 1SRZA 3ZD1A 2O39C 1ZJKA 3L89M 1HCCA 1OK9A 5I0QB 1MD7A 4B2SA 2YBYA 3EJHA 3ZD2A 4AYMA 4AYIA 3MQLA 1PPQA 2IZ4A 3OXUD 2RL0A 4KKDA 4FXGG 4WJG2 2KRIA 1LY2A 1U5MA 3R62A 2A55A 2LOJA 4CSYA 4DJZA 3ZRZA 5HYPA 2G7IA 2YRAA 1UOTP 4A5WB 1OK3A 3KXVA 1TPMA 2JGWA 1Z92B 2XWJI 2IZ3A 2CG7A 1QUBA 4LOTA 2XRBA 2W81A 1SS2A 4LOSA 4MUCA 2RLQA 4YNXA 4B2RA 2EC3A 5JPMG 2XRDA 3IU3I 4IGDA 4ONTD 3SW0X 3KZJA 1GKNA 5HZPB 1ELVA 2WIIC 1OJWA 1G4GA 1MD8A 1CKLA 2RKZA 4K12A 2KMSA 3OP8A 1G4FA 1FBRA 1HFHA 2EHFA 1H03P 4F4OC 4AYEA 4PZ5A 1GKGA 4C16A 3T5OA 2BZMA 1HFIA 2MCZA 4AYDA 1TPNA 2UWNA 2XQWC 1H04P 2RKYA 3IX0A 1O9AA 1OJVA 3TVJA 2B5ID 1E88A 1H2PP 4J38B 2QY0A 1OK2A 1QGBA 3RJ3D 2RLPA 1OK1A 5HYTB 1VVDA 3OEDC 3M7PA 1TPGA 3NFPI 2JRAA 1GPZA 3CALA 2MCYA 1NWVA 3O8EB 2W80A 2JGXA 3ERBA 5HYUB 1C1ZA 3GXEA 2CG6A 4JHSA 5FO8C 1E8BA 1GHQB 1VVCA 2ERJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XWB F;  1E5G A;  3GOV A;  3INB C;  4ZH1 D;  1QO6 A;  2V8E A;  1OJY A;  1Q3X A;  1H2Q P;  2CKU A;  1SRZ A;  3ZD1 A;  2O39 C;  1ZJK A;  3L89 M;  1HCC A;  1OK9 A;  5I0Q B;  1MD7 A;  4B2S A;  2YBY A;  3EJH A;  3ZD2 A;  4AYM A;  4AYI A;  3MQL A;  1PPQ A;  2IZ4 A;  3OXU D;  2RL0 A;  4KKD A;  4FXG G;  4WJG 2;  2KRI A;  1LY2 A;  1U5M A;  3R62 A;  2A55 A;  2LOJ A;  4CSY A;  4DJZ A;  3ZRZ A;  5HYP A;  2G7I A;  2YRA A;  1UOT P;  4A5W B;  1OK3 A;  3KXV A;  1TPM A;  2JGW A;  1Z92 B;  2XWJ I;  2IZ3 A;  2CG7 A;  1QUB A;  4LOT A;  2XRB A;  2W81 A;  1SS2 A;  4LOS A;  4MUC A;  2RLQ A;  4YNX A;  4B2R A;  2EC3 A;  5JPM G;  2XRD A;  3IU3 I;  4IGD A;  4ONT D;  3SW0 X;  3KZJ A;  1GKN A;  5HZP B;  1ELV A;  2WII C;  1OJW A;  1G4G A;  1MD8 A;  1CKL A;  2RKZ A;  4K12 A;  2KMS A;  3OP8 A;  1G4F A;  1FBR A;  1HFH A;  2EHF A;  1H03 P;  4F4O C;  4AYE A;  4PZ5 A;  1GKG A;  4C16 A;  3T5O A;  2BZM A;  1HFI A;  2MCZ A;  4AYD A;  1TPN A;  2UWN A;  2XQW C;  1H04 P;  2RKY A;  3IX0 A;  1O9A A;  1OJV A;  3TVJ A;  2B5I D;  1E88 A;  1H2P P;  4J38 B;  2QY0 A;  1OK2 A;  1QGB A;  3RJ3 D;  2RLP A;  1OK1 A;  5HYT B;  1VVD A;  3OED C;  3M7P A;  1TPG A;  3NFP I;  2JRA A;  1GPZ A;  3CAL A;  2MCY A;  1NWV A;  3O8E B;  2W80 A;  2JGX A;  3ERB A;  5HYU B;  1C1Z A;  3GXE A;  2CG6 A;  4JHS A;  5FO8 C;  1E8B A;  1GHQ B;  1VVC A;  2ERJ A; 
#chains in the Genus database with same CATH topology
 2XWB F;  2I2L A;  1E5G A;  3GOV A;  3INB C;  3ZLD A;  3VWO A;  4ZH1 D;  1QO6 A;  2V8E A;  1OJY A;  1Q3X A;  1H2Q P;  2CKU A;  1SRZ A;  3ZD1 A;  2O39 C;  1ZJK A;  3L89 M;  1HCC A;  3CI0 J;  1OK9 A;  5I0Q B;  1MD7 A;  4B2S A;  2YBY A;  5DN5 A;  4N7E A;  3EJH A;  3ZD2 A;  4AYM A;  4AYI A;  3MQL A;  1PPQ A;  2IZ4 A;  3OXU D;  2RL0 A;  2Y8T A;  4KKD A;  4FXG G;  4WJG 2;  3WSX A;  2KRI A;  1LY2 