5IEIA

X-ray crystallographic structure of a high affinity igf2 antagonist (domain11 ab5 rhh) based on human igf2r domain 11
Total Genus 36
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
137
structure length
132
Chain Sequence
NEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYAKGWGVYMSICGENENCPPGVGACFGRTRISVGKANKRLRYVDQVLQLVYKDGSHCPSKHGLSYKSVISFVCRPNRPMLISLDKQTCTLFFSWHTPLACE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transport protein
molecule keywords Cation-independent mannose-6-phosphate receptor
publication title Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
pubmed doi rcsb
source organism Homo sapiens
total genus 36
structure length 132
sequence length 137
ec nomenclature
pdb deposition date 2016-02-25
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 5ieiA00
1KEOA 3K42A 1SYOA 2RL7A 2V5OA 5IEIA 1C39A 2RLBA 1GP3A 2V5NA 2KVAA 1GQBA 1E6FA 2M68A 2L29A 2N1HA 2KVBA 1SZ0A 3K41A 2L21A 2LVXA 2L2AA 2LLAA 2CNJD 3AIHA 2M6TA 1M6PA 1GP0A 3K43A 3CY4A 2RL9A 1Q25A 2RL8A 2L2GA 4XQMA
chains in the Genus database with same CATH superfamily
1KEOA 3K42A 1SYOA 2RL7A 2V5OA 5IEIA 1C39A 2RLBA 1GP3A 2V5NA 2KVAA 1GQBA 1E6FA 2M68A 2L29A 2N1HA 2KVBA 1SZ0A 3K41A 2L21A 2LVXA 2L2AA 2LLAA 2CNJD 3AIHA 2M6TA 1M6PA 1GP0A 3K43A 3CY4A 2RL9A 1Q25A 2RL8A 2L2GA 4XQMA
chains in the Genus database with same CATH topology
1KEOA 3K42A 1SYOA 2RL7A 2V5OA 5IEIA 1C39A 2RLBA 1GP3A 2V5NA 2KVAA 1GQBA 1E6FA 2M68A 2L29A 2N1HA 2KVBA 1SZ0A 3K41A 2L21A 2LVXA 2L2AA 2LLAA 2CNJD 3AIHA 2M6TA 1M6PA 1GP0A 3K43A 3CY4A 2RL9A 1Q25A 2RL8A 2L2GA 4XQMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KEO A;  3K42 A;  1SYO A;  2RL7 A;  2V5O A;  5IEI A;  1C39 A;  2RLB A;  1GP3 A;  2V5N A;  2KVA A;  1GQB A;  1E6F A;  2M68 A;  2L29 A;  2N1H A;  2KVB A;  1SZ0 A;  3K41 A;  2L21 A;  2LVX A;  2L2A A;  2LLA A;  2CNJ D;  3AIH A;  2M6T A;  1M6P A;  1GP0 A;  3K43 A;  3CY4 A;  2RL9 A;  1Q25 A;  2RL8 A;  2L2G A;  4XQM A; 
#chains in the Genus database with same CATH topology
 1KEO A;  3K42 A;  1SYO A;  2RL7 A;  2V5O A;  5IEI A;  1C39 A;  2RLB A;  1GP3 A;  2V5N A;  2KVA A;  1GQB A;  1E6F A;  2M68 A;  2L29 A;  2N1H A;  2KVB A;  1SZ0 A;  3K41 A;  2L21 A;  2LVX A;  2L2A A;  2LLA A;  2CNJ D;  3AIH A;  2M6T A;  1M6P A;  1GP0 A;  3K43 A;  3CY4 A;  2RL9 A;  1Q25 A;  2RL8 A;  2L2G A;  4XQM A; 
#chains in the Genus database with same CATH homology
 1KEO A;  3K42 A;  1SYO A;  2RL7 A;  2V5O A;  5IEI A;  1C39 A;  2RLB A;  1GP3 A;  2V5N A;  2KVA A;  1GQB A;  1E6F A;  2M68 A;  2L29 A;  2N1H A;  2KVB A;  1SZ0 A;  3K41 A;  2L21 A;  2LVX A;  2L2A A;  2LLA A;  2CNJ D;  3AIH A;  2M6T A;  1M6P A;  1GP0 A;  3K43 A;  3CY4 A;  2RL9 A;  1Q25 A;  2RL8 A;  2L2G A;  4XQM A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...