5I2ZA

Crystal structure of the catalytic domain of mmp-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelating water-soluble inhibitor (dc24).
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
157
structure length
157
Chain Sequence
PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors.
pubmed doi rcsb
molecule keywords Macrophage metalloelastase
molecule tags Hydrolase
source organism Homo sapiens
total genus 50
structure length 157
sequence length 157
chains with identical sequence B, C, D
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2016-02-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 5i2zA00
3G42A 3LUNA 4HMAA 1GO7P 2RJQA 5I2ZA 3HB2P 4WKIA 4JPAA 1KUIA 3BA0A 4PKTA 2W14A 4H3XA 5CXAA 1GKCA 1MMPA 1J7NA 1ROSA 3EWJA 4Q1LA 1K7IA 1ZTQA 3AYKA 2OI0A 1I1IP 3UVCA 4ILWD 2K2GA 1G49A 3LK8A 4JIJA 1MNCA 1IADA 1QJIA 1Z3JA 3DPEA 3VI1A 1EB6A 2E3XA 3KECA 1PWWA 1O0QA 1S4BP 1UMSA 2DW1A 2J0TA 4FVLA 3F18A 4GWMA 1FM1A 3B92A 3USNA 3SHIA 1IAAA 1XFVA 1CQRA 1JKYA 3O2XA 3OHOA 3LJZA 5H8XA 4L19A 1XURA 1K7GA 3KEJA 2JSDA 3KHIA 1QICA 3B2ZA 4I35A 1AF0A 1HFSA 3HY9A 2N8RA 1HY7A 5L79A 1XFZA 2OXUA 1I73A 2MLSA 2YB9A 4R3VA 456CA 5L7FA 2O36A 3F15A 3HDAP 1D8MA 1BKCI 2L0RA 3HDBA 4H82A 5I43A 4J4MA 1IAGA 1XUDA 3KMEA 4PKUA 1KUFA 1R55A 1HV5A 1ZP5A 1XFUA 3RTSA 2ERQA 1QJJA 1ASTA 1B8YA 1D8FA 1L6JA 1SATA 1JK3A 3I7GA 1RM8A 5BPAA 2W0DA 3EDIA 3MA2A 1EUBA 3N2UA 5JMYA 1KUHA 1CXVA 3ZUKA 4IUWA 2DDYA 3F16A 2PJTA 4G0DA 1C3IA 1DMTA 4PKWA 3LKAA 1JAPA 1O0TA 1UMTA 2V4BA 1PWVA 2W13A 4WKEA 5LABA 5D3CA 1R1IA 1Q3AA 4GF1A 1G9KA 1AYKA 3LIKA 4I03A 3HBVP 1XFYA 1ZVXA 2I47A 1PWQA 4FU4A 3LILA 3LJGA 1I76A 2MLRA 4JP4A 4DV8A 2OVZA 3NX7A 1JAOA 1JIWP 4DD8A 1BM6A 1C7KA 2D1NA 3VTGA 1CGLA 1A86A 2Y6DA 4FXYP 2OVXA 1ATLA 3LEAA 4XM7A 830CA 2QPJA 3KRYA 3LUMA 4GQLA 2TCLA 2J83A 2X7MA 1KUKA 1IACA 2WO8A 1R54A 2USNA 2FV5A 1QUAA 4GR0A 966CA 1KAPP 3K7LA 5D2BA 1OO9A 4H76A 1OM7A 4JA1A 5BOYA 1H71P 5D7WA 5I3MA 4GWNA 1ND1A 4HX3A 2OW9A 2ERPA 1BQOA 3LMCA 3WV2A 3EHYA 1SLNA 2POJA 2DW2A 1QIBA 5CZMA 4PKSA 3LIRA 2D1OA 1SLMA 2XS3A 1USNA 2Z2DA 3F1AA 2MZIA 1ZXCA 4A3WA 4PKRA 3DPFA 2OY2A 2WO9A 1D5JA 2XS4A 3E8RA 3DWBA 1YQYA 3KMCA 3LGPA 1JIZA 1Y93A 5I12A 4H30A 5I4OA 3P1VA 2DW0A 4WZVA 1CAQA 1XFXA 4AXQA 3HBUP 2K9CA 4H1QA 4AIGA 1GO8P 5D1SA 1C8TA 1WNIA 1SMPA 2E2DA 3DSLA 2JNPA 3L0TA 2OXZA 1BUVM 1OS9A 3EHXA 4H49A 3TS4A 1R1HA 4GR3A 3WV1A 1FBLA 3RTTA 1CK7A 1BZSA 3HYGA 1OM6A 1GKDA 2OY4A 3P24A 1FLSA 2JIHA 4H2EA 3DNGA 1CIZA 3GBOA 1OS2A 1G12A 3TVCA 1PWUA 1JH1A 4XM8A 1JJ9A 1EAKA 1KBCA 1OMJA 1BKCE 3L0VA 1IABA 1XFWA 2RJPA 3U1RA 4A7BA 4G9LA 3V96B 1DTHA 3KWVC 2HU6A 4PKQA 4JQGA 1A85A 2FV9A 1G4KA 1JAQA 1YP1A 1XUCA 3LQBA 2O3EA 2OW0A 1OM8A 1SU3A 1QIAA 3Q2HA 3N2VA 3LE9A 4GUYA 2OXWA 2SRTA 2A8HA 4DF9A 2JT5A 3KEKA 2OW2A 2MZHA 3DL1A 3WV3A 