5THUA

Crystal structure of g304a hdac8 in complex with m344
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
365
structure length
358
Chain Sequence
LVPVYIYSPEYVSMCDSKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGAGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Histone deacetylase 8
publication title Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 134
structure length 358
sequence length 365
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5thuA00
5G13A 2VQVA 4BZ7A 4BZ9A 2VQWG 3MZ6A 4ZUMA 5G1AA 5EEIA 5A2SA 2V5XA 5EFJD 5ICNB 5G12A 3MZ4A 2GH6A 5G0IA 3MENA 3ZNSA 5EFHA 5DC6A 3EZTA 5IX0A 3F07A 5DC5A 5JI5A 4RN2A 1ZZ1A 4QA3A 5G0GA 4CBTA 2VQQA 5G0XA 5IWGA 4LXZA 5FUEA 2V5WA 2VQJA 3MAXA 3MZ7A 5D1CA 5DC8A 4QA7A 5G0YA 5G0JA 4A69A 1VKGA 4ZUQA 5G0HA 5EENA 3F0RA 4CQFA 1T64A 5EF7A 3EZPA 4BZ5A 4QA2A 3Q9EA 5EFBD 3Q9CA 5G11A 5EEMA 2VCGA 5D1DA 5THSA 3MZ3A 4QA5A 3ZNRA 4ZUNA 3Q9BA 4BZ6A 4QA0A 4RN0A 3SFFA 3RQDA 2VQMA 5DC7A 4LY1A 2VQOA 5EFKB 4ZUOA 5THUA 1T67A 5EFGA 3Q9FA 5LI3A 4QA6A 5THTA 1W22A 3F06A 1ZZ0A 3C0ZA 5D1BA 5THVA 1C3SA 3SFHA 3EW8A 3C10A 5G1CA 5EFNA 5G17A 1C3PA 1C3RA 4ZUPA 4ZURA 4QA4A 5EEKA 5FCWA 3EWFA 5EF8A 5EEFA 4CBYA 4BZ8A 1ZZ3A 5BWZA 5G10A 4RN1A 1T69A 4QA1A 5G3WA 4BKXB 3C0YA 5G1BA
chains in the Genus database with same CATH superfamily
5HJ9A 3E8ZA 1GQ7A 4Q3TA 5G13A 3GMZA 2VQVA 1P8RA 3F80A 4ITYA 4BZ7A 1ZPEA 4BZ9A 2VQWG 3RLAA 3MZ6A 4ZUMA 4Q3QA 3E6KA 5G1AA 1P8MA 1XFKA 3NIOA 1WOGA 5EEIA 1WVAA 4RHIA 5A2SA 2V5XA 3PZLA 5EFJD 4IXVA 5ICNB 4Q42A 4GSMA 5G12A 2EF4A 3MZ4A 3SKKA 4IU4A 2GH6A 1T4SA 5G0IA 3MENA 3DJ8A 4Q41A 3ZNSA 4MYLA 3E9BA 4RHJA 1R1OA 1T4PA 4Q3VA 5EFHA 1TBJA 5DC6A 4RHLA 3EZTA 4Q3SA 5IX0A 3F07A 1HQFA 5DC5A 5JI5A 4CEVA 4Q40A 4RN2A 1ZZ1A 4QA3A 5G0GA 3THEA 1WVBA 2VQQA 3MMRA 5G0XA 4GSVA 4LXZA 3LP7A 5IWGA 3CEVA 5FUEA 2V5WA 2VQJA 5RLAA 1T4TA 3MAXA 3MZ7A 4IE1A 1HQHA 5D1CA 5DC8A 3THHA 4DZ4A 4FCKA 4Q3PA 5CEVA 5HJAA 4QA7A 5G0YA 4HXQA 3KV2A 5G0JA 1T4RA 4A69A 1VKGA 4IU0A 4ZUQA 1TBHA 5G0HA 4MYKA 4Q3UA 4IXUA 4FCIA 5EENA 3F0RA 1D3VA 4CQFA 1T5GA 3E8QA 1T64A 4GSZA 3SL0A 5EF7A 3EZPA 1GQ6A 2AEBA 2PHAA 4IE2A 4QA2A 4BZ5A 3Q9EA 3M1RA 5EFBD 3TH7A 3Q9CA 5G11A 