5IDPB

Cdk8-cycc in complex with (3-amino-1h-indazol-5-yl)-[(s)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
268
structure length
268
Chain Sequence
DDKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Cyclin-dependent kinase 8
total genus 93
structure length 268
sequence length 268
ec nomenclature
pdb deposition date 2016-02-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00134 Cyclin_N Cyclin, N-terminal domain
B PF16899 Cyclin_C_2 Cyclin C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 5idpB02
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 5idpB01
1JKWA 2CJMB 4YOOA 2C6TB 2V22B 3BLRB 2WMAB 3F5XB 2IW8B 3MY1B 4YOSA 4BCND 1H25B 4CFMB 1BU2A 1URCB 2W2HA 1FINB 3TNIB 1H1SB 4Y72B 1OL2B 2WMBB 1XO2A 1UNHD 2JGZB 4RODA 3TNWB 4CFWB 1F5QB 2I40B 3EOCB 4ELLA 2WHBB 2BPMB 3POMA 5HBJB 3LQ5B 3TN8B 3MIAB 2UZBB 4BCKB 2R7GA 4EOLB 2C5XB 4BCMB 1E9HB 4BCNB 2B9RA 1GY3B 3DDQB 1KXUA 2IW6B 4YC3B 2W9FA 5BNJB 1JSUB 4ROEA 3DOGB 1H1QB 2WIHB 4G6LB 4EOIB 4F7SB 4F6UB 5ICPB 4F7NB 1D3UB 5IDNB 2WFYB 2IW9B 2F2CA 4ROCA 4BCOB 2WXVB 4BCQB 1W98B 1UNGD 4CRLB 4EOKB 5HBEB 2QDJA 2WPAB 4FX3B 5FGKB 1N4MA 3BHUB 4CFUD 4CFXB 2PHGA 1VYWB 1FVVB 1OIYB 4F6WB 3TNHB 1OKWB 4CFNB 3QHWB 5CYIB 1JSTB 1H1PB 3BHTB 2WEVB 4II5B 4F7LB 1OIUB 5HQ0B 4CFVB 4EORB 5LQFB 2W9ZA 1P5EB 4F70B 2IVXA 4BCHB 4BCIB 1UNLD 4EC8B 3BLHB 1OKVB 4IMYB 3EIDB 1OGUB 4EOOB 4ELJA 3BLQB 3BHVB 3MY5B 2W96A 4BCPB 4EOJB 1GH6B 2EUFA 3H4CA 4CXAB 3RGFB 5I5ZB 1H1RB 1C9BA 1QMZB 1OI9B 5IF1B 2I53A 2X1NB 4EOQB 1H24B 2C5OB 2CCIB 2G9XB 5HBHB 4F6SB 2WIPB 3O0GD 1H28B 4EOMB 2C4GB 4EOPB 2PMIB 1AD6A 4KRDB 2PK9B 2UUEB 3EJ1B 3MI9B 4EONB 4EC9B 1O9KB 4I3ZB 4YOZA 1H27B 4F7JB 1O9KA 1JOWA 4OR5B 4KRCB 5HNBB 4BCMD 1VOLA 3DDPB 4CFUB 2C5NB 1G3NC 1TFBA 4NSTB 2PK2A 1PKDB 1ZP2A 4BCGB 5IDPB 5LMKB 2UZLB 5CEIB 4BCQD 4BCJB 1VINA 2BKZB 4TTHA 4EOSB 1GUXB 2W99A 4OGRB 5EFQB 5HVYB 4UN0A 1OL1B 1GUXA 2UZDB 4BCFB 3G33B 3QHRB 1AISB 2UZEB 3M03A 5ACBA 1H26B 5L2WB 3K7AM 2CCHB 2C5VB 1H4LD
chains in the Genus database with same CATH superfamily
