5SYOA

Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp) containing loop c from the human alpha 3 nicotinic acetylcholine receptor in complex with cytisine
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
207
structure length
199
Chain Sequence
LHSQANLMRLKSDLFYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQYKHDIKYEEIYPDVVLVVKFRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with Cytisine
rcsb
molecule keywords Soluble acetylcholine receptor, Neuronal acetylcholine recep
molecule tags Acetylcholine-binding protein
source organism Aplysia californica, homo sapiens
total genus 46
structure length 199
sequence length 207
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2016-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5syoA00
2BG9C 3RQUA 4BFQA 2UZ6A 4QABA 4XK9A 4F8HA 2WNJA 3JAFA 2YMEA 4QH4A 2XQ4A 3PEOA 4ZR6A 4HFBA 3TLUA 5HEJA 4TNVA 4TWHA 4Z91A 3U8NA 4A97A 4HFHA 1UV6A 2XYSA 2ZJUA 4TNWA 4ZRUA 2PGZA 3SIOA 2XQ5A 3UU5A 2XQ3A 1UW6A 3TLWA 4ZZCA 4UM1A 4X5TA 5AFMA 5KZUA 4HFIA 3P50A 5HEGA 3UU6A 4HFEA 5J5IA 4D01A 3IGQA 2BG9A 3EAMA 2XQAA 3LSVA 3U8MA 2XNVA 2XQ6A 4IL4A 3TLVA 3WTIA 5AFLA 3UQ7A 4QH1A 5HCMA 4ZZBA 3WTOA 2XNTA 4B5DA 5CFBA 2W8FA 5AFJA 5LXBA 2BYRA 5HEHA 2WNCA 2Y56A 4ILAA 5J5FA 2Y54A 3JAEA 5TVCA 3GUAA 3RQWA 3WTNA 2PH9A 4TWDA 3U8LA 3P4WA 2X00D 3WTMA 2XZ6A 3UU3A 4QAAA 3ZDHA 2XNUA 3UUBA 3WTJA 2C9TA 2BYPA 4ZK4A 4Z90A 5IUXA 3JADA 3WIPA 5AFHA 4FRRA 3U8JA 3C84A 2YN6A 2W8GA 2X00A 2VL0A 5HCJA 3WTLA 4A98A 3TLSA 3ZKRA 5JMEA 2BR8A 5J0ZA 2Y58A 2BYQA 2WZYA 3EI0A 2XQ7A 4PIRA 4ZJSA 4HFDA 4LMKA 4QH5A 5BP0A 5L47A 4UM3S 4HQPA 3UU8A 4AFTA 1I9BA 4HFCA 5J5HA 3RHWA 4UM3P 5AFNA 2XZ5A 5L4EA 4TWFA 3UQ4A 5FJVA 3EHZA 3ZDGA 4AFHA 3SQ6A 4LMLA 3T4MA 3U8KA 4NZBA 2YOEA 4NPPA 4UY2A 2YKSA 5HEOA 4AFGA 5HEUA 5KE4A 2YMDA 2XQ9A 3SH1A 4ZK1A 5CO5A 5J5GA 4COFA 3WTKA 2BYNA 5SYOA 4UM3A 5AFMB 4ILBA 4ILCA 3TLTA 2BJ0A 1UX2A 4DBMA 3PMZA 2XQ8A 2ZJVA 3UU4A 3WTHA 5AFKA 2BG9B 4EZ1A 3RI5A 2BYSA 2WN9A 4ALXA 4QACA 4ZJTA 4XHEA 2XYTA 5BW2A 2Y57A 5LG3A 3SQ9A 2WNLA 2QC1B 4IL9A 5L4HA 3C79A 3RIFA 2Y7YA 5AINA 4BQTA 5BRXA 3RIAA 4IREA 2BG9E 4LMJA 2BR7A 4WV9A 4UXUA
chains in the Genus database with same CATH superfamily
