5LXBA

Crystal structure of a mutant binding protein (5htbp-achbp) in complex with palonosetron
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
205
structure length
205
Chain Sequence
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDLVYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
pubmed doi rcsb
molecule tags Acetylcholine binding protein
source organism Aplysia californica
molecule keywords Soluble acetylcholine receptor
total genus 49
structure length 205
sequence length 205
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2016-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5lxbA00
2XYSA 3WTHA 3RIAA 2XNVA 4F8HA 5CFBA 4UM1A 2Y54A 4IL4A 4DBMA 2YKSA 4ZRUA 5AINA 2VL0A 5TVCA 4X5TA 3U8KA 3RQUA 3UU5A 3U8LA 3TLSA 5HEJA 5J0ZA 4HFEA 2Y7YA 4HFBA 4ZZBA 5AFHA 3U8MA 4TWDA 3PEOA 5L4HA 4HFHA 3UQ4A 2BYSA 4A98A 4TNWA 2XQ9A 2XQAA 3C84A 3UU6A 5J5HA 5AFMA 2XQ8A 2BG9E 4Z91A 4NPPA 3WTLA 4EZ1A 2Y56A 4ILCA 4QABA 4WV9A 5AFKA 3IGQA 2XQ3A 4PIRA 4ZZCA 3EHZA 4ZK1A 3P50A 3WTIA 2ZJVA 3TLVA 4XK9A 4B5DA 5J5GA 3TLWA 2XNUA 4LMLA 4FRRA 3SH1A 2PGZA 2WZYA 3JADA 3PMZA 2Y58A 5HEUA 4UM3A 2PH9A 2BYNA 2YMEA 3JAEA 4LMJA 2BYQA 4QACA 4LMKA 2BG9C 3ZDHA 4QAAA 2XZ6A 2X00A 5IUXA 4AFGA 2YOEA 5L47A 2YN6A 2XZ5A 3UU3A 1I9BA 3U8JA 3WTKA 5JMEA 5LG3A 3JAFA 2WN9A 2WNLA 5BRXA 2XQ4A 5AFLA 3U8NA 2BG9A 4HQPA 4XHEA 5LXBA 4TWHA 3C79A 5HCMA 2XYTA 4BFQA 4HFIA 1UX2A 2BR7A 5BW2A 2W8GA 4TNVA 5AFMB 5J5IA 3UQ7A 3T4MA 4UM3S 4IREA 3WTJA 2XQ5A 4Z90A 3ZDGA 5AFNA 3ZKRA 2WNJA 2W8FA 3RIFA 2X00D 4UM3P 5CO5A 2XQ6A 2Y57A 4AFHA 5KZUA 4ZJTA 4A97A 2ZJUA 4NZBA 4HFCA 3UUBA 5SYOA 3WTNA 3SQ6A 2WNCA 4BQTA 2XQ7A 4COFA 5HCJA 5FJVA 4QH5A 3P4WA 4QH1A 3RQWA 2XNTA 4ALXA 3GUAA 4UY2A 5HEGA 4ZK4A 3LSVA 3RHWA 4ILBA 2BR8A 3UU8A 3WTMA 4QH4A 4HFDA 2BYRA 5L4EA 3WTOA 2BJ0A 3EI0A 1UV6A 2YMDA 2BYPA 2C9TA 5AFJA 4TWFA 3TLTA 3EAMA 4IL9A 2BG9B 4ILAA 3SIOA 5KE4A 3WIPA 4D01A 1UW6A 5BP0A 5HEOA 5HEHA 2QC1B 3TLUA 3RI5A 4UXUA 3UU4A 4ZR6A 4AFTA 3SQ9A 5J5FA 2UZ6A 4ZJSA
chains in the Genus database with same CATH superfamily
