5JHNA

Structure of g9a set-domain with histone h3k9ala mutant peptide and bound s-adenosylmethionine
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 78
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jhnA00
4LDGA 3M53A 3TG4A 1MUFA 4Z4PA 1ZKKA 4NVQA 5ARGA 3M59A 5JINA 3EP0A 4RZ0A 3VV0A 5JJ0A 4NJ5A 3RQ4A 5CPRB 3SW9A 3M56A 3PDNA 3F9YA 2F69A 5HQ8A 4JLGA 3QWPA 4QEOA 5F59A 5F6KC 3S7FA 4YPUA 2O8JA 3QWWA 3MO5A 2QPWA 1XQHA 1MT6A 2W5YA 5EX0A 1N6AA 5T0MA 4QEPA 4C1QA 3VUZA 4BUPA 3F9WA 5TH7A 3FPDA 2JV0A 4AU7A 4WUYA 3KMTA 5T0KA 5F5EA 4JDSA 5ARFA 3TG5A 3S7JA 5KJMA 3KMJA 2RFIA 5CCLA 4YNMA 4E47A 4YNPA 3RIBA 3DALA 3MEKA 4FMUA 5EX3A 3F9XA 4YPEA 3F9ZA 5TEGA 1H3IA 3DB5A 4MI0A 1PEGA 3M5AA 3RAYA 4O6FA 4YNDA 1O9SA 2R3AA 3M57A 5LSZA 1N6CA 4YPAA 3CBMA 5HI7A 3IHXA 3S8PA 4QENA 3SWCA 4J7FA 5KJKA 5CCMA 3HNAA 4IJ8A 3MO2A 3S7BA 3CBOA 4MI5A 2BQZA 2IGQA 5F6LA 3CBPA 5T5GA 3M55A 3MO0A 3OXFA 5AYFA 1ML9A 5JIYA 3OPEA 1MVXA 1N3JA 3S7DA 4H12A 3RJWA 3RU0A 5LSXA 5EG2A 2W5ZA 5JHNA 3K5KA 3M54A 4J7IA 2G46A 3OS5A 4J83A 3KMAA 5TTFA 3BO5A 4I51A 3QWVA 1MVHA 4J8OA 3N71A 3OXGA 4IJDA 5KJNA 3OOIA 3OXLA 3M58A 5KJLA 4O30A
chains in the Genus database with same CATH superfamily
4LDGA 3M53A 3TG4A 1MUFA 4Z4PA 1ZKKA 4NVQA 5ARGA 3M59A 5JINA 3EP0A 4RZ0A 3VV0A 5JJ0A 4NJ5A 3RQ4A 5CPRB 3SW9A 3M56A 3PDNA 3F9YA 2F69A 5HQ8A 4JLGA 3QWPA 4QEOA 5F59A 5F6KC 3S7FA 4YPUA 2O8JA 3QWWA 3MO5A 2QPWA 1XQHA 1MT6A 2W5YA 5EX0A 1N6AA 5T0MA 4QEPA 4C1QA 3VUZA 4BUPA 3F9WA 5TH7A 3FPDA 2JV0A 4AU7A 4WUYA 3KMTA 5T0KA 5F5EA 4JDSA 5ARFA 3TG5A 3S7JA 5KJMA 3KMJA 2RFIA 5CCLA 4YNMA 4E47A 4YNPA 3RIBA 3DALA 3MEKA 4FMUA 5EX3A 3F9XA 4YPEA 3F9ZA 5TEGA 1H3IA 3DB5A 4MI0A 1PEGA 3M5AA 3RAYA 4O6FA 4YNDA 1O9SA 2R3AA 3M57A 5LSZA 1N6CA 4YPAA 3CBMA 5HI7A 3IHXA 3S8PA 4QENA 3SWCA 4J7FA 5KJKA 5CCMA 3HNAA 4IJ8A 3MO2A 3S7BA 3CBOA 4MI5A 2BQZA 2IGQA 5F6LA 3CBPA 5T5GA 3M55A 3MO0A 3OXFA 5AYFA 1ML9A 5JIYA 3OPEA 1MVXA 1N3JA 3S7DA 4H12A 3RJWA 3RU0A 5LSXA 5EG2A 2W5ZA 5JHNA 3K5KA 3M54A 4J7IA 2G46A 3OS5A 4J83A 3KMAA 5TTFA 3BO5A 4I51A 3QWVA 1MVHA 4J8OA 3N71A 3OXGA 4IJDA 5KJNA 3OOIA 3OXLA 3M58A 5KJLA 4O30A
chains in the Genus database with same CATH topology
