5JHNA

Structure of g9a set-domain with histone h3k9ala mutant peptide and bound s-adenosylmethionine
Total Genus 78
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 78
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jhnA00
3DALA 5KJMA 5TEGA 4H12A 3QWWA 3TG4A 3RIBA 1N3JA 3VV0A 4O6FA 4QEOA 5F5EA 1MUFA 4WUYA 5HQ8A 5ARFA 2O8JA 4J83A 3MO0A 1N6AA 4BUPA 3OXLA 5F6KC 5JJ0A 5KJLA 4QENA 2JV0A 3S7FA 1MT6A 5ARGA 3OPEA 3FPDA 3RAYA 2IGQA 4YNMA 1MVXA 4YPEA 4C1QA 3M56A 4MI5A 1O9SA 1PEGA 4YPAA 5F59A 4YPUA 1XQHA 4J7FA 3M53A 3OXGA 2RFIA 5EX0A 4IJ8A 3BO5A 5JIYA 3MO5A 3IHXA 1ZKKA 3RU0A 2W5YA 3DB5A 3QWVA 5KJKA 3QWPA 3S8PA 4RZ0A 5LSXA 3HNAA 5JINA 3KMJA 3RJWA 4NVQA 4E47A 2F69A 3M58A 4FMUA 3M55A 4Z4PA 5CPRB 5AYFA 4AU7A 4LDGA 4O30A 4MI0A 3SWCA 4NJ5A 3F9XA 3F9ZA 3M5AA 4QEPA 5T0KA 3CBPA 3F9YA 4YNDA 3M57A 5EG2A 5TH7A 3TG5A 5TTFA 5CCLA 3PDNA 3RQ4A 1N6CA 3MEKA 4J8OA 3EP0A 5KJNA 3S7BA 3OOIA 3SW9A 3KMAA 3CBMA 1MVHA 3KMTA 2W5ZA 2R3AA 2BQZA 3OS5A 3VUZA 5EX3A 3N71A 5CCMA 3MO2A 3CBOA 1H3IA 3F9WA 5LSZA 3M54A 3K5KA 2QPWA 4J7IA 5T5GA 1ML9A 4YNPA 4JDSA 4I51A 5F6LA 5JHNA 4JLGA 5HI7A 3OXFA 3S7JA 5T0MA 3S7DA 3M59A 4IJDA 2G46A
chains in the Genus database with same CATH superfamily
3DALA 5KJMA 5TEGA 4H12A 3QWWA 3TG4A 3RIBA 1N3JA 3VV0A 4O6FA 4QEOA 5F5EA 1MUFA 4WUYA 5HQ8A 5ARFA 2O8JA 4J83A 3MO0A 1N6AA 4BUPA 3OXLA 5F6KC 5JJ0A 5KJLA 4QENA 2JV0A 3S7FA 1MT6A 5ARGA 3OPEA 3FPDA 3RAYA 2IGQA 4YNMA 1MVXA 4YPEA 4C1QA 3M56A 4MI5A 1O9SA 1PEGA 4YPAA 5F59A 4YPUA 1XQHA 4J7FA 3M53A 3OXGA 2RFIA 5EX0A 4IJ8A 3BO5A 5JIYA 3MO5A 3IHXA 1ZKKA 3RU0A 2W5YA 3DB5A 3QWVA 5KJKA 3QWPA 3S8PA 4RZ0A 5LSXA 3HNAA 5JINA 3KMJA 3RJWA 4NVQA 4E47A 2F69A 3M58A 4FMUA 3M55A 4Z4PA 5CPRB 5AYFA 4AU7A 4LDGA 4O30A 4MI0A 3SWCA 4NJ5A 3F9XA 3F9ZA 3M5AA 4QEPA 5T0KA 3CBPA 3F9YA 4YNDA 3M57A 5EG2A 5TH7A 3TG5A 5TTFA 5CCLA 3PDNA 3RQ4A 1N6CA 3MEKA 4J8OA 3EP0A 5KJNA 3S7BA 3OOIA 3SW9A 3KMAA 3CBMA 1MVHA 3KMTA 2W5ZA 2R3AA 2BQZA 3OS5A 3VUZA 5EX3A 3N71A 5CCMA 3MO2A 3CBOA 1H3IA 3F9WA 5LSZA 3M54A 3K5KA 2QPWA 4J7IA 5T5GA 1ML9A 4YNPA 4JDSA 4I51A 5F6LA 5JHNA 4JLGA 5HI7A 3OXFA 3S7JA 5T0MA 3S7DA 3M59A 4IJDA 2G46A
chains in the Genus database with same CATH topology