2XYSA 3WTHA 3RIAA 2XNVA 4F8HA 5CFBA 4UM1A 2Y54A 4IL4A 4DBMA 2YKSA 4ZRUA 5AINA 2VL0A 5TVCA 4X5TA 3U8KA 3RQUA 3UU5A 3U8LA 3TLSA 5HEJA 5J0ZA 4HFEA 2Y7YA 4HFBA 4ZZBA 5AFHA 3U8MA 4TWDA 3PEOA 5L4HA 4HFHA 3UQ4A 2BYSA 4A98A 4TNWA 2XQ9A 2XQAA 3C84A 3UU6A 5J5HA 5AFMA 2XQ8A 2BG9E 4Z91A 4NPPA 3WTLA 4EZ1A 2Y56A 4ILCA 4QABA 4WV9A 5AFKA 3IGQA 2XQ3A 4PIRA 4ZZCA 3EHZA 4ZK1A 3P50A 3WTIA 2ZJVA 3TLVA 4XK9A 4B5DA 5J5GA 3TLWA 2XNUA 4LMLA 4FRRA 3SH1A 2PGZA 2WZYA 3JADA 3PMZA 2Y58A 5HEUA 4UM3A 2PH9A 2BYNA 2YMEA 3JAEA 4LMJA 2BYQA 4QACA 4LMKA 2BG9C 3ZDHA 4QAAA 2XZ6A 2X00A 5IUXA 4AFGA 2YOEA 5L47A 2YN6A 2XZ5A 3UU3A 1I9BA 3U8JA 3WTKA 5JMEA 5LG3A 3JAFA 2WN9A 2WNLA 5BRXA 2XQ4A 5AFLA 3U8NA 2BG9A 4HQPA 4XHEA 5LXBA 4TWHA 3C79A 5HCMA 2XYTA 4BFQA 4HFIA 1UX2A 2BR7A 5BW2A 2W8GA 4TNVA 5AFMB 5J5IA 3UQ7A 3T4MA 4UM3S 4IREA 3WTJA 2XQ5A 4Z90A 3ZDGA 5AFNA 3ZKRA 2WNJA 2W8FA 3RIFA 2X00D 4UM3P 5CO5A 2XQ6A 2Y57A 4AFHA 5KZUA 4ZJTA 4A97A 2ZJUA 4NZBA 4HFCA 3UUBA 5SYOA 3WTNA 3SQ6A 2WNCA 4BQTA 2XQ7A 4COFA 5HCJA 5FJVA 4QH5A 3P4WA 4QH1A 3RQWA 2XNTA 4ALXA 3GUAA 4UY2A 5HEGA 4ZK4A 3LSVA 3RHWA 4ILBA 2BR8A 3UU8A 3WTMA 4QH4A 4HFDA 2BYRA 5L4EA 3WTOA 2BJ0A 3EI0A 1UV6A 2YMDA 2BYPA 2C9TA 5AFJA 4TWFA 3TLTA 3EAMA 4IL9A 2BG9B 4ILAA 3SIOA 5KE4A 3WIPA 4D01A 1UW6A 5BP0A 5HEOA 5HEHA 2QC1B 3TLUA 3RI5A 4UXUA 3UU4A 4ZR6A 4AFTA 3SQ9A 5J5FA 2UZ6A 4ZJSA
chains in the Genus database with same CATH topology
2XYSA 3WTHA 3RIAA 2XNVA 4F8HA 5CFBA 4UM1A 2Y54A 4IL4A 4DBMA 2YKSA 4ZRUA 5AINA 2VL0A 5TVCA 4X5TA 3U8KA 3RQUA 3UU5A 3U8LA 3TLSA 5HEJA 5J0ZA 4HFEA 2Y7YA 4HFBA 4ZZBA 5AFHA 3U8MA 4TWDA 3PEOA 5L4HA 4HFHA 3UQ4A 2BYSA 4A98A 4TNWA 2XQ9A 2XQAA 3C84A 3UU6A 5J5HA 5AFMA 2XQ8A 2BG9E 4Z91A 4NPPA 3WTLA 4EZ1A 2Y56A 4ILCA 4QABA 4WV9A 5AFKA 3IGQA 2XQ3A 4PIRA 4ZZCA 3EHZA 4ZK1A 3P50A 3WTIA 2ZJVA 3TLVA 4XK9A 4B5DA 5J5GA 3TLWA 2XNUA 4LMLA 4FRRA 3SH1A 2PGZA 2WZYA 3JADA 3PMZA 2Y58A 5HEUA 4UM3A 2PH9A 2BYNA 2YMEA 3JAEA 4LMJA 2BYQA 4QACA 4LMKA 2BG9C 3ZDHA 4QAAA 2XZ6A 2X00A 5IUXA 4AFGA 2YOEA 5L47A 2YN6A 2XZ5A 3UU3A 1I9BA 3U8JA 3WTKA 5JMEA 5LG3A 3JAFA 2WN9A 2WNLA 5BRXA 2XQ4A 5AFLA 3U8NA 2BG9A 4HQPA 4XHEA 5LXBA 4TWHA 3C79A 5HCMA 2XYTA 4BFQA 4HFIA 1UX2A 2BR7A 5BW2A 2W8GA 4TNVA 5AFMB 5J5IA 3UQ7A 3T4MA 4UM3S 4IREA 3WTJA 2XQ5A 4Z90A 3ZDGA 5AFNA 3ZKRA 2WNJA 2W8FA 3RIFA 2X00D 4UM3P 5CO5A 2XQ6A 2Y57A 4AFHA 5KZUA 4ZJTA 4A97A 2ZJUA 4NZBA 4HFCA 3UUBA 5SYOA 3WTNA 3SQ6A 2WNCA 4BQTA 2XQ7A 