5JHNA

Structure of g9a set-domain with histone h3k9ala mutant peptide and bound s-adenosylmethionine
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
273
structure length
273
Chain Sequence
b'IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 78
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jhnA00
4YNDA 5AYFA 4MI0A 4JLGA 3RAYA 5CCMA 3RQ4A 3M55A 1MVXA 5T0MA 1N6AA 2W5ZA 4IJ8A 3MO0A 3MO2A 2IGQA 5TTFA 1MT6A 3F9XA 3F9ZA 3OOIA 3M53A 3MO5A 1H3IA 3OPEA 5KJLA 3DB5A 1PEGA 4YPEA 3M57A 5KJMA 3M58A 4Z4PA 4YNPA 3RU0A 3SW9A 4LDGA 3S7JA 4C1QA 4J7FA 5TEGA 1ML9A 5T0KA 4RZ0A 3MEKA 2QPWA 3VV0A 1O9SA 4BUPA 3M59A 4MI5A 3CBMA 3M56A 5ARFA 4AU7A 4JDSA 3IHXA 4YPUA 4QENA 4O30A 3KMAA 5F6LA 4QEOA 4O6FA 1N3JA 4NVQA 3DALA 1XQHA 3FPDA 3OXGA 3RJWA 5T5GA 3K5KA 4IJDA 4YNMA 3S7BA 5JJ0A 4J8OA 3SWCA 5JHNA 5CPRB 4H12A 3F9WA 3CBPA 4E47A 5ARGA 3VUZA 5JINA 3OXFA 3CBOA 5EG2A 1ZKKA 4J7IA 4I51A 2F69A 5HI7A 3M54A 5KJNA 2G46A 1MVHA 2BQZA 3OS5A 3M5AA 5F59A 4YPAA 3S7FA 5JIYA 3BO5A 4NJ5A 3TG4A 3EP0A 3TG5A 3KMTA 5F5EA 3OXLA 3S8PA 2JV0A 5KJKA 3QWPA 3QWWA 3QWVA 5F6KC 3HNAA 2O8JA 5HQ8A 4QEPA 3PDNA 2R3AA 4J83A 2RFIA 4FMUA 3RIBA 5EX3A 5LSXA 5LSZA 2W5YA 3S7DA 3F9YA 5CCLA 1N6CA 3KMJA 4WUYA 5TH7A 5EX0A 1MUFA 3N71A
chains in the Genus database with same CATH superfamily
4YNDA 5AYFA 4MI0A 4JLGA 3RAYA 5CCMA 3RQ4A 3M55A 1MVXA 5T0MA 1N6AA 2W5ZA 4IJ8A 3MO0A 3MO2A 2IGQA 5TTFA 1MT6A 3F9XA 3F9ZA 3OOIA 3M53A 3MO5A 1H3IA 3OPEA 5KJLA 3DB5A 1PEGA 4YPEA 3M57A 5KJMA 3M58A 4Z4PA 4YNPA 3RU0A 3SW9A 4LDGA 3S7JA 4C1QA 4J7FA 5TEGA 1ML9A 5T0KA 4RZ0A 3MEKA 2QPWA 3VV0A 1O9SA 4BUPA 3M59A 4MI5A 3CBMA 3M56A 5ARFA 4AU7A 4JDSA 3IHXA 4YPUA 4QENA 4O30A 3KMAA 5F6LA 4QEOA 4O6FA 1N3JA 4NVQA 3DALA 1XQHA 3FPDA 3OXGA 3RJWA 5T5GA 3K5KA 4IJDA 4YNMA 3S7BA 5JJ0A 4J8OA 3SWCA 5JHNA 5CPRB 4H12A 3F9WA 3CBPA 4E47A 5ARGA 3VUZA 5JINA 3OXFA 3CBOA 5EG2A 1ZKKA 4J7IA 4I51A 2F69A 5HI7A 3M54A 5KJNA 2G46A 1MVHA 2BQZA 3OS5A 3M5AA 5F59A 4YPAA 3S7FA 5JIYA 3BO5A 4NJ5A 3TG4A 3EP0A 3TG5A 3KMTA 5F5EA 3OXLA 3S8PA 2JV0A 5KJKA 3QWPA 3QWWA 3QWVA 5F6KC 3HNAA 2O8JA 5HQ8A 4QEPA 3PDNA 2R3AA 4J83A 2RFIA 4FMUA 3RIBA 5EX3A 5LSXA 5LSZA 2W5YA 3S7DA 3F9YA 5CCLA 1N6CA 3KMJA 4WUYA 5TH7A 5EX0A 1MUFA 3N71A
chains in the Genus database with same CATH topology
