5ICNB

Hdac1:mta1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone h4
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
369
structure length
369
Chain Sequence
RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transcription
molecule keywords Metastasis-associated protein MTA1
publication title Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.
pubmed doi rcsb
source organism Homo sapiens
total genus 124
structure length 369
sequence length 369
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5icnB00
5G0HA 4BZ8A 3MZ7A 3MZ4A 5G10A 4LXZA 5DC7A 5EF7A 4ZUOA 1C3SA 5EFBD 5DC8A 1T67A 1VKGA 3C10A 4ZUNA 5G0YA 4CBYA 5IX0A 3Q9BA 2VCGA 3F0RA 3EZTA 1ZZ3A 4ZURA 5EEMA 4BZ6A 3F06A 4ZUMA 2VQQA 5FUEA 3MZ3A 5EFHA 3EZPA 2V5XA 5EFNA 2VQOA 4RN1A 4QA1A 5D1BA 3MAXA 5A2SA 1C3PA 4BZ9A 5DC6A 5BWZA 3Q9EA 4QA4A 5JI5A 4QA5A 3C0YA 4CQFA 4BZ7A 2V5WA 5G17A 4BKXB 3ZNSA 5EEIA 5THSA 5G11A 4CBTA 5D1CA 5EFGA 1T69A 3C0ZA 3Q9CA 4A69A 5EFKB 1ZZ1A 5G1CA 5THVA 2VQVA 5G1AA 5G13A 5THUA 4QA3A 5LI3A 5G0IA 5IWGA 3MZ6A 4ZUPA 3Q9FA 5G0XA 5G12A 3MENA 5G3WA 3F07A 2GH6A 3RQDA 4RN0A 2VQWG 3SFFA 5DC5A 5EEFA 4ZUQA 2VQJA 4QA2A 5EFJD 1T64A 5ICNB 1C3RA 5G0JA 3EW8A 2VQMA 4BZ5A 5EEKA 4QA6A 5FCWA 4QA0A 5EENA 5G0GA 1ZZ0A 5G1BA 4RN2A 4LY1A 5THTA 1W22A 5EF8A 4QA7A 3SFHA 5D1DA 3EWFA 3ZNRA
chains in the Genus database with same CATH superfamily
5G0HA 4BZ8A 2AEBA 3MZ7A 3MZ4A 4Q3VA 5G10A 4LXZA 1TBLA 5DC7A 4CEVA 1CEVA 4MYNA 3LP7A 5EF7A 3F80A 4ZUOA 1C3SA 4Q3QA 1T5GA 5EFBD 4Q42A 5DC8A 1WOHA 1T67A 1VKGA 1ZPGA 2CEVA 1WVAA 3C10A 3MFVA 4G3HA 4ZUNA 5G0YA 1T5FA 4CBYA 1T4SA 4IE2A 3Q9BA 5IX0A 2VCGA 3F0RA 3MFWA 4GSVA 4HXQA 4I06A 4IE3A 3THEA 3EZTA 1ZZ3A 4ZURA 4Q3RA 1R1OA 1GQ7A 5EEMA 4BZ6A 3M1RA 1TA1A 4Q3RC 4ITYA 3E6VA 1TBHA 3F06A 2VQQA 4MXRA 2ZAVA 4ZUMA 5FUEA 2EF5A 3MZ3A 1HQHA 4GWCA 2EIVA 3EZPA 2V5XA 5EFHA 3MJLA 5EFNA 4IU0A 4RHMA 1ZPEA 2VQOA 3E9BA 4FCKA 3NIQA 4RN1A 4GWDA 4IXUA 1P8SA 1P8QA 4QA1A 3MAXA 5D1BA 5A2SA 2PHOA 3E8QA 4IU5A 1C3PA 4GSMA 5HJ9A 4BZ9A 5DC6A 1P8MA 4FCIA 5BWZA 3Q9EA 4QA4A 3SKKA 4QA5A 4Q41A 5JI5A 3C0YA 1HQ5A 4CQFA 1HQXA 4BZ7A 2V5WA 3E8ZA 3RLAA 5G17A 4BKXB 1P8OA 4Q3UA 3ZNSA 5EEIA 5THSA 5G11A 4CBTA 5D1CA 4HZEA 