4COFA 5HCJA 5FJVA 4QH5A 3P4WA 4QH1A 3RQWA 2XNTA 4ALXA 3GUAA 4UY2A 5HEGA 4ZK4A 3LSVA 3RHWA 4ILBA 2BR8A 3UU8A 3WTMA 4QH4A 4HFDA 2BYRA 5L4EA 3WTOA 2BJ0A 3EI0A 1UV6A 2YMDA 2BYPA 2C9TA 5AFJA 4TWFA 3TLTA 3EAMA 4IL9A 2BG9B 4ILAA 3SIOA 5KE4A 3WIPA 4D01A 1UW6A 5BP0A 5HEOA 5HEHA 2QC1B 3TLUA 3RI5A 4UXUA 3UU4A 4ZR6A 4AFTA 3SQ9A 5J5FA 2UZ6A 4ZJSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XYS A;  3WTH A;  3RIA A;  2XNV A;  4F8H A;  5CFB A;  4UM1 A;  2Y54 A;  4IL4 A;  4DBM A;  2YKS A;  4ZRU A;  5AIN A;  2VL0 A;  5TVC A;  4X5T A;  3U8K A;  3RQU A;  3UU5 A;  3U8L A;  3TLS A;  5HEJ A;  5J0Z A;  4HFE A;  2Y7Y A;  4HFB A;  4ZZB A;  5AFH A;  3U8M A;  4TWD A;  3PEO A;  5L4H A;  4HFH A;  3UQ4 A;  2BYS A;  4A98 A;  4TNW A;  2XQ9 A;  2XQA A;  3C84 A;  3UU6 A;  5J5H A;  5AFM A;  2XQ8 A;  2BG9 E;  4Z91 A;  4NPP A;  3WTL A;  4EZ1 A;  2Y56 A;  4ILC A;  4QAB A;  4WV9 A;  5AFK A;  3IGQ A;  2XQ3 A;  4PIR A;  4ZZC A;  3EHZ A;  4ZK1 A;  3P50 A;  3WTI A;  2ZJV A;  3TLV A;  4XK9 A;  4B5D A;  5J5G A;  3TLW A;  2XNU A;  4LML A;  4FRR A;  3SH1 A;  2PGZ A;  2WZY A;  3JAD A;  3PMZ A;  2Y58 A;  5HEU A;  4UM3 A;  2PH9 A;  2BYN A;  2YME A;  3JAE A;  4LMJ A;  2BYQ A;  4QAC A;  4LMK A;  2BG9 C;  3ZDH A;  4QAA A;  2XZ6 A;  2X00 A;  5IUX A;  4AFG A;  2YOE A;  5L47 A;  2YN6 A;  2XZ5 A;  3UU3 A;  1I9B A;  3U8J A;  3WTK A;  5JME A;  5LG3 A;  3JAF A;  2WN9 A;  2WNL A;  5BRX A;  2XQ4 A;  5AFL A;  3U8N A;  2BG9 A;  4HQP A;  4XHE A;  5LXB A;  4TWH A;  3C79 A;  5HCM A;  2XYT A;  4BFQ A;  4HFI A;  1UX2 A;  2BR7 A;  5BW2 A;  2W8G A;  4TNV A;  5AFM B;  5J5I A;  3UQ7 A;  3T4M A;  4UM3 S;  4IRE A;  3WTJ A;  2XQ5 A;  4Z90 A;  3ZDG A;  5AFN A;  3ZKR A;  2WNJ A;  2W8F A;  3RIF A;  2X00 D;  4UM3 P;  5CO5 A;  2XQ6 A;  2Y57 A;  4AFH A;  5KZU A;  4ZJT A;  4A97 A;  2ZJU A;  4NZB A;  4HFC A;  3UUB A;  5SYO A;  3WTN A;  3SQ6 A;  2WNC A;  4BQT A;  2XQ7 A;  4COF A;  5HCJ A;  5FJV A;  4QH5 A;  3P4W A;  4QH1 A;  3RQW A;  2XNT A;  4ALX A;  3GUA A;  4UY2 A;  5HEG A;  4ZK4 A;  3LSV A;  3RHW A;  4ILB A;  2BR8 A;  3UU8 A;  3WTM A;  4QH4 A;  4HFD A;  2BYR A;  5L4E A;  3WTO A;  2BJ0 A;  3EI0 A;  1UV6 A;  2YMD A;  2BYP A;  2C9T A;  5AFJ A;  4TWF A;  3TLT A;  3EAM A;  4IL9 A;  2BG9 B;  4ILA A;  3SIO A;  5KE4 A;  3WIP A;  4D01 A;  1UW6 A;  5BP0 A;  5HEO A;  5HEH A;  2QC1 B;  3TLU A;  3RI5 A;  4UXU A;  3UU4 A;  4ZR6 A;  4AFT A;  3SQ9 A;  5J5F A;  2UZ6 A;  4ZJS A; 