4YOOA 2C6TB 4ZGDB 3A8LB 2KMGA 4NC6A 3MY1B 3VYGB 1FINB 5EJCA 3VKHA 1XO2A 2WJ9A 2JGZB 2LW4A 3EOCB 1E9HB 4YC3B 5ICPB 2ZPBB 2IW9B 4BCQB 4EOKB 4OB3B 4CFUD 2PHGA 4ZGJB 2WEVB 4II5B 4Z6YA 4EORB 2DD5B 4HLQA 4IMYB 4EOOB 3EIDB 3BG3A 3BHVB 2W96A 3BG5A 3PO3S 5I5ZB 4LOCA 1OI9B 3TW7A 2ZPIB 1H24B 2G9XB 1ENWA 4AKIA 2WIPB 3O0GD 1H28B 4KRDB 3X28B 4I3ZB 1H27B 1O9KA 3DJBA 2C5NB 3A8OB 1G3NC 1TFBA 1TD6A 2ZPFB 1VINA 4TTHA 1GUXB 5HVYB 3X26B 4UN0A 3TW6A 3NDQA 3G33B 5L2WB 3KHIA 1JKWA 2QDYB 3DL1A 4YOSA 4BCND 1H25B 4HL4A 2WMBB 4BY1X 4CFWB 1F5QB 2WHBB 2BPMB 3POMA 5HBJB 3MIAB 2UZBB 4BCMB 4BCNB 1GY3B 1KXUA 2AHJB 4ROEA 4EOIB 4F7SB 2PJQA 5IDNB 2WFYB 4ROCA 4CRLB 2WXVB 2CZ0B 5HBEB 4FX3B 1N4MA 3HB9A 2ZPGB 3GTMS 1OIYB 3TNHB 4CFNB 2QGSA 1H1PB 5HQ0B 5LQFB 2G77A 1UGPB 1UNLD 4EC8B 4ELJA 3MY5B 4QSHA 1AHJB 1GH6B 3RGFB 1QMZB 2I53A 4ZGEB 2C5OB 4EOMB 2C4GB 2DMEA 1AD6A 3MI9B 1QLBA 3QZ5B 2ZZDB 3HZJA 4YOZA 4OR5B 3DDPB 4CFUB 2CYZB 4NSTB 2QFZA 2PK2A 3QYHB 1ZP2A 3QXEB 4BBRM 4OB2B 5LMKB 2UZLB 5CEIB 4OGRB 4OB1B 2BS2A 1GUXA 2UZDB 1AISB 3M03A 2QF7A 2KR6A 3BLRB 4HNUA 1URCB 3WVDB 4Y72B 3HO8A 1UNHD 4MFEA 2CZ7B 3LQ5B 4BCKB 2R7GA 2B9RA 3DDQB 5BNJB 1IREB 3DOGB 2WIHB 3QZ9B 4G6LB 4F6UB 1D3UB 1W98B 1UNGD 2WPAB 5FGKB 4JX5A 1UGSB 5IHYA 4OB0B 1VYWB 2DXBB 2BS3A 3QHWB 5CYIB 1JSTB 3BHTB 1OIUB 2W9ZA 1P5EB 2IVXA 2D0QB 4BCHB 4AKGA 3A8GB 3BLHB 4M6VA 1OKVB 3BLQB 3HHTB 4BCPB 4EOJB 3QWLA 1C9BA 2CZ6B 1V29B 2X1NB 4EOQB 5HBHB 4F6SB 4FM4B 1UGQB 2PMIB 4BBSM 2PK9B 5HNBB 1VOLA 4AKHA 3VKGA 4BCGB 1PKDB 5IDPB 4BCQD 3A8MB 4MFDA 2BKZB 1FKMA 1OL1B 4HNVA 3QHRB 2DD4B 5ACBA 3K7AM 3TNWB 2C5VB 1H4LD 1UGRB 2CJMB 2V22B 2WMAB 3F5XB 2IW8B 3DTOA 4CFMB 1BU2A 2W2HA 4JX6A 3A8HB 3TNIB 1H1SB 1OL2B 3QYBA 4RODA 4HNTA 3WVEB 2I40B 3HBLA 4ELLA 3TN8B 4EOLB 2C5XB 2IW6B 2W9FA 1JSUB 4MIMA 1H1QB 2CZ1B 4F7NB 2F2CA 4BCOB 2QDJA 4BY7X 3QYEA 3BHUB 4CFXB 1FVVB 4F6WB 1OKWB 2DPPB 4F7LB 4CFVB 4BXXX 3BG9A 4F70B 2ZPHB 4BCIB 3QYGB 3X20B 1OGUB 2QQ8A 2DXCB 2EUFA 1E7PA 3H4CA 4CXAB 2ZPEB 1H1RB 5IF1B 2CCIB 2IN3A 5DQWA 4EOPB 2UUEB 3EJ1B 4EONB 3X25B 4EC9B 1O9KB 2ZCFB 4F7JB 1JOWA 4KRCB 4BCMD 3B57A 3X24B 3VYHB 4BCJB 4EOSB 2W99A 2BS4A 5EFQB 4BCFB 4JX4A 5DQVA 2UZEB 4AI6A 1H26B 2CCHB
chains in the Genus database with same CATH topology