4LDGA 3M53A 3TG4A 1MUFA 4Z4PA 1ZKKA 4NVQA 5ARGA 3M59A 5JINA 3EP0A 4RZ0A 3VV0A 5JJ0A 4NJ5A 3RQ4A 5CPRB 3SW9A 3M56A 3PDNA 3F9YA 2F69A 5HQ8A 4JLGA 3QWPA 4QEOA 5F59A 5F6KC 3S7FA 4YPUA 2O8JA 3QWWA 3MO5A 2QPWA 1XQHA 1MT6A 2W5YA 5EX0A 1N6AA 5T0MA 4QEPA 4C1QA 3VUZA 4BUPA 3F9WA 5TH7A 3FPDA 2JV0A 4AU7A 4WUYA 3KMTA 5T0KA 5F5EA 4JDSA 5ARFA 3TG5A 3S7JA 5KJMA 3KMJA 2RFIA 5CCLA 4YNMA 4E47A 4YNPA 3RIBA 3DALA 3MEKA 4FMUA 5EX3A 3F9XA 4YPEA 3F9ZA 5TEGA 1H3IA 3DB5A 4MI0A 1PEGA 3M5AA 3RAYA 4O6FA 4YNDA 1O9SA 2R3AA 3M57A 5LSZA 1N6CA 4YPAA 3CBMA 5HI7A 3IHXA 3S8PA 4QENA 3SWCA 4J7FA 5KJKA 5CCMA 3HNAA 4IJ8A 3MO2A 3S7BA 3CBOA 4MI5A 2BQZA 2IGQA 5F6LA 3CBPA 5T5GA 3M55A 3MO0A 3OXFA 5AYFA 1ML9A 5JIYA 3OPEA 1MVXA 1N3JA 3S7DA 4H12A 3RJWA 3RU0A 5LSXA 5EG2A 2W5ZA 5JHNA 3K5KA 3M54A 4J7IA 2G46A 3OS5A 4J83A 3KMAA 5TTFA 3BO5A 4I51A 3QWVA 1MVHA 4J8OA 3N71A 3OXGA 4IJDA 5KJNA 3OOIA 3OXLA 3M58A 5KJLA 4O30A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LDG A;  3M53 A;  3TG4 A;  1MUF A;  4Z4P A;  1ZKK A;  4NVQ A;  5ARG A;  3M59 A;  5JIN A;  3EP0 A;  4RZ0 A;  3VV0 A;  5JJ0 A;  4NJ5 A;  3RQ4 A;  5CPR B;  3SW9 A;  3M56 A;  3PDN A;  3F9Y A;  2F69 A;  5HQ8 A;  4JLG A;  3QWP A;  4QEO A;  5F59 A;  5F6K C;  3S7F A;  4YPU A;  2O8J A;  3QWW A;  3MO5 A;  2QPW A;  1XQH A;  1MT6 A;  2W5Y A;  5EX0 A;  1N6A A;  5T0M A;  4QEP A;  4C1Q A;  3VUZ A;  4BUP A;  3F9W A;  5TH7 A;  3FPD A;  2JV0 A;  4AU7 A;  4WUY A;  3KMT A;  5T0K A;  5F5E A;  4JDS A;  5ARF A;  3TG5 A;  3S7J A;  5KJM A;  3KMJ A;  2RFI A;  5CCL A;  4YNM A;  4E47 A;  4YNP A;  3RIB A;  3DAL A;  3MEK A;  4FMU A;  5EX3 A;  3F9X A;  4YPE A;  3F9Z A;  5TEG A;  1H3I A;  3DB5 A;  4MI0 A;  1PEG A;  3M5A A;  3RAY A;  4O6F A;  4YND A;  1O9S A;  2R3A A;  3M57 A;  5LSZ A;  1N6C A;  4YPA A;  3CBM A;  5HI7 A;  3IHX A;  3S8P A;  4QEN A;  3SWC A;  4J7F A;  5KJK A;  5CCM A;  3HNA A;  4IJ8 A;  3MO2 A;  3S7B A;  3CBO A;  4MI5 A;  2BQZ A;  2IGQ A;  5F6L A;  3CBP A;  5T5G A;  3M55 A;  3MO0 A;  3OXF A;  5AYF A;  1ML9 A;  5JIY A;  3OPE A;  1MVX A;  1N3J A;  3S7D A;  4H12 A;  3RJW A;  3RU0 A;  5LSX A;  5EG2 A;  2W5Z A;  5JHN A;  3K5K A;  3M54 A;  4J7I A;  2G46 A;  3OS5 A;  4J83 A;  3KMA A;  5TTF A;  3BO5 A;  4I51 A;  3QWV A;  1MVH A;  4J8O A;  3N71 A;  3OXG A;  4IJD A;  5KJN A;  3OOI A;  3OXL A;  3M58 A;  5KJL A;  4O30 A; 
#chains in the Genus database with same CATH topology
 4LDG A;  3M53 A;  3TG4 A;  1MUF A;  4Z4P A;  1ZKK A;  4NVQ A;  5ARG A;  3M59 A;  5JIN A;  3EP0 A;  4RZ0 A;  3VV0 A;  5JJ0 A;  4NJ5 A;  3RQ4 A;  5CPR B;  3SW9 A;  3M56 A;  3PDN A;  3F9Y A;  2F69 A;  5HQ8 A;  4JLG A;  3QWP A;  4QEO A;  5F59 A;  5F6K C;  3S7F A;  4YPU A;  2O8J A;  3QWW A;  3MO5 A;  2QPW A;  1XQH A;  1MT6 A;  2W5Y A;  5EX0 A;  1N6A A;  5T0M A;  4QEP A;  4C1Q A;  3VUZ A;  4BUP A;  