5J3ZA

Crystal structure of m2htdp2-cat in complex with a small molecule inhibitor
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
249
structure length
249
Chain Sequence
STISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTRGHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRDREVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAACKLRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Tyrosyl-DNA phosphodiesterase 2
publication title Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
pubmed doi rcsb
source organism Mus musculus
total genus 78
structure length 249
sequence length 249
chains with identical sequence B
ec nomenclature ec 3.1.4.-:
pdb deposition date 2016-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 5j3zA00
5DV2A 2A41B 4JG3A 4CMNA 4B5IA 3G3YA 2UYRX 1HD7A 3I5VA 2DDTA 3G2CA 4GZ2A 5DFIA 1Y21A 4FVAA 1I9YA 5INMA 1ZWXA 3U8UA 5CFGA 4L1YA 3MTCA 4QHEA 5J42A 1AKOA 3I48A 1DNKA 2V0RA 3G2DA 5EWTA 3G4TA 4B5GA 4B5MA 5INKA 4L1ZA 1WDUA 2DDRA 3G8VA 4F1IA 3N9VA 3G00A 3K55A 3W2YA 4QHDA 2XSWA 5INLA 2F1NA 4GEWA 4L20A 4GZ1A 3NR8A 2V0SA 5HT2A 2JC4A 3NGQA 1SI6X 5INNA 5INQA 4B5JA 1DE9A 3MPRA 4IEMA 3W3DB 5J3SA 3G6SA 4F1HB 4C1RA 5DFHA 5A7IA 4PUQA 3GA6A 3W2XA 3G38A 4GYZA 5DFFA 4CMLA 2J63A 2O3CA 2EI9A 4RUWA 2O3HA 1ATND 2D1KB 2A42B 3NGNA 3I41A 2JC5A 3G0RA 5INPA 3TEBA 4B5FA 1BIXA 5J3PA 1VYBA 1DE8A 1E9NA 5INOA 3FZIA 3G91A 1I9ZA 1YJHA 2F2FB 4F1RA 4FPVA 5CFEA 5DV4A 4K6LF 2ISIA 3L1WA 1NTFA 3CJCD 3I46A 2A40B 4L21A 5A7JA 3DNIA 2IMQX 4AWNA 2DDSA 5J3ZA 4A9CA 4QH9A 4F1HA 3G3CA 5J8NA 3WCXA 5DFJA 5DG0A 1SR4B 4B5HA 4GZ0A 3G0AA 2DNJA 3G1KA 2A3ZB 2VOAA 4LNDA 1DEWA 3NGOA
chains in the Genus database with same CATH superfamily
5DV2A 2A41B 4JG3A 4CMNA 4B5IA 3G3YA 2UYRX 1HD7A 3I5VA 2DDTA 3G2CA 4GZ2A 5DFIA 1Y21A 4FVAA 1I9YA 5INMA 1ZWXA 3U8UA 5CFGA 4L1YA 3MTCA 4QHEA 5J42A 1AKOA 3I48A 1DNKA 2V0RA 3G2DA 5EWTA 3G4TA 4B5GA 4B5MA 5INKA 4L1ZA 1WDUA 2DDRA 3G8VA 4F1IA 3N9VA 3G00A 3K55A 3W2YA 4QHDA 2XSWA 5INLA 2F1NA 4GEWA 4L20A 4GZ1A 3NR8A 2V0SA 5HT2A 2JC4A 3NGQA 1SI6X 5INNA 5INQA 4B5JA 1DE9A 3MPRA 4IEMA 3W3DB 5J3SA 3G6SA 4F1HB 4C1RA 5DFHA 5A7IA 4PUQA 3GA6A 3W2XA 3G38A 4GYZA 5DFFA 4CMLA 2J63A 2O3CA 2EI9A 4RUWA 2O3HA 1ATND 2D1KB 2A42B 3NGNA 3I41A 2JC5A 3G0RA 5INPA 3TEBA 4B5FA 1BIXA 5J3PA 1VYBA 1DE8A 1E9NA 5INOA 3FZIA 3G91A 1I9ZA 1YJHA 2F2FB 4F1RA 4FPVA 5CFEA 5DV4A 4K6LF 2ISIA 3L1WA 1NTFA 3CJCD 3I46A 2A40B 4L21A 5A7JA 3DNIA 2IMQX 4AWNA 2DDSA 5J3ZA 4A9CA 4QH9A 4F1HA 3G3CA 5J8NA 3WCXA 5DFJA 5DG0A 1SR4B 4B5HA 4GZ0A 3G0AA 2DNJA 3G1KA 2A3ZB 2VOAA 4LNDA 1DEWA 3NGOA