3DALA 5KJMA 5TEGA 4H12A 3QWWA 3TG4A 3RIBA 1N3JA 3VV0A 4O6FA 4QEOA 5F5EA 1MUFA 4WUYA 5HQ8A 5ARFA 2O8JA 4J83A 3MO0A 1N6AA 4BUPA 3OXLA 5F6KC 5JJ0A 5KJLA 4QENA 2JV0A 3S7FA 1MT6A 5ARGA 3OPEA 3FPDA 3RAYA 2IGQA 4YNMA 1MVXA 4YPEA 4C1QA 3M56A 4MI5A 1O9SA 1PEGA 4YPAA 5F59A 4YPUA 1XQHA 4J7FA 3M53A 3OXGA 2RFIA 5EX0A 4IJ8A 3BO5A 5JIYA 3MO5A 3IHXA 1ZKKA 3RU0A 2W5YA 3DB5A 3QWVA 5KJKA 3QWPA 3S8PA 4RZ0A 5LSXA 3HNAA 5JINA 3KMJA 3RJWA 4NVQA 4E47A 2F69A 3M58A 4FMUA 3M55A 4Z4PA 5CPRB 5AYFA 4AU7A 4LDGA 4O30A 4MI0A 3SWCA 4NJ5A 3F9XA 3F9ZA 3M5AA 4QEPA 5T0KA 3CBPA 3F9YA 4YNDA 3M57A 5EG2A 5TH7A 3TG5A 5TTFA 5CCLA 3PDNA 3RQ4A 1N6CA 3MEKA 4J8OA 3EP0A 5KJNA 3S7BA 3OOIA 3SW9A 3KMAA 3CBMA 1MVHA 3KMTA 2W5ZA 2R3AA 2BQZA 3OS5A 3VUZA 5EX3A 3N71A 5CCMA 3MO2A 3CBOA 1H3IA 3F9WA 5LSZA 3M54A 3K5KA 2QPWA 4J7IA 5T5GA 1ML9A 4YNPA 4JDSA 4I51A 5F6LA 5JHNA 4JLGA 5HI7A 3OXFA 3S7JA 5T0MA 3S7DA 3M59A 4IJDA 2G46A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DAL A;  5KJM A;  5TEG A;  4H12 A;  3QWW A;  3TG4 A;  3RIB A;  1N3J A;  3VV0 A;  4O6F A;  4QEO A;  5F5E A;  1MUF A;  4WUY A;  5HQ8 A;  5ARF A;  2O8J A;  4J83 A;  3MO0 A;  1N6A A;  4BUP A;  3OXL A;  5F6K C;  5JJ0 A;  5KJL A;  4QEN A;  2JV0 A;  3S7F A;  1MT6 A;  5ARG A;  3OPE A;  3FPD A;  3RAY A;  2IGQ A;  4YNM A;  1MVX A;  4YPE A;  4C1Q A;  3M56 A;  4MI5 A;  1O9S A;  1PEG A;  4YPA A;  5F59 A;  4YPU A;  1XQH A;  4J7F A;  3M53 A;  3OXG A;  2RFI A;  5EX0 A;  4IJ8 A;  3BO5 A;  5JIY A;  3MO5 A;  3IHX A;  1ZKK A;  3RU0 A;  2W5Y A;  3DB5 A;  3QWV A;  5KJK A;  3QWP A;  3S8P A;  4RZ0 A;  5LSX A;  3HNA A;  5JIN A;  3KMJ A;  3RJW A;  4NVQ A;  4E47 A;  2F69 A;  3M58 A;  4FMU A;  3M55 A;  4Z4P A;  5CPR B;  5AYF A;  4AU7 A;  4LDG A;  4O30 A;  4MI0 A;  3SWC A;  4NJ5 A;  3F9X A;  3F9Z A;  3M5A A;  4QEP A;  5T0K A;  3CBP A;  3F9Y A;  4YND A;  3M57 A;  5EG2 A;  5TH7 A;  3TG5 A;  5TTF A;  5CCL A;  3PDN A;  3RQ4 A;  1N6C A;  3MEK A;  4J8O A;  3EP0 A;  5KJN A;  3S7B A;  3OOI A;  3SW9 A;  3KMA A;  3CBM A;  1MVH A;  3KMT A;  2W5Z A;  2R3A A;  2BQZ A;  3OS5 A;  3VUZ A;  5EX3 A;  3N71 A;  5CCM A;  3MO2 A;  3CBO A;  1H3I A;  3F9W A;  5LSZ A;  3M54 A;  3K5K A;  2QPW A;  4J7I A;  5T5G A;  1ML9 A;  4YNP A;  4JDS A;  4I51 A;  5F6L A;  5JHN A;  4JLG A;  5HI7 A;  3OXF A;  3S7J A;  5T0M A;  3S7D A;  3M59 A;  4IJD A;  2G46 A; 
#chains in the Genus database with same CATH topology
 3DAL A;  5KJM A;  5TEG A;  4H12 A;  3QWW A;  3TG4 A;  3RIB A;  1N3J A;  3VV0 A;  4O6F A;  4QEO A;  5F5E A;  1MUF A;  4WUY A;  5HQ8 A;  5ARF A;  2O8J A;  4J83 A;  3MO0 A;  1N6A A;  4BUP A;  3OXL A;  5F6K C;  5JJ0 A;  5KJL A;  4QEN A;  2JV0 A;  3S7F A;  1MT6 A;  5ARG A;  3OPE A;  3FPD A;  3RAY A;  2IGQ A;  4YNM A;  1MVX A;  4YPE A;  4C1Q A;  3M56 A;  4MI5 A;  