5JHNA

Structure of g9a set-domain with histone h3k9ala mutant peptide and bound s-adenosylmethionine
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 78
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jhnA00
3RU0A 4NJ5A 5ARFA 5F6LA 3M58A 3M57A 5T0MA 4JLGA 3MO2A 3IHXA 3S7BA 3OXGA 4O30A 3TG4A 3QWPA 3RJWA 5JINA 3KMAA 2JV0A 4O6FA 3EP0A 4H12A 5TH7A 3DALA 1ZKKA 3OS5A 5HI7A 2F69A 5JJ0A 4YPEA 3S8PA 3MO0A 4QEOA 2W5ZA 5LSZA 4BUPA 1ML9A 5TTFA 3F9ZA 1MUFA 3RQ4A 5KJNA 3M5AA 4J8OA 1N3JA 5JIYA 3F9YA 4YNDA 3RIBA 3SWCA 2RFIA 3F9WA 3FPDA 3QWVA 4FMUA 5CCMA 3M55A 3DB5A 5T0KA 3M53A 4MI0A 4C1QA 5F59A 3S7JA 5F5EA 2O8JA 4YPAA 5KJMA 3M59A 4J7IA 3RAYA 2QPWA 3CBOA 3MO5A 5LSXA 4Z4PA 3K5KA 5KJLA 4QENA 3S7FA 5KJKA 5TEGA 4YNMA 3MEKA 2IGQA 3CBPA 1MT6A 3OXLA 3VUZA 5JHNA 4YPUA 3N71A 2G46A 5EX3A 3VV0A 4I51A 4MI5A 5EG2A 3F9XA 2R3AA 4AU7A 4NVQA 2BQZA 3KMJA 4WUYA 1MVHA 5CPRB 4RZ0A 1MVXA 4YNPA 3S7DA 4J83A 4QEPA 3OOIA 3BO5A 5AYFA 1N6CA 1XQHA 1PEGA 1O9SA 3HNAA 5ARGA 4J7FA 1N6AA 3CBMA 5CCLA 3PDNA 3M54A 2W5YA 3KMTA 3TG5A 5T5GA 5HQ8A 3OPEA 4IJDA 4JDSA 4E47A 3M56A 4LDGA 1H3IA 4IJ8A 3SW9A 5F6KC 3QWWA 5EX0A 3OXFA
chains in the Genus database with same CATH superfamily
3RU0A 4NJ5A 5ARFA 5F6LA 3M58A 3M57A 5T0MA 4JLGA 3MO2A 3IHXA 3S7BA 3OXGA 4O30A 3TG4A 3QWPA 3RJWA 5JINA 3KMAA 2JV0A 4O6FA 3EP0A 4H12A 5TH7A 3DALA 1ZKKA 3OS5A 5HI7A 2F69A 5JJ0A 4YPEA 3S8PA 3MO0A 4QEOA 2W5ZA 5LSZA 4BUPA 1ML9A 5TTFA 3F9ZA 1MUFA 3RQ4A 5KJNA 3M5AA 4J8OA 1N3JA 5JIYA 3F9YA 4YNDA 3RIBA 3SWCA 2RFIA 3F9WA 3FPDA 3QWVA 4FMUA 5CCMA 3M55A 3DB5A 5T0KA 3M53A 4MI0A 4C1QA 5F59A 3S7JA 5F5EA 2O8JA 4YPAA 5KJMA 3M59A 4J7IA 3RAYA 2QPWA 3CBOA 3MO5A 5LSXA 4Z4PA 3K5KA 5KJLA 4QENA 3S7FA 5KJKA 5TEGA 4YNMA 3MEKA 2IGQA 3CBPA 1MT6A 3OXLA 3VUZA 5JHNA 4YPUA 3N71A 2G46A 5EX3A 3VV0A 4I51A 4MI5A 5EG2A 3F9XA 2R3AA 4AU7A 4NVQA 2BQZA 3KMJA 4WUYA 1MVHA 5CPRB 4RZ0A 1MVXA 4YNPA 3S7DA 4J83A 4QEPA 3OOIA 3BO5A 5AYFA 1N6CA 1XQHA 1PEGA 1O9SA 3HNAA 5ARGA 4J7FA 1N6AA 3CBMA 5CCLA 3PDNA 3M54A 2W5YA 3KMTA 3TG5A 5T5GA 5HQ8A 3OPEA 4IJDA 4JDSA 4E47A 3M56A 4LDGA 1H3IA 4IJ8A 3SW9A 5F6KC 3QWWA 5EX0A 3OXFA
chains in the Genus database with same CATH topology