chains in the Genus database with same CATH topology
5DV2A 2A41B 4JG3A 4CMNA 4B5IA 3G3YA 2UYRX 1HD7A 3I5VA 2DDTA 3G2CA 4GZ2A 5DFIA 1Y21A 4FVAA 1I9YA 5INMA 1ZWXA 3U8UA 5CFGA 4L1YA 3MTCA 4QHEA 5J42A 1AKOA 3I48A 1DNKA 2V0RA 3G2DA 5EWTA 3G4TA 4B5GA 4B5MA 5INKA 4L1ZA 1WDUA 2DDRA 3G8VA 4F1IA 3N9VA 3G00A 3K55A 3W2YA 4QHDA 2XSWA 5INLA 2F1NA 4GEWA 4L20A 4GZ1A 3NR8A 2V0SA 5HT2A 2JC4A 3NGQA 1SI6X 5INNA 5INQA 4B5JA 1DE9A 3MPRA 4IEMA 3W3DB 5J3SA 3G6SA 4F1HB 4C1RA 5DFHA 5A7IA 4PUQA 3GA6A 3W2XA 3G38A 4GYZA 5DFFA 4CMLA 2J63A 2O3CA 2EI9A 4RUWA 2O3HA 1ATND 2D1KB 2A42B 3NGNA 3I41A 2JC5A 3G0RA 5INPA 3TEBA 4B5FA 1BIXA 5J3PA 1VYBA 1DE8A 1E9NA 5INOA 3FZIA 3G91A 1I9ZA 1YJHA 2F2FB 4F1RA 4FPVA 5CFEA 5DV4A 4K6LF 2ISIA 3L1WA 1NTFA 3CJCD 3I46A 2A40B 4L21A 5A7JA 3DNIA 2IMQX 4AWNA 2DDSA 5J3ZA 4A9CA 4QH9A 4F1HA 3G3CA 5J8NA 3WCXA 5DFJA 5DG0A 1SR4B 4B5HA 4GZ0A 3G0AA 2DNJA 3G1KA 2A3ZB 2VOAA 4LNDA 1DEWA 3NGOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DV2 A;  2A41 B;  4JG3 A;  4CMN A;  4B5I A;  3G3Y A;  2UYR X;  1HD7 A;  3I5V A;  2DDT A;  3G2C A;  4GZ2 A;  5DFI A;  1Y21 A;  4FVA A;  1I9Y A;  5INM A;  1ZWX A;  3U8U A;  5CFG A;  4L1Y A;  3MTC A;  4QHE A;  5J42 A;  1AKO A;  3I48 A;  1DNK A;  2V0R A;  3G2D A;  5EWT A;  3G4T A;  4B5G A;  4B5M A;  5INK A;  4L1Z A;  1WDU A;  2DDR A;  3G8V A;  4F1I A;  3N9V A;  3G00 A;  3K55 A;  3W2Y A;  4QHD A;  2XSW A;  5INL A;  2F1N A;  4GEW A;  4L20 A;  4GZ1 A;  3NR8 A;  2V0S A;  5HT2 A;  2JC4 A;  3NGQ A;  1SI6 X;  5INN A;  5INQ A;  4B5J A;  1DE9 A;  3MPR A;  4IEM A;  3W3D B;  5J3S A;  3G6S A;  4F1H B;  4C1R A;  5DFH A;  5A7I A;  4PUQ A;  3GA6 A;  3W2X A;  3G38 A;  4GYZ A;  5DFF A;  4CML A;  2J63 A;  2O3C A;  2EI9 A;  4RUW A;  2O3H A;  1ATN D;  2D1K B;  2A42 B;  3NGN A;  3I41 A;  2JC5 A;  3G0R A;  5INP A;  3TEB A;  4B5F A;  1BIX A;  5J3P A;  1VYB A;  1DE8 A;  1E9N A;  5INO A;  3FZI A;  3G91 A;  1I9Z A;  1YJH A;  2F2F B;  4F1R A;  4FPV A;  5CFE A;  5DV4 A;  4K6L F;  2ISI A;  3L1W A;  1NTF A;  3CJC D;  3I46 A;  2A40 B;  4L21 A;  5A7J A;  3DNI A;  2IMQ X;  4AWN A;  2DDS A;  5J3Z A;  4A9C A;  4QH9 A;  4F1H A;  3G3C A;  5J8N A;  3WCX A;  5DFJ A;  5DG0 A;  1SR4 B;  4B5H A;  4GZ0 A;  3G0A A;  2DNJ A;  3G1K A;  2A3Z B;  2VOA A;  4LND A;  1DEW A;  3NGO A; 
#chains in the Genus database with same CATH topology