2BG9C 3RQUA 4BFQA 2UZ6A 4QABA 4XK9A 4F8HA 2WNJA 3JAFA 2YMEA 4QH4A 2XQ4A 3PEOA 4ZR6A 4HFBA 3TLUA 5HEJA 4TNVA 4TWHA 4Z91A 3U8NA 4A97A 4HFHA 1UV6A 2XYSA 2ZJUA 4TNWA 4ZRUA 2PGZA 3SIOA 2XQ5A 3UU5A 2XQ3A 1UW6A 3TLWA 4ZZCA 4UM1A 4X5TA 5AFMA 5KZUA 4HFIA 3P50A 5HEGA 3UU6A 4HFEA 5J5IA 4D01A 3IGQA 2BG9A 3EAMA 2XQAA 3LSVA 3U8MA 2XNVA 2XQ6A 4IL4A 3TLVA 3WTIA 5AFLA 3UQ7A 4QH1A 5HCMA 4ZZBA 3WTOA 2XNTA 4B5DA 5CFBA 2W8FA 5AFJA 5LXBA 2BYRA 5HEHA 2WNCA 2Y56A 4ILAA 5J5FA 2Y54A 3JAEA 5TVCA 3GUAA 3RQWA 3WTNA 2PH9A 4TWDA 3U8LA 3P4WA 2X00D 3WTMA 2XZ6A 3UU3A 4QAAA 3ZDHA 2XNUA 3UUBA 3WTJA 2C9TA 2BYPA 4ZK4A 4Z90A 5IUXA 3JADA 3WIPA 5AFHA 4FRRA 3U8JA 3C84A 2YN6A 2W8GA 2X00A 2VL0A 5HCJA 3WTLA 4A98A 3TLSA 3ZKRA 5JMEA 2BR8A 5J0ZA 2Y58A 2BYQA 2WZYA 3EI0A 2XQ7A 4PIRA 4ZJSA 4HFDA 4LMKA 4QH5A 5BP0A 5L47A 4UM3S 4HQPA 3UU8A 4AFTA 1I9BA 4HFCA 5J5HA 3RHWA 4UM3P 5AFNA 2XZ5A 5L4EA 4TWFA 3UQ4A 5FJVA 3EHZA 3ZDGA 4AFHA 3SQ6A 4LMLA 3T4MA 3U8KA 4NZBA 2YOEA 4NPPA 4UY2A 2YKSA 5HEOA 4AFGA 5HEUA 5KE4A 2YMDA 2XQ9A 3SH1A 4ZK1A 5CO5A 5J5GA 4COFA 3WTKA 2BYNA 5SYOA 4UM3A 5AFMB 4ILBA 4ILCA 3TLTA 2BJ0A 1UX2A 4DBMA 3PMZA 2XQ8A 2ZJVA 3UU4A 3WTHA 5AFKA 2BG9B 4EZ1A 3RI5A 2BYSA 2WN9A 4ALXA 4QACA 4ZJTA 4XHEA 2XYTA 5BW2A 2Y57A 5LG3A 3SQ9A 2WNLA 2QC1B 4IL9A 5L4HA 3C79A 3RIFA 2Y7YA 5AINA 4BQTA 5BRXA 3RIAA 4IREA 2BG9E 4LMJA 2BR7A 4WV9A 4UXUA
chains in the Genus database with same CATH topology
2BG9C 3RQUA 4BFQA 2UZ6A 4QABA 4XK9A 4F8HA 2WNJA 3JAFA 2YMEA 4QH4A 2XQ4A 3PEOA 4ZR6A 4HFBA 3TLUA 5HEJA 4TNVA 4TWHA 4Z91A 3U8NA 4A97A 4HFHA 1UV6A 2XYSA 2ZJUA 4TNWA 4ZRUA 2PGZA 3SIOA 2XQ5A 3UU5A 2XQ3A 1UW6A 3TLWA 4ZZCA 4UM1A 4X5TA 5AFMA 5KZUA 4HFIA 3P50A 5HEGA 3UU6A 4HFEA 5J5IA 4D01A 3IGQA 2BG9A 3EAMA 2XQAA 3LSVA 3U8MA 2XNVA 2XQ6A 4IL4A 3TLVA 3WTIA 5AFLA 3UQ7A 4QH1A 5HCMA 4ZZBA 3WTOA 2XNTA 4B5DA 5CFBA 2W8FA 5AFJA 5LXBA 2BYRA 5HEHA 2WNCA 2Y56A 4ILAA 5J5FA 2Y54A 3JAEA 5TVCA 3GUAA 3RQWA 3WTNA 2PH9A 4TWDA 3U8LA 3P4WA 2X00D 3WTMA 2XZ6A 3UU3A 4QAAA 3ZDHA 2XNUA 3UUBA 3WTJA 2C9TA 2BYPA 4ZK4A 4Z90A 5IUXA 3JADA 3WIPA 5AFHA 4FRRA 3U8JA 3C84A 2YN6A 2W8GA 2X00A 2VL0A 5HCJA 3WTLA 4A98A 3TLSA 3ZKRA 5JMEA 2BR8A 5J0ZA 2Y58A 2BYQA 2WZYA 3EI0A 2XQ7A 4PIRA 4ZJSA 4HFDA 4LMKA 4QH5A 5BP0A 5L47A 4UM3S 4HQPA 3UU8A 4AFTA 1I9BA 4HFCA 5J5HA 3RHWA 4UM3P 5AFNA 2XZ5A 5L4EA 4TWFA 3UQ4A 5FJVA 3EHZA 