#chains in the Genus database with same CATH topology
 2XYS A;  3WTH A;  3RIA A;  2XNV A;  4F8H A;  5CFB A;  4UM1 A;  2Y54 A;  4IL4 A;  4DBM A;  2YKS A;  4ZRU A;  5AIN A;  2VL0 A;  5TVC A;  4X5T A;  3U8K A;  3RQU A;  3UU5 A;  3U8L A;  3TLS A;  5HEJ A;  5J0Z A;  4HFE A;  2Y7Y A;  4HFB A;  4ZZB A;  5AFH A;  3U8M A;  4TWD A;  3PEO A;  5L4H A;  4HFH A;  3UQ4 A;  2BYS A;  4A98 A;  4TNW A;  2XQ9 A;  2XQA A;  3C84 A;  3UU6 A;  5J5H A;  5AFM A;  2XQ8 A;  2BG9 E;  4Z91 A;  4NPP A;  3WTL A;  4EZ1 A;  2Y56 A;  4ILC A;  4QAB A;  4WV9 A;  5AFK A;  3IGQ A;  2XQ3 A;  4PIR A;  4ZZC A;  3EHZ A;  4ZK1 A;  3P50 A;  3WTI A;  2ZJV A;  3TLV A;  4XK9 A;  4B5D A;  5J5G A;  3TLW A;  2XNU A;  4LML A;  4FRR A;  3SH1 A;  2PGZ A;  2WZY A;  3JAD A;  3PMZ A;  2Y58 A;  5HEU A;  4UM3 A;  2PH9 A;  2BYN A;  2YME A;  3JAE A;  4LMJ A;  2BYQ A;  4QAC A;  4LMK A;  2BG9 C;  3ZDH A;  4QAA A;  2XZ6 A;  2X00 A;  5IUX A;  4AFG A;  2YOE A;  5L47 A;  2YN6 A;  2XZ5 A;  3UU3 A;  1I9B A;  3U8J A;  3WTK A;  5JME A;  5LG3 A;  3JAF A;  2WN9 A;  2WNL A;  5BRX A;  2XQ4 A;  5AFL A;  3U8N A;  2BG9 A;  4HQP A;  4XHE A;  5LXB A;  4TWH A;  3C79 A;  5HCM A;  2XYT A;  4BFQ A;  4HFI A;  1UX2 A;  2BR7 A;  5BW2 A;  2W8G A;  4TNV A;  5AFM B;  5J5I A;  3UQ7 A;  3T4M A;  4UM3 S;  4IRE A;  3WTJ A;  2XQ5 A;  4Z90 A;  3ZDG A;  5AFN A;  3ZKR A;  2WNJ A;  2W8F A;  3RIF A;  2X00 D;  4UM3 P;  5CO5 A;  2XQ6 A;  2Y57 A;  4AFH A;  5KZU A;  4ZJT A;  4A97 A;  2ZJU A;  4NZB A;  4HFC A;  3UUB A;  5SYO A;  3WTN A;  3SQ6 A;  2WNC A;  4BQT A;  2XQ7 A;  4COF A;  5HCJ A;  5FJV A;  4QH5 A;  3P4W A;  4QH1 A;  3RQW A;  2XNT A;  4ALX A;  3GUA A;  4UY2 A;  5HEG A;  4ZK4 A;  3LSV A;  3RHW A;  4ILB A;  2BR8 A;  3UU8 A;  3WTM A;  4QH4 A;  4HFD A;  2BYR A;  5L4E A;  3WTO A;  2BJ0 A;  3EI0 A;  1UV6 A;  2YMD A;  2BYP A;  2C9T A;  5AFJ A;  4TWF A;  3TLT A;  3EAM A;  4IL9 A;  2BG9 B;  4ILA A;  3SIO A;  5KE4 A;  3WIP A;  4D01 A;  1UW6 A;  5BP0 A;  5HEO A;  5HEH A;  2QC1 B;  3TLU A;  3RI5 A;  4UXU A;  3UU4 A;  4ZR6 A;  4AFT A;  3SQ9 A;  5J5F A;  2UZ6 A;  4ZJS A; 
