5THUA

Crystal structure of g304a hdac8 in complex with m344
Total Genus 134
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
365
structure length
358
Chain Sequence
b'LVPVYIYSPEYVSMCDSKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGAGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Histone deacetylase 8
publication title Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 134
structure length 358
sequence length 365
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5thuA00
3Q9FA 3MZ3A 5BWZA 3MZ6A 1C3RA 4ZUQA 5G12A 4BZ8A 5IWGA 4CBYA 5G0JA 1C3PA 5EENA 3MAXA 3MZ4A 4QA5A 5G1CA 3Q9BA 4ZURA 4CQFA 1ZZ3A 4A69A 1T69A 3ZNRA 5A2SA 5EFJD 5G0GA 4QA2A 3ZNSA 3C10A 4QA3A 3F07A 2GH6A 5JI5A 1VKGA 4QA6A 5G0XA 2VQVA 4QA1A 5G1BA 5EFBD 3SFFA 5ICNB 4ZUPA 3C0YA 5THSA 3Q9CA 3SFHA 5FCWA 4QA0A 5DC7A 5G17A 2VCGA 3MENA 5EFNA 3EWFA 5G13A 5EFHA 5G3WA 3EW8A 4BZ7A 4BKXB 3EZPA 5EF8A 2VQQA 5G11A 4RN2A 4ZUMA 4BZ6A 2VQOA 4CBTA 5D1BA 5THUA 5LI3A 3F0RA 5FUEA 1ZZ1A 4ZUOA 3EZTA 2VQMA 5D1CA 3Q9EA 5EFGA 1C3SA 5G0YA 4RN0A 5THTA 5EFKB 2V5WA 5G1AA 5EF7A 5EEKA 5EEMA 1T64A 5EEFA 5IX0A 2V5XA 3RQDA 2VQJA 4LXZA 5G10A 5EEIA 3F06A 4QA4A 4BZ9A 1T67A 5THVA 4ZUNA 5DC6A 1ZZ0A 5G0IA 3MZ7A 1W22A 4QA7A 4RN1A 4BZ5A 2VQWG 3C0ZA 5G0HA 5D1DA 5DC8A 5DC5A 4LY1A
chains in the Genus database with same CATH superfamily
3SL1A 3Q9FA 3MZ3A 2EF4A 4IXUA 3MZ6A 5BWZA 4MYFA 4RHLA 1C3RA 4ZUQA 4DZ4A 1ZPGA 1T5GA 3NIOA 1P8NA 2RLAA 5G12A 4Q40A 4BZ8A 5IWGA 4BZ5A 4CBYA 1TA1A 1WOIA 4Q3UA 4GSMA 1P8MA 5G0JA 1C3PA 4IU4A 1WVBA 3MAXA 3MZ4A 5EENA 4QA5A 3SJTA 5G1CA 4MXRA 3Q9BA 4ZURA 4CQFA 4IU0A 1ZZ3A 4IE3A 4IE2A 1T69A 3ZNRA 4A69A 5A2SA 3E8ZA 3NIPA 5EFJD 1T4PA 1GQ7A 3SKKA 4GWCA 3MMRA 3NIQA 4QA2A 5G0GA 3ZNSA 3C10A 4QA3A 3TH7A 1P8OA 5RLAA 5HJAA 2PHAA 3F07A 4HXQA 2GH6A 5JI5A 1TBHA 1VKGA 4QA6A 3KV2A 2CEVA 5G0XA 4Q3SA 2VQVA 4Q3RC 4QA1A 5G1BA 5EFBD 1P8RA 3SFFA 5ICNB 1D3VA 4RLAA 3SL0A 4ZUPA 1HQFA 3C0YA 5THSA 4IE1A 4Q3RA 5HJ9A 3Q9CA 4MYLA 4GWDA 3M1RA 2A0MA 1P8PA 1T4RA 1XFKA 5G0IA 3THHA 4RHQA 3SFHA 4GSVA 5FCWA 4QA0A 5DC7A 5G17A 3E8QA 4RHIA 2VCGA 3MENA 4RHMA 5EFNA 3DJ8A 3EWFA 4GSZA 3CEVA 4Q3QA 2PLLA 1CEVA 5EFHA 5G3WA 5G13A 3EW8A 