4XM6A 3B8ZA 4QKZA 2CKIA 3ZXHA 2OZRA 3CKIA 4IJOA 5D1UA 3EDGA 1MMRA 5B5PA 1GE6A 3EDZA 3AYUA 3HY7A 3O64A 5D1TA 4IN9A 1K7QA 4PKVA 5CUHA 4ON1A 1MMQA 4L63A 2OW1A 2X3AA 1KUGA 1BUDA 2X3BA 1YOUA 2EROA 3TSKA 1Y8JA 4ZR5A 1GXDA 1ZS0A 3I7IA 2X3CA 3F17A 2JT6A 1B3DA 3LJTA 3TT4A 1BSWA 1SRPA 4WF6A 2YIGA 1R1JA 2W15A 5B5OA 1UTTA 3G5CA 1D7XA 2DDFA 4GR8A 1HTDA 3OHLA 1RMZA 2W12A 1AKLA 1JANA 4AYKA 4DPEA 1BIWA 4CTHA 5BOTA 1HOVA 1Y0VA 1UTZA 1YCMA 4XBHA 4H84A 1G05A 1PWPA 1ZXVA 4AUOA 1UEAA 2Y6CA 4L6TA 3ZVSA 1BQQM 4FXQA 1BKCA 4WK7A 3Q2GA 4XCTA 2KRJA 1HFCA 1IAEA 3F19A 4EFSA 5I0LA 1GE7A 2AYKA 1MMBA 1GE5A 2MZEA 3EDHA 2CLTA 3K7NA 1CGFA 2WOAA 2AIGP 3AIGA 1CGEA 3ELMA 3LQ0A
chains in the Genus database with same CATH superfamily
3G42A 3LUNA 4HMAA 1GO7P 2RJQA 5I2ZA 3HB2P 4WKIA 4JPAA 1KUIA 3BA0A 4PKTA 2W14A 4H3XA 5CXAA 1GKCA 1MMPA 1J7NA 1ROSA 3EWJA 4Q1LA 1K7IA 1ZTQA 3AYKA 2OI0A 1I1IP 3DTEA 3UVCA 4ILWD 2K2GA 1G49A 3LK8A 4JIJA 1MNCA 1IADA 1QJIA 1Z3JA 3DPEA 3VI1A 1EB6A 2E3XA 3KECA 1PWWA 1O0QA 1S4BP 1UMSA 2DW1A 2J0TA 4FVLA 3F18A 4GWMA 1FM1A 3B92A 3USNA 3SHIA 1IAAA 1XFVA 1CQRA 1JKYA 3O2XA 3OHOA 3LJZA 5H8XA 4L19A 1XURA 1K7GA 3KEJA 2JSDA 3KHIA 1XM5A 1QICA 3B2ZA 4I35A 1AF0A 1HFSA 3HY9A 2N8RA 1HY7A 5L79A 1XFZA 2OXUA 1I73A 2MLSA 2YB9A 4R3VA 456CA 5L7FA 2O36A 3F15A 3HDAP 1D8MA 1BKCI 2L0RA 1TVIA 3HDBA 4H82A 5I43A 4J4MA 1IAGA 1XUDA 3KMEA 4PKUA 1KUFA 1R55A 1HV5A 1ZP5A 1XFUA 3RTSA 2ERQA 2YUFA 1QJJA 1ASTA 1B8YA 1D8FA 3DTKA 1L6JA 1SATA 1JK3A 3I7GA 1RM8A 5BPAA 2W0DA 3EDIA 3MA2A 1EUBA 3N2UA 5JMYA 1KUHA 1CXVA 3ZUKA 4IUWA 2DDYA 3F16A 2PJTA 4G0DA 1C3IA 1DMTA 4PKWA 3LKAA 1JAPA 1O0TA 1UMTA 2V4BA 1PWVA 2W13A 4WKEA 5LABA 5D3CA 1R1IA 1Q3AA 4GF1A 1G9KA 1AYKA 3LIKA 4L7AA 4I03A 3HBVP 1XFYA 1ZVXA 2I47A 1PWQA 4FU4A 3LILA 3LJGA 1I76A 2MLRA 4JP4A 4DV8A 2OVZA 3NX7A 1JAOA 1JIWP 4DD8A 1BM6A 1C7KA 2D1NA 3VTGA 1CGLA 1A86A 2Y6DA 4FXYP 2OVXA 1ATLA 3LEAA 4XM7A 830CA 2QPJA 3KRYA 3LUMA 4GQLA 2TCLA 2J83A 2X7MA 1KUKA 1IACA 2WO8A 1R54A 2USNA 2FV5A 1QUAA 4GR0A 966CA 1KAPP 3K7LA 5D2BA 1OO9A 4H76A 1OM7A 4JA1A 5BOYA 1H71P 5D7WA 5I3MA 4GWNA 1ND1A 4HX3A 2OW9A 2ERPA 1BQOA 3LMCA 3WV2A 3EHYA 1SLNA 3DTIA 2POJA 2DW2A 1QIBA 5CZMA 4PKSA 3LIRA 2D1OA 1SLMA 2XS3A 1USNA 2Z2DA 3F1AA 2MZIA 1ZXCA 4A3WA 4PKRA 3DPFA 2OY2A 2WO9A 1D5JA 2XS4A 3E8RA 3DWBA 1YQYA 3KMCA 3LGPA 1JIZA 1Y93A 5I12A 4H30A 5I4OA 3P1VA 2DW0A 4WZVA 1CAQA 1XFXA 4AXQA 3HBUP 2K9CA 4H1QA 4AIGA 1GO8P 5D1SA 1C8TA 1WNIA 1SMPA 2E2DA 3DSLA 2JNPA 3L0TA 2OXZA 1BUVM 1OS9A 3EHXA 4H49A 3TS4A 1R1HA 4GR3A 3WV1A 1FBLA 3RTTA 1CK7A 1BZSA 3HYGA 1XAXA 1OM6A 1GKDA 2OY4A 3P24A 1FLSA 2JIHA 4H2EA 3DNGA 1CIZA 3GBOA 1OS2A 1G12A 3TVCA 1PWUA 1JH1A 4XM8A 1JJ9A 1EAKA 1KBCA 1OMJA 1BKCE 3L0VA 1IABA 1XFWA 2RJPA 3U1RA 4A7BA 4G9LA 3V96B 1DTHA 3KWVC 2HU6A 4PKQA 4JQGA 1A85A 2FV9A 1G4KA 1JAQA 1YP1A 