1O9S A;  1PEG A;  4YPA A;  5F59 A;  4YPU A;  1XQH A;  4J7F A;  3M53 A;  3OXG A;  2RFI A;  5EX0 A;  4IJ8 A;  3BO5 A;  5JIY A;  3MO5 A;  3IHX A;  1ZKK A;  3RU0 A;  2W5Y A;  3DB5 A;  3QWV A;  5KJK A;  3QWP A;  3S8P A;  4RZ0 A;  5LSX A;  3HNA A;  5JIN A;  3KMJ A;  3RJW A;  4NVQ A;  4E47 A;  2F69 A;  3M58 A;  4FMU A;  3M55 A;  4Z4P A;  5CPR B;  5AYF A;  4AU7 A;  4LDG A;  4O30 A;  4MI0 A;  3SWC A;  4NJ5 A;  3F9X A;  3F9Z A;  3M5A A;  4QEP A;  5T0K A;  3CBP A;  3F9Y A;  4YND A;  3M57 A;  5EG2 A;  5TH7 A;  3TG5 A;  5TTF A;  5CCL A;  3PDN A;  3RQ4 A;  1N6C A;  3MEK A;  4J8O A;  3EP0 A;  5KJN A;  3S7B A;  3OOI A;  3SW9 A;  3KMA A;  3CBM A;  1MVH A;  3KMT A;  2W5Z A;  2R3A A;  2BQZ A;  3OS5 A;  3VUZ A;  5EX3 A;  3N71 A;  5CCM A;  3MO2 A;  3CBO A;  1H3I A;  3F9W A;  5LSZ A;  3M54 A;  3K5K A;  2QPW A;  4J7I A;  5T5G A;  1ML9 A;  4YNP A;  4JDS A;  4I51 A;  5F6L A;  5JHN A;  4JLG A;  5HI7 A;  3OXF A;  3S7J A;  5T0M A;  3S7D A;  3M59 A;  4IJD A;  2G46 A; 
#chains in the Genus database with same CATH homology
 3DAL A;  5KJM A;  5TEG A;  4H12 A;  3QWW A;  3TG4 A;  3RIB A;  1N3J A;  3VV0 A;  4O6F A;  4QEO A;  5F5E A;  1MUF A;  4WUY A;  5HQ8 A;  5ARF A;  2O8J A;  4J83 A;  3MO0 A;  1N6A A;  4BUP A;  3OXL A;  5F6K C;  5JJ0 A;  5KJL A;  4QEN A;  2JV0 A;  3S7F A;  1MT6 A;  5ARG A;  3OPE A;  3FPD A;  3RAY A;  2IGQ A;  4YNM A;  1MVX A;  4YPE A;  4C1Q A;  3M56 A;  4MI5 A;  1O9S A;  1PEG A;  4YPA A;  5F59 A;  4YPU A;  1XQH A;  4J7F A;  3M53 A;  3OXG A;  2RFI A;  5EX0 A;  4IJ8 A;  3BO5 A;  5JIY A;  3MO5 A;  3IHX A;  1ZKK A;  3RU0 A;  2W5Y A;  3DB5 A;  3QWV A;  5KJK A;  3QWP A;  3S8P A;  4RZ0 A;  5LSX A;  3HNA A;  5JIN A;  3KMJ A;  3RJW A;  4NVQ A;  4E47 A;  2F69 A;  3M58 A;  4FMU A;  3M55 A;  4Z4P A;  5CPR B;  5AYF A;  4AU7 A;  4LDG A;  4O30 A;  4MI0 A;  3SWC A;  4NJ5 A;  3F9X A;  3F9Z A;  3M5A A;  4QEP A;  5T0K A;  3CBP A;  3F9Y A;  4YND A;  3M57 A;  5EG2 A;  5TH7 A;  3TG5 A;  5TTF A;  5CCL A;  3PDN A;  3RQ4 A;  1N6C A;  3MEK A;  4J8O A;  3EP0 A;  5KJN A;  3S7B A;  3OOI A;  3SW9 A;  3KMA A;  3CBM A;  1MVH A;  3KMT A;  2W5Z A;  2R3A A;  2BQZ A;  3OS5 A;  3VUZ A;  5EX3 A;  3N71 A;  5CCM A;  3MO2 A;  3CBO A;  1H3I A;  3F9W A;  5LSZ A;  3M54 A;  3K5K A;  2QPW A;  4J7I A;  5T5G A;  1ML9 A;  4YNP A;  4JDS A;  4I51 A;  5F6L A;  5JHN A;  4JLG A;  5HI7 A;  3OXF A;  3S7J A;  5T0M A;  3S7D A;  3M59 A;  4IJD A;  2G46 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...