5IWGA

Hdac2 with ligand brd4884
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
368
structure length
368
Chain Sequence
GKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Histone deacetylase 2
publication title Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 145
structure length 368
sequence length 368
chains with identical sequence B, C
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-03-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5iwgA00
2V5XA 1ZZ0A 4BZ9A 5G11A 2V5WA 3Q9CA 5D1DA 5DC6A 4QA3A 4RN1A 3EZTA 4RN2A 5EFHA 5D1BA 4BZ7A 3EWFA 4CBTA 4QA1A 1T67A 5G13A 5EFJD 3SFFA 5DC7A 1C3PA 3F06A 3MZ6A 5EFGA 5G0HA 3MZ4A 4ZUQA 5IWGA 4ZUPA 3MZ3A 5THUA 5THVA 5EFBD 4ZUNA 5FUEA 5THSA 4CQFA 5EEKA 4BZ5A 3Q9EA 1ZZ3A 5JI5A 5G1BA 3ZNRA 5EF7A 4CBYA 5DC5A 2VCGA 3F07A 3RQDA 4QA4A 3C0YA 5G12A 4LXZA 1ZZ1A 5EFNA 5EEFA 3ZNSA 3MZ7A 4QA5A 1C3SA 2GH6A 5ICNB 2VQVA 2VQQA 4BKXB 4BZ6A 5IX0A 5G1AA 2VQWG 5G0JA 4LY1A 5G0IA 5EENA 5G0GA 2VQMA 3MAXA 5EF8A 1T64A 1VKGA 5LI3A 3Q9BA 5G0YA 5THTA 4QA2A 5A2SA 3Q9FA 2VQOA 3F0RA 4QA0A 3MENA 4ZUOA 4A69A 5G10A 4QA6A 5G0XA 3C10A 5D1CA 5DC8A 4QA7A 5G17A 5G1CA 5BWZA 3C0ZA 4ZURA 1W22A 5EEIA 5EFKB 1T69A 4BZ8A 1C3RA 5G3WA 3EZPA 4RN0A 2VQJA 4ZUMA 3EW8A 5FCWA 5EEMA 3SFHA
chains in the Genus database with same CATH superfamily
4RHQA 3CEVA 4Q3SA 4IE3A 2V5XA 3LP4A 4IU5A 1ZZ0A 1T4SA 4BZ9A 5G11A 2V5WA 3Q9CA 4HZEA 5D1DA 2PHAA 4Q3VA 5DC6A 1TBLA 4QA3A 3E6VA 1D3VA 3EZTA 1T4PA 4RN1A 4RN2A 5EFHA 5D1BA 4BZ7A 3E8QA 3EWFA 3NIPA 4CBTA 1P8RA 1T5FA 1T67A 1WOIA 3E8ZA 3MFVA 1CEVA 4IXUA 4Q40A 4QA1A 5EFJD 1T4TA 3SFFA 2CEVA 1HQXA 4FCKA 1HQ5A 3THHA 5DC7A 1C3PA 1P8SA 3F06A 4I06A 3MZ6A 1HQHA 5EFGA 5G0HA 2AEBA 4G3HA 3THEA 3MZ4A 3PZLA 3DJ8A 4RHMA 4ZUQA 5IWGA 4FCIA 3MZ3A 4ZUPA 5THUA 4DZ4A 5THVA 1R1OA 1HQFA 3GN0A 3TF3A 5EFBD 4ZUNA 5FUEA 5THSA 4CEVA 4CQFA 3KV2A 5RLAA 5EEKA 1ZPEA 1P8OA 3F80A 4HWWA 4BZ5A 1TA1A 1T4RA 3Q9EA 1TBJA 1ZZ3A 4IE1A 5JI5A 2PLLA 4MYKA 5G1BA 2EF4A 3ZNRA 3SKKA 4Q3PA 5EF7A 4GSVA 3MMRA 4Q3UA 1WOHA 4CBYA 5CEVA 5DC5A 4GWDA 2VCGA 3F07A 3RQDA 4QA4A 3SL1A 3C0YA 5G12A 4LXZA 3LHLA 1PQ3A 1P8NA 1ZZ1A 5EFNA 5EEFA 3ZNSA 1P8MA 3MZ7A 4QA5A 1C3SA 5HJAA 2GH6A 