1JKWA 2CJMB 4YOOA 2C6TB 2V22B 3BLRB 2WMAB 3F5XB 2IW8B 3MY1B 4YOSA 4BCND 1H25B 4CFMB 1BU2A 1URCB 2W2HA 1FINB 3TNIB 1H1SB 4Y72B 1OL2B 2WMBB 1XO2A 1UNHD 2JGZB 4RODA 3TNWB 4CFWB 1F5QB 2I40B 3EOCB 4ELLA 2WHBB 2BPMB 3POMA 5HBJB 3LQ5B 3TN8B 3MIAB 2UZBB 4BCKB 2R7GA 4EOLB 2C5XB 4BCMB 1E9HB 4BCNB 2B9RA 1GY3B 3DDQB 1KXUA 2IW6B 4YC3B 2W9FA 5BNJB 1JSUB 4ROEA 3DOGB 1H1QB 2WIHB 4G6LB 4EOIB 4F7SB 4F6UB 5ICPB 4F7NB 1D3UB 5IDNB 2WFYB 2IW9B 2F2CA 4ROCA 4BCOB 2WXVB 4BCQB 1W98B 1UNGD 4CRLB 4EOKB 5HBEB 2QDJA 2WPAB 4FX3B 5FGKB 1N4MA 3BHUB 4CFUD 4CFXB 2PHGA 1VYWB 1FVVB 1OIYB 4F6WB 3TNHB 1OKWB 4CFNB 3QHWB 5CYIB 1JSTB 1H1PB 3BHTB 2WEVB 4II5B 4F7LB 1OIUB 5HQ0B 4CFVB 4EORB 5LQFB 2W9ZA 1P5EB 4F70B 2IVXA 4BCHB 4BCIB 1UNLD 4EC8B 3BLHB 1OKVB 4IMYB 3EIDB 1OGUB 4EOOB 4ELJA 3BLQB 3BHVB 3MY5B 2W96A 4BCPB 4EOJB 1GH6B 2EUFA 3H4CA 4CXAB 3RGFB 5I5ZB 1H1RB 1C9BA 1QMZB 1OI9B 5IF1B 2I53A 2X1NB 4EOQB 1H24B 2C5OB 2CCIB 2G9XB 5HBHB 4F6SB 2WIPB 3O0GD 1H28B 4EOMB 2C4GB 4EOPB 2PMIB 1AD6A 4KRDB 2PK9B 2UUEB 3EJ1B 3MI9B 4EONB 4EC9B 1O9KB 4I3ZB 4YOZA 1H27B 4F7JB 1O9KA 1JOWA 4OR5B 4KRCB 5HNBB 4BCMD 1VOLA 3DDPB 4CFUB 2C5NB 1G3NC 1TFBA 4NSTB 2PK2A 1PKDB 1ZP2A 4BCGB 5IDPB 5LMKB 2UZLB 5CEIB 4BCQD 4BCJB 1VINA 2BKZB 4TTHA 4EOSB 1GUXB 2W99A 4OGRB 5EFQB 5HVYB 4UN0A 1OL1B 1GUXA 2UZDB 4BCFB 3G33B 3QHRB 1AISB 2UZEB 3M03A 5ACBA 1H26B 5L2WB 3K7AM 2CCHB 2C5VB 1H4LD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JKW A;  2CJM B;  4YOO A;  2C6T B;  2V22 B;  3BLR B;  2WMA B;  3F5X B;  2IW8 B;  3MY1 B;  4YOS A;  4BCN D;  1H25 B;  4CFM B;  1BU2 A;  1URC B;  2W2H A;  1FIN B;  3TNI B;  1H1S B;  4Y72 B;  1OL2 B;  2WMB B;  1XO2 A;  1UNH D;  2JGZ B;  4ROD A;  3TNW B;  4CFW B;  1F5Q B;  2I40 B;  3EOC B;  4ELL A;  2WHB B;  2BPM B;  3POM A;  5HBJ B;  3LQ5 B;  3TN8 B;  3MIA B;  2UZB B;  4BCK B;  2R7G A;  4EOL B;  2C5X B;  4BCM B;  1E9H B;  4BCN B;  2B9R A;  1GY3 B;  3DDQ B;  1KXU A;  2IW6 B;  4YC3 B;  2W9F A;  5BNJ B;  1JSU B;  4ROE A;  3DOG B;  1H1Q B;  2WIH B;  4G6L B;  4EOI B;  4F7S B;  4F6U B;  5ICP B;  4F7N B;  1D3U B;  5IDN B;  2WFY B;  2IW9 B;  2F2C A;  4ROC A;  4BCO B;  2WXV B;  4BCQ B;  1W98 B;  1UNG D;  4CRL B;  4EOK B;  5HBE B;  2QDJ A;  2WPA B;  4FX3 B;  5FGK B;  1N4M A;  3BHU B;  4CFU D;  4CFX B;  2PHG A;  1VYW B;  1FVV B;  1OIY B;  4F6W B;  3TNH B;  1OKW B;  4CFN B;  3QHW B;  5CYI B;  1JST B;  1H1P B;  3BHT