1XUCA 3LQBA 2O3EA 2OW0A 1OM8A 1SU3A 1QIAA 3Q2HA 1OZ9A 3N2VA 3LE9A 4GUYA 2OXWA 2SRTA 2A8HA 4DF9A 2JT5A 3KEKA 2OW2A 2MZHA 3DL1A 3WV3A 4XM6A 3B8ZA 4QKZA 2CKIA 3ZXHA 2OZRA 3CKIA 4IJOA 5D1UA 3EDGA 1MMRA 5B5PA 1GE6A 3EDZA 3AYUA 3HY7A 3O64A 5D1TA 4IN9A 1K7QA 4PKVA 5CUHA 4ON1A 1MMQA 4L63A 2OW1A 2X3AA 1KUGA 1BUDA 2X3BA 1YOUA 2EROA 3TSKA 1Y8JA 4ZR5A 1GXDA 1ZS0A 3I7IA 2X3CA 3F17A 2JT6A 1B3DA 3LJTA 3TT4A 1BSWA 1SRPA 4WF6A 2YIGA 1R1JA 2W15A 5B5OA 1UTTA 3G5CA 1D7XA 2DDFA 4GR8A 1HTDA 3OHLA 1RMZA 2W12A 1AKLA 1JANA 4AYKA 4DPEA 1BIWA 4CTHA 5BOTA 1HOVA 1Y0VA 1UTZA 1YCMA 4XBHA 4H84A 1G05A 1PWPA 1ZXVA 4AUOA 1UEAA 2Y6CA 4L6TA 3ZVSA 1BQQM 4FXQA 1BKCA 4WK7A 3Q2GA 4XCTA 2KRJA 1HFCA 1IAEA 3F19A 4EFSA 5I0LA 1GE7A 2AYKA 1MMBA 1GE5A 2MZEA 3EDHA 2CLTA 3K7NA 1CGFA 2WOAA 2AIGP 3AIGA 1CGEA 3ELMA 3LQ0A
chains in the Genus database with same CATH topology
3G42A 3LUNA 4HMAA 1GO7P 2RJQA 5I2ZA 3HB2P 4WKIA 4JPAA 1KUIA 3BA0A 4PKTA 2W14A 4H3XA 5CXAA 1GKCA 1MMPA 1J7NA 1ROSA 3EWJA 4Q1LA 1K7IA 1ZTQA 3AYKA 2OI0A 1I1IP 3DTEA 3UVCA 4ILWD 2K2GA 1G49A 3LK8A 4JIJA 1MNCA 1IADA 1QJIA 1Z3JA 3DPEA 3VI1A 1EB6A 2E3XA 3KECA 1PWWA 1O0QA 1S4BP 1UMSA 2DW1A 2J0TA 4FVLA 3F18A 4GWMA 1FM1A 3B92A 3USNA 3SHIA 1IAAA 1XFVA 1CQRA 1JKYA 3O2XA 3OHOA 3LJZA 5H8XA 4L19A 1XURA 1K7GA 3KEJA 2JSDA 3KHIA 1QICA 3B2ZA 4I35A 1AF0A 1HFSA 3HY9A 2N8RA 1HY7A 5L79A 1XFZA 2OXUA 1I73A 2MLSA 2YB9A 4R3VA 456CA 5L7FA 2O36A 3F15A 3HDAP 1D8MA 1BKCI 2L0RA 3HDBA 4H82A 5I43A 4J4MA 1IAGA 1XUDA 3KMEA 4PKUA 1KUFA 1R55A 1HV5A 1ZP5A 1XFUA 3RTSA 2ERQA 2YUFA 1QJJA 1ASTA 1B8YA 1D8FA 3DTKA 1L6JA 1SATA 1JK3A 3I7GA 1RM8A 5BPAA 2W0DA 3EDIA 3MA2A 1EUBA 3N2UA 5JMYA 1KUHA 1CXVA 3ZUKA 4IUWA 2DDYA 3F16A 2PJTA 4G0DA 1C3IA 1DMTA 4PKWA 3LKAA 1JAPA 1O0TA 1UMTA 2V4BA 1PWVA 2W13A 4WKEA 5LABA 5D3CA 1R1IA 1Q3AA 4GF1A 1G9KA 1AYKA 3LIKA 4L7AA 4I03A 3HBVP 1XFYA 1ZVXA 2I47A 1PWQA 4FU4A 3LILA 3LJGA 1I76A 2MLRA 4JP4A 4DV8A 2OVZA 3NX7A 1JAOA 1JIWP 4DD8A 1BM6A 1C7KA 2D1NA 3VTGA 1CGLA 1A86A 2Y6DA 4FXYP 2OVXA 1ATLA 3LEAA 4XM7A 830CA 2QPJA 3KRYA 3LUMA 4GQLA 2TCLA 2J83A 2X7MA 1KUKA 1IACA 2WO8A 1R54A 2USNA 2FV5A 1QUAA 4GR0A 966CA 1KAPP 3K7LA 5D2BA 1OO9A 4H76A 1OM7A 4JA1A 5BOYA 1H71P 5D7WA 5I3MA 4GWNA 1ND1A 4HX3A 2OW9A 2ERPA 1BQOA 3LMCA 3WV2A 3EHYA 1SLNA 3DTIA 2POJA 2DW2A 1QIBA 5CZMA 4PKSA 3LIRA 2D1OA 1SLMA 2XS3A 1USNA 2Z2DA 3F1AA 2MZIA 1ZXCA 4A3WA 4PKRA 3DPFA 2OY2A 2WO9A 1D5JA 2XS4A 3E8RA 3DWBA 1YQYA 3KMCA 3LGPA 1JIZA 1Y93A 5I12A 4H30A 5I4OA 3P1VA 2DW0A 4WZVA 1CAQA 1XFXA 4AXQA 3HBUP 2K9CA 4H1QA 4AIGA 1GO8P 5D1SA 1C8TA 1WNIA 1SMPA 2E2DA 3DSLA 2JNPA 3L0TA 2OXZA 1BUVM 1OS9A 3EHXA 4H49A 3TS4A 1R1HA 4GR3A 3WV1A 1FBLA 3RTTA 1CK7A 1BZSA 3HYGA 1OM6A 1GKDA 2OY4A 3P24A 1FLSA 2JIHA 4H2EA 3DNGA 1CIZA 3GBOA 1OS2A 1G12A 3TVCA 1PWUA 1JH1A 4XM8A 1JJ9A 1EAKA 1KBCA 1OMJA 1BKCE 3L0VA 