1P8QA 4RHKA 4BZ7A 4BKXB 3PZLA 3E6VA 4Q41A 3EZPA 3E6KA 4HZEA 4MYNA 3LP7A 5EF8A 1HQGA 2VQQA 5G11A 1WOGA 4RN2A 1GQ6A 4ZUMA 3LHLA 3MJLA 1WOHA 1P8SA 4Q3VA 4BZ6A 2VQOA 4Q42A 4CBTA 5D1BA 5THUA 5LI3A 3MFVA 4MYKA 4Q3PA 3F0RA 5FUEA 2AEBA 4HWWA 4ITYA 3THJA 1ZZ1A 3EZTA 2VQMA 1T4TA 4ZUOA 5D1CA 3THEA 3Q9EA 2ZAVA 4IXVA 5EFGA 4I06A 1C3SA 5G0YA 2PHOA 4RN0A 1TBJA 3RLAA 5THTA 5EFKB 3E9BA 3F80A 2V5WA 4RHJA 5EF7A 5EEKA 5EEMA 5G1AA 1T64A 5EEFA 5IX0A 4G3HA 2V5XA 4FCKA 3RQDA 1T5FA 2VQJA 4LXZA 5G10A 5CEVA 5EEIA 1HQ5A 3TF3A 3F06A 4QA4A 4BZ9A 1HQHA 1T67A 3GN0A 5THVA 1ZPEA 2EIVA 4CEVA 1HQXA 1RLAA 5DC6A 1ZZ0A 4ZUNA 3MZ7A 3LP4A 4FCIA 4Q3TA 1W22A 1R1OA 4IU5A 4IU1A 2VQWG 3GMZA 3C0ZA 4QA7A 4RN1A 5G0HA 5D1DA 3MFWA 1WVAA 5DC8A 1T4SA 2EF5A 5DC5A 1PQ3A 4LY1A 1TBLA
chains in the Genus database with same CATH topology
3Q9FA 3MZ3A 5BWZA 3MZ6A 1C3RA 4ZUQA 5G12A 4BZ8A 5IWGA 4CBYA 5G0JA 1C3PA 5EENA 3MAXA 3MZ4A 4QA5A 5G1CA 3Q9BA 4ZURA 4CQFA 1ZZ3A 4A69A 1T69A 3ZNRA 5A2SA 5EFJD 5G0GA 4QA2A 3ZNSA 3C10A 4QA3A 3F07A 2GH6A 5JI5A 1VKGA 4QA6A 5G0XA 2VQVA 4QA1A 5G1BA 5EFBD 3SFFA 5ICNB 4ZUPA 3C0YA 5THSA 3Q9CA 3SFHA 5FCWA 4QA0A 5DC7A 5G17A 2VCGA 3MENA 5EFNA 3EWFA 5G13A 5EFHA 5G3WA 3EW8A 4BZ7A 4BKXB 3EZPA 5EF8A 2VQQA 5G11A 4RN2A 4ZUMA 4BZ6A 2VQOA 4CBTA 5D1BA 5THUA 5LI3A 3F0RA 5FUEA 1ZZ1A 4ZUOA 3EZTA 2VQMA 5D1CA 3Q9EA 5EFGA 1C3SA 5G0YA 4RN0A 5THTA 5EFKB 2V5WA 5G1AA 5EF7A 5EEKA 5EEMA 1T64A 5EEFA 5IX0A 2V5XA 3RQDA 2VQJA 4LXZA 5G10A 5EEIA 3F06A 4QA4A 4BZ9A 1T67A 5THVA 4ZUNA 5DC6A 1ZZ0A 5G0IA 3MZ7A 1W22A 4QA7A 4RN1A 4BZ5A 2VQWG 3C0ZA 5G0HA 5D1DA 5DC8A 5DC5A 4LY1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q9F A;  3MZ3 A;  5BWZ A;  3MZ6 A;  1C3R A;  4ZUQ A;  5G12 A;  4BZ8 A;  5IWG A;  4CBY A;  5G0J A;  1C3P A;  5EEN A;  3MAX A;  3MZ4 A;  4QA5 A;  5G1C A;  3Q9B A;  4ZUR A;  4CQF A;  1ZZ3 A;  4A69 A;  1T69 A;  3ZNR A;  5A2S A;  5EFJ D;  5G0G A;  4QA2 A;  3ZNS A;  3C10 A;  4QA3 A;  3F07 A;  2GH6 A;  5JI5 A;  1VKG A;  4QA6 A;  5G0X A;  2VQV A;  4QA1 A;  5G1B A;  5EFB D;  3SFF A;  5ICN B;  4ZUP A;  3C0Y A;  5THS A;  3Q9C A;  3SFH A;  5FCW A;  4QA0 A;  5DC7 A;  5G17 A;  2VCG A;  3MEN A;  5EFN A;  3EWF A;  