B;  2WEV B;  4II5 B;  4F7L B;  1OIU B;  5HQ0 B;  4CFV B;  4EOR B;  5LQF B;  2W9Z A;  1P5E B;  4F70 B;  2IVX A;  4BCH B;  4BCI B;  1UNL D;  4EC8 B;  3BLH B;  1OKV B;  4IMY B;  3EID B;  1OGU B;  4EOO B;  4ELJ A;  3BLQ B;  3BHV B;  3MY5 B;  2W96 A;  4BCP B;  4EOJ B;  1GH6 B;  2EUF A;  3H4C A;  4CXA B;  3RGF B;  5I5Z B;  1H1R B;  1C9B A;  1QMZ B;  1OI9 B;  5IF1 B;  2I53 A;  2X1N B;  4EOQ B;  1H24 B;  2C5O B;  2CCI B;  2G9X B;  5HBH B;  4F6S B;  2WIP B;  3O0G D;  1H28 B;  4EOM B;  2C4G B;  4EOP B;  2PMI B;  1AD6 A;  4KRD B;  2PK9 B;  2UUE B;  3EJ1 B;  3MI9 B;  4EON B;  4EC9 B;  1O9K B;  4I3Z B;  4YOZ A;  1H27 B;  4F7J B;  1O9K A;  1JOW A;  4OR5 B;  4KRC B;  5HNB B;  4BCM D;  1VOL A;  3DDP B;  4CFU B;  2C5N B;  1G3N C;  1TFB A;  4NST B;  2PK2 A;  1PKD B;  1ZP2 A;  4BCG B;  5IDP B;  5LMK B;  2UZL B;  5CEI B;  4BCQ D;  4BCJ B;  1VIN A;  2BKZ B;  4TTH A;  4EOS B;  1GUX B;  2W99 A;  4OGR B;  5EFQ B;  5HVY B;  4UN0 A;  1OL1 B;  1GUX A;  2UZD B;  4BCF B;  3G33 B;  3QHR B;  1AIS B;  2UZE B;  3M03 A;  5ACB A;  1H26 B;  5L2W B;  3K7A M;  2CCH B;  2C5V B;  1H4L D; 
#chains in the Genus database with same CATH topology
 4YOO A;  2C6T B;  4ZGD B;  3A8L B;  2KMG A;  4NC6 A;  3MY1 B;  3VYG B;  1FIN B;  5EJC A;  3VKH A;  1XO2 A;  2WJ9 A;  2JGZ B;  2LW4 A;  3EOC B;  1E9H B;  4YC3 B;  5ICP B;  2ZPB B;  2IW9 B;  4BCQ B;  4EOK B;  4OB3 B;  4CFU D;  2PHG A;  4ZGJ B;  2WEV B;  4II5 B;  4Z6Y A;  4EOR B;  2DD5 B;  4HLQ A;  4IMY B;  4EOO B;  3EID B;  3BG3 A;  3BHV B;  2W96 A;  3BG5 A;  3PO3 S;  5I5Z B;  4LOC A;  1OI9 B;  3TW7 A;  2ZPI B;  1H24 B;  2G9X B;  1ENW A;  4AKI A;  2WIP B;  3O0G D;  1H28 B;  4KRD B;  3X28 B;  4I3Z B;  1H27 B;  1O9K A;  3DJB A;  2C5N B;  3A8O B;  1G3N C;  1TFB A;  1TD6 A;  2ZPF B;  1VIN A;  4TTH A;  1GUX B;  5HVY B;  3X26 B;  4UN0 A;  3TW6 A;  3NDQ A;  3G33 B;  5L2W B;  3KHI A;  1JKW A;  2QDY B;  3DL1 A;  4YOS A;  4BCN D;  1H25 B;  4HL4 A;  2WMB B;  4BY1 X;  4CFW B;  1F5Q B;  2WHB B;  2BPM B;  3POM A;  5HBJ B;  3MIA B;  2UZB B;  4BCM B;  4BCN B;  1GY3 B;  1KXU A;  2AHJ B;  4ROE A;  4EOI B;  4F7S B;  2PJQ A;  5IDN B;  2WFY B;  4ROC A;  4CRL B;  2WXV B;  2CZ0 B;  5HBE B;  4FX3 B;  1N4M A;  3HB9 A;  