5L58A

Crystal structure of iso-citrate dehydrogenase 1 [idh1 (r132h)] in complex with a novel inhibitor (compound 2)
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
412
structure length
376
Chain Sequence
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDAARVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGATDFVVPGPEITTYLVGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKKYDGRFKDIFQEIYDKQYKSQFAAAAIWYEHRLIDDMVAQAMKSEGGFIWACKNYVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Isocitrate dehydrogenase [NADP] cytoplasmic
publication title Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
pubmed rcsb
source organism Homo sapiens
total genus 132
structure length 376
sequence length 412
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2016-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 5l58A00
2UXQA 4L03A 3FLKA 1GC8A 1XKDA 1W0DA 4JA8A 5GREB 3TSNA 4BNPA 2Y3ZA 4XXVA 1VI1A 1G2UA 1PS7A 3VMLA 4AJSA 4XS3A 3VMKA 4L04A 3LXYA 5GREA 2QFWA 3U1HA 4I3KA 1XABA 3DMSA 4UMYA 3BLXB 4AJAA 5GRHA 2D4VA 3FMXX 2QFVA 1HQSA 3INMA 1PS6A 4ATYA 1V53A 1LWDA 3US8A 1IKAA 5HN3A 3TY4A 3TY3A 3VL7A 3WZXA 1DR0A 1V5BA 2Y41A 3BLXA 4KZOA 2ZTWA 5GRFA 5I96A 1CM7A 1IDEA 1IDCA 4P69C 4HCXA 5I95A 1XACA 4YB4A 5GRHB 1XADA 2IV0A 5J33A 1WALA 2Y40A 1YCOA 7ICDA 3LCBC 2QFXA 5LGEA 1VLCA 1T0LA 1XGVA 3AH3A 2AYQA 3R8WA 3VKZA 4F7IA 1PB3A 5L57A 1IDMA 5GRFB 8ICDA 1ISOA 1GC9A 3ASJA 4AJBA 9ICDA 1IDFA 3MASA 1IDDA 3WZWA 5ICDA 5K11A 6ICDA 1PTMA 3TNGA 5L58A 1HEXA 3ICDA 2DHTA 1IPDA 3WZVA 1DPZA 2E5MA 3WZYA 4XRXA 3BLVB 4I3LA 2E0CA 5GRIB 1P8FA 4Y1PA 2Y42A 4ICDA 1SJSA 5K10A 4AJ3A 5J32A 3MASB 1X0LA 4AOVA 3BLVA 5GRIA 4AJRA 1R8KA 3VL2A 1A05A 1CW1A 1DR8A 1GRPA 1CW7A 3VL3A 1HJ6A 5HN6A 1GROA 4AOYA 1OSIA 5DE1A 3VMJA 5J34A 4AJCA 3MAPA 2HI1A 1T09A 3UF6A 3MARA 4AOUA 5GRLB 1BL5A 1CNZA 2D1CA 1YXOA 3VL4A 2G4OA 2UXRA 3VL6A 4UMXA 1U7NA 5HN5A 4WUOA 1AI3A 1PB1A 2QFYA 4JQPA 5GRLA 1V94A 3UDUA 3UDOA 1OSJA 1TYOA 1WPWA 1XAAA 1ZORA 3U9EA 1AI2A 4IWHA 5HN4A 4L06A 1CW4A
chains in the Genus database with same CATH superfamily
2UXQA 4L03A 3FLKA 1GC8A 1XKDA 1W0DA 4JA8A 5GREB 3TSNA 4BNPA 2Y3ZA 4XXVA 1VI1A 1G2UA 1PS7A 3VMLA 4AJSA 4XS3A 3VMKA 4L04A 3LXYA 5GREA 2QFWA 3U1HA 4I3KA 1XABA 3DMSA 4UMYA 3BLXB 4AJAA 5GRHA 2D4VA 3FMXX 2QFVA 1HQSA 3INMA 1PS6A 4ATYA 1V53A 1LWDA 3US8A 1IKAA 5HN3A 3TY4A 3TY3A 3VL7A 3WZXA 1DR0A 1V5BA 2Y41A 3BLXA 4KZOA 2ZTWA 5GRFA 5I96A 1CM7A 1IDEA 1IDCA 4P69C 4HCXA 5I95A 1XACA 