A;  1U5M A;  3R62 A;  2A55 A;  2LOJ A;  4CSY A;  4DJZ A;  3ZRZ A;  5HYP A;  2G7I A;  1RLH A;  2YRA A;  1UOT P;  4A5W B;  1OK3 A;  3KXV A;  1TPM A;  2JGW A;  1Z92 B;  2XWJ I;  2IZ3 A;  2CG7 A;  1QUB A;  4LOT A;  2XRB A;  2W81 A;  1SS2 A;  4LOS A;  4MSL A;  4MUC A;  2RLQ A;  4YNX A;  4B2R A;  2EC3 A;  5JPM G;  2XRD A;  3IU3 I;  4IGD A;  4ONT D;  3SW0 X;  3KZJ A;  3FGR A;  1GKN A;  5HZP B;  1ELV A;  3F6K A;  2WII C;  1OJW A;  1G4G A;  1MD8 A;  1CKL A;  2RKZ A;  2Y8R A;  4K12 A;  2KMS A;  3OP8 A;  1G4F A;  1FBR A;  1HFH A;  3K3T A;  3ZLE A;  4YIZ A;  2EHF A;  1H03 P;  4F4O C;  4AYE A;  4PZ5 A;  1GKG A;  4C16 A;  3T5O A;  2BZM A;  1HFI A;  2X2Z A;  2MCZ A;  4AYD A;  1TPN A;  2UWN A;  2XQW C;  4APL A;  1H04 P;  2RKY A;  3IX0 A;  1O9A A;  1OJV A;  3FGT A;  3TVJ A;  2B5I D;  1E88 A;  1H2P P;  4J38 B;  3NJA A;  2QY0 A;  1OK2 A;  1QGB A;  5DN4 A;  2RLP A;  3RJ3 D;  1OK1 A;  2Y8S A;  5HYT B;  1VVD A;  3OED C;  4PO7 A;  3M7P A;  1TPG A;  2ZYC A;  3NFP I;  2JRA A;  1GPZ A;  3CAL A;  2MCY A;  1NWV A;  3O8E B;  2W80 A;  2JGX A;  3ERB A;  5HYU B;  4BWC A;  1C1Z A;  3GXE A;  2CG6 A;  4JHS A;  5FO8 C;  1E8B A;  1GHQ B;  1VVC A;  3WSY A;  2ERJ A; 
#chains in the Genus database with same CATH homology
 2XWB F;  1E5G A;  3GOV A;  3INB C;  4ZH1 D;  1QO6 A;  2V8E A;  1OJY A;  1Q3X A;  1H2Q P;  2CKU A;  1SRZ A;  3ZD1 A;  2O39 C;  1ZJK A;  3L89 M;  1HCC A;  1OK9 A;  5I0Q B;  1MD7 A;  4B2S A;  2YBY A;  3EJH A;  3ZD2 A;  4AYM A;  4AYI A;  3MQL A;  1PPQ A;  2IZ4 A;  3OXU D;  2RL0 A;  4KKD A;  4FXG G;  4WJG 2;  2KRI A;  1LY2 A;  1U5M A;  3R62 A;  2A55 A;  2LOJ A;  4CSY A;  4DJZ A;  3ZRZ A;  5HYP A;  2G7I A;  2YRA A;  1UOT P;  4A5W B;  1OK3 A;  3KXV A;  1TPM A;  2JGW A;  1Z92 B;  2XWJ I;  2IZ3 A;  2CG7 A;  1QUB A;  4LOT A;  2XRB A;  2W81 A;  1SS2 A;  4LOS A;  4MUC A;  2RLQ A;  4YNX A;  4B2R A;  2EC3 A;  5JPM G;  2XRD A;  3IU3 I;  4IGD A;  4ONT D;  3SW0 X;  3KZJ A;  1GKN A;  5HZP B;  1ELV A;  2WII C;  1OJW A;  1G4G A;  1MD8 A;  1CKL A;  2RKZ A;  4K12 A;  2KMS A;  3OP8 A;  1G4F A;  1FBR A;  1HFH A;  2EHF A;  1H03 P;  4F4O C;  4AYE A;  4PZ5 A;  1GKG A;  4C16 A;  3T5O A;  2BZM A;  1HFI A;  2MCZ A;  4AYD A;  1TPN A;  2UWN A;  2XQW C;  1H04 P;  2RKY A;  3IX0 A;  1O9A A;  1OJV A;  3TVJ A;  2B5I D;  1E88 A;  1H2P P;  4J38 B;  2QY0 A;  1OK2 A;  1QGB A;  3RJ3 D;  2RLP A;  1OK1 A;  5HYT B;  1VVD A;  3OED C;  3M7P A;  1TPG A;  3NFP I;  2JRA A;  1GPZ A;  3CAL A;  2MCY A;  1NWV A;  3O8E B;  2W80 A;  2JGX A;  3ERB A;  5HYU B;  1C1Z A;  3GXE A;  2CG6 A;  4JHS A;  5FO8 C;  1E8B A;  1GHQ B;  1VVC A;  2ERJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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