3ZDGA 4AFHA 3SQ6A 4LMLA 3T4MA 3U8KA 4NZBA 2YOEA 4NPPA 4UY2A 2YKSA 5HEOA 4AFGA 5HEUA 5KE4A 2YMDA 2XQ9A 3SH1A 4ZK1A 5CO5A 5J5GA 4COFA 3WTKA 2BYNA 5SYOA 4UM3A 5AFMB 4ILBA 4ILCA 3TLTA 2BJ0A 1UX2A 4DBMA 3PMZA 2XQ8A 2ZJVA 3UU4A 3WTHA 5AFKA 2BG9B 4EZ1A 3RI5A 2BYSA 2WN9A 4ALXA 4QACA 4ZJTA 4XHEA 2XYTA 5BW2A 2Y57A 5LG3A 3SQ9A 2WNLA 2QC1B 4IL9A 5L4HA 3C79A 3RIFA 2Y7YA 5AINA 4BQTA 5BRXA 3RIAA 4IREA 2BG9E 4LMJA 2BR7A 4WV9A 4UXUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BG9 C;  3RQU A;  4BFQ A;  2UZ6 A;  4QAB A;  4XK9 A;  4F8H A;  2WNJ A;  3JAF A;  2YME A;  4QH4 A;  2XQ4 A;  3PEO A;  4ZR6 A;  4HFB A;  3TLU A;  5HEJ A;  4TNV A;  4TWH A;  4Z91 A;  3U8N A;  4A97 A;  4HFH A;  1UV6 A;  2XYS A;  2ZJU A;  4TNW A;  4ZRU A;  2PGZ A;  3SIO A;  2XQ5 A;  3UU5 A;  2XQ3 A;  1UW6 A;  3TLW A;  4ZZC A;  4UM1 A;  4X5T A;  5AFM A;  5KZU A;  4HFI A;  3P50 A;  5HEG A;  3UU6 A;  4HFE A;  5J5I A;  4D01 A;  3IGQ A;  2BG9 A;  3EAM A;  2XQA A;  3LSV A;  3U8M A;  2XNV A;  2XQ6 A;  4IL4 A;  3TLV A;  3WTI A;  5AFL A;  3UQ7 A;  4QH1 A;  5HCM A;  4ZZB A;  3WTO A;  2XNT A;  4B5D A;  5CFB A;  2W8F A;  5AFJ A;  5LXB A;  2BYR A;  5HEH A;  2WNC A;  2Y56 A;  4ILA A;  5J5F A;  2Y54 A;  3JAE A;  5TVC A;  3GUA A;  3RQW A;  3WTN A;  2PH9 A;  4TWD A;  3U8L A;  3P4W A;  2X00 D;  3WTM A;  2XZ6 A;  3UU3 A;  4QAA A;  3ZDH A;  2XNU A;  3UUB A;  3WTJ A;  2C9T A;  2BYP A;  4ZK4 A;  4Z90 A;  5IUX A;  3JAD A;  3WIP A;  5AFH A;  4FRR A;  3U8J A;  3C84 A;  2YN6 A;  2W8G A;  2X00 A;  2VL0 A;  5HCJ A;  3WTL A;  4A98 A;  3TLS A;  3ZKR A;  5JME A;  2BR8 A;  5J0Z A;  2Y58 A;  2BYQ A;  2WZY A;  3EI0 A;  2XQ7 A;  4PIR A;  4ZJS A;  4HFD A;  4LMK A;  4QH5 A;  5BP0 A;  5L47 A;  4UM3 S;  4HQP A;  3UU8 A;  4AFT A;  1I9B A;  4HFC A;  5J5H A;  3RHW A;  4UM3 P;  5AFN A;  2XZ5 A;  5L4E A;  4TWF A;  3UQ4 A;  5FJV A;  3EHZ A;  3ZDG A;  4AFH A;  3SQ6 A;  4LML A;  3T4M A;  3U8K A;  4NZB A;  2YOE A;  4NPP A;  4UY2 A;  2YKS A;  5HEO A;  4AFG A;  5HEU A;  5KE4 A;  2YMD A;  2XQ9 A;  3SH1 A;  4ZK1 A;  5CO5 A;  5J5G A;  4COF A;  3WTK A;  2BYN A;  5SYO A;  4UM3 A;  5AFM B;  4ILB A;  4ILC A;  3TLT A;  2BJ0 A;  1UX2 A;  4DBM A;  3PMZ A;  2XQ8 A;  2ZJV A;  3UU4 A;  3WTH A;  5AFK A;  2BG9 B;  4EZ1 A;  3RI5 A;  2BYS A;  2WN9 A;  4ALX A;  4QAC A;  4ZJT A;  4XHE A;  2XYT A;  5BW2 A;  2Y57 A;  5LG3 A;  3SQ9 A;  2WNL A;  2QC1 B;  4IL9 A;  5L4H A;  3C79 A;  3RIF A;  2Y7Y A;  5AIN A;  4BQT A;  5BRX A;  3RIA A;  4IRE A;  2BG9 E;  4LMJ A;  2BR7 A;  4WV9 A;  4UXU A; 