4YB4A 5GRHB 1XADA 2IV0A 5J33A 1WALA 2Y40A 1YCOA 7ICDA 3LCBC 2QFXA 5LGEA 1VLCA 1T0LA 1XGVA 3AH3A 2AYQA 3R8WA 3VKZA 4F7IA 1PB3A 5L57A 1IDMA 5GRFB 8ICDA 1ISOA 1GC9A 3ASJA 4AJBA 9ICDA 1IDFA 3MASA 1IDDA 3WZWA 5ICDA 5K11A 6ICDA 1PTMA 3TNGA 5L58A 1HEXA 3ICDA 2DHTA 1IPDA 3WZVA 1DPZA 2E5MA 3WZYA 4XRXA 3BLVB 4I3LA 2E0CA 5GRIB 1P8FA 4Y1PA 2Y42A 4ICDA 1SJSA 5K10A 4AJ3A 5J32A 3MASB 1X0LA 4AOVA 3BLVA 5GRIA 4AJRA 1R8KA 3VL2A 1A05A 1CW1A 1DR8A 1GRPA 1CW7A 3VL3A 1HJ6A 5HN6A 1GROA 4AOYA 1OSIA 5DE1A 3VMJA 5J34A 4AJCA 3MAPA 2HI1A 1T09A 3UF6A 3MARA 4AOUA 5GRLB 1BL5A 1CNZA 2D1CA 1YXOA 3VL4A 2G4OA 2UXRA 3VL6A 4UMXA 1U7NA 5HN5A 4WUOA 1AI3A 1PB1A 2QFYA 4JQPA 5GRLA 1V94A 3UDUA 3UDOA 1OSJA 1TYOA 1WPWA 1XAAA 1ZORA 3U9EA 1AI2A 4IWHA 5HN4A 4L06A 1CW4A
chains in the Genus database with same CATH topology
2UXQA 4L03A 3FLKA 1GC8A 1XKDA 1W0DA 4JA8A 5GREB 3TSNA 4BNPA 2Y3ZA 4XXVA 1VI1A 1G2UA 1PS7A 3VMLA 4AJSA 4XS3A 3VMKA 4L04A 3LXYA 5GREA 2QFWA 3U1HA 4I3KA 1XABA 3DMSA 4UMYA 3BLXB 4AJAA 5GRHA 2D4VA 3FMXX 2QFVA 1HQSA 3INMA 1PS6A 4ATYA 1V53A 1LWDA 3US8A 1IKAA 5HN3A 3TY4A 3TY3A 3VL7A 3WZXA 1DR0A 1V5BA 2Y41A 3BLXA 4KZOA 2ZTWA 5GRFA 5I96A 1CM7A 1IDEA 1IDCA 4P69C 4HCXA 5I95A 1XACA 4YB4A 5GRHB 1XADA 2IV0A 5J33A 1WALA 2Y40A 1YCOA 7ICDA 3LCBC 2QFXA 5LGEA 1VLCA 1T0LA 1XGVA 3AH3A 2AYQA 3R8WA 3VKZA 4F7IA 1PB3A 5L57A 1IDMA 5GRFB 8ICDA 1ISOA 1GC9A 3ASJA 4AJBA 9ICDA 1IDFA 3MASA 1IDDA 3WZWA 5ICDA 5K11A 6ICDA 1PTMA 3TNGA 5L58A 1HEXA 3ICDA 2DHTA 1IPDA 3WZVA 1DPZA 2E5MA 3WZYA 4XRXA 3BLVB 4I3LA 2E0CA 5GRIB 1P8FA 4Y1PA 2Y42A 4ICDA 1SJSA 5K10A 4AJ3A 5J32A 3MASB 1X0LA 4AOVA 3BLVA 5GRIA 4AJRA 1R8KA 3VL2A 1A05A 1CW1A 1DR8A 1GRPA 1CW7A 3VL3A 1HJ6A 5HN6A 1GROA 4AOYA 1OSIA 5DE1A 3VMJA 5J34A 4AJCA 3MAPA 2HI1A 1T09A 3UF6A 3MARA 4AOUA 5GRLB 1BL5A 1CNZA 2D1CA 1YXOA 3VL4A 2G4OA 2UXRA 3VL6A 4UMXA 1U7NA 5HN5A 4WUOA 1AI3A 1PB1A 2QFYA 4JQPA 5GRLA 1V94A 3UDUA 3UDOA 1OSJA 1TYOA 1WPWA 1XAAA 1ZORA 3U9EA 1AI2A 4IWHA 5HN4A 4L06A 1CW4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2UXQ A;  4L03 A;  3FLK A;  1GC8 A;  1XKD A;  1W0D A;  4JA8 A;  5GRE B;  3TSN A;  4BNP A;  2Y3Z A;  4XXV A;  1VI1 A;  1G2U A;  1PS7 A;  3VML A;  4AJS A;  4XS3 A;  3VMK A;  4L04 A;  3LXY A;  5GRE A;  2QFW A;  3U1H A;  4I3K A;  1XAB A;  3DMS A;  4UMY A;  3BLX B;  4AJA A;  5GRH A;  2D4V A;  3FMX X;  2QFV A;  1HQS A;  3INM A;  1PS6 A;  4ATY A;  1V53 A;  1LWD A;  3US8 A;  1IKA A;  5HN3 A;  3TY4 A;  3TY3 A;  3VL7 A;  3WZX A;  1DR0 A;  1V5B