5INOA

Human tdp2 reaction product (5'-phosphorylated dna)-mg2+ complex
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
254
structure length
253
Chain Sequence
QENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDII
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/dna
molecule keywords Tyrosyl-DNA phosphodiesterase 2
publication title Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
pubmed doi rcsb
source organism Homo sapiens
total genus 77
structure length 253
sequence length 254
chains with identical sequence B
ec nomenclature ec 3.1.4.-:
pdb deposition date 2016-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 5inoA00
3W3DB 5J42A 3I48A 1WDUA 3G91A 5DFIA 3MPRA 5INOA 3G0RA 1ZWXA 2ISIA 4K6LF 2D1KB 2O3HA 3L1WA 1BIXA 4GEWA 3G6SA 2UYRX 5HT2A 5INMA 5CFEA 5INQA 5INPA 2JC5A 4B5IA 1YJHA 2IMQX 4GZ2A 4C1RA 2VOAA 1E9NA 2O3CA 4CMLA 2J63A 4GZ0A 4F1IA 2F1NA 5J8NA 2DDSA 3FZIA 2V0RA 5A7IA 4QHDA 2A41B 3NGOA 5DFFA 4L1YA 4GZ1A 4B5MA 3G00A 5J3ZA 3G8VA 4F1HB 4AWNA 4CMNA 3NR8A 4F1RA 4PUQA 3W2YA 3NGQA 4L1ZA 2DDRA 2A42B 3I41A 2A3ZB 3MTCA 3G2CA 4B5JA 4FVAA 5INLA 5J3PA 1DE8A 5DFHA 2JC4A 1I9YA 3W2XA 4B5FA 4QH9A 5DV4A 1VYBA 3DNIA 1I9ZA 3GA6A 1SI6X 3G3YA 3G4TA 3I5VA 4L21A 4LNDA 4GYZA 4L20A 5INKA 1DEWA 3G0AA 5DV2A 3G2DA 3G3CA 1HD7A 3N9VA 2V0SA 3NGNA 3U8UA 2XSWA 3CJCD 4RUWA 5CFGA 1Y21A 4QHEA 1ATND 1NTFA 4IEMA 2DNJA 3I46A 4B5HA 5EWTA 3G1KA 1DNKA 1AKOA 4JG3A 4FPVA 4F1HA 3K55A 3WCXA 4A9CA 5A7JA 5DG0A 3G38A 3TEBA 1SR4B 4B5GA 1DE9A 2A40B 2F2FB 2DDTA 2EI9A 5DFJA 5INNA 5J3SA
chains in the Genus database with same CATH superfamily
3W3DB 5J42A 3I48A 1WDUA 3G91A 5DFIA 3MPRA 5INOA 3G0RA 1ZWXA 2ISIA 4K6LF 2D1KB 2O3HA 3L1WA 1BIXA 4GEWA 3G6SA 2UYRX 5HT2A 5INMA 5CFEA 5INQA 5INPA 2JC5A 4B5IA 1YJHA 2IMQX 4GZ2A 4C1RA 2VOAA 1E9NA 2O3CA 4CMLA 2J63A 4GZ0A 4F1IA 2F1NA 5J8NA 2DDSA 3FZIA 2V0RA 5A7IA 4QHDA 2A41B 3NGOA 5DFFA 4L1YA 4GZ1A 4B5MA 3G00A 5J3ZA 3G8VA 4F1HB 4AWNA 4CMNA 3NR8A 4F1RA 4PUQA 3W2YA 3NGQA 4L1ZA 2DDRA 2A42B 3I41A 2A3ZB 3MTCA 3G2CA 4B5JA 4FVAA 5INLA 5J3PA 1DE8A 5DFHA 2JC4A 1I9YA 3W2XA 4B5FA 4QH9A 5DV4A 1VYBA 3DNIA 1I9ZA 3GA6A 1SI6X 3G3YA 3G4TA 3I5VA 4L21A 4LNDA 4GYZA 4L20A 5INKA 1DEWA 3G0AA 5DV2A 3G2DA 3G3CA 1HD7A 3N9VA 2V0SA 3NGNA 3U8UA 2XSWA 3CJCD 4RUWA 5CFGA 1Y21A 4QHEA 1ATND 1NTFA 4IEMA 2DNJA 3I46A 4B5HA 5EWTA 3G1KA 1DNKA 1AKOA 4JG3A 4FPVA 4F1HA 3K55A 3WCXA 4A9CA 5A7JA 5DG0A 3G38A 3TEBA 1SR4B 4B5GA 1DE9A 2A40B 2F2FB 2DDTA 2EI9A 5DFJA 5INNA 5J3SA
chains in the Genus database with same CATH topology