#chains in the Genus database with same CATH topology
 2BG9 C;  3RQU A;  4BFQ A;  2UZ6 A;  4QAB A;  4XK9 A;  4F8H A;  2WNJ A;  3JAF A;  2YME A;  4QH4 A;  2XQ4 A;  3PEO A;  4ZR6 A;  4HFB A;  3TLU A;  5HEJ A;  4TNV A;  4TWH A;  4Z91 A;  3U8N A;  4A97 A;  4HFH A;  1UV6 A;  2XYS A;  2ZJU A;  4TNW A;  4ZRU A;  2PGZ A;  3SIO A;  2XQ5 A;  3UU5 A;  2XQ3 A;  1UW6 A;  3TLW A;  4ZZC A;  4UM1 A;  4X5T A;  5AFM A;  5KZU A;  4HFI A;  3P50 A;  5HEG A;  3UU6 A;  4HFE A;  5J5I A;  4D01 A;  3IGQ A;  2BG9 A;  3EAM A;  2XQA A;  3LSV A;  3U8M A;  2XNV A;  2XQ6 A;  4IL4 A;  3TLV A;  3WTI A;  5AFL A;  3UQ7 A;  4QH1 A;  5HCM A;  4ZZB A;  3WTO A;  2XNT A;  4B5D A;  5CFB A;  2W8F A;  5AFJ A;  5LXB A;  2BYR A;  5HEH A;  2WNC A;  2Y56 A;  4ILA A;  5J5F A;  2Y54 A;  3JAE A;  5TVC A;  3GUA A;  3RQW A;  3WTN A;  2PH9 A;  4TWD A;  3U8L A;  3P4W A;  2X00 D;  3WTM A;  2XZ6 A;  3UU3 A;  4QAA A;  3ZDH A;  2XNU A;  3UUB A;  3WTJ A;  2C9T A;  2BYP A;  4ZK4 A;  4Z90 A;  5IUX A;  3JAD A;  3WIP A;  5AFH A;  4FRR A;  3U8J A;  3C84 A;  2YN6 A;  2W8G A;  2X00 A;  2VL0 A;  5HCJ A;  3WTL A;  4A98 A;  3TLS A;  3ZKR A;  5JME A;  2BR8 A;  5J0Z A;  2Y58 A;  2BYQ A;  2WZY A;  3EI0 A;  2XQ7 A;  4PIR A;  4ZJS A;  4HFD A;  4LMK A;  4QH5 A;  5BP0 A;  5L47 A;  4UM3 S;  4HQP A;  3UU8 A;  4AFT A;  1I9B A;  4HFC A;  5J5H A;  3RHW A;  4UM3 P;  5AFN A;  2XZ5 A;  5L4E A;  4TWF A;  3UQ4 A;  5FJV A;  3EHZ A;  3ZDG A;  4AFH A;  3SQ6 A;  4LML A;  3T4M A;  3U8K A;  4NZB A;  2YOE A;  4NPP A;  4UY2 A;  2YKS A;  5HEO A;  4AFG A;  5HEU A;  5KE4 A;  2YMD A;  2XQ9 A;  3SH1 A;  4ZK1 A;  5CO5 A;  5J5G A;  4COF A;  3WTK A;  2BYN A;  5SYO A;  4UM3 A;  5AFM B;  4ILB A;  4ILC A;  3TLT A;  2BJ0 A;  1UX2 A;  4DBM A;  3PMZ A;  2XQ8 A;  2ZJV A;  3UU4 A;  3WTH A;  5AFK A;  2BG9 B;  4EZ1 A;  3RI5 A;  2BYS A;  2WN9 A;  4ALX A;  4QAC A;  4ZJT A;  4XHE A;  2XYT A;  5BW2 A;  2Y57 A;  5LG3 A;  3SQ9 A;  2WNL A;  2QC1 B;  4IL9 A;  5L4H A;  3C79 A;  3RIF A;  2Y7Y A;  5AIN A;  4BQT A;  5BRX A;  3RIA A;  4IRE A;  2BG9 E;  4LMJ A;  2BR7 A;  4WV9 A;  4UXU A; 