1P8NA 5EEMA 2VCGA 4IU5A 2EIVA 5D1DA 4MXRA 5THSA 3MZ3A 2CEVA 1HQXA 1PQ3A 4QA5A 3NIPA 3ZNRA 4MYFA 1T5FA 1P8SA 4ZUNA 3Q9BA 4BZ6A 4QA0A 4GWCA 4Q3RA 4RN0A 3E6VA 3SFFA 3THJA 3RQDA 2VQMA 2A0MA 5DC7A 4LY1A 3MFVA 4CBTA 1WOIA 2VQOA 4RHMA 5EFKB 4HZEA 4ZUOA 5THUA 1T67A 5EFGA 4Q3RC 3Q9FA 1P8PA 5LI3A 3NIQA 4QA6A 5THTA 1W22A 1TBLA 3F06A 1ZZ0A 3SL1A 3C0ZA 5D1BA 5THVA 3TF3A 1C3SA 2PLLA 4GWDA 4RHQA 1ZPGA 4IE3A 3GN0A 2EF5A 2ZAVA 3SFHA 4RHKA 3EW8A 3C10A 1P8OA 5EFNA 5G1CA 1C3PA 1C3RA 5G17A 1TA1A 4ZUPA 2RLAA 4QA4A 4ZURA 1HQGA 3SJTA 1HQ5A 3MJLA 5EEKA 4G3HA 5FCWA 1CEVA 3EWFA 4IU1A 5EF8A 5EEFA 4CBYA 1P8QA 1ZZ3A 4BZ8A 4I06A 1RLAA 5BWZA 4RLAA 5G10A 4RN1A 4HWWA 1T69A 3LP4A 3MFWA 3LHLA 4MYNA 1WOHA 4QA1A 5G3WA 2PHOA 4BKXB 3C0YA 5G1BA
chains in the Genus database with same CATH topology
5G13A 2VQVA 4BZ7A 4BZ9A 2VQWG 3MZ6A 4ZUMA 5G1AA 5EEIA 5A2SA 2V5XA 5EFJD 5ICNB 5G12A 3MZ4A 2GH6A 5G0IA 3MENA 3ZNSA 5EFHA 5DC6A 3EZTA 5IX0A 3F07A 5DC5A 5JI5A 4RN2A 1ZZ1A 4QA3A 5G0GA 4CBTA 2VQQA 5G0XA 5IWGA 4LXZA 5FUEA 2V5WA 2VQJA 3MAXA 3MZ7A 5D1CA 5DC8A 4QA7A 5G0YA 5G0JA 4A69A 1VKGA 4ZUQA 5G0HA 5EENA 3F0RA 4CQFA 1T64A 5EF7A 3EZPA 4BZ5A 4QA2A 3Q9EA 5EFBD 3Q9CA 5G11A 5EEMA 2VCGA 5D1DA 5THSA 3MZ3A 4QA5A 3ZNRA 4ZUNA 3Q9BA 4BZ6A 4QA0A 4RN0A 3SFFA 3RQDA 2VQMA 5DC7A 4LY1A 2VQOA 5EFKB 4ZUOA 5THUA 1T67A 5EFGA 3Q9FA 5LI3A 4QA6A 5THTA 1W22A 3F06A 1ZZ0A 3C0ZA 5D1BA 5THVA 1C3SA 3SFHA 3EW8A 3C10A 5G1CA 5EFNA 5G17A 1C3PA 1C3RA 4ZUPA 4ZURA 4QA4A 5EEKA 5FCWA 3EWFA 5EF8A 5EEFA 4CBYA 4BZ8A 1ZZ3A 5BWZA 5G10A 4RN1A 1T69A 4QA1A 5G3WA 4BKXB 3C0YA 5G1BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G13 A;  2VQV A;  4BZ7 A;  4BZ9 A;  2VQW G;  3MZ6 A;  4ZUM A;  5G1A A;  5EEI A;  5A2S A;  2V5X A;  5EFJ D;  5ICN B;  5G12 A;  3MZ4 A;  2GH6 A;  5G0I A;  3MEN A;  3ZNS A;  5EFH A;  5DC6 A;  3EZT A;  5IX0 A;  3F07 A;  5DC5 A;  5JI5 A;  4RN2 A;  1ZZ1 A;  4QA3 A;  5G0G A;  4CBT A;  2VQQ A;  5G0X A;  5IWG A;  4LXZ A;  5FUE A;  2V5W A;  2VQJ A;  3MAX A;  3MZ7 A;  5D1C A;  5DC8 A;  4QA7 A;  5G0Y A;  5G0J A;  4A69 A;  1VKG A;  4ZUQ A;  5G0H A;  5EEN A;  3F0R A;  4CQF A;  1T64 A;  5EF7 A;  3EZP A;  4BZ5 A;  4QA2 A;  3Q9E A;  5EFB D;  3Q9C