2ZPG B;  3GTM S;  1OIY B;  3TNH B;  4CFN B;  2QGS A;  1H1P B;  5HQ0 B;  5LQF B;  2G77 A;  1UGP B;  1UNL D;  4EC8 B;  4ELJ A;  3MY5 B;  4QSH A;  1AHJ B;  1GH6 B;  3RGF B;  1QMZ B;  2I53 A;  4ZGE B;  2C5O B;  4EOM B;  2C4G B;  2DME A;  1AD6 A;  3MI9 B;  1QLB A;  3QZ5 B;  2ZZD B;  3HZJ A;  4YOZ A;  4OR5 B;  3DDP B;  4CFU B;  2CYZ B;  4NST B;  2QFZ A;  2PK2 A;  3QYH B;  1ZP2 A;  3QXE B;  4BBR M;  4OB2 B;  5LMK B;  2UZL B;  5CEI B;  4OGR B;  4OB1 B;  2BS2 A;  1GUX A;  2UZD B;  1AIS B;  3M03 A;  2QF7 A;  2KR6 A;  3BLR B;  4HNU A;  1URC B;  3WVD B;  4Y72 B;  3HO8 A;  1UNH D;  4MFE A;  2CZ7 B;  3LQ5 B;  4BCK B;  2R7G A;  2B9R A;  3DDQ B;  5BNJ B;  1IRE B;  3DOG B;  2WIH B;  3QZ9 B;  4G6L B;  4F6U B;  1D3U B;  1W98 B;  1UNG D;  2WPA B;  5FGK B;  4JX5 A;  1UGS B;  5IHY A;  4OB0 B;  1VYW B;  2DXB B;  2BS3 A;  3QHW B;  5CYI B;  1JST B;  3BHT B;  1OIU B;  2W9Z A;  1P5E B;  2IVX A;  2D0Q B;  4BCH B;  4AKG A;  3A8G B;  3BLH B;  4M6V A;  1OKV B;  3BLQ B;  3HHT B;  4BCP B;  4EOJ B;  3QWL A;  1C9B A;  2CZ6 B;  1V29 B;  2X1N B;  4EOQ B;  5HBH B;  4F6S B;  4FM4 B;  1UGQ B;  2PMI B;  4BBS M;  2PK9 B;  5HNB B;  1VOL A;  4AKH A;  3VKG A;  4BCG B;  1PKD B;  5IDP B;  4BCQ D;  3A8M B;  4MFD A;  2BKZ B;  1FKM A;  1OL1 B;  4HNV A;  3QHR B;  2DD4 B;  5ACB A;  3K7A M;  3TNW B;  2C5V B;  1H4L D;  1UGR B;  2CJM B;  2V22 B;  2WMA B;  3F5X B;  2IW8 B;  3DTO A;  4CFM B;  1BU2 A;  2W2H A;  4JX6 A;  3A8H B;  3TNI B;  1H1S B;  1OL2 B;  3QYB A;  4ROD A;  4HNT A;  3WVE B;  2I40 B;  3HBL A;  4ELL A;  3TN8 B;  4EOL B;  2C5X B;  2IW6 B;  2W9F A;  1JSU B;  4MIM A;  1H1Q B;  2CZ1 B;  4F7N B;  2F2C A;  4BCO B;  2QDJ A;  4BY7 X;  3QYE A;  3BHU B;  4CFX B;  1FVV B;  4F6W B;  1OKW B;  2DPP B;  4F7L B;  4CFV B;  4BXX X;  3BG9 A;  4F70 B;  2ZPH B;  4BCI B;  3QYG B;  3X20 B;  1OGU B;  2QQ8 A;  2DXC B;  2EUF A;  1E7P A;  3H4C A;  4CXA B;  2ZPE B;  1H1R B;  5IF1 B;  2CCI B;  2IN3 A;  5DQW A;  4EOP B;  2UUE B;  3EJ1 B;  4EON B;  3X25 B;  4EC9 B;  1O9K B;  2ZCF B;  4F7J B;  1JOW A;  4KRC B;  4BCM D;  3B57 A;  3X24 B;  3VYH B;  4BCJ B;  4EOS B;  2W99 A;  2BS4 A;  5EFQ B;  4BCF B;  4JX4 A;  5DQV A;  2UZE B;  4AI6 A;  1H26 B;  2CCH B; 