5ICNB 2VQVA 2VQQA 3E6KA 4RHJA 4BKXB 4BZ6A 5IX0A 5G1AA 4Q42A 1T5GA 2VQWG 5G0JA 4LY1A 5G0IA 5EENA 1RLAA 4IXVA 3M1RA 5G0GA 4MYNA 4Q3QA 2VQMA 3MAXA 3NIQA 4RHLA 5EF8A 1T64A 1VKGA 5LI3A 3Q9BA 3SL0A 4IU0A 5G0YA 4Q3TA 5THTA 4QA2A 5A2SA 2ZAVA 3Q9FA 2VQOA 4RHKA 2EF5A 4GSMA 1WOGA 3F0RA 4QA0A 3MENA 3TH7A 1ZPGA 4ZUOA 2A0MA 4A69A 4RLAA 1P8PA 1P8QA 5G10A 1GQ7A 4GWCA 4RHIA 4QA6A 5G0XA 4Q41A 3C10A 5D1CA 4MYFA 5DC8A 5HJ9A 3LP7A 4IU1A 4QA7A 1WVAA 5G17A 4MXRA 5G1CA 5BWZA 3C0ZA 4Q3RC 1W22A 1TBHA 3GMZA 3MFWA 5EEIA 4ZURA 5EFKB 1GQ6A 1T69A 3SJTA 4BZ8A 1C3RA 5G3WA 4IE2A 2EIVA 4MYLA 3EZPA 4RN0A 1HQGA 4GSZA 3RLAA 4IU4A 2PHOA 2RLAA 3THJA 4ITYA 3MJLA 2VQJA 3NIOA 4ZUMA 5G13A 1XFKA 3EW8A 1WVBA 4HXQA 5FCWA 4Q3RA 5EEMA 3E9BA 3SFHA
chains in the Genus database with same CATH topology
2V5XA 1ZZ0A 4BZ9A 5G11A 2V5WA 3Q9CA 5D1DA 5DC6A 4QA3A 4RN1A 3EZTA 4RN2A 5EFHA 5D1BA 4BZ7A 3EWFA 4CBTA 4QA1A 1T67A 5G13A 5EFJD 3SFFA 5DC7A 1C3PA 3F06A 3MZ6A 5EFGA 5G0HA 3MZ4A 4ZUQA 5IWGA 4ZUPA 3MZ3A 5THUA 5THVA 5EFBD 4ZUNA 5FUEA 5THSA 4CQFA 5EEKA 4BZ5A 3Q9EA 1ZZ3A 5JI5A 5G1BA 3ZNRA 5EF7A 4CBYA 5DC5A 2VCGA 3F07A 3RQDA 4QA4A 3C0YA 5G12A 4LXZA 1ZZ1A 5EFNA 5EEFA 3ZNSA 3MZ7A 4QA5A 1C3SA 2GH6A 5ICNB 2VQVA 2VQQA 4BKXB 4BZ6A 5IX0A 5G1AA 2VQWG 5G0JA 4LY1A 5G0IA 5EENA 5G0GA 2VQMA 3MAXA 5EF8A 1T64A 1VKGA 5LI3A 3Q9BA 5G0YA 5THTA 4QA2A 5A2SA 3Q9FA 2VQOA 3F0RA 4QA0A 3MENA 4ZUOA 4A69A 5G10A 4QA6A 5G0XA 3C10A 5D1CA 5DC8A 4QA7A 5G17A 5G1CA 5BWZA 3C0ZA 4ZURA 1W22A 5EEIA 5EFKB 1T69A 4BZ8A 1C3RA 5G3WA 3EZPA 4RN0A 2VQJA 4ZUMA 3EW8A 5FCWA 5EEMA 3SFHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V5X A;  1ZZ0 A;  4BZ9 A;  5G11 A;  2V5W A;  3Q9C A;  5D1D A;  5DC6 A;  4QA3 A;  4RN1 A;  3EZT A;  4RN2 A;  5EFH A;  5D1B A;  4BZ7 A;  3EWF A;  4CBT A;  4QA1 A;  1T67 A;  5G13 A;  5EFJ D;  3SFF A;  5DC7 A;  1C3P A;  3F06 A;  3MZ6 A;  5EFG A;  5G0H A;  3MZ4 A;  4ZUQ A;  5IWG A;  4ZUP A;  3MZ3 A;  5THU A;  5THV A;  5EFB D;  4ZUN A;  5FUE A;  5THS A;  4CQF A;  5EEK A;  4BZ5 A;  3Q9E A;  1ZZ3 A;  5JI5 A;  5G1B A;  3ZNR A;  5EF7 A;  4CBY A;  5DC5 A;  2VCG A;  3F07 A;  3RQD A;  4QA4 A;  3C0Y A;  5G12 A;  4LXZ A;  1ZZ1 A;  5EFN A;  5EEF A;  