1IABA 1XFWA 2RJPA 3U1RA 4A7BA 4G9LA 3V96B 1DTHA 3KWVC 2HU6A 4PKQA 4JQGA 1A85A 2FV9A 1G4KA 1JAQA 1YP1A 1XUCA 3LQBA 2O3EA 2OW0A 1OM8A 1SU3A 1QIAA 3Q2HA 3N2VA 3LE9A 4GUYA 2OXWA 2SRTA 2A8HA 4DF9A 2JT5A 3KEKA 2OW2A 2MZHA 3DL1A 3WV3A 4XM6A 3B8ZA 4QKZA 2CKIA 3ZXHA 2OZRA 3CKIA 4IJOA 5D1UA 3EDGA 1MMRA 5B5PA 1GE6A 3EDZA 3AYUA 3HY7A 3O64A 5D1TA 4IN9A 1K7QA 4PKVA 5CUHA 4ON1A 1MMQA 4L63A 2OW1A 2X3AA 1KUGA 1BUDA 2X3BA 1YOUA 2EROA 3TSKA 1Y8JA 4ZR5A 1GXDA 1ZS0A 3I7IA 2X3CA 3F17A 2JT6A 1B3DA 3LJTA 3TT4A 1BSWA 1SRPA 4WF6A 2YIGA 1R1JA 2W15A 5B5OA 1UTTA 3G5CA 1D7XA 2DDFA 4GR8A 1HTDA 3OHLA 1RMZA 2W12A 1AKLA 1JANA 4AYKA 4DPEA 1BIWA 4CTHA 5BOTA 1HOVA 1Y0VA 1UTZA 1YCMA 4XBHA 4H84A 1G05A 1PWPA 1ZXVA 4AUOA 1UEAA 2Y6CA 4L6TA 3ZVSA 1BQQM 4FXQA 1BKCA 4WK7A 3Q2GA 4XCTA 2KRJA 1HFCA 1IAEA 3F19A 4EFSA 5I0LA 1GE7A 2AYKA 1MMBA 1GE5A 2MZEA 3EDHA 2CLTA 3K7NA 1CGFA 2WOAA 2AIGP 3AIGA 1CGEA 3ELMA 3LQ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3G42 A;  3LUN A;  4HMA A;  1GO7 P;  2RJQ A;  5I2Z A;  3HB2 P;  4WKI A;  4JPA A;  1KUI A;  3BA0 A;  4PKT A;  2W14 A;  4H3X A;  5CXA A;  1GKC A;  1MMP A;  1J7N A;  1ROS A;  3EWJ A;  4Q1L A;  1K7I A;  1ZTQ A;  3AYK A;  2OI0 A;  1I1I P;  3UVC A;  4ILW D;  2K2G A;  1G49 A;  3LK8 A;  4JIJ A;  1MNC A;  1IAD A;  1QJI A;  1Z3J A;  3DPE A;  3VI1 A;  1EB6 A;  2E3X A;  3KEC A;  1PWW A;  1O0Q A;  1S4B P;  1UMS A;  2DW1 A;  2J0T A;  4FVL A;  3F18 A;  4GWM A;  1FM1 A;  3B92 A;  3USN A;  3SHI A;  1IAA A;  1XFV A;  1CQR A;  1JKY A;  3O2X A;  3OHO A;  3LJZ A;  5H8X A;  4L19 A;  1XUR A;  1K7G A;  3KEJ A;  2JSD A;  3KHI A;  1QIC A;  3B2Z A;  4I35 A;  1AF0 A;  1HFS A;  3HY9 A;  2N8R A;  1HY7 A;  5L79 A;  1XFZ A;  2OXU A;  1I73 A;  2MLS A;  2YB9 A;  4R3V A;  456C A;  5L7F A;  2O36 A;  3F15 A;  3HDA P;  1D8M A;  1BKC I;  2L0R A;  3HDB A;  4H82 A;  5I43 A;  4J4M A;  1IAG A;  1XUD A;  3KME A;  4PKU A;  1KUF A;  1R55 A;  1HV5 A;  1ZP5 A;  1XFU A;  3RTS A;  2ERQ A;  1QJJ A;  1AST A;  1B8Y A;  1D8F A;  1L6J A;  1SAT A;  1JK3 A;  3I7G A;  1RM8 A;  5BPA A;  2W0D A;  3EDI A;  3MA2 A;  1EUB A;  3N2U A;  5JMY A;  1KUH A;  1CXV A;  3ZUK A;  4IUW A;  2DDY A;  3F16 A;  2PJT A;  4G0D A;  1C3I A;  1DMT A;  4PKW A;  3LKA A;  1JAP A;  1O0T A;  1UMT A;  2V4B A;  1PWV A;  2W13 A;  4WKE A;  5LAB A;  5D3C A;  1R1I A;  1Q3A A;  4GF1 A;  1G9K A;  1AYK A;  3LIK A;  4I03 A;  3HBV P;  1XFY A;  1ZVX A;  2I47 A;  1PWQ A;  4FU4 A;  3LIL A;  3LJG A;  1I76 A;  2MLR A;  4JP4 A;  4DV8 A;  2OVZ A;  3NX7 A;  1JAO A;  1JIW P;  4DD8 A;  1BM6 A;  1C7K A;  2D1N A;  3VTG A;  1CGL A;  1A86 A;  2Y6D A;  4FXY P;  2OVX A;  1ATL A;  3LEA A;  4XM7 A;  830C A;  2QPJ A;  3KRY A;  3LUM A;  4GQL A;  2TCL A;  2J83 A;  2X7M A;  1KUK A;  1IAC A;  2WO8 A;  1R54 A;  2USN A;  2FV5 A;  1QUA A;  4GR0 