3W3DB 5J42A 3I48A 1WDUA 3G91A 5DFIA 3MPRA 5INOA 3G0RA 1ZWXA 2ISIA 4K6LF 2D1KB 2O3HA 3L1WA 1BIXA 4GEWA 3G6SA 2UYRX 5HT2A 5INMA 5CFEA 5INQA 5INPA 2JC5A 4B5IA 1YJHA 2IMQX 4GZ2A 4C1RA 2VOAA 1E9NA 2O3CA 4CMLA 2J63A 4GZ0A 4F1IA 2F1NA 5J8NA 2DDSA 3FZIA 2V0RA 5A7IA 4QHDA 2A41B 3NGOA 5DFFA 4L1YA 4GZ1A 4B5MA 3G00A 5J3ZA 3G8VA 4F1HB 4AWNA 4CMNA 3NR8A 4F1RA 4PUQA 3W2YA 3NGQA 4L1ZA 2DDRA 2A42B 3I41A 2A3ZB 3MTCA 3G2CA 4B5JA 4FVAA 5INLA 5J3PA 1DE8A 5DFHA 2JC4A 1I9YA 3W2XA 4B5FA 4QH9A 5DV4A 1VYBA 3DNIA 1I9ZA 3GA6A 1SI6X 3G3YA 3G4TA 3I5VA 4L21A 4LNDA 4GYZA 4L20A 5INKA 1DEWA 3G0AA 5DV2A 3G2DA 3G3CA 1HD7A 3N9VA 2V0SA 3NGNA 3U8UA 2XSWA 3CJCD 4RUWA 5CFGA 1Y21A 4QHEA 1ATND 1NTFA 4IEMA 2DNJA 3I46A 4B5HA 5EWTA 3G1KA 1DNKA 1AKOA 4JG3A 4FPVA 4F1HA 3K55A 3WCXA 4A9CA 5A7JA 5DG0A 3G38A 3TEBA 1SR4B 4B5GA 1DE9A 2A40B 2F2FB 2DDTA 2EI9A 5DFJA 5INNA 5J3SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3W3D B;  5J42 A;  3I48 A;  1WDU A;  3G91 A;  5DFI A;  3MPR A;  5INO A;  3G0R A;  1ZWX A;  2ISI A;  4K6L F;  2D1K B;  2O3H A;  3L1W A;  1BIX A;  4GEW A;  3G6S A;  2UYR X;  5HT2 A;  5INM A;  5CFE A;  5INQ A;  5INP A;  2JC5 A;  4B5I A;  1YJH A;  2IMQ X;  4GZ2 A;  4C1R A;  2VOA A;  1E9N A;  2O3C A;  4CML A;  2J63 A;  4GZ0 A;  4F1I A;  2F1N A;  5J8N A;  2DDS A;  3FZI A;  2V0R A;  5A7I A;  4QHD A;  2A41 B;  3NGO A;  5DFF A;  4L1Y A;  4GZ1 A;  4B5M A;  3G00 A;  5J3Z A;  3G8V A;  4F1H B;  4AWN A;  4CMN A;  3NR8 A;  4F1R A;  4PUQ A;  3W2Y A;  3NGQ A;  4L1Z A;  2DDR A;  2A42 B;  3I41 A;  2A3Z B;  3MTC A;  3G2C A;  4B5J A;  4FVA A;  5INL A;  5J3P A;  1DE8 A;  5DFH A;  2JC4 A;  1I9Y A;  3W2X A;  4B5F A;  4QH9 A;  5DV4 A;  1VYB A;  3DNI A;  1I9Z A;  3GA6 A;  1SI6 X;  3G3Y A;  3G4T A;  3I5V A;  4L21 A;  4LND A;  4GYZ A;  4L20 A;  5INK A;  1DEW A;  3G0A A;  5DV2 A;  3G2D A;  3G3C A;  1HD7 A;  3N9V A;  2V0S A;  3NGN A;  3U8U A;  2XSW A;  3CJC D;  4RUW A;  5CFG A;  1Y21 A;  4QHE A;  1ATN D;  1NTF A;  4IEM A;  2DNJ A;  3I46 A;  4B5H A;  5EWT A;  3G1K A;  1DNK A;  1AKO A;  4JG3 A;  4FPV A;  4F1H A;  3K55 A;  3WCX A;  4A9C A;  5A7J A;  5DG0 A;  3G38 A;  3TEB A;  1SR4 B;  4B5G A;  1DE9 A;  2A40 B;  2F2F B;  2DDT A;  2EI9 A;  5DFJ A;  5INN A;  5J3S A; 
#chains in the Genus database with same CATH topology