3ZNS A;  3MZ7 A;  4QA5 A;  1C3S A;  2GH6 A;  5ICN B;  2VQV A;  2VQQ A;  4BKX B;  4BZ6 A;  5IX0 A;  5G1A A;  2VQW G;  5G0J A;  4LY1 A;  5G0I A;  5EEN A;  5G0G A;  2VQM A;  3MAX A;  5EF8 A;  1T64 A;  1VKG A;  5LI3 A;  3Q9B A;  5G0Y A;  5THT A;  4QA2 A;  5A2S A;  3Q9F A;  2VQO A;  3F0R A;  4QA0 A;  3MEN A;  4ZUO A;  4A69 A;  5G10 A;  4QA6 A;  5G0X A;  3C10 A;  5D1C A;  5DC8 A;  4QA7 A;  5G17 A;  5G1C A;  5BWZ A;  3C0Z A;  4ZUR A;  1W22 A;  5EEI A;  5EFK B;  1T69 A;  4BZ8 A;  1C3R A;  5G3W A;  3EZP A;  4RN0 A;  2VQJ A;  4ZUM A;  3EW8 A;  5FCW A;  5EEM A;  3SFH A; 
#chains in the Genus database with same CATH topology
 4RHQ A;  3CEV A;  4Q3S A;  4IE3 A;  2V5X A;  3LP4 A;  4IU5 A;  1ZZ0 A;  1T4S A;  4BZ9 A;  5G11 A;  2V5W A;  3Q9C A;  4HZE A;  5D1D A;  2PHA A;  4Q3V A;  5DC6 A;  1TBL A;  4QA3 A;  3E6V A;  1D3V A;  3EZT A;  1T4P A;  4RN1 A;  4RN2 A;  5EFH A;  5D1B A;  4BZ7 A;  3E8Q A;  3EWF A;  3NIP A;  4CBT A;  1P8R A;  1T5F A;  1T67 A;  1WOI A;  3E8Z A;  3MFV A;  1CEV A;  4IXU A;  4Q40 A;  4QA1 A;  5EFJ D;  1T4T A;  3SFF A;  2CEV A;  1HQX A;  4FCK A;  1HQ5 A;  3THH A;  5DC7 A;  1C3P A;  1P8S A;  3F06 A;  4I06 A;  3MZ6 A;  1HQH A;  5EFG A;  5G0H A;  2AEB A;  4G3H A;  3THE A;  3MZ4 A;  3PZL A;  3DJ8 A;  4RHM A;  4ZUQ A;  5IWG A;  4FCI A;  3MZ3 A;  4ZUP A;  5THU A;  4DZ4 A;  5THV A;  1R1O A;  1HQF A;  3GN0 A;  3TF3 A;  5EFB D;  4ZUN A;  5FUE A;  5THS A;  4CEV A;  4CQF A;  3KV2 A;  5RLA A;  5EEK A;  1ZPE A;  1P8O A;  3F80 A;  4HWW A;  4BZ5 A;  1TA1 A;  1T4R A;  3Q9E A;  1TBJ A;  1ZZ3 A;  4IE1 A;  5JI5 A;  2PLL A;  4MYK A;  5G1B A;  2EF4 A;  3ZNR A;  3SKK A;  4Q3P A;  5EF7 A;  4GSV A;  3MMR A;  4Q3U A;  1WOH A;  4CBY A;  5CEV A;  5DC5 A;  4GWD A;  2VCG A;  3F07 A;  3RQD A;  4QA4 A;  3SL1 A;  3C0Y A;  5G12 A;  4LXZ A;  3LHL A;  1PQ3 A;  1P8N A;  1ZZ1 A;  5EFN A;  5EEF A;  3ZNS A;  1P8M A;  3MZ7 A;  4QA5 A;  1C3S A;  5HJA A;  2GH6 A;  5ICN B;  2VQV A;  2VQQ A;  3E6K A;  4RHJ A;  4BKX B;  4BZ6 A;  5IX0 A;  5G1A A;  4Q42 A;  1T5G A;  2VQW G;  5G0J A;  4LY1 A;  5G0I A;  5EEN A;  1RLA A;  4IXV A;  3M1R A;  5G0G A;  4MYN A;  4Q3Q A;  2VQM A;  3MAX A;  3NIQ A;  4RHL A;  