4RHLA 5EFGA 1T69A 3C0ZA 3SL0A 1D3VA 3Q9CA 3THHA 4RHIA 4A69A 4RLAA 3LP4A 4Q3SA 1PQ3A 5EFKB 2PLLA 3NIPA 1ZZ1A 3SL1A 3DJ8A 5G1CA 5THVA 2VQVA 5G1AA 4RHQA 1P8NA 4IU4A 2EF4A 3TF3A 1RLAA 5G13A 4MYFA 4RHJA 4Q40A 4QA3A 5THUA 3SJTA 3TH7A 3MMRA 4IE1A 5LI3A 5G0IA 1T4RA 5IWGA 3MZ6A 1P8RA 3PZLA 3Q9FA 4RHKA 4ZUPA 5G0XA 3MENA 5G3WA 3F07A 2GH6A 5G12A 4HWWA 3RQDA 4RN0A 1WOGA 2VQWG 4MYKA 5DC5A 3SFFA 1TBJA 5EEFA 4ZUQA 3THJA 2VQJA 4QA2A 5EFJD 1T64A 1WVBA 1T4TA 5ICNB 3KV2A 1C3RA 4IXVA 5G0JA 3EW8A 3GN0A 2VQMA 1WOIA 4BZ5A 5HJAA 3E6KA 4IU1A 2A0MA 1XFKA 3LHLA 5CEVA 4GSZA 5EEKA 2PHAA 5RLAA 2RLAA 4QA6A 5FCWA 4DZ4A 1P8PA 4Q3PA 4QA0A 5EENA 1ZZ0A 5G0GA 4RN2A 5G1BA 4Q3TA 4LY1A 5THTA 1W22A 4MYLA 5EF8A 1GQ6A 3CEVA 1HQFA 4QA7A 3NIOA 1HQGA 3SFHA 5D1DA 3GMZA 3EWFA 3ZNRA 1T4PA
chains in the Genus database with same CATH topology
5G0HA 4BZ8A 3MZ7A 3MZ4A 5G10A 4LXZA 5DC7A 5EF7A 4ZUOA 1C3SA 5EFBD 5DC8A 1T67A 1VKGA 3C10A 4ZUNA 5G0YA 4CBYA 5IX0A 3Q9BA 2VCGA 3F0RA 3EZTA 1ZZ3A 4ZURA 5EEMA 4BZ6A 3F06A 4ZUMA 2VQQA 5FUEA 3MZ3A 5EFHA 3EZPA 2V5XA 5EFNA 2VQOA 4RN1A 4QA1A 5D1BA 3MAXA 5A2SA 1C3PA 4BZ9A 5DC6A 5BWZA 3Q9EA 4QA4A 5JI5A 4QA5A 3C0YA 4CQFA 4BZ7A 2V5WA 5G17A 4BKXB 3ZNSA 5EEIA 5THSA 5G11A 4CBTA 5D1CA 5EFGA 1T69A 3C0ZA 3Q9CA 4A69A 5EFKB 1ZZ1A 5G1CA 5THVA 2VQVA 5G1AA 5G13A 5THUA 4QA3A 5LI3A 5G0IA 5IWGA 3MZ6A 4ZUPA 3Q9FA 5G0XA 5G12A 3MENA 5G3WA 3F07A 2GH6A 3RQDA 4RN0A 2VQWG 3SFFA 5DC5A 5EEFA 4ZUQA 2VQJA 4QA2A 5EFJD 1T64A 5ICNB 1C3RA 5G0JA 3EW8A 2VQMA 4BZ5A 5EEKA 4QA6A 5FCWA 4QA0A 5EENA 5G0GA 1ZZ0A 5G1BA 4RN2A 4LY1A 5THTA 1W22A 5EF8A 4QA7A 3SFHA 5D1DA 3EWFA 3ZNRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G0H A;  4BZ8 A;  3MZ7 A;  3MZ4 A;  5G10 A;  4LXZ A;  5DC7 A;  5EF7 A;  4ZUO A;  1C3S A;  5EFB D;  5DC8 A;  1T67 A;  1VKG A;  3C10 A;  4ZUN A;  5G0Y A;  4CBY A;  5IX0 A;  3Q9B A;  2VCG A;  3F0R A;  3EZT A;  1ZZ3 A;  4ZUR A;  5EEM A;  4BZ6 A;  3F06 A;  4ZUM A;  2VQQ A;  5FUE A;  3MZ3 A;  5EFH A;  3EZP A;  2V5X A;  5EFN A;  2VQO A;  4RN1 A;  4QA1 A;  5D1B A;  3MAX A;  5A2S A;  1C3P A;  4BZ9 A;  5DC6 A;  5BWZ A;  3Q9E A;  4QA4 A;  5JI5 A;  4QA5 A;  3C0Y A;  4CQF A;  4BZ7 A;  2V5W A;  5G17 A;  4BKX B;  3ZNS A;  