4YNDA 5AYFA 4MI0A 4JLGA 3RAYA 5CCMA 3RQ4A 3M55A 1MVXA 5T0MA 1N6AA 2W5ZA 4IJ8A 3MO0A 3MO2A 2IGQA 5TTFA 1MT6A 3F9XA 3F9ZA 3OOIA 3M53A 3MO5A 1H3IA 3OPEA 5KJLA 3DB5A 1PEGA 4YPEA 3M57A 5KJMA 3M58A 4Z4PA 4YNPA 3RU0A 3SW9A 4LDGA 3S7JA 4C1QA 4J7FA 5TEGA 1ML9A 5T0KA 4RZ0A 3MEKA 2QPWA 3VV0A 1O9SA 4BUPA 3M59A 4MI5A 3CBMA 3M56A 5ARFA 4AU7A 4JDSA 3IHXA 4YPUA 4QENA 4O30A 3KMAA 5F6LA 4QEOA 4O6FA 1N3JA 4NVQA 3DALA 1XQHA 3FPDA 3OXGA 3RJWA 5T5GA 3K5KA 4IJDA 4YNMA 3S7BA 5JJ0A 4J8OA 3SWCA 5JHNA 5CPRB 4H12A 3F9WA 3CBPA 4E47A 5ARGA 3VUZA 5JINA 3OXFA 3CBOA 5EG2A 1ZKKA 4J7IA 4I51A 2F69A 5HI7A 3M54A 5KJNA 2G46A 1MVHA 2BQZA 3OS5A 3M5AA 5F59A 4YPAA 3S7FA 5JIYA 3BO5A 4NJ5A 3TG4A 3EP0A 3TG5A 3KMTA 5F5EA 3OXLA 3S8PA 2JV0A 5KJKA 3QWPA 3QWWA 3QWVA 5F6KC 3HNAA 2O8JA 5HQ8A 4QEPA 3PDNA 2R3AA 4J83A 2RFIA 4FMUA 3RIBA 5EX3A 5LSXA 5LSZA 2W5YA 3S7DA 3F9YA 5CCLA 1N6CA 3KMJA 4WUYA 5TH7A 5EX0A 1MUFA 3N71A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YND A;  5AYF A;  4MI0 A;  4JLG A;  3RAY A;  5CCM A;  3RQ4 A;  3M55 A;  1MVX A;  5T0M A;  1N6A A;  2W5Z A;  4IJ8 A;  3MO0 A;  3MO2 A;  2IGQ A;  5TTF A;  1MT6 A;  3F9X A;  3F9Z A;  3OOI A;  3M53 A;  3MO5 A;  1H3I A;  3OPE A;  5KJL A;  3DB5 A;  1PEG A;  4YPE A;  3M57 A;  5KJM A;  3M58 A;  4Z4P A;  4YNP A;  3RU0 A;  3SW9 A;  4LDG A;  3S7J A;  4C1Q A;  4J7F A;  5TEG A;  1ML9 A;  5T0K A;  4RZ0 A;  3MEK A;  2QPW A;  3VV0 A;  1O9S A;  4BUP A;  3M59 A;  4MI5 A;  3CBM A;  3M56 A;  5ARF A;  4AU7 A;  4JDS A;  3IHX A;  4YPU A;  4QEN A;  4O30 A;  3KMA A;  5F6L A;  4QEO A;  4O6F A;  1N3J A;  4NVQ A;  3DAL A;  1XQH A;  3FPD A;  3OXG A;  3RJW A;  5T5G A;  3K5K A;  4IJD A;  4YNM A;  3S7B A;  5JJ0 A;  4J8O A;  3SWC A;  5JHN A;  5CPR B;  4H12 A;  3F9W A;  3CBP A;  4E47 A;  5ARG A;  3VUZ A;  5JIN A;  3OXF A;  3CBO A;  5EG2 A;  1ZKK A;  4J7I A;  4I51 A;  2F69 A;  5HI7 A;  3M54 A;  5KJN A;  2G46 A;  1MVH A;  2BQZ A;  3OS5 A;  3M5A A;  5F59 A;  4YPA A;  3S7F A;  5JIY A;  3BO5 A;  4NJ5 A;  3TG4 A;  3EP0 A;  3TG5 A;  3KMT A;  5F5E A;  3OXL A;  3S8P A;  2JV0 A;  5KJK A;  3QWP A;  3QWW A;  3QWV A;  5F6K C;  3HNA A;  2O8J A;  5HQ8 A;  4QEP A;  3PDN A;  2R3A A;  4J83 A;  2RFI A;  4FMU A;  3RIB A;  5EX3 A;  5LSX A;  5LSZ A;  2W5Y A;  3S7D A;  3F9Y A;  5CCL A;  1N6C A;  3KMJ A;  4WUY A;  5TH7 A;  5EX0 A;  1MUF A;  3N71 A; 
#chains in the Genus database with same CATH topology
 4YND A;  5AYF A;  4MI0 A;  4JLG A;  3RAY A;  5CCM A;  3RQ4 A;  3M55 A;  1MVX A;  5T0M A;  1N6A A;  2W5Z A;  4IJ8 A;  3MO0 A;  3MO2 A;  2IGQ A;  5TTF A;  1MT6 A;  3F9X A;  3F9Z A;  3OOI A;  3M53 A;  3MO5 A;  1H3I A;  3OPE A;  5KJL A;  3DB5 A;  1PEG A;  4YPE A;  3M57 A;  5KJM A;  3M58 A;  4Z4P A;  4YNP A;  3RU0 A;  3SW9 A;  4LDG A;  3S7J A;  4C1Q A;  4J7F A;  5TEG