 5DV2 A;  2A41 B;  4JG3 A;  4CMN A;  4B5I A;  3G3Y A;  2UYR X;  1HD7 A;  3I5V A;  2DDT A;  3G2C A;  4GZ2 A;  5DFI A;  1Y21 A;  4FVA A;  1I9Y A;  5INM A;  1ZWX A;  3U8U A;  5CFG A;  4L1Y A;  3MTC A;  4QHE A;  5J42 A;  1AKO A;  3I48 A;  1DNK A;  2V0R A;  3G2D A;  5EWT A;  3G4T A;  4B5G A;  4B5M A;  5INK A;  4L1Z A;  1WDU A;  2DDR A;  3G8V A;  4F1I A;  3N9V A;  3G00 A;  3K55 A;  3W2Y A;  4QHD A;  2XSW A;  5INL A;  2F1N A;  4GEW A;  4L20 A;  4GZ1 A;  3NR8 A;  2V0S A;  5HT2 A;  2JC4 A;  3NGQ A;  1SI6 X;  5INN A;  5INQ A;  4B5J A;  1DE9 A;  3MPR A;  4IEM A;  3W3D B;  5J3S A;  3G6S A;  4F1H B;  4C1R A;  5DFH A;  5A7I A;  4PUQ A;  3GA6 A;  3W2X A;  3G38 A;  4GYZ A;  5DFF A;  4CML A;  2J63 A;  2O3C A;  2EI9 A;  4RUW A;  2O3H A;  1ATN D;  2D1K B;  2A42 B;  3NGN A;  3I41 A;  2JC5 A;  3G0R A;  5INP A;  3TEB A;  4B5F A;  1BIX A;  5J3P A;  1VYB A;  1DE8 A;  1E9N A;  5INO A;  3FZI A;  3G91 A;  1I9Z A;  1YJH A;  2F2F B;  4F1R A;  4FPV A;  5CFE A;  5DV4 A;  4K6L F;  2ISI A;  3L1W A;  1NTF A;  3CJC D;  3I46 A;  2A40 B;  4L21 A;  5A7J A;  3DNI A;  2IMQ X;  4AWN A;  2DDS A;  5J3Z A;  4A9C A;  4QH9 A;  4F1H A;  3G3C A;  5J8N A;  3WCX A;  5DFJ A;  5DG0 A;  1SR4 B;  4B5H A;  4GZ0 A;  3G0A A;  2DNJ A;  3G1K A;  2A3Z B;  2VOA A;  4LND A;  1DEW A;  3NGO A; 
#chains in the Genus database with same CATH homology
 5DV2 A;  2A41 B;  4JG3 A;  4CMN A;  4B5I A;  3G3Y A;  2UYR X;  1HD7 A;  3I5V A;  2DDT A;  3G2C A;  4GZ2 A;  5DFI A;  1Y21 A;  4FVA A;  1I9Y A;  5INM A;  1ZWX A;  3U8U A;  5CFG A;  4L1Y A;  3MTC A;  4QHE A;  5J42 A;  1AKO A;  3I48 A;  1DNK A;  2V0R A;  3G2D A;  5EWT A;  3G4T A;  4B5G A;  4B5M A;  5INK A;  4L1Z A;  1WDU A;  2DDR A;  3G8V A;  4F1I A;  3N9V A;  3G00 A;  3K55 A;  3W2Y A;  4QHD A;  2XSW A;  5INL A;  2F1N A;  4GEW A;  4L20 A;  4GZ1 A;  3NR8 A;  2V0S A;  5HT2 A;  2JC4 A;  3NGQ A;  1SI6 X;  5INN A;  5INQ A;  4B5J A;  1DE9 A;  3MPR A;  4IEM A;  3W3D B;  5J3S A;  3G6S A;  4F1H B;  4C1R A;  5DFH A;  5A7I A;  4PUQ A;  3GA6 A;  3W2X A;  3G38 A;  4GYZ A;  5DFF A;  4CML A;  2J63 A;  2O3C A;  2EI9 A;  4RUW A;  2O3H A;  1ATN D;  2D1K B;  2A42 B;  3NGN A;  3I41 A;  2JC5 A;  3G0R A;  5INP A;  3TEB A;  4B5F A;  1BIX A;  5J3P A;  1VYB A;  1DE8 A;  1E9N A;  5INO A;  3FZI A;  3G91 A;  1I9Z A;  1YJH A;  2F2F B;  4F1R A;  4FPV A;  5CFE A;  5DV4 A;  4K6L F;  2ISI A;  3L1W A;  1NTF A;  3CJC D;  3I46 A;  2A40 B;  4L21 A;  5A7J A;  3DNI A;  2IMQ X;  4AWN A;  2DDS A;  5J3Z A;  4A9C A;  4QH9 A;  4F1H A;  3G3C A;  5J8N A;  3WCX A;  5DFJ A;  5DG0 A;  1SR4 B;  4B5H A;  4GZ0 A;  3G0A A;  2DNJ A;  3G1K A;  2A3Z B;  2VOA A;  4LND A;  1DEW A;  3NGO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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