5G13 A;  5EFH A;  5G3W A;  3EW8 A;  4BZ7 A;  4BKX B;  3EZP A;  5EF8 A;  2VQQ A;  5G11 A;  4RN2 A;  4ZUM A;  4BZ6 A;  2VQO A;  4CBT A;  5D1B A;  5THU A;  5LI3 A;  3F0R A;  5FUE A;  1ZZ1 A;  4ZUO A;  3EZT A;  2VQM A;  5D1C A;  3Q9E A;  5EFG A;  1C3S A;  5G0Y A;  4RN0 A;  5THT A;  5EFK B;  2V5W A;  5G1A A;  5EF7 A;  5EEK A;  5EEM A;  1T64 A;  5EEF A;  5IX0 A;  2V5X A;  3RQD A;  2VQJ A;  4LXZ A;  5G10 A;  5EEI A;  3F06 A;  4QA4 A;  4BZ9 A;  1T67 A;  5THV A;  4ZUN A;  5DC6 A;  1ZZ0 A;  5G0I A;  3MZ7 A;  1W22 A;  4QA7 A;  4RN1 A;  4BZ5 A;  2VQW G;  3C0Z A;  5G0H A;  5D1D A;  5DC8 A;  5DC5 A;  4LY1 A; 
#chains in the Genus database with same CATH topology
 3SL1 A;  3Q9F A;  3MZ3 A;  2EF4 A;  4IXU A;  3MZ6 A;  5BWZ A;  4MYF A;  4RHL A;  1C3R A;  4ZUQ A;  4DZ4 A;  1ZPG A;  1T5G A;  3NIO A;  1P8N A;  2RLA A;  5G12 A;  4Q40 A;  4BZ8 A;  5IWG A;  4BZ5 A;  4CBY A;  1TA1 A;  1WOI A;  4Q3U A;  4GSM A;  1P8M A;  5G0J A;  1C3P A;  4IU4 A;  1WVB A;  3MAX A;  3MZ4 A;  5EEN A;  4QA5 A;  3SJT A;  5G1C A;  4MXR A;  3Q9B A;  4ZUR A;  4CQF A;  4IU0 A;  1ZZ3 A;  4IE3 A;  4IE2 A;  1T69 A;  3ZNR A;  4A69 A;  5A2S A;  3E8Z A;  3NIP A;  5EFJ D;  1T4P A;  1GQ7 A;  3SKK A;  4GWC A;  3MMR A;  3NIQ A;  4QA2 A;  5G0G A;  3ZNS A;  3C10 A;  4QA3 A;  3TH7 A;  1P8O A;  5RLA A;  5HJA A;  2PHA A;  3F07 A;  4HXQ A;  2GH6 A;  5JI5 A;  1TBH A;  1VKG A;  4QA6 A;  3KV2 A;  2CEV A;  5G0X A;  4Q3S A;  2VQV A;  4Q3R C;  4QA1 A;  5G1B A;  5EFB D;  1P8R A;  3SFF A;  5ICN B;  1D3V A;  4RLA A;  3SL0 A;  4ZUP A;  1HQF A;  3C0Y A;  5THS A;  4IE1 A;  4Q3R A;  5HJ9 A;  3Q9C A;  4MYL A;  4GWD A;  3M1R A;  2A0M A;  1P8P A;  1T4R A;  1XFK A;  5G0I A;  3THH A;  4RHQ A;  3SFH A;  4GSV A;  5FCW A;  4QA0 A;  5DC7 A;  5G17 A;  3E8Q A;  4RHI A;  2VCG A;  3MEN A;  4RHM A;  5EFN A;  3DJ8 A;  3EWF A;  4GSZ A;  3CEV A;  4Q3Q A;  2PLL A;  1CEV A;  5EFH A;  5G3W A;  5G13 A;  3EW8 A;  1P8Q A;  4RHK A;  4BZ7 A;  4BKX B;  3PZL A;  3E6V A;  4Q41 A;  3EZP A;  3E6K A;  4HZE A;  4MYN A;  3LP7 A;  5EF8 A;  1HQG A;  2VQQ A;  5G11 A;  1WOG A;  4RN2 A;  1GQ6 A;  4ZUM A;  3LHL A;  3MJL A;  1WOH A;  1P8S A;  4Q3V A;  4BZ6 A;  2VQO