5EEI A;  5THS A;  5G11 A;  4CBT A;  5D1C A;  5EFG A;  1T69 A;  3C0Z A;  3Q9C A;  4A69 A;  5EFK B;  1ZZ1 A;  5G1C A;  5THV A;  2VQV A;  5G1A A;  5G13 A;  5THU A;  4QA3 A;  5LI3 A;  5G0I A;  5IWG A;  3MZ6 A;  4ZUP A;  3Q9F A;  5G0X A;  5G12 A;  3MEN A;  5G3W A;  3F07 A;  2GH6 A;  3RQD A;  4RN0 A;  2VQW G;  3SFF A;  5DC5 A;  5EEF A;  4ZUQ A;  2VQJ A;  4QA2 A;  5EFJ D;  1T64 A;  5ICN B;  1C3R A;  5G0J A;  3EW8 A;  2VQM A;  4BZ5 A;  5EEK A;  4QA6 A;  5FCW A;  4QA0 A;  5EEN A;  5G0G A;  1ZZ0 A;  5G1B A;  4RN2 A;  4LY1 A;  5THT A;  1W22 A;  5EF8 A;  4QA7 A;  3SFH A;  5D1D A;  3EWF A;  3ZNR A; 
#chains in the Genus database with same CATH topology
 5G0H A;  4BZ8 A;  2AEB A;  3MZ7 A;  3MZ4 A;  4Q3V A;  5G10 A;  4LXZ A;  1TBL A;  5DC7 A;  4CEV A;  1CEV A;  4MYN A;  3LP7 A;  5EF7 A;  3F80 A;  4ZUO A;  1C3S A;  4Q3Q A;  1T5G A;  5EFB D;  4Q42 A;  5DC8 A;  1WOH A;  1T67 A;  1VKG A;  1ZPG A;  2CEV A;  1WVA A;  3C10 A;  3MFV A;  4G3H A;  4ZUN A;  5G0Y A;  1T5F A;  4CBY A;  1T4S A;  4IE2 A;  3Q9B A;  5IX0 A;  2VCG A;  3F0R A;  3MFW A;  4GSV A;  4HXQ A;  4I06 A;  4IE3 A;  3THE A;  3EZT A;  1ZZ3 A;  4ZUR A;  4Q3R A;  1R1O A;  1GQ7 A;  5EEM A;  4BZ6 A;  3M1R A;  1TA1 A;  4Q3R C;  4ITY A;  3E6V A;  1TBH A;  3F06 A;  2VQQ A;  4MXR A;  2ZAV A;  4ZUM A;  5FUE A;  2EF5 A;  3MZ3 A;  1HQH A;  4GWC A;  2EIV A;  3EZP A;  2V5X A;  5EFH A;  3MJL A;  5EFN A;  4IU0 A;  4RHM A;  1ZPE A;  2VQO A;  3E9B A;  4FCK A;  3NIQ A;  4RN1 A;  4GWD A;  4IXU A;  1P8S A;  1P8Q A;  4QA1 A;  3MAX A;  5D1B A;  5A2S A;  2PHO A;  3E8Q A;  4IU5 A;  1C3P A;  4GSM A;  5HJ9 A;  4BZ9 A;  5DC6 A;  1P8M A;  4FCI A;  5BWZ A;  3Q9E A;  4QA4 A;  3SKK A;  4QA5 A;  4Q41 A;  5JI5 A;  3C0Y A;  1HQ5 A;  4CQF A;  1HQX A;  4BZ7 A;  2V5W A;  3E8Z A;  3RLA A;  5G17 A;  4BKX B;  1P8O A;  4Q3U A;  3ZNS A;  5EEI A;  5THS A;  5G11 A;  4CBT A;  5D1C A;  4HZE A;  4RHL A;  5EFG A;  1T69 A;  3C0Z A;  3SL0 A;  1D3V A;  3Q9C A;  3THH A;  4RHI A;  4A69 A;  4RLA A;  3LP4 A;  4Q3S A;  1PQ3 A;  5EFK B;  2PLL A;  3NIP A;  1ZZ1 A;  3SL1 A;  3DJ8 A;  5G1C A;  5THV A;  2VQV A;  5G1A A;  4RHQ A;  1P8N A;  4IU4 A;  2EF4 A;  3TF3 A;  1RLA A;  5G13 A;  4MYF