5J8EA

Crystal structure of human hook3's conserved hook domain
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
150
structure length
150
Chain Sequence
RAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
pubmed doi rcsb
molecule tags Protein transport
source organism Homo sapiens
molecule keywords Protein Hook homolog 3
total genus 54
structure length 150
sequence length 150
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-04-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 5j8eA00
2D88A 1VKAA 1PA7A 2R0OA 3F7PA 1WIXA 1UEGA 5L0OA 5A36A 5J8EA 2E9KA 2QJXA 3CO1A 4EDLA 1BHDA 1UJOA 5BVRA 3HOCA 2DK9A 1P5SA 2YRNA 4Q57B 1V5KA 4Q58A 1RT8A 3HORA 2WA7A 1WYNA 1DXXA 2WA6A 1P2XA 1QAGA 4TXIA 3JALM 2QJZA 2WA5A 1WYOA 5A38A 2D86A 3REPB 3JARM 1WYMA 4EDMA 4Q59A 1WYPA 2RR8A 3JAKM 1H67A 2L3GA 5A37A 1BKRA 2R8UA 2D89A 1WKUA 1SH6A 2VZIB 1WYLA 2K3SA 2EE7A 1PXYA 2WFNA 2JV9A 3HOPA 3KMUB 2VZCA 2EYIA 4B7LA 1TJTA 1WYRA 1AOAA 1MB8A 2K2RA 2EYNA 3I6XA 1WYQA 2VZDA 1WJOA 2VZGB 2D85A 1AA2A 4TXKA 5A4BA 3KMWB 3KY9A 2D87A 1SH5A 3FERA 4EDNA
chains in the Genus database with same CATH superfamily
2D88A 1VKAA 1PA7A 2R0OA 3F7PA 1WIXA 1UEGA 2HL9A 2EQOA 5L0OA 5A36A 5J8EA 2E9KA 2QJXA 3CO1A 4EDLA 1BHDA 1UJOA 2VE7C 3HOCA 5BVRA 2DK9A 2IGPA 1P5SA 2YRNA 4Q57B 1V5KA 4Q58A 1RT8A 3HORA 2WA7A 1WYNA 1DXXA 2WA6A 1P2XA 1QAGA 2WE6A 4TXIA 2WDTA 3JALM 2QJZA 2WA5A 1WYOA 5A38A 2D86A 3REPB 3JARM 1WYMA 4EDMA 3EAYA 4Q59A 1WYPA 2RR8A 3JAKM 1H67A 2L3GA 5A37A 1BKRA 2R8UA 2VE7A 2HL8A 4LVRA 1EUVA 2D89A 1WKUA 1SH6A 2VZIB 1WYLA 5FMTA 2K3SA 2EE7A 1PXYA 2WFNA 2JV9A 3HOPA 3KMUB 2VZCA 2EYIA 4B7LA 1TJTA 1WYRA 1AOAA 1MB8A 4DDPA 2K2RA 2EYNA 3I6XA 1WYQA 2VZDA 2HKPA 1WJOA 2VZGB 2D85A 1AA2A 4TXKA 4LVPA 5A4BA 3KMWB 3KY9A 5FMUA 3VP7A 2D87A 1SH5A 3FERA 4EDNA
chains in the Genus database with same CATH topology
2D88A 1VKAA 1PA7A 2R0OA 3F7PA 1WIXA 1UEGA 5L0OA 5A36A 5J8EA 2E9KA 2QJXA 3CO1A 4EDLA 1BHDA 1UJOA 5BVRA 3HOCA 2DK9A 1P5SA 2YRNA 4Q57B 1V5KA 4Q58A 1RT8A 3HORA 2WA7A 1WYNA 1DXXA 2WA6A 1P2XA 1QAGA 4TXIA 3JALM 2QJZA 2WA5A 1WYOA 5A38A 2D86A 3REPB 3JARM 1WYMA 4EDMA 4Q59A 1WYPA 2RR8A 3JAKM 1H67A 2L3GA 5A37A 1BKRA 2R8UA 2D89A 1WKUA 1SH6A 2VZIB 1WYLA 2K3SA 2EE7A 1PXYA 2WFNA 2JV9A 3HOPA 3KMUB 2VZCA 2EYIA 4B7LA 1TJTA 1WYRA 1AOAA 1MB8A 2K2RA 2EYNA 3I6XA 1WYQA 2VZDA 1WJOA 2VZGB 2D85A 1AA2A 4TXKA 5A4BA 3KMWB 3KY9A 2D87A 1SH5A 3FERA 4EDNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D88 A;  1VKA A;  1PA7 A;  2R0O A;  3F7P A;  1WIX A;  1UEG A;  5L0O A;  5A36 A;  5J8E A;  2E9K A;  2QJX A;  3CO1 A;  4EDL A;  1BHD A;  1UJO A;  5BVR A;  3HOC A;  2DK9 A;  1P5S A;  2YRN A;  4Q57 