3RU0A 4NJ5A 5ARFA 5F6LA 3M58A 3M57A 5T0MA 4JLGA 3MO2A 3IHXA 3S7BA 3OXGA 4O30A 3TG4A 3QWPA 3RJWA 5JINA 3KMAA 2JV0A 4O6FA 3EP0A 4H12A 5TH7A 3DALA 1ZKKA 3OS5A 5HI7A 2F69A 5JJ0A 4YPEA 3S8PA 3MO0A 4QEOA 2W5ZA 5LSZA 4BUPA 1ML9A 5TTFA 3F9ZA 1MUFA 3RQ4A 5KJNA 3M5AA 4J8OA 1N3JA 5JIYA 3F9YA 4YNDA 3RIBA 3SWCA 2RFIA 3F9WA 3FPDA 3QWVA 4FMUA 5CCMA 3M55A 3DB5A 5T0KA 3M53A 4MI0A 4C1QA 5F59A 3S7JA 5F5EA 2O8JA 4YPAA 5KJMA 3M59A 4J7IA 3RAYA 2QPWA 3CBOA 3MO5A 5LSXA 4Z4PA 3K5KA 5KJLA 4QENA 3S7FA 5KJKA 5TEGA 4YNMA 3MEKA 2IGQA 3CBPA 1MT6A 3OXLA 3VUZA 5JHNA 4YPUA 3N71A 2G46A 5EX3A 3VV0A 4I51A 4MI5A 5EG2A 3F9XA 2R3AA 4AU7A 4NVQA 2BQZA 3KMJA 4WUYA 1MVHA 5CPRB 4RZ0A 1MVXA 4YNPA 3S7DA 4J83A 4QEPA 3OOIA 3BO5A 5AYFA 1N6CA 1XQHA 1PEGA 1O9SA 3HNAA 5ARGA 4J7FA 1N6AA 3CBMA 5CCLA 3PDNA 3M54A 2W5YA 3KMTA 3TG5A 5T5GA 5HQ8A 3OPEA 4IJDA 4JDSA 4E47A 3M56A 4LDGA 1H3IA 4IJ8A 3SW9A 5F6KC 3QWWA 5EX0A 3OXFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RU0 A;  4NJ5 A;  5ARF A;  5F6L A;  3M58 A;  3M57 A;  5T0M A;  4JLG A;  3MO2 A;  3IHX A;  3S7B A;  3OXG A;  4O30 A;  3TG4 A;  3QWP A;  3RJW A;  5JIN A;  3KMA A;  2JV0 A;  4O6F A;  3EP0 A;  4H12 A;  5TH7 A;  3DAL A;  1ZKK A;  3OS5 A;  5HI7 A;  2F69 A;  5JJ0 A;  4YPE A;  3S8P A;  3MO0 A;  4QEO A;  2W5Z A;  5LSZ A;  4BUP A;  1ML9 A;  5TTF A;  3F9Z A;  1MUF A;  3RQ4 A;  5KJN A;  3M5A A;  4J8O A;  1N3J A;  5JIY A;  3F9Y A;  4YND A;  3RIB A;  3SWC A;  2RFI A;  3F9W A;  3FPD A;  3QWV A;  4FMU A;  5CCM A;  3M55 A;  3DB5 A;  5T0K A;  3M53 A;  4MI0 A;  4C1Q A;  5F59 A;  3S7J A;  5F5E A;  2O8J A;  4YPA A;  5KJM A;  3M59 A;  4J7I A;  3RAY A;  2QPW A;  3CBO A;  3MO5 A;  5LSX A;  4Z4P A;  3K5K A;  5KJL A;  4QEN A;  3S7F A;  5KJK A;  5TEG A;  4YNM A;  3MEK A;  2IGQ A;  3CBP A;  1MT6 A;  3OXL A;  3VUZ A;  5JHN A;  4YPU A;  3N71 A;  2G46 A;  5EX3 A;  3VV0 A;  4I51 A;  4MI5 A;  5EG2 A;  3F9X A;  2R3A A;  4AU7 A;  4NVQ A;  2BQZ A;  3KMJ A;  4WUY A;  1MVH A;  5CPR B;  4RZ0 A;  1MVX A;  4YNP A;  3S7D A;  4J83 A;  4QEP A;  3OOI A;  3BO5 A;  5AYF A;  1N6C A;  1XQH A;  1PEG A;  1O9S A;  3HNA A;  5ARG A;  4J7F A;  1N6A A;  3CBM A;  5CCL A;  3PDN A;  3M54 A;  2W5Y A;  3KMT A;  3TG5 A;  5T5G A;  5HQ8 A;  3OPE A;  4IJD A;  4JDS A;  4E47 A;  3M56 A;  4LDG A;  1H3I A;  4IJ8 A;  3SW9 A;  5F6K C;  3QWW A;  5EX0 A;  3OXF A; 
#chains in the Genus database with same CATH topology
 3RU0 A;  4NJ5 A;  5ARF A;  5F6L A;  3M58 A;  3M57 A;  5T0M A;  4JLG A;  3MO2 A;  3IHX A;  3S7B A;  3OXG A;  4O30 A;  3TG4 A;  3QWP A;  3RJW A;  5JIN A;  3KMA A;  2JV0 A;  4O6F A;  3EP0 A;  4H12 A;  5TH7 A;  3DAL A;  1ZKK A;  3OS5 A;  5HI7 A;  2F69 A;  5JJ0 A;  4YPE A;  3S8P A;  3MO0 A;  4QEO A;  2W5Z A;  5LSZ A;  4BUP A;  1ML9 A;  5TTF A;  3F9Z A;  1MUF A;  3RQ4 A;  5KJN A;  3M5A A;  4J8O A;  