A;  5G11 A;  5EEM A;  2VCG A;  5D1D A;  5THS A;  3MZ3 A;  4QA5 A;  3ZNR A;  4ZUN A;  3Q9B A;  4BZ6 A;  4QA0 A;  4RN0 A;  3SFF A;  3RQD A;  2VQM A;  5DC7 A;  4LY1 A;  2VQO A;  5EFK B;  4ZUO A;  5THU A;  1T67 A;  5EFG A;  3Q9F A;  5LI3 A;  4QA6 A;  5THT A;  1W22 A;  3F06 A;  1ZZ0 A;  3C0Z A;  5D1B A;  5THV A;  1C3S A;  3SFH A;  3EW8 A;  3C10 A;  5G1C A;  5EFN A;  5G17 A;  1C3P A;  1C3R A;  4ZUP A;  4ZUR A;  4QA4 A;  5EEK A;  5FCW A;  3EWF A;  5EF8 A;  5EEF A;  4CBY A;  4BZ8 A;  1ZZ3 A;  5BWZ A;  5G10 A;  4RN1 A;  1T69 A;  4QA1 A;  5G3W A;  4BKX B;  3C0Y A;  5G1B A; 
#chains in the Genus database with same CATH topology
 5HJ9 A;  3E8Z A;  1GQ7 A;  4Q3T A;  5G13 A;  3GMZ A;  2VQV A;  1P8R A;  3F80 A;  4ITY A;  4BZ7 A;  1ZPE A;  4BZ9 A;  2VQW G;  3RLA A;  3MZ6 A;  4ZUM A;  4Q3Q A;  3E6K A;  5G1A A;  1P8M A;  1XFK A;  3NIO A;  1WOG A;  5EEI A;  1WVA A;  4RHI A;  5A2S A;  2V5X A;  3PZL A;  5EFJ D;  4IXV A;  5ICN B;  4Q42 A;  4GSM A;  5G12 A;  2EF4 A;  3MZ4 A;  3SKK A;  4IU4 A;  2GH6 A;  1T4S A;  5G0I A;  3MEN A;  3DJ8 A;  4Q41 A;  3ZNS A;  4MYL A;  3E9B A;  4RHJ A;  1R1O A;  1T4P A;  4Q3V A;  5EFH A;  1TBJ A;  5DC6 A;  4RHL A;  3EZT A;  4Q3S A;  5IX0 A;  3F07 A;  1HQF A;  5DC5 A;  5JI5 A;  4CEV A;  4Q40 A;  4RN2 A;  1ZZ1 A;  4QA3 A;  5G0G A;  3THE A;  1WVB A;  2VQQ A;  3MMR A;  5G0X A;  4GSV A;  4LXZ A;  3LP7 A;  5IWG A;  3CEV A;  5FUE A;  2V5W A;  2VQJ A;  5RLA A;  1T4T A;  3MAX A;  3MZ7 A;  4IE1 A;  1HQH A;  5D1C A;  5DC8 A;  3THH A;  4DZ4 A;  4FCK A;  4Q3P A;  5CEV A;  5HJA A;  4QA7 A;  5G0Y A;  4HXQ A;  3KV2 A;  5G0J A;  1T4R A;  4A69 A;  1VKG A;  4IU0 A;  4ZUQ A;  1TBH A;  5G0H A;  4MYK A;  4Q3U A;  4IXU A;  4FCI A;  5EEN A;  3F0R A;  1D3V A;  4CQF A;  1T5G A;  3E8Q A;  1T64 A;  4GSZ A;  3SL0 A;  5EF7 A;  3EZP A;  1GQ6 A;  2AEB A;  2PHA A;  4IE2 A;  4QA2 A;  4BZ5 A;  3Q9E A;  3M1R A;  5EFB D;  3TH7 A;  3Q9C A;  5G11 A;  1P8N A;  5EEM A;  2VCG A;  4IU5 A;  2EIV A;  5D1D A;  4MXR A;  5THS A;  3MZ3 A;  2CEV A;  1HQX A;  1PQ3 A;  4QA5 A;  3NIP A;  3ZNR A;  4MYF A;  1T5F A;  1P8S A;  4ZUN A;  3Q9B A;  4BZ6 A;  4QA0 A;  4GWC A;  4Q3R A;  4RN0 A;  3E6V A;  3SFF A;  