A;  2Y41 A;  3BLX A;  4KZO A;  2ZTW A;  5GRF A;  5I96 A;  1CM7 A;  1IDE A;  1IDC A;  4P69 C;  4HCX A;  5I95 A;  1XAC A;  4YB4 A;  5GRH B;  1XAD A;  2IV0 A;  5J33 A;  1WAL A;  2Y40 A;  1YCO A;  7ICD A;  3LCB C;  2QFX A;  5LGE A;  1VLC A;  1T0L A;  1XGV A;  3AH3 A;  2AYQ A;  3R8W A;  3VKZ A;  4F7I A;  1PB3 A;  5L57 A;  1IDM A;  5GRF B;  8ICD A;  1ISO A;  1GC9 A;  3ASJ A;  4AJB A;  9ICD A;  1IDF A;  3MAS A;  1IDD A;  3WZW A;  5ICD A;  5K11 A;  6ICD A;  1PTM A;  3TNG A;  5L58 A;  1HEX A;  3ICD A;  2DHT A;  1IPD A;  3WZV A;  1DPZ A;  2E5M A;  3WZY A;  4XRX A;  3BLV B;  4I3L A;  2E0C A;  5GRI B;  1P8F A;  4Y1P A;  2Y42 A;  4ICD A;  1SJS A;  5K10 A;  4AJ3 A;  5J32 A;  3MAS B;  1X0L A;  4AOV A;  3BLV A;  5GRI A;  4AJR A;  1R8K A;  3VL2 A;  1A05 A;  1CW1 A;  1DR8 A;  1GRP A;  1CW7 A;  3VL3 A;  1HJ6 A;  5HN6 A;  1GRO A;  4AOY A;  1OSI A;  5DE1 A;  3VMJ A;  5J34 A;  4AJC A;  3MAP A;  2HI1 A;  1T09 A;  3UF6 A;  3MAR A;  4AOU A;  5GRL B;  1BL5 A;  1CNZ A;  2D1C A;  1YXO A;  3VL4 A;  2G4O A;  2UXR A;  3VL6 A;  4UMX A;  1U7N A;  5HN5 A;  4WUO A;  1AI3 A;  1PB1 A;  2QFY A;  4JQP A;  5GRL A;  1V94 A;  3UDU A;  3UDO A;  1OSJ A;  1TYO A;  1WPW A;  1XAA A;  1ZOR A;  3U9E A;  1AI2 A;  4IWH A;  5HN4 A;  4L06 A;  1CW4 A; 
#chains in the Genus database with same CATH topology
 2UXQ A;  4L03 A;  3FLK A;  1GC8 A;  1XKD A;  1W0D A;  4JA8 A;  5GRE B;  3TSN A;  4BNP A;  2Y3Z A;  4XXV A;  1VI1 A;  1G2U A;  1PS7 A;  3VML A;  4AJS A;  4XS3 A;  3VMK A;  4L04 A;  3LXY A;  5GRE A;  2QFW A;  3U1H A;  4I3K A;  1XAB A;  3DMS A;  4UMY A;  3BLX B;  4AJA A;  5GRH A;  2D4V A;  3FMX X;  2QFV A;  1HQS A;  3INM A;  1PS6 A;  4ATY A;  1V53 A;  1LWD A;  3US8 A;  1IKA A;  5HN3 A;  3TY4 A;  3TY3 A;  3VL7 A;  3WZX A;  1DR0 A;  1V5B A;  2Y41 A;  3BLX A;  4KZO A;  2ZTW A;  5GRF A;  5I96 A;  1CM7 A;  1IDE A;  1IDC A;  4P69 C;  4HCX A;  5I95 A;  1XAC A;  4YB4 A;  5GRH B;  1XAD A;  2IV0 A;  5J33 A;  1WAL A;  2Y40 A;  1YCO A;  7ICD A;  3LCB C;  2QFX A;  5LGE A;  1VLC A;  1T0L A;  1XGV A;  3AH3 A;  2AYQ A;  3R8W A;  3VKZ A;  4F7I A;  1PB3 A;  5L57 A;  1IDM A;  5GRF B;  8ICD A;  1ISO A;  1GC9 A;  3ASJ A;  4AJB A;  9ICD A;  1IDF A;  3MAS A;  1IDD A;  3WZW A;  5ICD A;  5K11 A;  6ICD A;  1PTM A;  3TNG A;  5L58 A;  1HEX A;  3ICD A;  2DHT A;  1IPD A;  3WZV A;  1DPZ A;  2E5M A;  3WZY A;  4XRX A;  3BLV B;  4I3L A;  2E0C A;  5GRI B;  1P8F A;  4Y1P A;  2Y42 A;  4ICD A;  1SJS A;  5K10 A;  4AJ3 