A;  966C A;  1KAP P;  3K7L A;  5D2B A;  1OO9 A;  4H76 A;  1OM7 A;  4JA1 A;  5BOY A;  1H71 P;  5D7W A;  5I3M A;  4GWN A;  1ND1 A;  4HX3 A;  2OW9 A;  2ERP A;  1BQO A;  3LMC A;  3WV2 A;  3EHY A;  1SLN A;  2POJ A;  2DW2 A;  1QIB A;  5CZM A;  4PKS A;  3LIR A;  2D1O A;  1SLM A;  2XS3 A;  1USN A;  2Z2D A;  3F1A A;  2MZI A;  1ZXC A;  4A3W A;  4PKR A;  3DPF A;  2OY2 A;  2WO9 A;  1D5J A;  2XS4 A;  3E8R A;  3DWB A;  1YQY A;  3KMC A;  3LGP A;  1JIZ A;  1Y93 A;  5I12 A;  4H30 A;  5I4O A;  3P1V A;  2DW0 A;  4WZV A;  1CAQ A;  1XFX A;  4AXQ A;  3HBU P;  2K9C A;  4H1Q A;  4AIG A;  1GO8 P;  5D1S A;  1C8T A;  1WNI A;  1SMP A;  2E2D A;  3DSL A;  2JNP A;  3L0T A;  2OXZ A;  1BUV M;  1OS9 A;  3EHX A;  4H49 A;  3TS4 A;  1R1H A;  4GR3 A;  3WV1 A;  1FBL A;  3RTT A;  1CK7 A;  1BZS A;  3HYG A;  1OM6 A;  1GKD A;  2OY4 A;  3P24 A;  1FLS A;  2JIH A;  4H2E A;  3DNG A;  1CIZ A;  3GBO A;  1OS2 A;  1G12 A;  3TVC A;  1PWU A;  1JH1 A;  4XM8 A;  1JJ9 A;  1EAK A;  1KBC A;  1OMJ A;  1BKC E;  3L0V A;  1IAB A;  1XFW A;  2RJP A;  3U1R A;  4A7B A;  4G9L A;  3V96 B;  1DTH A;  3KWV C;  2HU6 A;  4PKQ A;  4JQG A;  1A85 A;  2FV9 A;  1G4K A;  1JAQ A;  1YP1 A;  1XUC A;  3LQB A;  2O3E A;  2OW0 A;  1OM8 A;  1SU3 A;  1QIA A;  3Q2H A;  3N2V A;  3LE9 A;  4GUY A;  2OXW A;  2SRT A;  2A8H A;  4DF9 A;  2JT5 A;  3KEK A;  2OW2 A;  2MZH A;  3DL1 A;  3WV3 A;  4XM6 A;  3B8Z A;  4QKZ A;  2CKI A;  3ZXH A;  2OZR A;  3CKI A;  4IJO A;  5D1U A;  3EDG A;  1MMR A;  5B5P A;  1GE6 A;  3EDZ A;  3AYU A;  3HY7 A;  3O64 A;  5D1T A;  4IN9 A;  1K7Q A;  4PKV A;  5CUH A;  4ON1 A;  1MMQ A;  4L63 A;  2OW1 A;  2X3A A;  1KUG A;  1BUD A;  2X3B A;  1YOU A;  2ERO A;  3TSK A;  1Y8J A;  4ZR5 A;  1GXD A;  1ZS0 A;  3I7I A;  2X3C A;  3F17 A;  2JT6 A;  1B3D A;  3LJT A;  3TT4 A;  1BSW A;  1SRP A;  4WF6 A;  2YIG A;  1R1J A;  2W15 A;  5B5O A;  1UTT A;  3G5C A;  1D7X A;  2DDF A;  4GR8 A;  1HTD A;  3OHL A;  1RMZ A;  2W12 A;  1AKL A;  1JAN A;  4AYK A;  4DPE A;  1BIW A;  4CTH A;  5BOT A;  1HOV A;  1Y0V A;  1UTZ A;  1YCM A;  4XBH A;  4H84 A;  1G05 A;  1PWP A;  1ZXV A;  4AUO A;  1UEA A;  2Y6C A;  4L6T A;  3ZVS A;  1BQQ M;  4FXQ A;  1BKC A;  4WK7 A;  3Q2G A;  4XCT A;  2KRJ A;  1HFC A;  1IAE A;  3F19 A;  4EFS A;  5I0L A;  1GE7 A;  2AYK A;  1MMB A;  1GE5 A;  2MZE A;  3EDH A;  2CLT A;  3K7N A;  1CGF A;  2WOA A;  2AIG P;  3AIG A;  1CGE A;  3ELM A;  3LQ0 A; 
#chains in the Genus database with same CATH topology