B;  1V5K A;  4Q58 A;  1RT8 A;  3HOR A;  2WA7 A;  1WYN A;  1DXX A;  2WA6 A;  1P2X A;  1QAG A;  4TXI A;  3JAL M;  2QJZ A;  2WA5 A;  1WYO A;  5A38 A;  2D86 A;  3REP B;  3JAR M;  1WYM A;  4EDM A;  4Q59 A;  1WYP A;  2RR8 A;  3JAK M;  1H67 A;  2L3G A;  5A37 A;  1BKR A;  2R8U A;  2D89 A;  1WKU A;  1SH6 A;  2VZI B;  1WYL A;  2K3S A;  2EE7 A;  1PXY A;  2WFN A;  2JV9 A;  3HOP A;  3KMU B;  2VZC A;  2EYI A;  4B7L A;  1TJT A;  1WYR A;  1AOA A;  1MB8 A;  2K2R A;  2EYN A;  3I6X A;  1WYQ A;  2VZD A;  1WJO A;  2VZG B;  2D85 A;  1AA2 A;  4TXK A;  5A4B A;  3KMW B;  3KY9 A;  2D87 A;  1SH5 A;  3FER A;  4EDN A; 
#chains in the Genus database with same CATH topology
 2D88 A;  1VKA A;  1PA7 A;  2R0O A;  3F7P A;  1WIX A;  1UEG A;  2HL9 A;  2EQO A;  5L0O A;  5A36 A;  5J8E A;  2E9K A;  2QJX A;  3CO1 A;  4EDL A;  1BHD A;  1UJO A;  2VE7 C;  3HOC A;  5BVR A;  2DK9 A;  2IGP A;  1P5S A;  2YRN A;  4Q57 B;  1V5K A;  4Q58 A;  1RT8 A;  3HOR A;  2WA7 A;  1WYN A;  1DXX A;  2WA6 A;  1P2X A;  1QAG A;  2WE6 A;  4TXI A;  2WDT A;  3JAL M;  2QJZ A;  2WA5 A;  1WYO A;  5A38 A;  2D86 A;  3REP B;  3JAR M;  1WYM A;  4EDM A;  3EAY A;  4Q59 A;  1WYP A;  2RR8 A;  3JAK M;  1H67 A;  2L3G A;  5A37 A;  1BKR A;  2R8U A;  2VE7 A;  2HL8 A;  4LVR A;  1EUV A;  2D89 A;  1WKU A;  1SH6 A;  2VZI B;  1WYL A;  5FMT A;  2K3S A;  2EE7 A;  1PXY A;  2WFN A;  2JV9 A;  3HOP A;  3KMU B;  2VZC A;  2EYI A;  4B7L A;  1TJT A;  1WYR A;  1AOA A;  1MB8 A;  4DDP A;  2K2R A;  2EYN A;  3I6X A;  1WYQ A;  2VZD A;  2HKP A;  1WJO A;  2VZG B;  2D85 A;  1AA2 A;  4TXK A;  4LVP A;  5A4B A;  3KMW B;  3KY9 A;  5FMU A;  3VP7 A;  2D87 A;  1SH5 A;  3FER A;  4EDN A; 
#chains in the Genus database with same CATH homology
 2D88 A;  1VKA A;  1PA7 A;  2R0O A;  3F7P A;  1WIX A;  1UEG A;  5L0O A;  5A36 A;  5J8E A;  2E9K A;  2QJX A;  3CO1 A;  4EDL A;  1BHD A;  1UJO A;  5BVR A;  3HOC A;  2DK9 A;  1P5S A;  2YRN A;  4Q57 B;  1V5K A;  4Q58 A;  1RT8 A;  3HOR A;  2WA7 A;  1WYN A;  1DXX A;  2WA6 A;  1P2X A;  1QAG A;  4TXI A;  3JAL M;  2QJZ A;  2WA5 A;  1WYO A;  5A38 A;  2D86 A;  3REP B;  3JAR M;  1WYM A;  4EDM A;  4Q59 A;  1WYP A;  2RR8 A;  3JAK M;  1H67 A;  2L3G A;  5A37 A;  1BKR A;  2R8U A;  2D89 A;  1WKU A;  1SH6 A;  2VZI B;  1WYL A;  2K3S A;  2EE7 A;  1PXY A;  2WFN A;  2JV9 A;  3HOP A;  3KMU B;  2VZC A;  2EYI A;  4B7L A;  1TJT A;  1WYR A;  1AOA A;  1MB8 A;  2K2R A;  2EYN A;  3I6X A;  1WYQ A;  2VZD A;  1WJO A;  2VZG B;  2D85 A;  1AA2 A;  4TXK A;  5A4B A;  3KMW B;  3KY9 A;  2D87 A;  1SH5 A;  3FER A;  4EDN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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