A;  1ML9 A;  5T0K A;  4RZ0 A;  3MEK A;  2QPW A;  3VV0 A;  1O9S A;  4BUP A;  3M59 A;  4MI5 A;  3CBM A;  3M56 A;  5ARF A;  4AU7 A;  4JDS A;  3IHX A;  4YPU A;  4QEN A;  4O30 A;  3KMA A;  5F6L A;  4QEO A;  4O6F A;  1N3J A;  4NVQ A;  3DAL A;  1XQH A;  3FPD A;  3OXG A;  3RJW A;  5T5G A;  3K5K A;  4IJD A;  4YNM A;  3S7B A;  5JJ0 A;  4J8O A;  3SWC A;  5JHN A;  5CPR B;  4H12 A;  3F9W A;  3CBP A;  4E47 A;  5ARG A;  3VUZ A;  5JIN A;  3OXF A;  3CBO A;  5EG2 A;  1ZKK A;  4J7I A;  4I51 A;  2F69 A;  5HI7 A;  3M54 A;  5KJN A;  2G46 A;  1MVH A;  2BQZ A;  3OS5 A;  3M5A A;  5F59 A;  4YPA A;  3S7F A;  5JIY A;  3BO5 A;  4NJ5 A;  3TG4 A;  3EP0 A;  3TG5 A;  3KMT A;  5F5E A;  3OXL A;  3S8P A;  2JV0 A;  5KJK A;  3QWP A;  3QWW A;  3QWV A;  5F6K C;  3HNA A;  2O8J A;  5HQ8 A;  4QEP A;  3PDN A;  2R3A A;  4J83 A;  2RFI A;  4FMU A;  3RIB A;  5EX3 A;  5LSX A;  5LSZ A;  2W5Y A;  3S7D A;  3F9Y A;  5CCL A;  1N6C A;  3KMJ A;  4WUY A;  5TH7 A;  5EX0 A;  1MUF A;  3N71 A; 
#chains in the Genus database with same CATH homology
 4YND A;  5AYF A;  4MI0 A;  4JLG A;  3RAY A;  5CCM A;  3RQ4 A;  3M55 A;  1MVX A;  5T0M A;  1N6A A;  2W5Z A;  4IJ8 A;  3MO0 A;  3MO2 A;  2IGQ A;  5TTF A;  1MT6 A;  3F9X A;  3F9Z A;  3OOI A;  3M53 A;  3MO5 A;  1H3I A;  3OPE A;  5KJL A;  3DB5 A;  1PEG A;  4YPE A;  3M57 A;  5KJM A;  3M58 A;  4Z4P A;  4YNP A;  3RU0 A;  3SW9 A;  4LDG A;  3S7J A;  4C1Q A;  4J7F A;  5TEG A;  1ML9 A;  5T0K A;  4RZ0 A;  3MEK A;  2QPW A;  3VV0 A;  1O9S A;  4BUP A;  3M59 A;  4MI5 A;  3CBM A;  3M56 A;  5ARF A;  4AU7 A;  4JDS A;  3IHX A;  4YPU A;  4QEN A;  4O30 A;  3KMA A;  5F6L A;  4QEO A;  4O6F A;  1N3J A;  4NVQ A;  3DAL A;  1XQH A;  3FPD A;  3OXG A;  3RJW A;  5T5G A;  3K5K A;  4IJD A;  4YNM A;  3S7B A;  5JJ0 A;  4J8O A;  3SWC A;  5JHN A;  5CPR B;  4H12 A;  3F9W A;  3CBP A;  4E47 A;  5ARG A;  3VUZ A;  5JIN A;  3OXF A;  3CBO A;  5EG2 A;  1ZKK A;  4J7I A;  4I51 A;  2F69 A;  5HI7 A;  3M54 A;  5KJN A;  2G46 A;  1MVH A;  2BQZ A;  3OS5 A;  3M5A A;  5F59 A;  4YPA A;  3S7F A;  5JIY A;  3BO5 A;  4NJ5 A;  3TG4 A;  3EP0 A;  3TG5 A;  3KMT A;  5F5E A;  3OXL A;  3S8P A;  2JV0 A;  5KJK A;  3QWP A;  3QWW A;  3QWV A;  5F6K C;  3HNA A;  2O8J A;  5HQ8 A;  4QEP A;  3PDN A;  2R3A A;  4J83 A;  2RFI A;  4FMU A;  3RIB A;  5EX3 A;  5LSX A;  5LSZ A;  2W5Y A;  3S7D A;  3F9Y A;  5CCL A;  1N6C A;  3KMJ A;  4WUY A;  5TH7 A;  5EX0 A;  1MUF A;  3N71 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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