 3G42 A;  3LUN A;  4HMA A;  1GO7 P;  2RJQ A;  5I2Z A;  3HB2 P;  4WKI A;  4JPA A;  1KUI A;  3BA0 A;  4PKT A;  2W14 A;  4H3X A;  5CXA A;  1GKC A;  1MMP A;  1J7N A;  1ROS A;  3EWJ A;  4Q1L A;  1K7I A;  1ZTQ A;  3AYK A;  2OI0 A;  1I1I P;  3DTE A;  3UVC A;  4ILW D;  2K2G A;  1G49 A;  3LK8 A;  4JIJ A;  1MNC A;  1IAD A;  1QJI A;  1Z3J A;  3DPE A;  3VI1 A;  1EB6 A;  2E3X A;  3KEC A;  1PWW A;  1O0Q A;  1S4B P;  1UMS A;  2DW1 A;  2J0T A;  4FVL A;  3F18 A;  4GWM A;  1FM1 A;  3B92 A;  3USN A;  3SHI A;  1IAA A;  1XFV A;  1CQR A;  1JKY A;  3O2X A;  3OHO A;  3LJZ A;  5H8X A;  4L19 A;  1XUR A;  1K7G A;  3KEJ A;  2JSD A;  3KHI A;  1XM5 A;  1QIC A;  3B2Z A;  4I35 A;  1AF0 A;  1HFS A;  3HY9 A;  2N8R A;  1HY7 A;  5L79 A;  1XFZ A;  2OXU A;  1I73 A;  2MLS A;  2YB9 A;  4R3V A;  456C A;  5L7F A;  2O36 A;  3F15 A;  3HDA P;  1D8M A;  1BKC I;  2L0R A;  1TVI A;  3HDB A;  4H82 A;  5I43 A;  4J4M A;  1IAG A;  1XUD A;  3KME A;  4PKU A;  1KUF A;  1R55 A;  1HV5 A;  1ZP5 A;  1XFU A;  3RTS A;  2ERQ A;  2YUF A;  1QJJ A;  1AST A;  1B8Y A;  1D8F A;  3DTK A;  1L6J A;  1SAT A;  1JK3 A;  3I7G A;  1RM8 A;  5BPA A;  2W0D A;  3EDI A;  3MA2 A;  1EUB A;  3N2U A;  5JMY A;  1KUH A;  1CXV A;  3ZUK A;  4IUW A;  2DDY A;  3F16 A;  2PJT A;  4G0D A;  1C3I A;  1DMT A;  4PKW A;  3LKA A;  1JAP A;  1O0T A;  1UMT A;  2V4B A;  1PWV A;  2W13 A;  4WKE A;  5LAB A;  5D3C A;  1R1I A;  1Q3A A;  4GF1 A;  1G9K A;  1AYK A;  3LIK A;  4L7A A;  4I03 A;  3HBV P;  1XFY A;  1ZVX A;  2I47 A;  1PWQ A;  4FU4 A;  3LIL A;  3LJG A;  1I76 A;  2MLR A;  4JP4 A;  4DV8 A;  2OVZ A;  3NX7 A;  1JAO A;  1JIW P;  4DD8 A;  1BM6 A;  1C7K A;  2D1N A;  3VTG A;  1CGL A;  1A86 A;  2Y6D A;  4FXY P;  2OVX A;  1ATL A;  3LEA A;  4XM7 A;  830C A;  2QPJ A;  3KRY A;  3LUM A;  4GQL A;  2TCL A;  2J83 A;  2X7M A;  1KUK A;  1IAC A;  2WO8 A;  1R54 A;  2USN A;  2FV5 A;  1QUA A;  4GR0 A;  966C A;  1KAP P;  3K7L A;  5D2B A;  1OO9 A;  4H76 A;  1OM7 A;  4JA1 A;  5BOY A;  1H71 P;  5D7W A;  5I3M A;  4GWN A;  1ND1 A;  4HX3 A;  2OW9 A;  2ERP A;  1BQO A;  3LMC A;  3WV2 A;  3EHY A;  1SLN A;  3DTI A;  2POJ A;  2DW2 A;  1QIB A;  5CZM A;  4PKS A;  3LIR A;  2D1O A;  1SLM A;  2XS3 A;  1USN A;  2Z2D A;  3F1A A;  2MZI A;  1ZXC A;  4A3W A;  4PKR A;  3DPF A;  2OY2 A;  2WO9 A;  1D5J A;  2XS4 A;  3E8R A;  3DWB A;  1YQY A;  3KMC A;  3LGP A;  1JIZ A;  1Y93 A;  5I12 A;  4H30 A;  5I4O A;  3P1V A;  2DW0 A;  4WZV A;  1CAQ A;  1XFX A;  4AXQ A;  3HBU P;  2K9C A;  4H1Q A;  4AIG A;  1GO8 P;  5D1S A;  1C8T A;  1WNI A;  1SMP A;  2E2D A;  3DSL A;  2JNP A;  3L0T A;  2OXZ A;  1BUV M;  1OS9 A;  3EHX A;  4H49 A;  3TS4 A;  1R1H A;  4GR3 A;  3WV1 A;  1FBL A;  3RTT A;  1CK7 A;  1BZS A;  3HYG A;  1XAX A;  1OM6 A;  1GKD A;  2OY4 A;  3P24 A;  1FLS A;  2JIH A;  4H2E A;  3DNG A;  1CIZ A;  3GBO A;  1OS2 A;  1G12 A;  3TVC A;  1PWU A;  1JH1 A;  4XM8 A;  1JJ9 A;  1EAK A;  1KBC A;  1OMJ A;  1BKC E;  3L0V A;  1IAB A;  1XFW A;  2RJP A;  3U1R A;  4A7B A;  4G9L A;  3V96 B;  1DTH A;  3KWV C;  2HU6 A;  4PKQ A;  4JQG A;  1A85 A;  2FV9 A;  1G4K A;  1JAQ A;  1YP1 A;  1XUC A;  3LQB A;  2O3E A;  2OW0 A;  1OM8 A;  1SU3 A;  