 3W3D B;  5J42 A;  3I48 A;  1WDU A;  3G91 A;  5DFI A;  3MPR A;  5INO A;  3G0R A;  1ZWX A;  2ISI A;  4K6L F;  2D1K B;  2O3H A;  3L1W A;  1BIX A;  4GEW A;  3G6S A;  2UYR X;  5HT2 A;  5INM A;  5CFE A;  5INQ A;  5INP A;  2JC5 A;  4B5I A;  1YJH A;  2IMQ X;  4GZ2 A;  4C1R A;  2VOA A;  1E9N A;  2O3C A;  4CML A;  2J63 A;  4GZ0 A;  4F1I A;  2F1N A;  5J8N A;  2DDS A;  3FZI A;  2V0R A;  5A7I A;  4QHD A;  2A41 B;  3NGO A;  5DFF A;  4L1Y A;  4GZ1 A;  4B5M A;  3G00 A;  5J3Z A;  3G8V A;  4F1H B;  4AWN A;  4CMN A;  3NR8 A;  4F1R A;  4PUQ A;  3W2Y A;  3NGQ A;  4L1Z A;  2DDR A;  2A42 B;  3I41 A;  2A3Z B;  3MTC A;  3G2C A;  4B5J A;  4FVA A;  5INL A;  5J3P A;  1DE8 A;  5DFH A;  2JC4 A;  1I9Y A;  3W2X A;  4B5F A;  4QH9 A;  5DV4 A;  1VYB A;  3DNI A;  1I9Z A;  3GA6 A;  1SI6 X;  3G3Y A;  3G4T A;  3I5V A;  4L21 A;  4LND A;  4GYZ A;  4L20 A;  5INK A;  1DEW A;  3G0A A;  5DV2 A;  3G2D A;  3G3C A;  1HD7 A;  3N9V A;  2V0S A;  3NGN A;  3U8U A;  2XSW A;  3CJC D;  4RUW A;  5CFG A;  1Y21 A;  4QHE A;  1ATN D;  1NTF A;  4IEM A;  2DNJ A;  3I46 A;  4B5H A;  5EWT A;  3G1K A;  1DNK A;  1AKO A;  4JG3 A;  4FPV A;  4F1H A;  3K55 A;  3WCX A;  4A9C A;  5A7J A;  5DG0 A;  3G38 A;  3TEB A;  1SR4 B;  4B5G A;  1DE9 A;  2A40 B;  2F2F B;  2DDT A;  2EI9 A;  5DFJ A;  5INN A;  5J3S A; 
#chains in the Genus database with same CATH homology
 3W3D B;  5J42 A;  3I48 A;  1WDU A;  3G91 A;  5DFI A;  3MPR A;  5INO A;  3G0R A;  1ZWX A;  2ISI A;  4K6L F;  2D1K B;  2O3H A;  3L1W A;  1BIX A;  4GEW A;  3G6S A;  2UYR X;  5HT2 A;  5INM A;  5CFE A;  5INQ A;  5INP A;  2JC5 A;  4B5I A;  1YJH A;  2IMQ X;  4GZ2 A;  4C1R A;  2VOA A;  1E9N A;  2O3C A;  4CML A;  2J63 A;  4GZ0 A;  4F1I A;  2F1N A;  5J8N A;  2DDS A;  3FZI A;  2V0R A;  5A7I A;  4QHD A;  2A41 B;  3NGO A;  5DFF A;  4L1Y A;  4GZ1 A;  4B5M A;  3G00 A;  5J3Z A;  3G8V A;  4F1H B;  4AWN A;  4CMN A;  3NR8 A;  4F1R A;  4PUQ A;  3W2Y A;  3NGQ A;  4L1Z A;  2DDR A;  2A42 B;  3I41 A;  2A3Z B;  3MTC A;  3G2C A;  4B5J A;  4FVA A;  5INL A;  5J3P A;  1DE8 A;  5DFH A;  2JC4 A;  1I9Y A;  3W2X A;  4B5F A;  4QH9 A;  5DV4 A;  1VYB A;  3DNI A;  1I9Z A;  3GA6 A;  1SI6 X;  3G3Y A;  3G4T A;  3I5V A;  4L21 A;  4LND A;  4GYZ A;  4L20 A;  5INK A;  1DEW A;  3G0A A;  5DV2 A;  3G2D A;  3G3C A;  1HD7 A;  3N9V A;  2V0S A;  3NGN A;  3U8U A;  2XSW A;  3CJC D;  4RUW A;  5CFG A;  1Y21 A;  4QHE A;  1ATN D;  1NTF A;  4IEM A;  2DNJ A;  3I46 A;  4B5H A;  5EWT A;  3G1K A;  1DNK A;  1AKO A;  4JG3 A;  4FPV A;  4F1H A;  3K55 A;  3WCX A;  4A9C A;  5A7J A;  5DG0 A;  3G38 A;  3TEB A;  1SR4 B;  4B5G A;  1DE9 A;  2A40 B;  2F2F B;  2DDT A;  2EI9 A;  5DFJ A;  5INN A;  5J3S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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