3F9W A;  5TH7 A;  3FPD A;  2JV0 A;  4AU7 A;  4WUY A;  3KMT A;  5T0K A;  5F5E A;  4JDS A;  5ARF A;  3TG5 A;  3S7J A;  5KJM A;  3KMJ A;  2RFI A;  5CCL A;  4YNM A;  4E47 A;  4YNP A;  3RIB A;  3DAL A;  3MEK A;  4FMU A;  5EX3 A;  3F9X A;  4YPE A;  3F9Z A;  5TEG A;  1H3I A;  3DB5 A;  4MI0 A;  1PEG A;  3M5A A;  3RAY A;  4O6F A;  4YND A;  1O9S A;  2R3A A;  3M57 A;  5LSZ A;  1N6C A;  4YPA A;  3CBM A;  5HI7 A;  3IHX A;  3S8P A;  4QEN A;  3SWC A;  4J7F A;  5KJK A;  5CCM A;  3HNA A;  4IJ8 A;  3MO2 A;  3S7B A;  3CBO A;  4MI5 A;  2BQZ A;  2IGQ A;  5F6L A;  3CBP A;  5T5G A;  3M55 A;  3MO0 A;  3OXF A;  5AYF A;  1ML9 A;  5JIY A;  3OPE A;  1MVX A;  1N3J A;  3S7D A;  4H12 A;  3RJW A;  3RU0 A;  5LSX A;  5EG2 A;  2W5Z A;  5JHN A;  3K5K A;  3M54 A;  4J7I A;  2G46 A;  3OS5 A;  4J83 A;  3KMA A;  5TTF A;  3BO5 A;  4I51 A;  3QWV A;  1MVH A;  4J8O A;  3N71 A;  3OXG A;  4IJD A;  5KJN A;  3OOI A;  3OXL A;  3M58 A;  5KJL A;  4O30 A; 
#chains in the Genus database with same CATH homology
 4LDG A;  3M53 A;  3TG4 A;  1MUF A;  4Z4P A;  1ZKK A;  4NVQ A;  5ARG A;  3M59 A;  5JIN A;  3EP0 A;  4RZ0 A;  3VV0 A;  5JJ0 A;  4NJ5 A;  3RQ4 A;  5CPR B;  3SW9 A;  3M56 A;  3PDN A;  3F9Y A;  2F69 A;  5HQ8 A;  4JLG A;  3QWP A;  4QEO A;  5F59 A;  5F6K C;  3S7F A;  4YPU A;  2O8J A;  3QWW A;  3MO5 A;  2QPW A;  1XQH A;  1MT6 A;  2W5Y A;  5EX0 A;  1N6A A;  5T0M A;  4QEP A;  4C1Q A;  3VUZ A;  4BUP A;  3F9W A;  5TH7 A;  3FPD A;  2JV0 A;  4AU7 A;  4WUY A;  3KMT A;  5T0K A;  5F5E A;  4JDS A;  5ARF A;  3TG5 A;  3S7J A;  5KJM A;  3KMJ A;  2RFI A;  5CCL A;  4YNM A;  4E47 A;  4YNP A;  3RIB A;  3DAL A;  3MEK A;  4FMU A;  5EX3 A;  3F9X A;  4YPE A;  3F9Z A;  5TEG A;  1H3I A;  3DB5 A;  4MI0 A;  1PEG A;  3M5A A;  3RAY A;  4O6F A;  4YND A;  1O9S A;  2R3A A;  3M57 A;  5LSZ A;  1N6C A;  4YPA A;  3CBM A;  5HI7 A;  3IHX A;  3S8P A;  4QEN A;  3SWC A;  4J7F A;  5KJK A;  5CCM A;  3HNA A;  4IJ8 A;  3MO2 A;  3S7B A;  3CBO A;  4MI5 A;  2BQZ A;  2IGQ A;  5F6L A;  3CBP A;  5T5G A;  3M55 A;  3MO0 A;  3OXF A;  5AYF A;  1ML9 A;  5JIY A;  3OPE A;  1MVX A;  1N3J A;  3S7D A;  4H12 A;  3RJW A;  3RU0 A;  5LSX A;  5EG2 A;  2W5Z A;  5JHN A;  3K5K A;  3M54 A;  4J7I A;  2G46 A;  3OS5 A;  4J83 A;  3KMA A;  5TTF A;  3BO5 A;  4I51 A;  3QWV A;  1MVH A;  4J8O A;  3N71 A;  3OXG A;  4IJD A;  5KJN A;  3OOI A;  3OXL A;  3M58 A;  5KJL A;  4O30 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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