A;  5J32 A;  3MAS B;  1X0L A;  4AOV A;  3BLV A;  5GRI A;  4AJR A;  1R8K A;  3VL2 A;  1A05 A;  1CW1 A;  1DR8 A;  1GRP A;  1CW7 A;  3VL3 A;  1HJ6 A;  5HN6 A;  1GRO A;  4AOY A;  1OSI A;  5DE1 A;  3VMJ A;  5J34 A;  4AJC A;  3MAP A;  2HI1 A;  1T09 A;  3UF6 A;  3MAR A;  4AOU A;  5GRL B;  1BL5 A;  1CNZ A;  2D1C A;  1YXO A;  3VL4 A;  2G4O A;  2UXR A;  3VL6 A;  4UMX A;  1U7N A;  5HN5 A;  4WUO A;  1AI3 A;  1PB1 A;  2QFY A;  4JQP A;  5GRL A;  1V94 A;  3UDU A;  3UDO A;  1OSJ A;  1TYO A;  1WPW A;  1XAA A;  1ZOR A;  3U9E A;  1AI2 A;  4IWH A;  5HN4 A;  4L06 A;  1CW4 A; 
#chains in the Genus database with same CATH homology
 2UXQ A;  4L03 A;  3FLK A;  1GC8 A;  1XKD A;  1W0D A;  4JA8 A;  5GRE B;  3TSN A;  4BNP A;  2Y3Z A;  4XXV A;  1VI1 A;  1G2U A;  1PS7 A;  3VML A;  4AJS A;  4XS3 A;  3VMK A;  4L04 A;  3LXY A;  5GRE A;  2QFW A;  3U1H A;  4I3K A;  1XAB A;  3DMS A;  4UMY A;  3BLX B;  4AJA A;  5GRH A;  2D4V A;  3FMX X;  2QFV A;  1HQS A;  3INM A;  1PS6 A;  4ATY A;  1V53 A;  1LWD A;  3US8 A;  1IKA A;  5HN3 A;  3TY4 A;  3TY3 A;  3VL7 A;  3WZX A;  1DR0 A;  1V5B A;  2Y41 A;  3BLX A;  4KZO A;  2ZTW A;  5GRF A;  5I96 A;  1CM7 A;  1IDE A;  1IDC A;  4P69 C;  4HCX A;  5I95 A;  1XAC A;  4YB4 A;  5GRH B;  1XAD A;  2IV0 A;  5J33 A;  1WAL A;  2Y40 A;  1YCO A;  7ICD A;  3LCB C;  2QFX A;  5LGE A;  1VLC A;  1T0L A;  1XGV A;  3AH3 A;  2AYQ A;  3R8W A;  3VKZ A;  4F7I A;  1PB3 A;  5L57 A;  1IDM A;  5GRF B;  8ICD A;  1ISO A;  1GC9 A;  3ASJ A;  4AJB A;  9ICD A;  1IDF A;  3MAS A;  1IDD A;  3WZW A;  5ICD A;  5K11 A;  6ICD A;  1PTM A;  3TNG A;  5L58 A;  1HEX A;  3ICD A;  2DHT A;  1IPD A;  3WZV A;  1DPZ A;  2E5M A;  3WZY A;  4XRX A;  3BLV B;  4I3L A;  2E0C A;  5GRI B;  1P8F A;  4Y1P A;  2Y42 A;  4ICD A;  1SJS A;  5K10 A;  4AJ3 A;  5J32 A;  3MAS B;  1X0L A;  4AOV A;  3BLV A;  5GRI A;  4AJR A;  1R8K A;  3VL2 A;  1A05 A;  1CW1 A;  1DR8 A;  1GRP A;  1CW7 A;  3VL3 A;  1HJ6 A;  5HN6 A;  1GRO A;  4AOY A;  1OSI A;  5DE1 A;  3VMJ A;  5J34 A;  4AJC A;  3MAP A;  2HI1 A;  1T09 A;  3UF6 A;  3MAR A;  4AOU A;  5GRL B;  1BL5 A;  1CNZ A;  2D1C A;  1YXO A;  3VL4 A;  2G4O A;  2UXR A;  3VL6 A;  4UMX A;  1U7N A;  5HN5 A;  4WUO A;  1AI3 A;  1PB1 A;  2QFY A;  4JQP A;  5GRL A;  1V94 A;  3UDU A;  3UDO A;  1OSJ A;  1TYO A;  1WPW A;  1XAA A;  1ZOR A;  3U9E A;  1AI2 A;  4IWH A;  5HN4 A;  4L06 A;  1CW4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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