#chains in the Genus database with same CATH homology
 1JKW A;  2CJM B;  4YOO A;  2C6T B;  2V22 B;  3BLR B;  2WMA B;  3F5X B;  2IW8 B;  3MY1 B;  4YOS A;  4BCN D;  1H25 B;  4CFM B;  1BU2 A;  1URC B;  2W2H A;  1FIN B;  3TNI B;  1H1S B;  4Y72 B;  1OL2 B;  2WMB B;  1XO2 A;  1UNH D;  2JGZ B;  4ROD A;  3TNW B;  4CFW B;  1F5Q B;  2I40 B;  3EOC B;  4ELL A;  2WHB B;  2BPM B;  3POM A;  5HBJ B;  3LQ5 B;  3TN8 B;  3MIA B;  2UZB B;  4BCK B;  2R7G A;  4EOL B;  2C5X B;  4BCM B;  1E9H B;  4BCN B;  2B9R A;  1GY3 B;  3DDQ B;  1KXU A;  2IW6 B;  4YC3 B;  2W9F A;  5BNJ B;  1JSU B;  4ROE A;  3DOG B;  1H1Q B;  2WIH B;  4G6L B;  4EOI B;  4F7S B;  4F6U B;  5ICP B;  4F7N B;  1D3U B;  5IDN B;  2WFY B;  2IW9 B;  2F2C A;  4ROC A;  4BCO B;  2WXV B;  4BCQ B;  1W98 B;  1UNG D;  4CRL B;  4EOK B;  5HBE B;  2QDJ A;  2WPA B;  4FX3 B;  5FGK B;  1N4M A;  3BHU B;  4CFU D;  4CFX B;  2PHG A;  1VYW B;  1FVV B;  1OIY B;  4F6W B;  3TNH B;  1OKW B;  4CFN B;  3QHW B;  5CYI B;  1JST B;  1H1P B;  3BHT B;  2WEV B;  4II5 B;  4F7L B;  1OIU B;  5HQ0 B;  4CFV B;  4EOR B;  5LQF B;  2W9Z A;  1P5E B;  4F70 B;  2IVX A;  4BCH B;  4BCI B;  1UNL D;  4EC8 B;  3BLH B;  1OKV B;  4IMY B;  3EID B;  1OGU B;  4EOO B;  4ELJ A;  3BLQ B;  3BHV B;  3MY5 B;  2W96 A;  4BCP B;  4EOJ B;  1GH6 B;  2EUF A;  3H4C A;  4CXA B;  3RGF B;  5I5Z B;  1H1R B;  1C9B A;  1QMZ B;  1OI9 B;  5IF1 B;  2I53 A;  2X1N B;  4EOQ B;  1H24 B;  2C5O B;  2CCI B;  2G9X B;  5HBH B;  4F6S B;  2WIP B;  3O0G D;  1H28 B;  4EOM B;  2C4G B;  4EOP B;  2PMI B;  1AD6 A;  4KRD B;  2PK9 B;  2UUE B;  3EJ1 B;  3MI9 B;  4EON B;  4EC9 B;  1O9K B;  4I3Z B;  4YOZ A;  1H27 B;  4F7J B;  1O9K A;  1JOW A;  4OR5 B;  4KRC B;  5HNB B;  4BCM D;  1VOL A;  3DDP B;  4CFU B;  2C5N B;  1G3N C;  1TFB A;  4NST B;  2PK2 A;  1PKD B;  1ZP2 A;  4BCG B;  5IDP B;  5LMK B;  2UZL B;  5CEI B;  4BCQ D;  4BCJ B;  1VIN A;  2BKZ B;  4TTH A;  4EOS B;  1GUX B;  2W99 A;  4OGR B;  5EFQ B;  5HVY B;  4UN0 A;  1OL1 B;  1GUX A;  2UZD B;  4BCF B;  3G33 B;  3QHR B;  1AIS B;  2UZE B;  3M03 A;  5ACB A;  1H26 B;  5L2W B;  3K7A M;  2CCH B;  2C5V B;  1H4L D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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