#chains in the Genus database with same CATH homology
 2XYS A;  3WTH A;  3RIA A;  2XNV A;  4F8H A;  5CFB A;  4UM1 A;  2Y54 A;  4IL4 A;  4DBM A;  2YKS A;  4ZRU A;  5AIN A;  2VL0 A;  5TVC A;  4X5T A;  3U8K A;  3RQU A;  3UU5 A;  3U8L A;  3TLS A;  5HEJ A;  5J0Z A;  4HFE A;  2Y7Y A;  4HFB A;  4ZZB A;  5AFH A;  3U8M A;  4TWD A;  3PEO A;  5L4H A;  4HFH A;  3UQ4 A;  2BYS A;  4A98 A;  4TNW A;  2XQ9 A;  2XQA A;  3C84 A;  3UU6 A;  5J5H A;  5AFM A;  2XQ8 A;  2BG9 E;  4Z91 A;  4NPP A;  3WTL A;  4EZ1 A;  2Y56 A;  4ILC A;  4QAB A;  4WV9 A;  5AFK A;  3IGQ A;  2XQ3 A;  4PIR A;  4ZZC A;  3EHZ A;  4ZK1 A;  3P50 A;  3WTI A;  2ZJV A;  3TLV A;  4XK9 A;  4B5D A;  5J5G A;  3TLW A;  2XNU A;  4LML A;  4FRR A;  3SH1 A;  2PGZ A;  2WZY A;  3JAD A;  3PMZ A;  2Y58 A;  5HEU A;  4UM3 A;  2PH9 A;  2BYN A;  2YME A;  3JAE A;  4LMJ A;  2BYQ A;  4QAC A;  4LMK A;  2BG9 C;  3ZDH A;  4QAA A;  2XZ6 A;  2X00 A;  5IUX A;  4AFG A;  2YOE A;  5L47 A;  2YN6 A;  2XZ5 A;  3UU3 A;  1I9B A;  3U8J A;  3WTK A;  5JME A;  5LG3 A;  3JAF A;  2WN9 A;  2WNL A;  5BRX A;  2XQ4 A;  5AFL A;  3U8N A;  2BG9 A;  4HQP A;  4XHE A;  5LXB A;  4TWH A;  3C79 A;  5HCM A;  2XYT A;  4BFQ A;  4HFI A;  1UX2 A;  2BR7 A;  5BW2 A;  2W8G A;  4TNV A;  5AFM B;  5J5I A;  3UQ7 A;  3T4M A;  4UM3 S;  4IRE A;  3WTJ A;  2XQ5 A;  4Z90 A;  3ZDG A;  5AFN A;  3ZKR A;  2WNJ A;  2W8F A;  3RIF A;  2X00 D;  4UM3 P;  5CO5 A;  2XQ6 A;  2Y57 A;  4AFH A;  5KZU A;  4ZJT A;  4A97 A;  2ZJU A;  4NZB A;  4HFC A;  3UUB A;  5SYO A;  3WTN A;  3SQ6 A;  2WNC A;  4BQT A;  2XQ7 A;  4COF A;  5HCJ A;  5FJV A;  4QH5 A;  3P4W A;  4QH1 A;  3RQW A;  2XNT A;  4ALX A;  3GUA A;  4UY2 A;  5HEG A;  4ZK4 A;  3LSV A;  3RHW A;  4ILB A;  2BR8 A;  3UU8 A;  3WTM A;  4QH4 A;  4HFD A;  2BYR A;  5L4E A;  3WTO A;  2BJ0 A;  3EI0 A;  1UV6 A;  2YMD A;  2BYP A;  2C9T A;  5AFJ A;  4TWF A;  3TLT A;  3EAM A;  4IL9 A;  2BG9 B;  4ILA A;  3SIO A;  5KE4 A;  3WIP A;  4D01 A;  1UW6 A;  5BP0 A;  5HEO A;  5HEH A;  2QC1 B;  3TLU A;  3RI5 A;  4UXU A;  3UU4 A;  4ZR6 A;  4AFT A;  3SQ9 A;  5J5F A;  2UZ6 A;  4ZJS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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