3THJ A;  3RQD A;  2VQM A;  2A0M A;  5DC7 A;  4LY1 A;  3MFV A;  4CBT A;  1WOI A;  2VQO A;  4RHM A;  5EFK B;  4HZE A;  4ZUO A;  5THU A;  1T67 A;  5EFG A;  4Q3R C;  3Q9F A;  1P8P A;  5LI3 A;  3NIQ A;  4QA6 A;  5THT A;  1W22 A;  1TBL A;  3F06 A;  1ZZ0 A;  3SL1 A;  3C0Z A;  5D1B A;  5THV A;  3TF3 A;  1C3S A;  2PLL A;  4GWD A;  4RHQ A;  1ZPG A;  4IE3 A;  3GN0 A;  2EF5 A;  2ZAV A;  3SFH A;  4RHK A;  3EW8 A;  3C10 A;  1P8O A;  5EFN A;  5G1C A;  1C3P A;  1C3R A;  5G17 A;  1TA1 A;  4ZUP A;  2RLA A;  4QA4 A;  4ZUR A;  1HQG A;  3SJT A;  1HQ5 A;  3MJL A;  5EEK A;  4G3H A;  5FCW A;  1CEV A;  3EWF A;  4IU1 A;  5EF8 A;  5EEF A;  4CBY A;  1P8Q A;  1ZZ3 A;  4BZ8 A;  4I06 A;  1RLA A;  5BWZ A;  4RLA A;  5G10 A;  4RN1 A;  4HWW A;  1T69 A;  3LP4 A;  3MFW A;  3LHL A;  4MYN A;  1WOH A;  4QA1 A;  5G3W A;  2PHO A;  4BKX B;  3C0Y A;  5G1B A; 
#chains in the Genus database with same CATH homology
 5G13 A;  2VQV A;  4BZ7 A;  4BZ9 A;  2VQW G;  3MZ6 A;  4ZUM A;  5G1A A;  5EEI A;  5A2S A;  2V5X A;  5EFJ D;  5ICN B;  5G12 A;  3MZ4 A;  2GH6 A;  5G0I A;  3MEN A;  3ZNS A;  5EFH A;  5DC6 A;  3EZT A;  5IX0 A;  3F07 A;  5DC5 A;  5JI5 A;  4RN2 A;  1ZZ1 A;  4QA3 A;  5G0G A;  4CBT A;  2VQQ A;  5G0X A;  5IWG A;  4LXZ A;  5FUE A;  2V5W A;  2VQJ A;  3MAX A;  3MZ7 A;  5D1C A;  5DC8 A;  4QA7 A;  5G0Y A;  5G0J A;  4A69 A;  1VKG A;  4ZUQ A;  5G0H A;  5EEN A;  3F0R A;  4CQF A;  1T64 A;  5EF7 A;  3EZP A;  4BZ5 A;  4QA2 A;  3Q9E A;  5EFB D;  3Q9C A;  5G11 A;  5EEM A;  2VCG A;  5D1D A;  5THS A;  3MZ3 A;  4QA5 A;  3ZNR A;  4ZUN A;  3Q9B A;  4BZ6 A;  4QA0 A;  4RN0 A;  3SFF A;  3RQD A;  2VQM A;  5DC7 A;  4LY1 A;  2VQO A;  5EFK B;  4ZUO A;  5THU A;  1T67 A;  5EFG A;  3Q9F A;  5LI3 A;  4QA6 A;  5THT A;  1W22 A;  3F06 A;  1ZZ0 A;  3C0Z A;  5D1B A;  5THV A;  1C3S A;  3SFH A;  3EW8 A;  3C10 A;  5G1C A;  5EFN A;  5G17 A;  1C3P A;  1C3R A;  4ZUP A;  4ZUR A;  4QA4 A;  5EEK A;  5FCW A;  3EWF A;  5EF8 A;  5EEF A;  4CBY A;  4BZ8 A;  1ZZ3 A;  5BWZ A;  5G10 A;  4RN1 A;  1T69 A;  4QA1 A;  5G3W A;  4BKX B;  3C0Y A;  5G1B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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