1N3J A;  5JIY A;  3F9Y A;  4YND A;  3RIB A;  3SWC A;  2RFI A;  3F9W A;  3FPD A;  3QWV A;  4FMU A;  5CCM A;  3M55 A;  3DB5 A;  5T0K A;  3M53 A;  4MI0 A;  4C1Q A;  5F59 A;  3S7J A;  5F5E A;  2O8J A;  4YPA A;  5KJM A;  3M59 A;  4J7I A;  3RAY A;  2QPW A;  3CBO A;  3MO5 A;  5LSX A;  4Z4P A;  3K5K A;  5KJL A;  4QEN A;  3S7F A;  5KJK A;  5TEG A;  4YNM A;  3MEK A;  2IGQ A;  3CBP A;  1MT6 A;  3OXL A;  3VUZ A;  5JHN A;  4YPU A;  3N71 A;  2G46 A;  5EX3 A;  3VV0 A;  4I51 A;  4MI5 A;  5EG2 A;  3F9X A;  2R3A A;  4AU7 A;  4NVQ A;  2BQZ A;  3KMJ A;  4WUY A;  1MVH A;  5CPR B;  4RZ0 A;  1MVX A;  4YNP A;  3S7D A;  4J83 A;  4QEP A;  3OOI A;  3BO5 A;  5AYF A;  1N6C A;  1XQH A;  1PEG A;  1O9S A;  3HNA A;  5ARG A;  4J7F A;  1N6A A;  3CBM A;  5CCL A;  3PDN A;  3M54 A;  2W5Y A;  3KMT A;  3TG5 A;  5T5G A;  5HQ8 A;  3OPE A;  4IJD A;  4JDS A;  4E47 A;  3M56 A;  4LDG A;  1H3I A;  4IJ8 A;  3SW9 A;  5F6K C;  3QWW A;  5EX0 A;  3OXF A; 
#chains in the Genus database with same CATH homology
 3RU0 A;  4NJ5 A;  5ARF A;  5F6L A;  3M58 A;  3M57 A;  5T0M A;  4JLG A;  3MO2 A;  3IHX A;  3S7B A;  3OXG A;  4O30 A;  3TG4 A;  3QWP A;  3RJW A;  5JIN A;  3KMA A;  2JV0 A;  4O6F A;  3EP0 A;  4H12 A;  5TH7 A;  3DAL A;  1ZKK A;  3OS5 A;  5HI7 A;  2F69 A;  5JJ0 A;  4YPE A;  3S8P A;  3MO0 A;  4QEO A;  2W5Z A;  5LSZ A;  4BUP A;  1ML9 A;  5TTF A;  3F9Z A;  1MUF A;  3RQ4 A;  5KJN A;  3M5A A;  4J8O A;  1N3J A;  5JIY A;  3F9Y A;  4YND A;  3RIB A;  3SWC A;  2RFI A;  3F9W A;  3FPD A;  3QWV A;  4FMU A;  5CCM A;  3M55 A;  3DB5 A;  5T0K A;  3M53 A;  4MI0 A;  4C1Q A;  5F59 A;  3S7J A;  5F5E A;  2O8J A;  4YPA A;  5KJM A;  3M59 A;  4J7I A;  3RAY A;  2QPW A;  3CBO A;  3MO5 A;  5LSX A;  4Z4P A;  3K5K A;  5KJL A;  4QEN A;  3S7F A;  5KJK A;  5TEG A;  4YNM A;  3MEK A;  2IGQ A;  3CBP A;  1MT6 A;  3OXL A;  3VUZ A;  5JHN A;  4YPU A;  3N71 A;  2G46 A;  5EX3 A;  3VV0 A;  4I51 A;  4MI5 A;  5EG2 A;  3F9X A;  2R3A A;  4AU7 A;  4NVQ A;  2BQZ A;  3KMJ A;  4WUY A;  1MVH A;  5CPR B;  4RZ0 A;  1MVX A;  4YNP A;  3S7D A;  4J83 A;  4QEP A;  3OOI A;  3BO5 A;  5AYF A;  1N6C A;  1XQH A;  1PEG A;  1O9S A;  3HNA A;  5ARG A;  4J7F A;  1N6A A;  3CBM A;  5CCL A;  3PDN A;  3M54 A;  2W5Y A;  3KMT A;  3TG5 A;  5T5G A;  5HQ8 A;  3OPE A;  4IJD A;  4JDS A;  4E47 A;  3M56 A;  4LDG A;  1H3I A;  4IJ8 A;  3SW9 A;  5F6K C;  3QWW A;  5EX0 A;  3OXF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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