A;  4Q42 A;  4CBT A;  5D1B A;  5THU A;  5LI3 A;  3MFV A;  4MYK A;  4Q3P A;  3F0R A;  5FUE A;  2AEB A;  4HWW A;  4ITY A;  3THJ A;  1ZZ1 A;  3EZT A;  2VQM A;  1T4T A;  4ZUO A;  5D1C A;  3THE A;  3Q9E A;  2ZAV A;  4IXV A;  5EFG A;  4I06 A;  1C3S A;  5G0Y A;  2PHO A;  4RN0 A;  1TBJ A;  3RLA A;  5THT A;  5EFK B;  3E9B A;  3F80 A;  2V5W A;  4RHJ A;  5EF7 A;  5EEK A;  5EEM A;  5G1A A;  1T64 A;  5EEF A;  5IX0 A;  4G3H A;  2V5X A;  4FCK A;  3RQD A;  1T5F A;  2VQJ A;  4LXZ A;  5G10 A;  5CEV A;  5EEI A;  1HQ5 A;  3TF3 A;  3F06 A;  4QA4 A;  4BZ9 A;  1HQH A;  1T67 A;  3GN0 A;  5THV A;  1ZPE A;  2EIV A;  4CEV A;  1HQX A;  1RLA A;  5DC6 A;  1ZZ0 A;  4ZUN A;  3MZ7 A;  3LP4 A;  4FCI A;  4Q3T A;  1W22 A;  1R1O A;  4IU5 A;  4IU1 A;  2VQW G;  3GMZ A;  3C0Z A;  4QA7 A;  4RN1 A;  5G0H A;  5D1D A;  3MFW A;  1WVA A;  5DC8 A;  1T4S A;  2EF5 A;  5DC5 A;  1PQ3 A;  4LY1 A;  1TBL A; 
#chains in the Genus database with same CATH homology
 3Q9F A;  3MZ3 A;  5BWZ A;  3MZ6 A;  1C3R A;  4ZUQ A;  5G12 A;  4BZ8 A;  5IWG A;  4CBY A;  5G0J A;  1C3P A;  5EEN A;  3MAX A;  3MZ4 A;  4QA5 A;  5G1C A;  3Q9B A;  4ZUR A;  4CQF A;  1ZZ3 A;  4A69 A;  1T69 A;  3ZNR A;  5A2S A;  5EFJ D;  5G0G A;  4QA2 A;  3ZNS A;  3C10 A;  4QA3 A;  3F07 A;  2GH6 A;  5JI5 A;  1VKG A;  4QA6 A;  5G0X A;  2VQV A;  4QA1 A;  5G1B A;  5EFB D;  3SFF A;  5ICN B;  4ZUP A;  3C0Y A;  5THS A;  3Q9C A;  3SFH A;  5FCW A;  4QA0 A;  5DC7 A;  5G17 A;  2VCG A;  3MEN A;  5EFN A;  3EWF A;  5G13 A;  5EFH A;  5G3W A;  3EW8 A;  4BZ7 A;  4BKX B;  3EZP A;  5EF8 A;  2VQQ A;  5G11 A;  4RN2 A;  4ZUM A;  4BZ6 A;  2VQO A;  4CBT A;  5D1B A;  5THU A;  5LI3 A;  3F0R A;  5FUE A;  1ZZ1 A;  4ZUO A;  3EZT A;  2VQM A;  5D1C A;  3Q9E A;  5EFG A;  1C3S A;  5G0Y A;  4RN0 A;  5THT A;  5EFK B;  2V5W A;  5G1A A;  5EF7 A;  5EEK A;  5EEM A;  1T64 A;  5EEF A;  5IX0 A;  2V5X A;  3RQD A;  2VQJ A;  4LXZ A;  5G10 A;  5EEI A;  3F06 A;  4QA4 A;  4BZ9 A;  1T67 A;  5THV A;  4ZUN A;  5DC6 A;  1ZZ0 A;  5G0I A;  3MZ7 A;  1W22 A;  4QA7 A;  4RN1 A;  4BZ5 A;  2VQW G;  3C0Z A;  5G0H A;  5D1D A;  5DC8 A;  5DC5 A;  4LY1 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...