1QIA A;  3Q2H A;  1OZ9 A;  3N2V A;  3LE9 A;  4GUY A;  2OXW A;  2SRT A;  2A8H A;  4DF9 A;  2JT5 A;  3KEK A;  2OW2 A;  2MZH A;  3DL1 A;  3WV3 A;  4XM6 A;  3B8Z A;  4QKZ A;  2CKI A;  3ZXH A;  2OZR A;  3CKI A;  4IJO A;  5D1U A;  3EDG A;  1MMR A;  5B5P A;  1GE6 A;  3EDZ A;  3AYU A;  3HY7 A;  3O64 A;  5D1T A;  4IN9 A;  1K7Q A;  4PKV A;  5CUH A;  4ON1 A;  1MMQ A;  4L63 A;  2OW1 A;  2X3A A;  1KUG A;  1BUD A;  2X3B A;  1YOU A;  2ERO A;  3TSK A;  1Y8J A;  4ZR5 A;  1GXD A;  1ZS0 A;  3I7I A;  2X3C A;  3F17 A;  2JT6 A;  1B3D A;  3LJT A;  3TT4 A;  1BSW A;  1SRP A;  4WF6 A;  2YIG A;  1R1J A;  2W15 A;  5B5O A;  1UTT A;  3G5C A;  1D7X A;  2DDF A;  4GR8 A;  1HTD A;  3OHL A;  1RMZ A;  2W12 A;  1AKL A;  1JAN A;  4AYK A;  4DPE A;  1BIW A;  4CTH A;  5BOT A;  1HOV A;  1Y0V A;  1UTZ A;  1YCM A;  4XBH A;  4H84 A;  1G05 A;  1PWP A;  1ZXV A;  4AUO A;  1UEA A;  2Y6C A;  4L6T A;  3ZVS A;  1BQQ M;  4FXQ A;  1BKC A;  4WK7 A;  3Q2G A;  4XCT A;  2KRJ A;  1HFC A;  1IAE A;  3F19 A;  4EFS A;  5I0L A;  1GE7 A;  2AYK A;  1MMB A;  1GE5 A;  2MZE A;  3EDH A;  2CLT A;  3K7N A;  1CGF A;  2WOA A;  2AIG P;  3AIG A;  1CGE A;  3ELM A;  3LQ0 A; 
#chains in the Genus database with same CATH homology
 3G42 A;  3LUN A;  4HMA A;  1GO7 P;  2RJQ A;  5I2Z A;  3HB2 P;  4WKI A;  4JPA A;  1KUI A;  3BA0 A;  4PKT A;  2W14 A;  4H3X A;  5CXA A;  1GKC A;  1MMP A;  1J7N A;  1ROS A;  3EWJ A;  4Q1L A;  1K7I A;  1ZTQ A;  3AYK A;  2OI0 A;  1I1I P;  3DTE A;  3UVC A;  4ILW D;  2K2G A;  1G49 A;  3LK8 A;  4JIJ A;  1MNC A;  1IAD A;  1QJI A;  1Z3J A;  3DPE A;  3VI1 A;  1EB6 A;  2E3X A;  3KEC A;  1PWW A;  1O0Q A;  1S4B P;  1UMS A;  2DW1 A;  2J0T A;  4FVL A;  3F18 A;  4GWM A;  1FM1 A;  3B92 A;  3USN A;  3SHI A;  1IAA A;  1XFV A;  1CQR A;  1JKY A;  3O2X A;  3OHO A;  3LJZ A;  5H8X A;  4L19 A;  1XUR A;  1K7G A;  3KEJ A;  2JSD A;  3KHI A;  1QIC A;  3B2Z A;  4I35 A;  1AF0 A;  1HFS A;  3HY9 A;  2N8R A;  1HY7 A;  5L79 A;  1XFZ A;  2OXU A;  1I73 A;  2MLS A;  2YB9 A;  4R3V A;  456C A;  5L7F A;  2O36 A;  3F15 A;  3HDA P;  1D8M A;  1BKC I;  2L0R A;  3HDB A;  4H82 A;  5I43 A;  4J4M A;  1IAG A;  1XUD A;  3KME A;  4PKU A;  1KUF A;  1R55 A;  1HV5 A;  1ZP5 A;  1XFU A;  3RTS A;  2ERQ A;  2YUF A;  1QJJ A;  1AST A;  1B8Y A;  1D8F A;  3DTK A;  1L6J A;  1SAT A;  1JK3 A;  3I7G A;  1RM8 A;  5BPA A;  2W0D A;  3EDI A;  3MA2 A;  1EUB A;  3N2U A;  5JMY A;  1KUH A;  1CXV A;  3ZUK A;  4IUW A;  2DDY A;  3F16 A;  2PJT A;  4G0D A;  1C3I A;  1DMT A;  4PKW A;  3LKA A;  1JAP A;  1O0T A;  1UMT A;  2V4B A;  1PWV A;  2W13 A;  4WKE A;  5LAB A;  5D3C A;  1R1I A;  1Q3A A;  4GF1 A;  1G9K A;  1AYK A;  3LIK A;  4L7A A;  4I03 A;  3HBV P;  1XFY A;  1ZVX A;  2I47 A;  1PWQ A;  4FU4 A;  3LIL A;  3LJG A;  1I76 A;  2MLR A;  4JP4 A;  4DV8 A;  2OVZ A;  3NX7 