5EF8 A;  1T64 A;  1VKG A;  5LI3 A;  3Q9B A;  3SL0 A;  4IU0 A;  5G0Y A;  4Q3T A;  5THT A;  4QA2 A;  5A2S A;  2ZAV A;  3Q9F A;  2VQO A;  4RHK A;  2EF5 A;  4GSM A;  1WOG A;  3F0R A;  4QA0 A;  3MEN A;  3TH7 A;  1ZPG A;  4ZUO A;  2A0M A;  4A69 A;  4RLA A;  1P8P A;  1P8Q A;  5G10 A;  1GQ7 A;  4GWC A;  4RHI A;  4QA6 A;  5G0X A;  4Q41 A;  3C10 A;  5D1C A;  4MYF A;  5DC8 A;  5HJ9 A;  3LP7 A;  4IU1 A;  4QA7 A;  1WVA A;  5G17 A;  4MXR A;  5G1C A;  5BWZ A;  3C0Z A;  4Q3R C;  1W22 A;  1TBH A;  3GMZ A;  3MFW A;  5EEI A;  4ZUR A;  5EFK B;  1GQ6 A;  1T69 A;  3SJT A;  4BZ8 A;  1C3R A;  5G3W A;  4IE2 A;  2EIV A;  4MYL A;  3EZP A;  4RN0 A;  1HQG A;  4GSZ A;  3RLA A;  4IU4 A;  2PHO A;  2RLA A;  3THJ A;  4ITY A;  3MJL A;  2VQJ A;  3NIO A;  4ZUM A;  5G13 A;  1XFK A;  3EW8 A;  1WVB A;  4HXQ A;  5FCW A;  4Q3R A;  5EEM A;  3E9B A;  3SFH A; 
#chains in the Genus database with same CATH homology
 2V5X A;  1ZZ0 A;  4BZ9 A;  5G11 A;  2V5W A;  3Q9C A;  5D1D A;  5DC6 A;  4QA3 A;  4RN1 A;  3EZT A;  4RN2 A;  5EFH A;  5D1B A;  4BZ7 A;  3EWF A;  4CBT A;  4QA1 A;  1T67 A;  5G13 A;  5EFJ D;  3SFF A;  5DC7 A;  1C3P A;  3F06 A;  3MZ6 A;  5EFG A;  5G0H A;  3MZ4 A;  4ZUQ A;  5IWG A;  4ZUP A;  3MZ3 A;  5THU A;  5THV A;  5EFB D;  4ZUN A;  5FUE A;  5THS A;  4CQF A;  5EEK A;  4BZ5 A;  3Q9E A;  1ZZ3 A;  5JI5 A;  5G1B A;  3ZNR A;  5EF7 A;  4CBY A;  5DC5 A;  2VCG A;  3F07 A;  3RQD A;  4QA4 A;  3C0Y A;  5G12 A;  4LXZ A;  1ZZ1 A;  5EFN A;  5EEF A;  3ZNS A;  3MZ7 A;  4QA5 A;  1C3S A;  2GH6 A;  5ICN B;  2VQV A;  2VQQ A;  4BKX B;  4BZ6 A;  5IX0 A;  5G1A A;  2VQW G;  5G0J A;  4LY1 A;  5G0I A;  5EEN A;  5G0G A;  2VQM A;  3MAX A;  5EF8 A;  1T64 A;  1VKG A;  5LI3 A;  3Q9B A;  5G0Y A;  5THT A;  4QA2 A;  5A2S A;  3Q9F A;  2VQO A;  3F0R A;  4QA0 A;  3MEN A;  4ZUO A;  4A69 A;  5G10 A;  4QA6 A;  5G0X A;  3C10 A;  5D1C A;  5DC8 A;  4QA7 A;  5G17 A;  5G1C A;  5BWZ A;  3C0Z A;  4ZUR A;  1W22 A;  5EEI A;  5EFK B;  1T69 A;  4BZ8 A;  1C3R A;  5G3W A;  3EZP A;  4RN0 A;  2VQJ A;  4ZUM A;  3EW8 A;  5FCW A;  5EEM A;  3SFH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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