#chains in the Genus database with same CATH homology
 2BG9 C;  3RQU A;  4BFQ A;  2UZ6 A;  4QAB A;  4XK9 A;  4F8H A;  2WNJ A;  3JAF A;  2YME A;  4QH4 A;  2XQ4 A;  3PEO A;  4ZR6 A;  4HFB A;  3TLU A;  5HEJ A;  4TNV A;  4TWH A;  4Z91 A;  3U8N A;  4A97 A;  4HFH A;  1UV6 A;  2XYS A;  2ZJU A;  4TNW A;  4ZRU A;  2PGZ A;  3SIO A;  2XQ5 A;  3UU5 A;  2XQ3 A;  1UW6 A;  3TLW A;  4ZZC A;  4UM1 A;  4X5T A;  5AFM A;  5KZU A;  4HFI A;  3P50 A;  5HEG A;  3UU6 A;  4HFE A;  5J5I A;  4D01 A;  3IGQ A;  2BG9 A;  3EAM A;  2XQA A;  3LSV A;  3U8M A;  2XNV A;  2XQ6 A;  4IL4 A;  3TLV A;  3WTI A;  5AFL A;  3UQ7 A;  4QH1 A;  5HCM A;  4ZZB A;  3WTO A;  2XNT A;  4B5D A;  5CFB A;  2W8F A;  5AFJ A;  5LXB A;  2BYR A;  5HEH A;  2WNC A;  2Y56 A;  4ILA A;  5J5F A;  2Y54 A;  3JAE A;  5TVC A;  3GUA A;  3RQW A;  3WTN A;  2PH9 A;  4TWD A;  3U8L A;  3P4W A;  2X00 D;  3WTM A;  2XZ6 A;  3UU3 A;  4QAA A;  3ZDH A;  2XNU A;  3UUB A;  3WTJ A;  2C9T A;  2BYP A;  4ZK4 A;  4Z90 A;  5IUX A;  3JAD A;  3WIP A;  5AFH A;  4FRR A;  3U8J A;  3C84 A;  2YN6 A;  2W8G A;  2X00 A;  2VL0 A;  5HCJ A;  3WTL A;  4A98 A;  3TLS A;  3ZKR A;  5JME A;  2BR8 A;  5J0Z A;  2Y58 A;  2BYQ A;  2WZY A;  3EI0 A;  2XQ7 A;  4PIR A;  4ZJS A;  4HFD A;  4LMK A;  4QH5 A;  5BP0 A;  5L47 A;  4UM3 S;  4HQP A;  3UU8 A;  4AFT A;  1I9B A;  4HFC A;  5J5H A;  3RHW A;  4UM3 P;  5AFN A;  2XZ5 A;  5L4E A;  4TWF A;  3UQ4 A;  5FJV A;  3EHZ A;  3ZDG A;  4AFH A;  3SQ6 A;  4LML A;  3T4M A;  3U8K A;  4NZB A;  2YOE A;  4NPP A;  4UY2 A;  2YKS A;  5HEO A;  4AFG A;  5HEU A;  5KE4 A;  2YMD A;  2XQ9 A;  3SH1 A;  4ZK1 A;  5CO5 A;  5J5G A;  4COF A;  3WTK A;  2BYN A;  5SYO A;  4UM3 A;  5AFM B;  4ILB A;  4ILC A;  3TLT A;  2BJ0 A;  1UX2 A;  4DBM A;  3PMZ A;  2XQ8 A;  2ZJV A;  3UU4 A;  3WTH A;  5AFK A;  2BG9 B;  4EZ1 A;  3RI5 A;  2BYS A;  2WN9 A;  4ALX A;  4QAC A;  4ZJT A;  4XHE A;  2XYT A;  5BW2 A;  2Y57 A;  5LG3 A;  3SQ9 A;  2WNL A;  2QC1 B;  4IL9 A;  5L4H A;  3C79 A;  3RIF A;  2Y7Y A;  5AIN A;  4BQT A;  5BRX A;  3RIA A;  4IRE A;  2BG9 E;  4LMJ A;  2BR7 A;  4WV9 A;  4UXU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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