A;  1JAO A;  1JIW P;  4DD8 A;  1BM6 A;  1C7K A;  2D1N A;  3VTG A;  1CGL A;  1A86 A;  2Y6D A;  4FXY P;  2OVX A;  1ATL A;  3LEA A;  4XM7 A;  830C A;  2QPJ A;  3KRY A;  3LUM A;  4GQL A;  2TCL A;  2J83 A;  2X7M A;  1KUK A;  1IAC A;  2WO8 A;  1R54 A;  2USN A;  2FV5 A;  1QUA A;  4GR0 A;  966C A;  1KAP P;  3K7L A;  5D2B A;  1OO9 A;  4H76 A;  1OM7 A;  4JA1 A;  5BOY A;  1H71 P;  5D7W A;  5I3M A;  4GWN A;  1ND1 A;  4HX3 A;  2OW9 A;  2ERP A;  1BQO A;  3LMC A;  3WV2 A;  3EHY A;  1SLN A;  3DTI A;  2POJ A;  2DW2 A;  1QIB A;  5CZM A;  4PKS A;  3LIR A;  2D1O A;  1SLM A;  2XS3 A;  1USN A;  2Z2D A;  3F1A A;  2MZI A;  1ZXC A;  4A3W A;  4PKR A;  3DPF A;  2OY2 A;  2WO9 A;  1D5J A;  2XS4 A;  3E8R A;  3DWB A;  1YQY A;  3KMC A;  3LGP A;  1JIZ A;  1Y93 A;  5I12 A;  4H30 A;  5I4O A;  3P1V A;  2DW0 A;  4WZV A;  1CAQ A;  1XFX A;  4AXQ A;  3HBU P;  2K9C A;  4H1Q A;  4AIG A;  1GO8 P;  5D1S A;  1C8T A;  1WNI A;  1SMP A;  2E2D A;  3DSL A;  2JNP A;  3L0T A;  2OXZ A;  1BUV M;  1OS9 A;  3EHX A;  4H49 A;  3TS4 A;  1R1H A;  4GR3 A;  3WV1 A;  1FBL A;  3RTT A;  1CK7 A;  1BZS A;  3HYG A;  1OM6 A;  1GKD A;  2OY4 A;  3P24 A;  1FLS A;  2JIH A;  4H2E A;  3DNG A;  1CIZ A;  3GBO A;  1OS2 A;  1G12 A;  3TVC A;  1PWU A;  1JH1 A;  4XM8 A;  1JJ9 A;  1EAK A;  1KBC A;  1OMJ A;  1BKC E;  3L0V A;  1IAB A;  1XFW A;  2RJP A;  3U1R A;  4A7B A;  4G9L A;  3V96 B;  1DTH A;  3KWV C;  2HU6 A;  4PKQ A;  4JQG A;  1A85 A;  2FV9 A;  1G4K A;  1JAQ A;  1YP1 A;  1XUC A;  3LQB A;  2O3E A;  2OW0 A;  1OM8 A;  1SU3 A;  1QIA A;  3Q2H A;  3N2V A;  3LE9 A;  4GUY A;  2OXW A;  2SRT A;  2A8H A;  4DF9 A;  2JT5 A;  3KEK A;  2OW2 A;  2MZH A;  3DL1 A;  3WV3 A;  4XM6 A;  3B8Z A;  4QKZ A;  2CKI A;  3ZXH A;  2OZR A;  3CKI A;  4IJO A;  5D1U A;  3EDG A;  1MMR A;  5B5P A;  1GE6 A;  3EDZ A;  3AYU A;  3HY7 A;  3O64 A;  5D1T A;  4IN9 A;  1K7Q A;  4PKV A;  5CUH A;  4ON1 A;  1MMQ A;  4L63 A;  2OW1 A;  2X3A A;  1KUG A;  1BUD A;  2X3B A;  1YOU A;  2ERO A;  3TSK A;  1Y8J A;  4ZR5 A;  1GXD A;  1ZS0 A;  3I7I A;  2X3C A;  3F17 A;  2JT6 A;  1B3D A;  3LJT A;  3TT4 A;  1BSW A;  1SRP A;  4WF6 A;  2YIG A;  1R1J A;  2W15 A;  5B5O A;  1UTT A;  3G5C A;  1D7X A;  2DDF A;  4GR8 A;  1HTD A;  3OHL A;  1RMZ A;  2W12 A;  1AKL A;  1JAN A;  4AYK A;  4DPE A;  1BIW A;  4CTH A;  5BOT A;  1HOV A;  1Y0V A;  1UTZ A;  1YCM A;  4XBH A;  4H84 A;  1G05 A;  1PWP A;  1ZXV A;  4AUO A;  1UEA A;  2Y6C A;  4L6T A;  3ZVS A;  1BQQ M;  4FXQ A;  1BKC A;  4WK7 A;  3Q2G A;  4XCT A;  2KRJ A;  1HFC A;  1IAE A;  3F19 A;  4EFS A;  5I0L A;  1GE7 A;  2AYK A;  1MMB A;  1GE5 A;  2MZE A;  3EDH A;  2CLT A;  3K7N A;  1CGF A;  2WOA A;  2AIG P;  3AIG A;  1CGE A;  3ELM A;  3LQ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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