A;  4RHJ A;  4Q40 A;  4QA3 A;  5THU A;  3SJT A;  3TH7 A;  3MMR A;  4IE1 A;  5LI3 A;  5G0I A;  1T4R A;  5IWG A;  3MZ6 A;  1P8R A;  3PZL A;  3Q9F A;  4RHK A;  4ZUP A;  5G0X A;  3MEN A;  5G3W A;  3F07 A;  2GH6 A;  5G12 A;  4HWW A;  3RQD A;  4RN0 A;  1WOG A;  2VQW G;  4MYK A;  5DC5 A;  3SFF A;  1TBJ A;  5EEF A;  4ZUQ A;  3THJ A;  2VQJ A;  4QA2 A;  5EFJ D;  1T64 A;  1WVB A;  1T4T A;  5ICN B;  3KV2 A;  1C3R A;  4IXV A;  5G0J A;  3EW8 A;  3GN0 A;  2VQM A;  1WOI A;  4BZ5 A;  5HJA A;  3E6K A;  4IU1 A;  2A0M A;  1XFK A;  3LHL A;  5CEV A;  4GSZ A;  5EEK A;  2PHA A;  5RLA A;  2RLA A;  4QA6 A;  5FCW A;  4DZ4 A;  1P8P A;  4Q3P A;  4QA0 A;  5EEN A;  1ZZ0 A;  5G0G A;  4RN2 A;  5G1B A;  4Q3T A;  4LY1 A;  5THT A;  1W22 A;  4MYL A;  5EF8 A;  1GQ6 A;  3CEV A;  1HQF A;  4QA7 A;  3NIO A;  1HQG A;  3SFH A;  5D1D A;  3GMZ A;  3EWF A;  3ZNR A;  1T4P A; 
#chains in the Genus database with same CATH homology
 5G0H A;  4BZ8 A;  3MZ7 A;  3MZ4 A;  5G10 A;  4LXZ A;  5DC7 A;  5EF7 A;  4ZUO A;  1C3S A;  5EFB D;  5DC8 A;  1T67 A;  1VKG A;  3C10 A;  4ZUN A;  5G0Y A;  4CBY A;  5IX0 A;  3Q9B A;  2VCG A;  3F0R A;  3EZT A;  1ZZ3 A;  4ZUR A;  5EEM A;  4BZ6 A;  3F06 A;  4ZUM A;  2VQQ A;  5FUE A;  3MZ3 A;  5EFH A;  3EZP A;  2V5X A;  5EFN A;  2VQO A;  4RN1 A;  4QA1 A;  5D1B A;  3MAX A;  5A2S A;  1C3P A;  4BZ9 A;  5DC6 A;  5BWZ A;  3Q9E A;  4QA4 A;  5JI5 A;  4QA5 A;  3C0Y A;  4CQF A;  4BZ7 A;  2V5W A;  5G17 A;  4BKX B;  3ZNS A;  5EEI A;  5THS A;  5G11 A;  4CBT A;  5D1C A;  5EFG A;  1T69 A;  3C0Z A;  3Q9C A;  4A69 A;  5EFK B;  1ZZ1 A;  5G1C A;  5THV A;  2VQV A;  5G1A A;  5G13 A;  5THU A;  4QA3 A;  5LI3 A;  5G0I A;  5IWG A;  3MZ6 A;  4ZUP A;  3Q9F A;  5G0X A;  5G12 A;  3MEN A;  5G3W A;  3F07 A;  2GH6 A;  3RQD A;  4RN0 A;  2VQW G;  3SFF A;  5DC5 A;  5EEF A;  4ZUQ A;  2VQJ A;  4QA2 A;  5EFJ D;  1T64 A;  5ICN B;  1C3R A;  5G0J A;  3EW8 A;  2VQM A;  4BZ5 A;  5EEK A;  4QA6 A;  5FCW A;  4QA0 A;  5EEN A;  5G0G A;  1ZZ0 A;  5G1B A;  4RN2 A;  4LY1 A;  5THT A;  1W22 A;  5EF8 A;  4QA7 A;  3SFH A;  5D1D A;  3EWF A;  3ZNR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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